Course of long COVID symptoms over time in the ComPaRe long COVID prospective e-cohort

Abstract About 10% of the people infected by the severe acute respiratory syndrome coronavirus 2 are reported to experience “long COVID,” that is, persistence of symptoms several weeks after infection. Day-by-day prevalence of long COVID symptoms was determined from responses to the Long COVID Symptom Tool by 837 patients (3075 person-months) with a confirmed infection and enrolled in the ComPaRe long COVID cohort, a prospective cohort of such patients in France. Nine months after disease onset, 88.7% patients reported persistent symptoms and 70% reported a high burden of disease. Over time, the prevalence progressively decreased for 19/53 symptoms (e.g., loss of taste/smell) and was stable for 29/53 symptoms (e.g., fatigue). For 5/53 symptoms (e.g., memory problems), prevalence increased rapidly over the first two months and then reached a plateau. These findings are important for understanding the underlying etiologies and mechanisms of long COVID.

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Course of long COVID symptoms over time in the ComPaRe long COVID prospective e-cohort

10.21203/rs.3.rs-753615/v2 ◽

2021 ◽

Author(s):

Viet-Thi Tran ◽

Raphael Porcher ◽

Isabelle Pane ◽

Philippe Ravaud

Keyword(s):

Chronic Disease ◽

Severe Acute Respiratory Syndrome ◽

Symptom Onset ◽

Adult Patients ◽

Lower Prevalence ◽

Disease Symptoms ◽

Disease Impact ◽

One Year ◽

Day By Day ◽

Over Time

Abstract About 10% of people infected by severe acute respiratory syndrome coronavirus 2 experience post COVID-19 disease. We analysed data from 968 adult patients (5350 person-months) with a confirmed infection enrolled in the ComPaRe long COVID cohort, a disease prevalent prospective e-cohort of such patients in France. Day-by-day prevalence of post COVID-19 symptoms was determined from patients’ responses to the Long COVID Symptom Tool, an online validated self-reported questionnaire assessing 53 post COVID-19 disease symptoms. One year after symptom onset, 84.9% patients still reported their persistence, with a progressively lower prevalence of 27/53 symptoms (e.g., loss of taste/smell); 18/53 symptoms (e.g., dyspnoea) were stable, while the prevalence of 8/53 symptoms (e.g., paraesthesia) had increased. The disease impact on patients’ lives began increasing 6 months after onset, as patients realized they had a chronic disease. Our results should be useful for researchers seeking the potential pathophysiological mechanisms underlying post COVID-19 disease.

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Symptoms persisting after hospitalization for COVID-19: 12 months interim results of the COFLOW study

10.1101/2021.12.11.21267652 ◽

2021 ◽

Author(s):

Martine Bek ◽

Julia C Berentschot ◽

Majanka Heijenbrok ◽

Susanne Huijts ◽

Michel E van Genderen ◽

...

Keyword(s):

