scholarly journals Common Sonographic Patterns of Kidney Diseases in Nnewi North, Anambra State, Nigeria

2021 ◽  
Author(s):  
MICHAEL SUNDAY OKPALEKE ◽  
AKOCHI FAVOUR ONYINYECHI
Keyword(s):  
Kidney Disease ◽  
Kidney Diseases ◽  
Renal Parenchyma ◽  
University Teaching ◽  
Anambra State ◽  
Diagnostic Center ◽  
Sonographic Patterns ◽  
Grade Ii ◽  
Disease Grade ◽  
Age And Sex

Abstract Introduction: Despite the increasing prevalence of kidney diseases in Nigeria, and the value of ultrasonography in the diagnosis of these diseases, there is a paucity of data on the sonographic patterns of kidney diseases peculiar to people in Nnewi North Anambra state, Nigeria.Objective: The objective of this study was to document the common sonographic patterns of kidney diseases in Nnewi-North, Anambra state, Nigeria and to correlate certain Ultrasound detectable kidney diseases of patients with age and sex.Methods: This study adopted a cross-sectional retrospective design. Secondary records from files, folders were retrieved from patient’s records from the Radiography departments of Waves diagnostic center and Nnamdi Azikiwe University teaching hospital both in Anambra State, Nigeria. A total of 400 patients were reviewed from the health institutions between April 2020 and April 2021. The data were analyzed using descriptive and inferential statistics.Results: Common kidney diseases were: hydronephrosis [74(17.8%)], nephrolithiasis [69 (17.3%)], renal cyst [39(9.8)], urolithiasis [9(75%)], renal parenchyma disease grade I [27(6.8%)], renal parenchyma disease grade II [12(3.0%)], renal parenchyma disease grade III [12(3.0%)],renal parenchyma disease grade I-II [6(1.5%)], renal parenchyma disease grade II-III [1(0.3)], nephritis [6(1.5%)], ectopic kidney [3(0.8)], polycystic kidney disease[ 9(2.3%)], pyelonephritis [14(3.5%)], nephrocalcinosis [29(7.2%)]. It was found out that normal patients had the highest occurrence [81 (21.3%)], the most prevalent kidney disease was hydronephrosis [74(17.8%)] and the least prevalent was renal parenchyma disease grade II-III [1(0.3%)]. The prevalence of hydronephrosis was seen more in male patients [42 (59.2%)] than their female counterparts [29 (40.8%)]. The subjects between the ages of 37-52 years were more likely to develop hydronephrosis than other age groups and also there was no significant relationship between kidney diseases and age. It is therefore recommended that Ultrasound should be used as the first line of diagnosis in kidney pathologies and suspected flank pain, because of its availability, cheapness, improved safety profile, and level of diagnostic accuracy.Conclusion: Common sonographic patterns of kidney diseases were those of hydronephrosis, nephrolithiasis, and renal parenchyma diseases grade I-III predominantly among male subjects. Age and sex had no significant effect on sonographic patterns of kidney diseases.

scholarly journals Prevalence of Specific Types of Kidney Disease in Patients Undergoing Kidney Biopsy: A Single Centre Experience

2014 ◽  
Vol 3 (1) ◽  
pp. 5-10 ◽  
Author(s):  
Mukunda Prasad Kafle ◽  
Dibya Singh Shah ◽  
Shailendra Shrestha ◽  
Mahesh Raj Sigdel ◽  
Kanak Bahadur Raut
Keyword(s):  
Kidney Disease ◽  
Lupus Nephritis ◽  
Minimal Change Disease ◽  
Kidney Biopsy ◽  
Kidney Diseases ◽  
University Teaching ◽  
Treatment Modalities ◽  
Clinical Indication ◽  
Single Centre ◽  
Single Centre Experience

