scholarly journals Huge Cystadenocarcinoma of the Ovary Disguising as Degenerating Uterine Fibroid in Pregnancy: Case Report and Literature Review

2021 ◽  
Author(s):  
Adedapo Ande ◽  
Maradona Isikhuemen ◽  
Weyinmi Kubeyinje ◽  
Michael Ezeanochie
Keyword(s):  
Uterine Fibroid ◽  
Uterine Fibroids ◽  
Abdominal Distension ◽  
Case Presentation ◽  
Serous Cystadenocarcinoma ◽  
Index Pregnancy ◽  
Ovarian Tumours ◽  
Adenocarcinoma Of The Ovary ◽  
High Index Of Suspicion ◽  
In Pregnancy

Abstract Background: Ovarian malignancy is rare in pregnancy and constitutes 3 – 6% of all ovarian tumours associated with pregnancy. It is usually asymptomatic, detected during routine antenatal ultrasound scan. Treatment is mainly surgical. The aim of this report is to share our experience in the management of a referred case of papillary serous cystadenocarcinoma of the ovary disguising as degenerating uterine fibroid in pregnancy. The diagnostic challenges and treatment are highlighted with a view to improving care in our setting.Case presentation: A 29 year old gravida 2 para 1 with one living child was referred to our unit at 25 weeks gestation with complaint of progressive painful abdominal distension with dyspnoea noticed in the index pregnancy. Ultrasound scans were suggestive of uterine fibroid in pregnancy with degenerative changes for which she had conservative management. Due to worsening symptoms, she had laparotomy and a huge ovarian mass was removed alongside the affected ovary. Histology confirmed Serous Papillary Cyst Adenocarcinoma of the ovary. She is doing well on adjuvant chemotherapy. Conclusion: A high index of suspicion for ovarian malignancies in pregnancy, coupled with complementing MRI (when available) with ultrasound to differentiate degenerating uterine fibroids is suggested/recommended.

scholarly journals Alban Doran. Two cases of small ovarian tumours simulating uterine fibroid; removal; recovery (Brit. Med. Journ. lune 4, 1892). Two cases of small ovarian tumors mimicking uterine fibroids.

2020 ◽  
Vol 7 (2) ◽  
pp. 189-190
Author(s):  
F. Kuhn
Keyword(s):  
Tumor Growth ◽  
Young Women ◽  
Uterine Fibroid ◽  
Rapid Growth ◽  
Ovarian Tumor ◽  
Uterine Fibroids ◽  
The Other ◽  
Ovarian Disease ◽  
Ovarian Tumours ◽  
Tight Connection

Both cases reported by the author have the following clinical and surgical interest: in both - the tumor was not large and so tightly connected to the uterus that the uterus and tumor moved together; this made one suspect the existence of a uterine fibroid. On the other hand, the age (30 and 24 years) of the patients and the relatively rapid growth of the tumor spoke in favor of ovarian disease, although, again, fibroids can appear in young women and grow quickly, moreover, the indication of the patients themselves regarding tumor growth is usually very erroneous and they deserve full confidence. Under such conditions, exploratory charevoschene was not only justified, but also directly demonstrated. The result of the operation really showed that the further waiting would only increase the danger of the later operation. An ovarian tumor cannot be removed early enough, and this rule is made even more mandatory for the surgeon when the bimanual examination and probe indicate a tight connection of the tumor with the uterus. Removal of a large ovarian tumor with a very short stem or without a stem is an extremely serious operation.

scholarly journals A Case Report of Ovarian Fibrothecoma in a Premenopausal Women with Recurrent Menorrhagia

2020 ◽  
Vol 8 (C) ◽  
pp. 101-105
Author(s):  
Meral Rexhepi ◽  
Elizabeta Trajkovska ◽  
Hysni Ismaili ◽  
Majlinda Azemi
Keyword(s):  
Uterine Fibroids ◽  
Premenopausal Women ◽  
Granulosa Cell Tumor ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Case Presentation ◽  
Mixed Features ◽  
Ovarian Tumours ◽  
Adnexal Tumor ◽  
Proliferative Endometrium

