scholarly journals Pathological Investigations And Correlation Research of Microfibrillar-Associated Protein 4 And Tropoelastin In Oral Submucous Fibrosis

2021 ◽  
Author(s):  
Binjie Liu ◽  
Wenqun Gou ◽  
Hui Feng
Keyword(s):  
Pearson Correlation ◽  
Oral Submucous Fibrosis ◽  
Treatment Strategies ◽  
Clinicopathological Characteristics ◽  
Expression Level ◽  
Categorical Variables ◽  
Chi Square ◽  
Chi Square Test ◽  
Submucous Fibrosis ◽  
Student’S T

Abstract Background: Oral submucous fibrosis (OSF), distinguished by abnormal collagen deposition, is a precancerous disorder with 7%-30% of malignant transformation and rising global prevalence. However, the precise pathogenesis and effective treatment still remains elusive and controversial despite superfluity of literature. Therefore, it is extremely necessary and significant to explore the clinicopathological characteristics and potential markers for diagnosis and prognosis of OSF. Here, the objective of this research is to evaluate the influence and correlation of Microfibrillar-associated protein 4 [MFAP4] and tropoelastin [TE] on the development of OSF patients. Material and Methods: Classic clinicopathological factors, HE and Masson trichome staining, immunohistochemical characteristics and the correlation (MFAP4 and TE) were recorded and compared among different stages of OSF cases (n = 60) and among those normal individuals (n = 10). Then, the comparison using Student's t test, ANOVA analysis, the chi-square test for categorical variables was conducted in clinicopathological characteristics and the expression level of MFAP4 and TE between the patients' and normal tissue. The correlation analysis of MFAP4 and TE were assessed via means of Pearson's correlation test and linear regression. Results: MFAP4 and TE proteins are upregulated and even increasing gradually in varying grades of OSF patients relative to the normal cases. Furthermore, statistical analyses yielded that the expression level of MFAP4 was positively associated with TE, and the Pearson correlation coefficient was 0.3781 (p = 0.0048). Clinically, we found that OSF affected more male than female with a ratio of 29: 1. The age range was 16-60 years, and the mean age was 36.25 ± 10.25 years old. Moreover, the positive expression rate of MFAP4 and TE in patients less than 40 years old is higher than that of those over 40 years old. Meanwhile, all OSF cases had chewed areca nut, with 51.67% smoking tobacco. Conclusions: Our study elucidates that the accumulation of MFAP4 and TE proteins may play a vitally important effect in the occurrence and development of OSF and has a hope to become a promising candidate molecular for prevention, diagnosis, and treatment strategies of OSF in the future.

scholarly journals Pathological investigations and correlation research of microfibrillar-associated protein 4 and tropoelastin in oral submucous fibrosis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Binjie Liu ◽  
Wenqun Gou ◽  
Hui Feng
Keyword(s):  
Pearson Correlation ◽  
Oral Submucous Fibrosis ◽  
Treatment Strategies ◽  
Clinicopathological Characteristics ◽  
Vital Role ◽  
Expression Level ◽  
Categorical Variables ◽  
Control Group ◽  
Chi Square ◽  
Submucous Fibrosis