Background and aims: Prevalence of various types of kidney diseases in Nepalese population has largely been unknown. Knowledge of the prevalence of specific type kidney disease in renal patients has important implications in starting the treatment modalities and prognostification of these patients. We tried to find out the various types of kidney diseases in patient population undergoing kidney biopsy at our centre. Methods: We retrospectively analyzed kidney biopsy reports of patients who underwent Kidney Biopsy from 2007 to 2009 in Tribhuvan University Teaching Hospital (TUTH), Kathmandu. Results: Of the 194 kidney biopsy reports analyzed, 100(51.5%) were females and 94(48.5%) males. Most of the patients 75.773% (n=147) were 16-45yrs age (Mean age 33.7years). Biopsy reports showed Lupus Nephritis in 20.6%(n=40), Focal Segmental Glomerulosclerosis (FSGS) in 19.6%(n=38), IgA Nephropathy in 9.8%(n=19), MPGN 9.8%(n=19), Membranous Nephropathy 8.2%(n=16) and Minimal Change Disease (MCD) in 8.2%(n=16) of the population biopsied. Nephrotic syndrome was the commonest clinical indication for kidney biopsy. Conclusion: Our study demonstrated that Lupus Nephritis is the commonest indication for kidney biopsy at our centre. DOI: http://dx.doi.org/10.3126/jaim.v3i1.10695   Journal of Advances in Internal Medicine 2014;03(01):5-10

scholarly journals Cardiovascular Autonomic Neuropathyin Chronic Kidney Diseases

2010 ◽  
Vol 49 (178) ◽  
Author(s):  
L Thapa ◽  
P Karki ◽  
SK Sharma ◽  
BK Bajaj
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Kidney Disease ◽  
Heart Rate ◽  
Kidney Disease ◽  
Autonomic Neuropathy ◽  
Autonomic Function ◽  
Heart Rate Response ◽  
Kidney Diseases ◽  
Diabetic Patients ◽  
Age And Sex

INTRODUCTION: This study was conducted to explore cardiovascular autonomic neuropathy and its pattern in chronic kidney disease patients. METHODS: Autonomic function using five standard tests was examined in 20 diabetic patients with CKD, 20 age and sex matched diabetic patients without CKD and 20 age and sex matched controls. Analysis of difference between the autonomic function was done in the three groups using Chi-square test or Fischer's test. RESULTS: Total 20 (100%) diabetic CKD patients were found to have autonomic neuropathy. Of these, 2 (10%) patients had early parasympathetic damage, 8 (40%) patients had definite parasympathetic damage, and 10 (50%) patients had combined damage. Heart rate response to standing was statistically significant (p = 0.014) among diabetic CKD patients when compared with diabetic patients without CKD. Combined form of autonomicdysfunction was more frequent in advanced stages of diabetic CKD. Three (42.85%) patients in stage 3 CKD, 4 (66.66%) patients in stage 4 CKD and 5 (71.42%) patients in stage 5 CKD, had combined autonomic failure. CONCLUSIONS: Autonomic neuropathy is common in native Nepalese diabetic CKD patients. Heart rate response to standing is significantly abnormal in diabetic CKD patients in comparison with diabetes mellitus patient without CKD. Severity of autonomic dysfunction increases with severity of CKD..  KEYWORDS: cardiovascualr autonomic neuropathy, chronic kidney disease, diabetes mellitus.

Stroke in chronic renal failure

2008 ◽  
Vol 149 (15) ◽  
pp. 691-696
Author(s):  
Dániel Bereczki
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Disease ◽  
Chronic Renal Disease ◽  
Kidney Diseases ◽  
Cerebrovascular Diseases ◽  
Lipid Lowering ◽  
Increased Risk ◽  
Intracerebral Hemorrhages

Chronic kidney diseases and cardiovascular diseases have several common risk factors like hypertension and diabetes. In chronic renal disease stroke risk is several times higher than in the average population. The combination of classical risk factors and those characteristic of chronic kidney disease might explain this increased risk. Among acute cerebrovascular diseases intracerebral hemorrhages are more frequent than in those with normal kidney function. The outcome of stroke is worse in chronic kidney disease. The treatment of stroke (thrombolysis, antiplatelet and anticoagulant treatment, statins, etc.) is an area of clinical research in this patient group. There are no reliable data on the application of thrombolysis in acute stroke in patients with chronic renal disease. Aspirin might be administered. Carefulness, individual considerations and lower doses might be appropriate when using other treatments. The condition of the kidney as well as other associated diseases should be considered during administration of antihypertensive and lipid lowering medications.