BACKGROUND: Ovarian fibrothecoma is a rare, benign, sex cord-stromal neoplasm, with a typically unilateral location in the ovary, characterized by mixed features of both fibroma and thecoma. Ovarian fibrothecoma is uncommon tumor of gonadal stromal cell origin accounting for 3-4% of all ovarian tumours. CASE PRESENTATION: We presented a rare case of a 46-year-old patient with recurrent menorrhagia in the past two years with no previous medical, surgical or gynecological history. She underwent two times curettage procedures. At the admission to hospital ultrasonography showed a homogenous solid right ovarian mass of size 2.5 cm x 3.5 cm. Endometrial curettage revealed simple hyperplasia of the endometrium. Diagnostic evaluation and surgical management are discussed along with a brief review of the literature. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was carried out. Histopathology confirmed fibrothecoma of the ovary, proliferative endometrium with hyperplasia without atypia and multiple uterine fibroids. CONCLUSION: In all patients presenting with recurrent menorrhagia and adnexal tumor the possibility of a granulosa cell tumor must be kept in mind during evaluation.

scholarly journals Comparative study between vaginal natural progesterone and oral dydrogesterone in prevention of red degeneration of uterine fibroid in pregnancy

2020 ◽  
Vol 9 (8) ◽  
pp. 3330
Author(s):  
Nermeen M. Hefila ◽  
Tarek A. Karkour ◽  
Sara M. Elghareeb ◽  
Tamer M. Abdeldaiem
Keyword(s):  
Uterine Fibroid ◽  
Gestational Age ◽  
Uterine Fibroids ◽  
Pregnant Females ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Red Degeneration ◽  
In Pregnancy ◽  
Natural Progesterone

Background: Uterine leiomyomas are highly prevalent benign monoclonal tumors, arising from the smooth muscle of the myometrium; they occur in up to 50-60% of reproductive age women, causing significant morbidity in up to 30% of women. The most serious complication of uterine fibroids; is red degeneration that causes severe pain, and may lead to preterm labour, miscarriage, fetal and maternal morbidity and mortality. Objective of this study was designed to compare between the effect of vaginal natural MP and oral dydrogesterone in prevention of red degeneration of uterine fibroid during pregnancy.Methods: Patients were recruited from El-Shatby Maternity University Hospital. They were 50 pregnant females, diagnosed having a uterine fibroid more than 3 cm in size then there were divided into two groups, Group A: twenty-five treated by vaginal natural progesterone, Group B: twenty-five treated by oral dydrogesterone. All patients at 14-15 weeks of gestational age underwent complete history taking, clinical examination and ultrasound examination for mean gestational age and assessment of the type and uterine fibroid.Results: Results showed that there were no statistically significant differences as regards age, obstetric history (gravidity and parity), number, Site, grade and size of the fibroid. There was a significant difference between the two studied groups, regarding the acute abdominal pain, it occurred to only 3 cases (12%) in Group A, versus to 16 cases (64%) in Group B. Regarding occurrence of red degeneration, it occurred only to 3 cases (12%) in Group A, while in Group B it occurred to 15 cases (60%).Conclusions: Vaginal natural micronized progesterone is more effective than oral dydrogesterone in prevention of red degeneration of uterine fibroid in pregnancy with fewer complications. Vaginal natural progesterone daily dose of 200 mg is recommended to all pregnant females with uterine fibroids.

scholarly journals Large Uterine Fibroids in Pregnancy with Successful Caesarean Myomectomy

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Edu Eyong ◽  
Okon A. Okon
Keyword(s):  
Birth Weight ◽  
Uterine Fibroid ◽  
Reproductive Tract ◽  
Uterine Fibroids ◽  
Female Reproductive Tract ◽  
Benign Tumour ◽  
First Line ◽  
Female Baby ◽  
In Pregnancy

Uterine fibroid is the commonest benign tumour of the female reproductive tract. It occurs in 20–40% of women, whereas the estimated incidence in pregnancy is 0.1–3.9%. Uterine fibroid in pregnancy is usually asymptomatic with complications occurring in 10–30% of cases. The first line of management is conservative with counselling for myomectomy after delivery. However, in the presence of intractable symptoms, both antepartum myomectomy and caesarean myomectomy have been reported to be successfully performed in carefully selected cases. We report a case of large subserous uterine fibroid in pregnancy that was referred to our centre at 14 weeks of gestation. She developed generalized body weakness, backache, and breathlessness at 27 weeks gestation. Thus, she was admitted and managed conservatively for eight weeks with significant relief of symptoms. She eventually had a caesarean myomectomy at 35 weeks of gestation; the outcome was a live female baby with a birth weight of 2.3 kg and a large subserous fibroid weighing 9.5 kg. We can therefore say that caesarean myomectomy can be safely performed in carefully selected cases.