Abstract Background Oral submucous fibrosis (OSF), distinguished by abnormal collagen deposition, is a potentially malignant disorder with 4.2% (95% CI 2.7–5.6%) of malignant transformation and rising global prevalence. However, the precise pathogenesis and effective treatment remain elusive and controversial despite the abundance of literature on this topic. Therefore, it is crucial to explore the clinicopathological characteristics and potential markers for the diagnosis and prognosis of OSF. The objective of this study was to evaluate the influence and correlation of Microfibrillar-associated protein 4 (MFAP4) and tropoelastin (TE) in the development of OSF patients. Material and methods Clinicopathological factors, hematoxylin–eosin (HE) and Masson trichome staining, immunohistochemical characteristics and the correlation between MFAP4 and TE were recorded and compared among different stages of OSF progression among cases (n = 60) and controls (n = 10). Student's t test, ANOVA analysis, and the chi-square test were performed to compare the categorical variables for clinicopathological characteristics and the expression level of MFAP4 and TE between the fibrotic and normal tissues. Correlation analysis of MFAP4 and TE was performed using Pearson's correlation test and linear regression. Results MFAP4 and TE proteins are upregulated and increased gradually in patients with varying stages of OSF, relative to the control group. Furthermore, statistical analyses revealed that the expression level of MFAP4 was positively associated with TE, with a Pearson correlation coefficient of 0.3781 (p = 0.0048). Clinically, we found that OSF affected more males than females, with a ratio of 29:1. The age range was 16–60 years, and the mean age was 36.25 ± 10.25 years. In patients younger than 40 years, the positive expression rate of MFAP4 and TE was higher than in those over 40 years. All OSF cases had chewed areca nut, with 51.67% smoking tobacco. Conclusions Our study elucidates that the accumulation of MFAP4 and TE proteins may play a vital role in the occurrence and development of OSF and may be promising candidate moleculars for prevention, diagnosis, and treatment strategies for OSF in the future.

CERVICAL CANCER AMONG 39 YEARS OR YOUNGER FEMALES IN SOUTH INDIA; A RETROSPECTIVE STUDY

2021 ◽  
pp. 15-17
Author(s):  
B Ramkumar ◽  
Srigopal Mohanty ◽  
Kiranmayee Narapaneni ◽  
Amit Saklani ◽  
J Kannan
Keyword(s):  
Cervical Cancer ◽  
Retrospective Study ◽  
Older Women ◽  
Young Women ◽  
Clinicopathological Characteristics ◽  
Categorical Variables ◽  
Chi Square ◽  
Younger Women ◽  
Ciency Virus ◽  
Chi Square Test

Background: Cervical cancer in young women is rare and disparity exists in its characteristics in the available reports. The study aimed to determine the disease burden and to compare its clinicopathological characteristics with older women. Materials and methods: Retrospective study was performed by retrieving data from the cancer registry for consecutive 843 cervical cancer patients treated in the center between 2017 and 2020. Patients were divided into younger (<40 years) and older (≥ 40 years) age. Statistical analysis was performed using SPSS software version 23 for windows. Chi square test was used for analyzing the categorical variables and P < 0.05 was considered signicant. Results: Cervical cancer in young women constituted 9.4%, with majority (96.2%) belonged to 30-39 years age. Higher prevalence of human immunodeciency virus (HIV) was found among younger compared to older women (P = 0.000). Younger women commonly presented late compared to older women (patients presented after 4 months are 49.4% vs. 18.8% respectively, P=0.000). Squamous cell carcinoma was commonest histology in both the groups and no difference in histology pattern between the two groups. Younger women had higher rate of bulky tumor (>4cm) compared to older (62.2% vs. 44.4%, P = 0.023). Conclusion: Delayed and advanced stage of presentation of cervical cancer in younger women in this region of India warrants promotion of health education, knowledge translation, regular cervical cancer screening for its prevention and early detection

Validation of a Breastfeeding History Questionnaire for the Risk of In-Hospital Formula Supplementation Among Multiparous Women

2019 ◽  
Vol 35 (4) ◽  
pp. 665-671
Author(s):  
Whitney R. Bender ◽  
Nathanael C. Koelper ◽  
Mary D. Sammel ◽  
Celeste Durnwald
Keyword(s):  
Hospital Stay ◽  
Care Center ◽  
Tertiary Care ◽  
Categorical Variables ◽  
Chi Square ◽  
Multiparous Women ◽  
Chi Square Test ◽  
Student’S T ◽  
Relationship Of ◽  
The Relationship

