Factors Influencing Quality of Life in Patients with Nasopharyngeal Cancer Based on QLICP-NA (Version 2.0)

2021 ◽  
Author(s):  
Yangchen Fang ◽  
Chonghua Wan ◽  
Zheng Yang ◽  
Jiayuan Wu ◽  
Liren Hu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Linear Regression ◽  
Correlation Analysis ◽  
Multiple Linear Regression ◽  
Physical Function ◽  
Canonical Correlation ◽  
Economic Status ◽  
Clinical Stage ◽  
Function Domain

Abstract Objective To determine the quality of life (QoL) of patients with nasopharyngeal carcinoma (NPC) and the clinical factors that influence QoL. Methods Multiple linear regression, simple and canonical correlation analyses were used to analyze the factors that affected QoL in patients with NPC. Results The QoL scores were as follows: physical function domain, 61.03±15.03; mental function domain, 60.95±15.35; social function domain, 59.17±14.16; specific module domain, 75.62±14.87; and total scale score, 66.10±97.18. Multiple linear regression analyses showed that family economic status and clinical stage of the disease are the factors affecting the overall QoL among NPC patients. The simple correlation analysis showed that the hemoglobin level had a positive correlation with physical function, social function, specific module domains, and the total score of the total scale. Canonical correlation analysis revealed a pair of statistically significant typical variables and the canonical correlation coefficient was 0.561 (P<0.05). Conclusion The indicators related to the QoL among patients with NPC included family economic status, clinical stage of the disease, red blood cell count, and albumin, total bilirubin, blood urea nitrogen, creatinine, aspartate aminotransferase, and hemoglobin levels. A focus on these indicators and implementing the corresponding treatment measures had value in improving the QoL among patients with NPC.

scholarly journals A139 IMPROVED QUALITY OF LIFE AFTER ENDOSCOPIC THERAPY FOR BARRETT’S ESOPHAGUS AND EARLY ESOPHAGEAL CANCER IN SOUTHERN ALBERTA

2021 ◽  
Vol 4 (Supplement_1) ◽  
pp. 125-126
Author(s):  
T Jeyalingam ◽  
M Woo ◽  
S E Congly ◽  
J David ◽  
P J Belletrutti ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Endoscopic Therapy ◽  
Negative Impact ◽  
Older Age ◽  
The Impact

Abstract Background In patients with Barrett’s esophagus (BE), endoscopic therapy reduces the risk of progression to invasive esophageal adenocarcinoma (EAC). Data on the impact of endoscopic therapy on patient quality of life (QoL) is limited. Aims We aimed to assess: (1) change in QoL during the course of endoscopic therapy for BE, (2) factors which predict this change, (3) whether achieving complete remission of dysplasia (CRD) or intestinal metaplasia (CRIM) affect the degree of change. Methods We conducted a retrospective observational study using a prospectively maintained database of BE patients treated in Calgary, Alberta from 2013–2020 containing data on demographics, BE disease characteristics and therapeutics, QoL, and follow-up. QoL was determined prior to initiation of therapy and after each treatment session using a validated questionnaire. Descriptive statistics were calculated and change in QoL was compared using a Wilcoxon signed ranks test. Backwards multiple linear regression analysis was performed to determine predictors of change in QoL. Results Of 130 BE patients, 112 (86.1%) were male and 104 (80%) had dysplastic histology or intramucosal carcinoma on index endoscopy. Mean (SD) age was 65.6 (12.0) years. At time of analysis, 76 patients (58.5%) had completed endoscopic therapy, of whom 69 (90.8%) achieved CRIM; 54 patients (41.5%) were still undergoing treatment. There was significant improvement in all QoL measures during the treatment course except for “depression” (Table 1). Patients with CRIM or CRD had reductions in “sleep difficulty” and “negative impact on life” to a significantly greater degree vs patients not achieving CRIM (Δ sleep -0.45 vs 0.0, P=0.002; Δ negative impact -0.4 vs -0.05, P=0.014) or CRD (Δ sleep -0.40 vs +0.60, P=0.002; Δ negative impact -0.40 vs +0.20, P=0.04). Multiple linear regression revealed older age (B=-0.03, P=0.008) and fewer number of EMR sessions (B=0.254, P=0.008) were correlated with greater improvement in QoL. Conclusions Endoscopic therapy improves QoL in BE patients, especially in those achieving CRIM/CRD. Older age and fewer EMRs are correlated with greater improvement in QoL. These results further reinforce the role of endoscopic therapy as the first line treatment of BE and early EAC. Funding Agencies None