Ethnopharmacological Survey of Medicinal Plants Used in Traditional Treatment of Kidney Diseases in Fez–Meknes Region, Morocco

2019 ◽  
Vol 18 (2) ◽  
pp. 99-114
Author(s):  
M. Chebaibi ◽  
D. Bousta ◽  
I. Iken ◽  
H. Hoummani ◽  
A. Ech-Choayeby ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Medicinal Plants ◽  
Kidney Diseases ◽  
Rank Order ◽  
Pearson Correlation ◽  
Use Value ◽  
Traditional Treatment ◽  
Toxic Plants ◽  
A Value ◽  
Chi Squared

The purpose of this study was to inventory and collect information on plants and mixtures commonly used by herbalists to treat kidney disease in the Fez–Meknes region. We also aimed to compare the results obtained with the results of the other studies and exploit the correlations between different factors. An ethnopharmacological survey was conducted from 289 local herbalists in eight different areas of Fez–Meknes region. Ethnomedicinal uses and ethnobotanical indices were analyzed using quantitative tools, i.e., the total number of citation (TNC), use value (UV), family use value (FUV), fidelity level (FL), and rank order priority (ROP). Statistical analyses such as Pearson correlation and chi-squared test were performed to delineate any correlation. Two hundred and eighty-nine herbalists were questioned. Sixty-nine plant species belonging to 38 families were cited by herbalists for traditional treatment of kidney disease. The highest value of UV was obtained for Herniaria glabra L. (UV = 0.79), and Caryophyllaceae was the family frequently cited (FUV = 0.795). Ammodaucus leucotrichus Coss. & Dur. had the highest value of FL with a value of 100%, and the highest value of ROP was recorded for Herniaria glabra L. (ROP = 91%). Sociodemographic characteristics had a significant impact on the knowledge of toxic plants. Our study has revealed a cultural heritage linked to herbalism and a great wealth of medicinal plants, whose valorization and protection are necessary. Several studies are needed to sensitize herbalists and population on the danger of toxic plants, to extract chemical compounds from the main plants used, and to evaluate their toxicity.

scholarly journals CD73 Overexpression in Podocytes: A Novel Marker of Podocyte Injury in Human Kidney Disease

2021 ◽  
Vol 22 (14) ◽  
pp. 7642
Author(s):  
Zoran V. Popovic ◽  
Felix Bestvater ◽  
Damir Krunic ◽  
Bernhard K. Krämer ◽  
Raoul Bergner ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Kidney Diseases ◽  
Kidney Injury ◽  
Membranous Glomerulonephritis ◽  
Human Kidney ◽  
Protective Role ◽  
Control Group ◽  
Podocyte Injury ◽  
Ccr2 Expression ◽  
Cd73 Expression