Background: A woman’s prior breastfeeding history may influence future decisions regarding infant feeding. Few quantitative tools utilizing this information have been demonstrated to predict breastfeeding success. Research aim: To evaluate the efficacy of a prenatal breastfeeding history (BAP) questionnaire administered in prenatal care to predict in-hospital formula supplementation among multiparous women. Methods: This is a prospective observational study of multiparous women with singleton pregnancies who presented to a Baby-Friendly urban tertiary care center for 1st prenatal visit at < 20 weeks’ gestation. The BAP tool generates a numerical score, with higher score (≥ 2) indicating prior successful breastfeeding experiences. The primary outcome was occurrence of non-medically indicated formula supplementation during the postpartum hospital stay. Student’s t test and Pearson’s chi-square test were used to compare continuous and categorical variables. A multivariable logistic regression was performed to assess the relationship of BAP score to formula supplementation. Of 587 women screened, 433 (73.8%) mother–infant dyads were analyzed. Results: Rates of formula supplementation in women with BAP scores ≤ 1 were 67% (156/234) compared with 37% (73/199) in women with higher scores ( p < 0.0001). After controlling for race/ethnicity, insurance, and obesity, women with BAP scores of ≤ 1 were 2.6 times more likely to supplement formula than women with higher scores (a OR 2.62, 95% CI [1.70, 4.04], p < .0001). Conclusion: In this prospective validation study, women with negative prior breastfeeding experiences, as evidenced by a lower BAP score, were more likely to supplement formula during the postpartum hospital stay.

Can racial and financial disparities be overcome in the surgical treatment of NSCLC?

2013 ◽  
Vol 31 (31_suppl) ◽  
pp. 208-208
Author(s):  
Jordan R. Sasson ◽  
Gary Schwartz ◽  
Sadiq Rehmani ◽  
Hassan S Moghaddas ◽  
Sarah Almubarak ◽  
...  
Keyword(s):  
Induction Therapy ◽  
Categorical Variables ◽  
Continuous Variables ◽  
Urban Hospital ◽  
Chi Square ◽  
Black Patients ◽  
Diverse Patient Population ◽  
Chi Square Test ◽  
Student’S T ◽  
Nsclc Patients

208 Background: Considerable data exists examining disparities in the treatment of non-small cell lung cancer (NSCLC) patients. Black patients, in particular those of lower socioeconomic status (SES), are less likely to receive appropriate care, including induction therapy and resection of surgically treatable lesions. We analyzed the outcomes of resection of NSCLC among a racially and financially diverse patient population at a large urban hospital network with a comprehensive thoracic oncology program. In this system, a patient navigation support team helped overcome barriers to preoperative preparation and multidisciplinary referral. Methods: A retrospective review of 345 patients who underwent lobectomy at our institution from 2002 - 2011 was performed. Data was retrieved from the Society of Thoracic Surgeons (STS) database and patient charts. Patient demographics, payor information and preoperative characteristics were noted. Postoperative complications, 30-day survival and 3-year survival were compared. Statistical analysis was performed using SPSS 17.0 (SPSS Inc, Chicago, IL). Chi-square test was used to compare categorical variables and Student's t-test was used to compare continuous variables. Results: Demographics of black and non-black patients were similar. There were more black patients within the Medicaid group than non-Medicaid (48.9% and 25.3%, p=0.001). Physiologic characteristics, risk factors and use of pre-operative RT and chemotherapy were similar. Post-operative complications were comparable in Medicaid vs. non-Medicaid (11.1% and 14.7%, p=0.524), however black patients had a lower rate of complications vs. non-black (6.1% and 17.4%, p=0.007). 3-year survival was similar in the black vs. non-black (82.3% and 78.6%, p=0.879) and Medicaid vs. non-Medicaid (66.7% and 78.8%, p=0.342) groups. Conclusions: We demonstrated equivalent surgical outcomes for NSCLC in addition to the similar use of induction therapy. Surprisingly, complications were lower in the black cohort. Our results reveal that appropriate treatment is being provided regardless of race or SES, and postulate that our system of preoperative patient support eliminates potential barriers to care.

scholarly journals Risk factors of mortality for intensive care COVID-19 patients: A retrospective cohort study.