A Canonical Correlation Analysis of Factors that Influence Quality of Life Among Patients with Chronic Obstructive Pulmonary Disease Based on QLICD-COPD (V2.0)

2021 ◽  
Author(s):  
Yuxi Liu ◽  
Jinghao Ruan ◽  
Chonghua Wan ◽  
Jianfeng Tan ◽  
Bin Wu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Alkaline Phosphatase ◽  
Correlation Analysis ◽  
Canonical Correlation Analysis ◽  
Canonical Correlation ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Objective Indicators

Abstract Background Chronic obstructive pulmonary disease (COPD) is one of the diseases with the highest morbidity and mortality globally. The Quality of Life Instrument for Chronic Diseases(QLICD)-COPD(V2.0) was designed to assess the health condition of patients with COPD. The objective of this study was to evaluate the quality of life (QOL) of patients, the influential clinical factors, and the relationships between QOL and clinical objective indicators. Methods Two hundred and sixty-one in-patients with COPD in the acute exacerbation stage were evaluated using the QLICD-COPD(V2.0) and data on clinical objective indicators were collected. The relationships between QOL and the clinical objective indicators were determined using canonical correlation analysis. Results The standardized scores for the patients in four domains, namely physical function, psychological function, social function, and a disease-specific module, were 49.00 ± 12.91, 59.89 ± 13.51, 68.59 ± 11.94, and 51.84 ± 13.58, respectively. The total score for the QOL of patients was 57.17 ± 10.26. Two pairs of canonical correlation variables were statistically significant (P < 0.05), with coefficients of 0.35 and 0.26. These variables respectively accounted for 45.8% and 33.8% of the variance. The levels of total protein, albumin, serum sodium, and alkaline phosphatase and the percentages of neutrophils and lymphocytes were correlated with the QOL. Conclusion During COPD treatment, clinicians should pay close attention to the levels of total protein, albumin, serum sodium, and alkaline phosphatase and the percentages of neutrophils and lymphocytes to improve the QOL of patients.

Cross-sectional study of quality of life, cortisol, testosterone, and metabolic abnormalities in male schizophrenics (Preprint)

2019 ◽  
Author(s):  
Yuncheng Zhu ◽  
Xixi Jiang ◽  
Haifeng Ji
Keyword(s):  
Quality Of Life ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Testosterone Level ◽  
Metabolic Diseases ◽  
Linear Regression Analysis ◽  
Fasting Blood Glucose ◽  
Metabolic Abnormalities ◽  
Metabolic Indices

BACKGROUND Compared with demography and symptomatology of schizophrenia, the treatment strategies1 and quality of life (QOL) for patients are of more urgent concern for the therapeutic alliance. OBJECTIVE The study aims to investigate the current situation and correlation of metabolic characteristics of male schizophrenics by measuring serum concentrations of cortisol and testosterone related with metabolic abnormalities in male schizophrenics. METHODS The 174 patients were grouped based on their risk of metabolic syndrome (MetS),into Non-MetS, High-risk-MetS (HR-MetS), or MetS groups. Multiple linear regression analysis was used to associate the correlations between WHO Quality of Life-BREF (WHOQOL-BREF) score and five metabolic indices (Body mass index (BMI), Mean arterial pressure (MAP), Cholesterol, Triglyceride and Fasting blood glucose (FBG)). Metabolic diseases were associated with cortisol and testosterone levels using Pearson’s correlations. RESULTS Compared to HR-MetS and MetS groups, the WHOQOL-BREF score in Non-MetS group has statistical difference. Multiple linear regression via stepwise analysis eventually constructed a regression model of WHOQOL-BREF score with four variables including MAP, IQ, FBG and age. The triglyceride level was positively correlated with the cortisol level while all the five metabolic indices were negatively correlated with the testosterone level. CONCLUSIONS In the five metabolic indices, the risks of hyperglycemia and hypertension are correlated with the quality of life in male schizophrenics rather than those of obesity or hyperlipidemia. The correlation analysis then showed that there was a weak linear correlation between testosterone level and all of the five metabolic indices.