The CD73 pathway is an important anti-inflammatory mechanism in various disease settings. Observations in mouse models suggested that CD73 might have a protective role in kidney damage; however, no direct evidence of its role in human kidney disease has been described to date. Here, we hypothesized that podocyte injury in human kidney diseases alters CD73 expression that may facilitate the diagnosis of podocytopathies. We assessed the expression of CD73 and one of its functionally important targets, the C-C chemokine receptor type 2 (CCR2), in podocytes from kidney biopsies of 39 patients with podocytopathy (including focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD), membranous glomerulonephritis (MGN) and amyloidosis) and a control group. Podocyte CD73 expression in each of the disease groups was significantly increased in comparison to controls (p < 0.001–p < 0.0001). Moreover, there was a marked negative correlation between CD73 and CCR2 expression, as confirmed by immunohistochemistry and immunofluorescence (Pearson r = −0.5068, p = 0.0031; Pearson r = −0.4705, p = 0.0313, respectively), thus suggesting a protective role of CD73 in kidney injury. Finally, we identify CD73 as a novel potential diagnostic marker of human podocytopathies, particularly of MCD that has been notorious for the lack of pathological features recognizable by light microscopy and immunohistochemistry.

scholarly journals The Mitochondrial Kinase PINK1 in Diabetic Kidney Disease

2021 ◽  
Vol 22 (4) ◽  
pp. 1525
Author(s):  
Chunling Huang ◽  
Ji Bian ◽  
Qinghua Cao ◽  
Xin-Ming Chen ◽  
Carol A. Pollock
Keyword(s):  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Kidney Diseases ◽  
Mitochondrial Protein ◽  
Physiological Role ◽  
Close Link ◽  
Promising Alternative ◽  
Diabetic Kidney ◽  
Phosphatase And Tensin Homolog ◽  
Tensin Homolog

Mitochondria are critical organelles that play a key role in cellular metabolism, survival, and homeostasis. Mitochondrial dysfunction has been implicated in the pathogenesis of diabetic kidney disease. The function of mitochondria is critically regulated by several mitochondrial protein kinases, including the phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1). The focus of PINK1 research has been centered on neuronal diseases. Recent studies have revealed a close link between PINK1 and many other diseases including kidney diseases. This review will provide a concise summary of PINK1 and its regulation of mitochondrial function in health and disease. The physiological role of PINK1 in the major cells involved in diabetic kidney disease including proximal tubular cells and podocytes will also be summarized. Collectively, these studies suggested that targeting PINK1 may offer a promising alternative for the treatment of diabetic kidney disease.

scholarly journals COVID-19 in children treated with immunosuppressive medication for kidney diseases

2020 ◽  
pp. archdischild-2020-320616
Author(s):  
Matko Marlais ◽  
Tanja Wlodkowski ◽  
Samhar Al-Akash ◽  
Petr Ananin ◽  
Varun Kumar Bandi ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Immunosuppressive Therapy ◽  
Low Income ◽  
Kidney Diseases ◽  
Low Income Countries ◽  
Reference Network ◽  
Immunosuppressive Medication ◽  
Immunosuppressive Medications ◽  
Significant Difference ◽  
The Impact

BackgroundChildren are recognised as at lower risk of severe COVID-19 compared with adults, but the impact of immunosuppression is yet to be determined. This study aims to describe the clinical course of COVID-19 in children with kidney disease taking immunosuppressive medication and to assess disease severity.MethodsCross-sectional study hosted by the European Rare Kidney Disease Reference Network and supported by the European, Asian and International paediatric nephrology societies. Anonymised data were submitted online for any child (age <20 years) with COVID-19 taking immunosuppressive medication for a kidney condition. Study recruited for 16 weeks from 15 March 2020 to 05 July 2020. The primary outcome was severity of COVID-19.Results113 children were reported in this study from 30 different countries. Median age: 13 years (49% male). Main underlying reasons for immunosuppressive therapy: kidney transplant (47%), nephrotic syndrome (27%), systemic lupus erythematosus (10%). Immunosuppressive medications used include: glucocorticoids (76%), mycophenolate mofetil (MMF) (54%), tacrolimus/ciclosporine A (58%), rituximab/ofatumumab (11%). 78% required no respiratory support during COVID-19 illness, 5% required bi-level positive airway pressure or ventilation. Four children died; all deaths reported were from low-income countries with associated comorbidities. There was no significant difference in severity of COVID-19 based on gender, dialysis status, underlying kidney condition, and type or number of immunosuppressive medications.ConclusionsThis global study shows most children with a kidney disease taking immunosuppressive medication have mild disease with SARS-CoV-2 infection. We therefore suggest that children on immunosuppressive therapy should not be more strictly isolated than children who are not on immunosuppressive therapy.