2020 ◽  
Author(s):  
Yanli Gu ◽  
Donghui Wang ◽  
Cen Chen ◽  
Wanjun Lu ◽  
Hongbing Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Intensive Care ◽  
Multivariate Logistic Regression Analysis ◽  
Categorical Variables ◽  
Continuous Variables ◽  
Chi Square ◽  
Laboratory Findings ◽  
Chi Square Test ◽  
Student’S T

Abstract Aims: To identify the risk factors of mortality for coronavirus disease 19 (COVID-19) patients admitted to intensive care units (ICU), we conducted a retrospective analysis.Methods: The demographic characteristics, laboratory findings and chest X-ray data of COVID-19 patients admitted to ICU of Huoshenshan Hospital from February 10 to April 10, 2020 were retrospectively analyzed. Student's t test and chi-square test were used to compare continuous variables, categorical variables respectively. Logistic regression model was used to seek risk factors of mortality.Results: A total of 57 patients (38 males and 19 females) were included in this retrospective study, including 20 patients in deceased group and 37 patients in surviving group. Leukocyte count, neutrophil count, lymphocyte count, eosinophil count, neutrophil-to-lymphocyte ratio (NLR), urea nitrogen, lactate dehydrogenase (LDH), interleukin-6 (IL-6), C-reactive protein (CRP), arterial partial pressure of oxygen/oxygen concentration (PaO2/FiO2) and imaging findings were statistically different between the two groups. The multivariate logistic regression analysis identified IL-6 and PaO2/FiO2 as independent risk factors of mortality. The area of under curves (AUC) of IL-6 and PaO2/FiO2 were 0.9 (95%CI:0.823-0.977, p<0.0001) and 0.865 (95%CI:0.774-0.956, p<0.0001) respectively. The cut-off value of IL-6 was 25.69 pg/mL, the sensitivity was 95% and the specificity was 75.7%, while the cut-off value of PaO2/FiO2 was 167.79 mmHg, the sensitivity was 75.7% and the specificity was 85%.Conclusion: Clinicians should pay enough attention to IL-6 and PaO2/FiO2, especially when IL-6>25.69 pg/ml and PaO2/FiO2<167.79 mmHg, and take active intervention measures as early as possible.

scholarly journals Comparative analysis of the prevalence of congenital malformations of the brain in children of the radioactively contaminated territories of the Bryansk region after the Chernobyl disaster (1999-2014)

2020 ◽  
Vol 99 (4) ◽  
pp. 356-362
Author(s):  
Антон Вячеславович Корсаков ◽  
Э. В. Гегерь ◽  
Д. Г. Лагерев ◽  
Л. И. Пугач ◽  
Ю. П. Пивоваров ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Congenital Malformations ◽  
Pearson Correlation ◽  
Chi Square ◽  
Chernobyl Disaster ◽  
Strontium 90 ◽  
Cesium 137 ◽  
Chi Square Test ◽  
Student’S T ◽  
The Brain