scholarly journals Selection of Appropriate Model for Quality of Life Data of Strabismus Patients Despite Censorship

2021 ◽  
Author(s):  
Zahra Ghassemi ◽  
Mehdi Yaseri ◽  
Mostafa Hosseini
Keyword(s):  
Quality Of Life ◽  
Linear Regression ◽  
Regression Model ◽  
Multiple Linear Regression ◽  
Linear Regression Model ◽  
Multiple Linear Regression Model ◽  
Tobit Model ◽  
P Value ◽  
Response Variable

Introduction: Previous studies on the quality of life of strabismus patients have not examined the existence of censoring to express the relation between the response variable and its predictors. Methods & Materials: The information used in this study is a conducted cross-sectional study in 2012. The sample size is 90 children in the age range (4-18) years and with congenital strabismus. We used the RAND Health Insurance Study questionnaire with ten subscales to evaluate the quality of life, which was increased to 11 dimensions by adding some items related to eye alignment concerns introduced by Archer et al. The demographic profile is also recorded by 13 other questions. We have expressed the relationship between the independent and response variables in each of the 11 dimensions of the questionnaire and the overall quality of life score by fitting the multiple linear regression model. Then we fitted the two models of classic Tobit and CLAD, which are for censoring, to all dimensions of the questionnaire. Results: We showed that in fitting the models to the overall quality of life scale variable, the best model is the multiple linear regression. Because the response variable was normal, and there was no censoring (ceiling and floor effect). However, in the depression subscale, due to the high censoring (28.89% of the ceiling effect) and the almost normal distribution of the response variable (p-value of skewness< 0.05), the appropriate model according to the criteria is the classic Tobit (AIC = 546.33). That is, the classic Tobit model is the best alternative to the multiple linear regression model in the presence of censoring. But these conditions did not exist in all variables. In the subscale, there was a severe censoring performance constraint (67.78% of the ceiling effect). When censoring is high, the distribution of the response variable becomes very skewed, and the distribution of response variables deviates drastically from normal. The distribution of the performance constraint variable was very skewed (p-value <0.001). Here the RMSE standard scale for the classic Tobit model was 28.74, which is much higher than the standard scale for the multiple linear regression model (14.23). The best model for the high censoring was CLAD. Conclusion: To use the appropriate statistical method in the analysis, one must look at how the response variable is distributed. The multiple linear regression model is very widely used, but in the presence of censoring, the use of this model gives skewed results. In this case, the classic Tobit model and its derived model, CLAD, are replaced. The nonparametric CLAD model calculates accurate estimates with minimum defaults and censoring.

scholarly journals The Combined Effects of Patient Activation and Relational Aspects on the Quality of Life in Atrial Fibrillation Patients

2021 ◽  
Vol 12 ◽  
Author(s):  
Jie Wang ◽  
Qin Wang ◽  
Zhipeng Bao ◽  
Yuanyuan Peng ◽  
Shenxinyu Liu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
Regression Analysis ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Linear Regression Analysis ◽  
Patient Activation ◽  
Multiple Linear Regression Analysis ◽  
Daily Activities