Hospital Stay ◽

Muscle Weakness ◽

Length Of Hospital Stay ◽

Female Gender ◽

Severe Illness ◽

Exertional Dyspnea ◽

Persistent Symptoms ◽

Memory Problems ◽

Wide Range ◽

Over Time

Introduction: A large proportion of patients experiences a wide range of sequelae after acute COVID-19 infection, especially after severe illness. The long-term health sequelae need to be assessed. Our objective was to longitudinally assess persistence of symptoms and clusters of symptoms up to 12 months after hospitalization for COVID-19, and to assess determinants of the main persistent symptoms. Methods: In this multicenter prospective cohort study patients with COVID-19 are followed up for 2 years with measurements at 3, 6, 12, and 24 months after hospital discharge. Here, we present interim results regarding persistent symptoms up to 12 months. Symptoms were clustered into physical, respiratory, cognitive and fatigue symptoms. Results: We included 492 patients; mean age was 60.2 years, 335 (68.1%) males, median length of hospital stay 11 days. At 3 months after discharge 97.0% of the patients had at least 1 persisting symptom, this declined to 95.5% and 92.0% at 6 and 12 months, respectively (p=0.010). Muscle weakness, exertional dyspnea, fatigue, and memory and concentration problems were the most prevalent symptoms with rates over 50% during follow-up. Over time, muscle weakness, hair loss, and exertional dyspnea decreased significantly (p<0.001), while other symptoms, such as fatigue, concentration and memory problems, anosmia, and ageusia persisted. Symptoms from the physical and respiratory cluster declined significantly over time, in contrast to symptoms from the fatigue and cognitive clusters. Female gender was the most important predictor of persistent symptoms and co-occurrence of symptoms from all clusters. Shorter hospital stay and treatment with steroids were related with decreased muscle weakness; comorbidity and being employed were related with increased fatigue; and shorter hospital stay and comorbidity were related with memory problems. Conclusion: The majority of patients experienced COVID-19 sequelae up to 12 months after hospitalization. Whereas physical and respiratory symptoms showed slow gradual decline, fatigue and cognitive symptoms did not evidently resolve over time. This finding stresses the importance of finding the underlying causes and effective treatments for post-COVID condition, beside adequate COVID-19 prevention.

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Long COVID in a prospective cohort of home-isolated patients

Nature Medicine ◽

10.1038/s41591-021-01433-3 ◽

2021 ◽

Author(s):

Bjørn Blomberg ◽

Kristin Greve-Isdahl Mohn ◽

Karl Albert Brokstad ◽

Fan Zhou ◽

Dagrun Waag Linchausen ◽

...

Keyword(s):

Prospective Cohort ◽

Control Measures ◽

Persistent Symptoms ◽

Infection Control Measures ◽

Memory Problems ◽

Long Term Follow Up ◽

Antibody Titers ◽

Pandemic Wave

AbstractLong-term complications after coronavirus disease 2019 (COVID-19) are common in hospitalized patients, but the spectrum of symptoms in milder cases needs further investigation. We conducted a long-term follow-up in a prospective cohort study of 312 patients—247 home-isolated and 65 hospitalized—comprising 82% of total cases in Bergen during the first pandemic wave in Norway. At 6 months, 61% (189/312) of all patients had persistent symptoms, which were independently associated with severity of initial illness, increased convalescent antibody titers and pre-existing chronic lung disease. We found that 52% (32/61) of home-isolated young adults, aged 16–30 years, had symptoms at 6 months, including loss of taste and/or smell (28%, 17/61), fatigue (21%, 13/61), dyspnea (13%, 8/61), impaired concentration (13%, 8/61) and memory problems (11%, 7/61). Our findings that young, home-isolated adults with mild COVID-19 are at risk of long-lasting dyspnea and cognitive symptoms highlight the importance of infection control measures, such as vaccination.

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The relevance of dietetic approach of Ayurveda from the perspective of COVID-19 pandemic

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl1.3077 ◽

2020 ◽

Vol 11 (SPL1) ◽

pp. 748-752

Author(s):

Swapnali Khabade ◽

Bharat Rathi ◽

Renu Rathi

Keyword(s):

Severe Acute Respiratory Syndrome ◽

Healthy Person ◽

World Health ◽

Physical And Mental Health ◽

Leading Role ◽

Global Pandemic ◽

The People ◽

The World ◽

Health Organization ◽

The Individual

A novel, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes severe acute respiratory syndrome and spread globally from Wuhan, China. In March 2020 the World Health Organization declared the SARS-Cov-2 virus as a COVID- 19, a global pandemic. This pandemic happened to be followed by some restrictions, and specially lockdown playing the leading role for the people to get disassociated with their personal and social schedules. And now the food is the most necessary thing to take care of. It seems the new challenge for the individual is self-isolation to maintain themselves on the health basis and fight against the pandemic situation by boosting their immunity. Food organised by proper diet may maintain the physical and mental health of the individual. Ayurveda aims to promote and preserve the health, strength and the longevity of the healthy person and to cure the disease by properly channelling with and without Ahara. In Ayurveda, diet (Ahara) is considered as one of the critical pillars of life, and Langhana plays an important role too. This article will review the relevance of dietetic approach described in Ayurveda with and without food (Asthavidhi visheshaytana & Lanhgan) during COVID-19 like a pandemic.