scholarly journals Beyond a Passive Conduit: Implications of Lymphatic Biology for Kidney Diseases

2020 ◽  
Vol 31 (6) ◽  
pp. 1178-1190 ◽  
Author(s):  
Daniyal J. Jafree ◽  
David A. Long
Keyword(s):  
Kidney Disease ◽  
Therapeutic Potential ◽  
Kidney Diseases ◽  
Transplant Rejection ◽  
Lymphatic Vessels ◽  
Renal Physiology ◽  
Clear Fluid ◽  
Adult Kidney ◽  
And Function ◽  
Development Structure

The kidney contains a network of lymphatic vessels that clear fluid, small molecules, and cells from the renal interstitium. Through modulating immune responses and via crosstalk with surrounding renal cells, lymphatic vessels have been implicated in the progression and maintenance of kidney disease. In this Review, we provide an overview of the development, structure, and function of lymphatic vessels in the healthy adult kidney. We then highlight the contributions of lymphatic vessels to multiple forms of renal pathology, emphasizing CKD, transplant rejection, and polycystic kidney disease and discuss strategies to target renal lymphatics using genetic and pharmacologic approaches. Overall, we argue the case for lymphatics playing a fundamental role in renal physiology and pathology and treatments modulating these vessels having therapeutic potential across the spectrum of kidney disease.

scholarly journals Where Are You Going, Nephrology? Considerations on Models of Care in an Evolving Discipline

2018 ◽  
Vol 7 (8) ◽  
pp. 199 ◽  
Author(s):  
Giorgina Piccoli ◽  
Conrad Breuer ◽  
Gianfranca Cabiddu ◽  
Angelo Testa ◽  
Christelle Jadeau ◽  
...  
Keyword(s):  
Internal Medicine ◽  
Kidney Disease ◽  
Kidney Diseases ◽  
Models Of Care ◽  
Scientific Model ◽  
Dialysis Treatment ◽  
Cost Constraints ◽  
Common Diseases ◽  
Nephrology Care ◽  
Immunologic Diseases

Nephrology is a complex discipline, including care of kidney disease, dialysis, and transplantation. While in Europe, about 1:10 individuals is affected by chronic kidney disease (CKD), 1:1000 lives thanks to dialysis or transplantation, whose costs are as high as 2% of all the health care budget. Nephrology has important links with surgery, bioethics, cardiovascular and internal medicine, and is, not surprisingly, in a delicate balance between specialization and comprehensiveness, development and consolidation, cost constraints, and competition with internal medicine and other specialties. This paper proposes an interpretation of the different systems of nephrology care summarising the present choices into three not mutually exclusive main models (“scientific”, “pragmatic”, “holistic”, or “comprehensive”), and hypothesizing an “ideal-utopic” prevention-based fourth one. The so-called scientific model is built around kidney transplantation and care of glomerulonephritis and immunologic diseases, which probably pose the most important challenges in our discipline, but do not mirror the most common clinical problems. Conversely, the pragmatic one is built around dialysis (the most expensive and frequent mode of renal replacement therapy) and pre-dialysis treatment, focusing attention on the most common diseases, the holistic, or comprehensive, model comprehends both, and is integrated by several subspecialties, such as interventional nephrology, obstetric nephrology, and the ideal-utopic one is based upon prevention, and early care of common diseases. Each model has strength and weakness, which are commented to enhance discussion on the crucial issue of the philosophy of care behind its practical organization. Increased reflection and research on models of nephrology care is urgently needed if we wish to rise to the challenge of providing earlier and better care for older and more complex kidney patients with acute and chronic kidney diseases, with reduced budgets.

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