Objective: This study aims to explore the influence of patient activation (PA) and relational aspects on the quality of life (QoL) in patients with Atrial Fibrillation (AF) for developing measures to improve PA and QoL.Methods: A cross-sectional study was undertaken in 2021 among 190 AF patients in Nanjing, China. Research instruments included a self-designed social-demographic characteristics scale, the Patient Activation Measure (PAM), the Atrial Fibrillation Effect on Quality of Life (AFEQT). The data analysis was performed using IBM SPSS 25.0. Spearman correlation analysis, multiple linear regression analysis, and Wilcoxon rank-sum tests were used to assess the association accordingly.Results: The average AFEQT score for the 190 AF patients was 69.32 ± 14.52. The distribution of activation Levels 1, 2, 3, and 4, were where 4.7, 34.2, 47.4, and 13.7%, respectively. The multiple linear regression analysis revealed that patient activation, work status, and cardiac rehabilitation of AF patients predicted AF-related QoL (β = 0.270, −0.205, and 0.183, respectively; all P &lt; 0.05). The influences of PA level on subdimensions of AF-related QoL were as follows: symptoms, daily activities and treatment concern.Conclusion: The level of QoL of patients with AF was moderate. Higher levels of patient activation in those with AF were associated with milder symptoms, more positive daily activities and fewer treatment concern. Based on our findings, we suggest that healthcare personnel should encourage AF patients to take active participation in cardiac rehabilitation, disease self-management and foster progression of PA level. Future research is warranted to develop tailor-made interventions aimed at the activation level.

scholarly journals Exploring the influencing factors of quality of life among the empty nesters in Shanxi, China: a structural equation model

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Chichen Zhang ◽  
Yuan Cai ◽  
Yaqing Xue ◽  
Xiao Zheng ◽  
Xiaozhao Yang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Linear Regression ◽  
Influencing Factors ◽  
Structural Equation ◽  
Economic Status ◽  
The Elderly ◽  
Equation Model ◽  
Shanxi Province ◽  
Socio Economic Status

Abstract Background As China’s aging trend intensifies and the proportion of empty nests increases, the health-related quality of life of the elderly is the focus of social attention. Previous studies focused on the quality of life of the elderly, rather than empty nesters, and lacked the discussion of the mechanism of influencing factors. Thus, this study aimed to explore the influencing factors of the quality of life (QOL) and interaction mechanisms among empty nesters in Shanxi Province, China, so as to provide practical reference for improving the QOL of empty nesters. Methods A total of 4901 empty nesters in Shanxi Province, China, were selected using multi-stage random cluster sampling method in this cross-sectional study. The quality of life was assessed with the Short Form 36 Health Survey (SF-36). Multiple linear regression analysis (stepwise) was performed to examine the factor associated with QOL. Structural equation model (SEM) approach was conducted to test the direct and indirect association between QOL influencing factors with QOL. Results The average QOL score of empty nesters was 63.34 (SD = 17.23). The multiple linear regression revealed that gender, age, education, monthly income, drinking status, exercise frequency, physical examination frequency, attention to daily nutritional health, relationship with a spouse and relationship with children were significant predictors of the empty nester’s QOL (P < 0.05) (R2 = 0.128). SEM showed that behavioral lifestyle had a direct effect on QOL (β = 0.446, P < 0.001). Socio-economic status had an indirect effect (β = 0.288, P < 0.001) on QOL through behavioral lifestyle. The family relationship had an indirect effect (β = 0.115, P < 0.001) on QOL. Conclusion Behavioral lifestyle was the strongest influencing factor in the quality of life among empty nesters, followed by socio-economic status and family relationships. Thus, maintaining a healthy behavioral lifestyle was important to improve the QOL of the empty nesters. Our findings provide a concrete and strong reference for the formulation of targeted intervention strategies.

scholarly journals Quality of Life of Stroke Patients at 1 Year after Discharge from Inpatient Rehabilitation: A Multicenter Study