Purpose of the study. Based on the official statistics for 1999-2014, we carried out a comparative analysis of the incidence of congenital brain malformations in children resided in the radiation-contaminated areas of the Bryansk region after the Chernobyl disaster with different densities of Cesium-137 and Strontium-90. Material and Methods. Student’s t-test, Pearson chi-square test, Pearson correlation test, linear regression. Results. As a result of the study, no statistically significant excess in the frequency of anencephaly, hydrocephalus and encephalocele in children in more radiation-contaminated south-western territories (SWT) was found compared to the average regional data. However, in the SWT, the prevalence of microcephaly is statistically significant (p<0,05) above the average regional values (5.8 times). While the maximum values are recorded in the most radioactively polluted areas of the region when high statistically significant correlations are detected with the density of radioactive contamination with Cesium-137 (r=0.69; p=0.040) and Strontium 90 (r=0.70; p=0.037), while there are no significant dependencies for other brain defects of the brain. A statistically significant decrease in the long-term trend in the prevalence of microcephaly throughout the region without SWT in the period 1999-2014, and an increase in the radiation-contaminated SWT, was found. Conclusions. The results obtained presumably indicate to the influence of the radiation factor on the increased incidence of microcephaly in SWT relative to the average regional values without SWT for a sixteen-year period (1999-2014). The further studies are needed to analyze the incidence of various types of congenital malformations in order to determine a strategy for preventing birth of children with congenital anomalies.

scholarly journals 791. Hyponatremia Incidence and Its Association With Mortality in Patients With Tuberculosis

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S283-S284
Author(s):  
Andrea Llamas-Lopez ◽  
Tania Vargas ◽  
Luis Morales-Garza ◽  
Rogelio Maya
Keyword(s):  
Strong Association ◽  
Serum Glucose ◽  
Categorical Variables ◽  
Chi Square ◽  
Electronic File ◽  
Kaplan Meier ◽  
Chi Square Test ◽  
Student’S T ◽  
Overall Mortality

Abstract Background In 2014, 26,000 new cases of tuberculosis were reported in Mexico. TB infection can cause hyponatremia which has a strong association with mortality. The objective of this study was to determine the association of mortality with hyponatremia in patients with tuberculosis infection. Methods Patients were collected from a 2-year period in the Hospital Dr. Bernardo Sepœlveda in Nuevo Leon, Mexico. Inclusion criteria were patients &gt;18 years of age, with positive tuberculosis tests, and sodium and serum glucose values upon admission. Clinical data from the electronic file were collected and analyzed by descriptive statistics; Student’s t-test and chi-square test were used to compare categorical variables, and Kaplan–Meier to estimate survival curves. Results There were 314 patients with suspected TB, 77 patients were included (Table 1). Mean follow-up was 6.5 ± 7.1 months. Overall mortality rate was 36.3%. Analysis of mortality is presented in Fig 2, and in severe hyponatremia in Figure 3. Conclusion Overall mortality was higher than previously reported, but there was no statistical association between hyponatremia and mortality compared with patients with normal sodium, or by severity. Within the limitations of this study, we must consider that 92% of patients were hospitalized patients at the time of diagnosis, implying that they were patients with complications and may be the reason why both mortality and the incidence of hyponatremia were higher. Disclosures All authors: No reported disclosures.

Comparative analysis of the prevalence of congenital malformations of the brain in children of the radioactively contaminated territories of the Bryansk region after the Chernobyl disaster (1999-2014)

2020 ◽  
Vol 99 (4) ◽  
pp. 356-362
Author(s):  
Anton V. Korsakov ◽  
E. V. Geger ◽  
D. G. Lagerev ◽  
L. I. Pugach ◽  
Yu. P. Pivovarov ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Congenital Malformations ◽  
Pearson Correlation ◽  
Chi Square ◽  
Chernobyl Disaster ◽  
Strontium 90 ◽  
Cesium 137 ◽  
Chi Square Test ◽  
Student’S T ◽  
The Brain