scholarly journals Enlarged uterine fibroid forming uterine diverticulum during pregnancy: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Erina Akashi ◽  
Tatsuya Ishiguro ◽  
Taro Nonaka ◽  
Akiko Kobayashi ◽  
Koichi Takakuwa ◽  
...  
Keyword(s):  
Uterine Fibroid ◽  
Uterine Fibroids ◽  
Uterine Cavity ◽  
Posterior Wall ◽  
Case Presentation ◽  
Future Fertility ◽  
Resected Tumor ◽  
Elective Cesarean ◽  
Natural Conception ◽  
Gynecologic Neoplasm

Abstract Background Although uterine fibroids are a common gynecologic neoplasm, uterine diverticulum accompanied by a uterine fibroid is unique. In addition, pregnancy complicated with uterine diverticulum is extremely rare. We experienced a case of a uterine fibroid that was associated with a uterine diverticulum that enlarged during pregnancy and puerperium. Case presentation A 25-year-old nulligravida woman had an abnormal uterine cavity surrounded by myomatous mass. After natural conception, the mass and pouch had enlarged during pregnancy. Six months after elective cesarean delivery, she underwent laparotomy because of abdominal pain caused by the myomatous mass and the fluid inside. The tumor was connected to the midline of the posterior wall of the normal uterus. The resected tumor was pathologically diagnosed as leiomyoma and diverticulum. Conclusions Pregnancy can stimulate uterine fibroids to form uterine diverticula. Resection of the diverticulum and fibroid is a useful option for symptomatic patients with desired future fertility.

Management in cases of large uterine myomas in pregnancy

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Aleksandra Stupak ◽  
Marcin Bobiński ◽  
Andrzej Miturski ◽  
Barbara Kalbarczyk ◽  
Anna Kwaśniewska ◽  
...  
Keyword(s):  
Pregnant Woman ◽  
Pain Control ◽  
Clinical Observation ◽  
Uterine Fibroids ◽  
Reproductive Organs ◽  
Benign Tumors ◽  
Premature Delivery ◽  
Case Presentation ◽  
Uterine Myomas ◽  
In Pregnancy

AbstractObjectivesUterine fibroids are the most common benign tumors in women of procreative age. The effects of their occurrence affect the course of pregnancy by increasing the frequency of abortions, premature delivery or premature abruption of the placenta. Medical treatment includes clinical observation, pharmacological pain control, myomectomy during pregnancy or perinatal hysterectomy.Case presentationWe present a survey of literature and the case of a pregnant woman with an enormous uterine fibroid 23×13×16 cm on the basis of which a diagnostic-therapeutic scheme for tumors of the reproductive organs during pregnancy has been developed.ConclusionsThe study presents improved recommendations for management the pregnancies in presence of the uterine myomas based on clinical practice.

scholarly journals Physiopathology and Management of Uterine Fibroids

2020 ◽  
Author(s):  
Joel Noutakdie Tochie ◽  
Therese Gaelle Badjand ◽  
Gregory Ayissi ◽  
Julius Sama Dohbit
Keyword(s):  
Urinary Incontinence ◽  
Pregnant Woman ◽  
Menstrual Cycle ◽  
Uterine Fibroid ◽  
Uterine Fibroids ◽  
Reproductive Age ◽  
Heavy Menstrual Bleeding ◽  
Spontaneous Abortions ◽  
Red Degeneration ◽  
In Pregnancy

Uterine fibroid is the most encountered benign tumour in women of reproductive age. It causes spontaneous abortions, missed abortions, painful red degeneration or infarction of the fibroids, abnormal foetal presentation, obstructed labour, and an increased likelihood of premature deliveries, caesarean deliveries, postpartum haemorrhage in pregnancy, whereas, in the non-pregnant women it is associated an irregular menstrual cycle sometimes associated with heavy menstrual bleeding, infertility, constipation, urinary incontinence, and leiosarcoma transformation. Till date is pathophysiology and management both in the non-pregnant and pregnant woman have not been well described. In this chapter, we present contemporary evidence to help elucidate this enigma.

scholarly journals SARS-CoV-2 infection in an infant with non-respiratory manifestations: a case report

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Muhammad Adel ◽  
Ahmed Magdy
Keyword(s):  
Computed Tomography ◽  
Aplastic Anemia ◽  
Rt Pcr ◽  
Positive Real ◽  
Case Presentation ◽  
Chest Computed Tomography ◽  
High Incidence ◽  
Laboratory Investigations ◽  
High Index Of Suspicion ◽  
Specific Symptoms