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Impact of Environmental Degradation on Human Health

International Research Journal of Management IT and Social Sciences ◽

10.21744/irjmis.v3i1.82 ◽

2016 ◽

Vol 3 (1) ◽

pp. 1 ◽

Cited By ~ 2

Author(s):

_______ Archana ◽

Charu Datta ◽

Pratibha Tiwari

Keyword(s):

Environmental Degradation ◽

Human Population ◽

Environmental Problems ◽

Population Increase ◽

Human Beings ◽

The People ◽

Wide Range ◽

Different Types ◽

Economic Institute ◽

Day By Day

Degradation of environment is one of the most serious challenges before the mankind in today’s world. Mankind has been facing a wide range of problem arising out of the degradation of environment. Not only the areas under human inhabitation, but the areas of the planet without human population have also been suffering from these problems. As the population increase day by day, the amenities are not improved simultaneously. With the advancement of science and technologies the needs of human beings has been changing rapidly. As a result different types of environmental problems have been rising. Environmental degradation is a wide- reaching problem and it is likely to influence the health of human population is great. It may be defined the deterioration of the environment through depletion of resources such as air, water, and soil. The destruction of ecosystem and extinction of wildlife. Environmental degradation has occurred due to the recent activities in the field of socio-economic, institute and technology. Poverty still remains a problem as the root of several environmental problems to create awareness among the people about the ill effect of environmental pollution. In the whole research it is clear that all factors of environmental degradation may be reduced through- Framing the new laws on environmental degradation, Environment friend policy, Controlling all the ways and means of noise, air, soil and water pollution, Through growing more and more trees and by adapting the proper sanitation policy.

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Immigration Dynamics and Changing Constructions of Jewish Nativeness in Israel

The Oxford Handbook of Israeli Politics and Society ◽

10.1093/oxfordhb/9780190675585.013.11 ◽

2019 ◽

Author(s):

Adane Zawdu ◽

Sarah S. Willen

Keyword(s):

Building Block ◽

Social Boundaries ◽

Institutional Practices ◽

Political Dynamics ◽

Fundamental Building Block ◽

The People ◽

Ancient Israel ◽

State Of Israel ◽

Historical Periods ◽

Over Time

A fundamental building block of the Zionist vision is the claim of a primordial link between modern-day Jews and the people and territory of ancient Israel. This claim, which has proven remarkably durable despite its changing form and its tension with understandings of Palestinian indigeneity, continues to inform conceptions of nativeness in the modern-day state of Israel. This chapter explores how constructions of Jewish nativeness in Israel have changed in relation to successive immigration processes. Taking sociocultural and political dynamics as its focus, the chapter examines the cultural and institutional practices through which the notion of Jewish nativeness, its boundaries, and its logics of inclusion and exclusion were constructed and enforced in four historical periods. In each period, an increase in ethnic and religious heterogeneity challenged established notions of Jewish nativeness and membership in new ways. Although conceptions of Jewish nativeness have changed over time, they continue to shape social boundaries by signaling, and qualifying, membership in the Israeli collective.

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Clinical characterization of dysautonomia in long COVID-19 patients

Scientific Reports ◽

10.1038/s41598-021-93546-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Nicolas Barizien ◽

Morgan Le Guen ◽

Stéphanie Russel ◽

Pauline Touche ◽

Florent Huang ◽

...