Purpose of the study. Based on the official statistics for 1999-2014, we carried out a comparative analysis of the incidence of congenital brain malformations in children resided in the radiation-contaminated areas of the Bryansk region after the Chernobyl disaster with different densities of Cesium-137 and Strontium-90. Material and Methods. Student’s t-test, Pearson chi-square test, Pearson correlation test, linear regression. Results. As a result of the study, no statistically significant excess in the frequency of anencephaly, hydrocephalus and encephalocele in children in more radiation-contaminated south-western territories (SWT) was found compared to the average regional data. However, in the SWT, the prevalence of microcephaly is statistically significant (p<0,05) above the average regional values (5.8 times). While the maximum values are recorded in the most radioactively polluted areas of the region when high statistically significant correlations are detected with the density of radioactive contamination with Cesium-137 (r=0.69; p=0.040) and Strontium 90 (r=0.70; p=0.037), while there are no significant dependencies for other brain defects of the brain. A statistically significant decrease in the long-term trend in the prevalence of microcephaly throughout the region without SWT in the period 1999-2014, and an increase in the radiation-contaminated SWT, was found. Conclusions. The results obtained presumably indicate to the influence of the radiation factor on the increased incidence of microcephaly in SWT relative to the average regional values without SWT for a sixteen-year period (1999-2014). The further studies are needed to analyze the incidence of various types of congenital malformations in order to determine a strategy for preventing birth of children with congenital anomalies.

scholarly journals The relationship between study skills and depressive symptoms among medical residents

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Eiad AlFaris ◽  
Muhannad AlMughthim ◽  
Farhana Irfan ◽  
Nassr Al Maflehi ◽  
Gominda Ponnamperuma ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Study Skills ◽  
Smoking Status ◽  
Pearson Correlation ◽  
Well Being ◽  
Depression Score ◽  
Categorical Variables ◽  
Chi Square ◽  
Chi Square Test ◽  
The Relationship

Abstract Background The cost of depression among residents is staggering as it extends into the quality and safety of patient care. Finding an explanation to resident depression by investigating the associated factors is therefore important. Study skills can be a possible factor, and a clear gap in the literature exists in this regard. We sought to investigate the relationship between depressive symptoms among residents and their study skills. Methods This was a correlational study and a non-probability sample of 240 residents completed the Beck Depression Inventory II (BDI-II) and the Study Skills Inventory (SSI). Chi-square test was used to compare different categorical variables, while student t-test and ANOVA for continuous data. Pearson’s correlation coefficient was performed to find the relationship between depressive symptoms and study skills and the association that these measures have with the demographic variables. Results Overall, 186 residents (76%) filled out the questionnaire. The SSI total score was found to have a significant negative association with the BDI-II depression score (Pearson correlation = − 0.447and p < 0.000). No significant association was found between the total SSI score and the residents’ sex, age, marital status, smoking status, training years or specialties. Conclusion Poor study skills were found to be correlated with higher depressive symptoms. Future studies are required to develop a deeper understanding of this relationship and reconfigure the approach to study skills for the well-being of the future physicians.

scholarly journals Ultrasonographic Evaluation of Oral Submucous Fibrosis and Masseteric Hypertrophy

2013 ◽  
Vol 3 ◽  
pp. 12 ◽  
Author(s):  
Jones Raja Devathambi ◽  
Nalini Aswath
Keyword(s):  
Buccal Mucosa ◽  
Masseter Muscle ◽  
Muscle Hypertrophy ◽  
Oral Submucous Fibrosis ◽  
Muscle Thickness ◽  
Chi Square ◽  
Non Invasive ◽  
Chi Square Test ◽  
Submucous Fibrosis ◽  
The Relationship

Objectives: To evaluate the efficacy of ultrasonography (USG) as a non-invasive tool in assessing the severity of oral submucous fibrosis (OSMF) and also to assess the relationship between OSMF and hypertrophy of the masseter muscle. Materials and Methods: The submucosal thickness in buccal mucosa and masseteric muscle hypertrophy were measured using ultrasound (10-15 MHz) in 60 patients comprising 30 OSMF patients and 30 controls. Results: Results were analyzed by one way analysis of variance, Chi-square test and t-test. As the stages of OSMF advanced there was an increase in submucosal thickness of the buccal mucosa as well as masseter muscle thickness in both relaxed and contracted state in the study group when compared with controls (P < 0.005). Conclusion: USG is an effective non-invasive zero radiation tool for assessing the progression of OSMF.

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