Abstract Background Coronavirus disease (COVID-19) presents in children usually with less severe manifestations than in adults. Although fever and cough were reported as the most common symptoms, children can have non-specific symptoms. We describe an infant with aplastic anemia as the main manifestation. Case presentation We describe a case of SARS-CoV-2 infection in an infant without any respiratory symptoms or signs while manifesting principally with pallor and purpura. Pancytopenia with reticulocytopenia was the predominant feature in the initial laboratory investigations, pointing to aplastic anemia. Chest computed tomography surprisingly showed typical findings suggestive of SARS-CoV-2 infection. Infection was later confirmed by positive real-time reverse transcription polymerase chain reaction assay (RT-PCR) for SARS-CoV-2. Conclusions Infants with COVID-19 can have non-specific manifestations and a high index of suspicion should be kept in mind especially in regions with a high incidence of the disease. Chest computed tomography (CT) and testing for SARS-CoV-2 infection by RT-PCR may be considered even in the absence of respiratory manifestations.

scholarly journals Transcriptome Analyses of Myometrium from Fibroid Patients Reveals Phenotypic Differences Compared to Non-Diseased Myometrium

2021 ◽  
Vol 22 (7) ◽  
pp. 3618
Author(s):  
Emmanuel N. Paul ◽  
Gregory W. Burns ◽  
Tyler J. Carpenter ◽  
Joshua A. Grey ◽  
Asgerally T. Fazleabas ◽  
...  
Keyword(s):  
Uterine Fibroid ◽  
Three Dimensional ◽  
Uterine Fibroids ◽  
Principal Component ◽  
Leading Edge ◽  
Gene Set Enrichment ◽  
Phenotypic Differences ◽  
False Discovery ◽  
Gene Sets ◽  
High Concordance

Uterine fibroid tissues are often compared to their matched myometrium in an effort to understand their pathophysiology, but it is not clear whether the myometria of uterine fibroid patients represent truly non-disease control tissues. We analyzed the transcriptomes of myometrial samples from non-fibroid patients (M) and compared them with fibroid (F) and matched myometrial (MF) samples to determine whether there is a phenotypic difference between fibroid and non-fibroid myometria. Multidimensional scaling plots revealed that M samples clustered separately from both MF and F samples. A total of 1169 differentially expressed genes (DEGs) (false discovery rate < 0.05) were observed in the MF comparison with M. Overrepresented Gene Ontology terms showed a high concordance of upregulated gene sets in MF compared to M, particularly extracellular matrix and structure organization. Gene set enrichment analyses showed that the leading-edge genes from the TGFβ signaling and inflammatory response gene sets were significantly enriched in MF. Overall comparison of the three tissues by three-dimensional principal component analyses showed that M, MF, and F samples clustered separately from each other and that a total of 732 DEGs from F vs. M were not found in the F vs. MF, which are likely understudied in the pathogenesis of uterine fibroids and could be key genes for future investigation. These results suggest that the transcriptome of fibroid-associated myometrium is different from that of non-diseased myometrium and that fibroid studies should consider using both matched myometrium and non-diseased myometrium as controls.

scholarly journals Concomitant hepatic tuberculosis and hepatocellular carcinoma: a case report and review of the literature

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hind S. Alsaif ◽  
Ali Hassan ◽  
Osamah Refai ◽  
Khaled Awary ◽  
Haitham Kussaibi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Malignancy ◽  
Ct Guided ◽  
Case Presentation ◽  
Hepatic Tuberculosis ◽  
Ct Guided Biopsy ◽  
History Of ◽  
Abdominal Examination ◽  
Peripheral Arterial ◽  
High Index Of Suspicion

Abstract Background Hepatocellular carcinoma (HCC) is the most common primary liver malignancy that is strongly associated with chronic liver disease. Isolated hepatic tuberculosis is an uncommon type of tuberculosis. Concomitant occurrence of both conditions is extremely rare. Case presentation We report the case of a 47-year-old man who presented with fever and abdominal pain for 3 months prior to presentation. He reported a history of anorexia and significant weight loss. Abdominal examination revealed a tender, enlarged liver. Abdominal computed tomography (CT) demonstrated a solid heterogeneous hepatic mass with peripheral arterial enhancement, but no venous washout, conferring a radiological impression of suspected cholangiocarcinoma. However, a CT-guided biopsy of the lesion resulted in the diagnosis of concomitant HCC and isolated hepatic tuberculosis. Conclusion A rapid increase in tumor size should draw attention to the possibility of a concomitant infectious process. Clinicians must have a high index of suspicion for tuberculosis, especially in patients from endemic areas, in order to initiate early and proper treatment.

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