Keyword(s):

Mixed Models ◽

Repeated Measures ◽

Physical Medicine ◽

Persistent Symptoms ◽

Index Changes ◽

Changes Over Time ◽

And Control ◽

Testing Group ◽

Over Time

AbstractIncreasing numbers of COVID-19 patients, continue to experience symptoms months after recovering from mild cases of COVID-19. Amongst these symptoms, several are related to neurological manifestations, including fatigue, anosmia, hypogeusia, headaches and hypoxia. However, the involvement of the autonomic nervous system, expressed by a dysautonomia, which can aggregate all these neurological symptoms has not been prominently reported. Here, we hypothesize that dysautonomia, could occur in secondary COVID-19 infection, also referred to as “long COVID” infection. 39 participants were included from December 2020 to January 2021 for assessment by the Department of physical medicine to enhance their physical capabilities: 12 participants with COVID-19 diagnosis and fatigue, 15 participants with COVID-19 diagnosis without fatigue and 12 control participants without COVID-19 diagnosis and without fatigue. Heart rate variability (HRV) during a change in position is commonly measured to diagnose autonomic dysregulation. In this cohort, to reflect HRV, parasympathetic/sympathetic balance was estimated using the NOL index, a multiparameter artificial intelligence-driven index calculated from extracted physiological signals by the PMD-200 pain monitoring system. Repeated-measures mixed-models testing group effect were performed to analyze NOL index changes over time between groups. A significant NOL index dissociation over time between long COVID-19 participants with fatigue and control participants was observed (p = 0.046). A trend towards significant NOL index dissociation over time was observed between long COVID-19 participants without fatigue and control participants (p = 0.109). No difference over time was observed between the two groups of long COVID-19 participants (p = 0.904). Long COVID-19 participants with fatigue may exhibit a dysautonomia characterized by dysregulation of the HRV, that is reflected by the NOL index measurements, compared to control participants. Dysautonomia may explain the persistent symptoms observed in long COVID-19 patients, such as fatigue and hypoxia. Trial registration: The study was approved by the Foch IRB: IRB00012437 (Approval Number: 20-12-02) on December 16, 2020.

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CKD: understanding the high burden of disease, healthcare costs and mortality in the US

PharmacoEconomics & Outcomes News ◽

10.1007/s40274-021-7446-0 ◽

2021 ◽

Vol 871 (1) ◽

pp. 8-8

Keyword(s):

Burden Of Disease ◽

Healthcare Costs ◽

High Burden ◽

The Us

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Customary physical activity and odds of depression: a systematic review and meta-analysis of 111 prospective cohort studies

British Journal of Sports Medicine ◽

10.1136/bjsports-2020-103140 ◽

2021 ◽

pp. bjsports-2020-103140

Author(s):

Rodney K Dishman ◽

Cillian P McDowell ◽

Matthew Payton Herring

Keyword(s):

Physical Activity ◽

Systematic Review ◽

Depressive Symptoms ◽

Cohort Studies ◽

Prospective Cohort ◽

Observational Studies ◽

Meta Analysis ◽

Vigorous Physical Activity ◽

Prospective Cohort Studies ◽

Over Time

ObjectiveTo explore whether physical activity is inversely associated with the onset of depression, we quantified the cumulative association of customary physical activity with incident depression and with an increase in subclinical depressive symptoms over time as reported from prospective observational studies.DesignSystematic review and meta-analysis.Data sourcesMEDLINE, PsycINFO, PsycARTICLES and CINAHL Complete databases, supplemented by Google Scholar.Eligibility criteriaProspective cohort studies in adults, published prior to January 2020, reporting associations between physical activity and depression.Study appraisal and synthesisMultilevel random-effects meta-analysis was performed adjusting for study and cohort or region. Mixed-model meta-regression of putative modifiers.ResultsSearches yielded 111 reports including over 3 million adults sampled from 11 nations in five continents. Odds of incident cases of depression or an increase in subclinical depressive symptoms were reduced after exposure to physical activity (OR, 95% CI) in crude (0.69, 0.63 to 0.75; I2=93.7) and adjusted (0.79, 0.75 to 0.82; I2=87.6) analyses. Results were materially the same for incident depression and subclinical symptoms. Odds were lower after moderate or vigorous physical activity that met public health guidelines than after light physical activity. These odds were also lower when exposure to physical activity increased over time during a study period compared with the odds when physical activity was captured as a single baseline measure of exposure.ConclusionCustomary and increasing levels of moderate-to-vigorous physical activity in observational studies are inversely associated with incident depression and the onset of subclinical depressive symptoms among adults regardless of global region, gender, age or follow-up period.

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