2021 ◽  
Vol 73 (4) ◽  
pp. 216-223
Author(s):  
Vilai Kuptniratsaikul
Keyword(s):  
Quality Of Life ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Linear Regression Analysis ◽  
Leisure Activity ◽  
Inpatient Rehabilitation ◽  
Stroke Patients ◽  
Functional Scores

Objective: To investigate quality of life (QoL) and its related factors 1-year after discharge from post-stroke inpatient rehabilitation. Methods: This longitudinal study was performed among 9 rehabilitation centres. Quality of life of stroke patients was evaluated using the WHOQOL-BREF. Its scores ranged from 26-130, with a higher score representing better quality of life. The QoL scores at 1-year follow-up were compared with the scores at discharge. Factors related to quality of life at 1-year after discharge were analysed using univariate and multiple linear regression. Results: One hundred and ninety-seven patients were recruited, with a mean age of 62.3 years. The mean quality of life score at 1-year after discharge was significantly lower than the score at discharge. In multiple linear regression analysis, only 5 factors were associated with quality of life, including having a leisure activity, modified Barthel (Activity of Daily Living, ADL) Index (mBI) at follow-up period, need caregiver, anxiety score, and depression score with the regression coefficient (b) of 6.29 (95%CI: 2.23, 10.35), 0.63 (95%CI: 0.07, 1.20), -7.72 (95%CI: -12.04, -3.40), -0.78 (95%CI: -1.40, -0.17), and -1.14 (95% CI: -1.72, -0.57) respectively. Conclusion: At one year after discharge from inpatient rehabilitation, patients with stroke had poorer quality of life. Factors related to poor quality of life included no leisure activity, and need for caregiver, low functional scores at follow-up, anxiety and depression. Strategies to prevent these factors could enhance QoL of stroke patients.

Chronic kidney disease-associated pruritus significantly impacts on quality of life of patients on haemodialysis and associates with increased levels of serum calcium and phosphorus

2021 ◽  
pp. postgradmedj-2020-139688
Author(s):  
Qiuyu Xie ◽  
Nan Hu ◽  
Yuqing Chen
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Short Form ◽  
Record System ◽  
Calcium And Phosphorus ◽  
The Impact

Purpose of the studyChronic kidney disease-associated pruritus (CKD-aP) is common among patients on maintenance haemodialysis (HD). We performed a study to explore the clinical features of patients with CKD-aP and evaluate the impact of CKD-aP on the quality of life of HD patients.Study designPatients who were receiving regular HD over 3 months were recruited. Quality of life was quantified by the Short Form-12 (SF-12) questionnaire. Pruritus was evaluated by the 5D-Itch Scale. Demographic characteristics and biochemical indicators were obtained from the medical record system. Multiple linear regression was used to assess the association between pruritus and targeting factors. The relationship between the scores on the 5D-Itch Scale and SF-12 was analysed using multiple linear regression, adjusted for other factors, to demonstrate the impact of CKD-aP on the quality of life of HD patients.ResultsIn total, 269 out of 301 (89.4%) patients accomplished all investigations. The prevalence of CKD-aP in our cohort was 40.9%. Age (B=0.339, p=0.042), treatment with haemoperfusion (B=1.853, p=0.018), and serum level of calcium (B=3.566, p=0.008) and phosphorus (B=1.543, p=0.002) were independently associated with pruritus. Score on the 5D-Itch Scale negatively impacted on physical component summary (B=−0.778, p<0.001) and mental component summary (B=−0.675, p<0.001).ConclusionsPruritus significantly aggravates the quality of life of HD patients. Irregularity in the metabolism of calcium and phosphorus may partially explain the mechanism of CKD-aP. More effective treatment of CKD-MBD may help to prevent pruritus and improve patients’ mental and physical health conditions.

Quality of life in patients with stroke at 1-year after discharge from inpatient rehabilitation: A multicenter study

2018 ◽  
Author(s):  
Vilai Kuptniratsaikul ◽  
Thanitta Thanakiatpinyo ◽  
Chawalit Hongsapol
Keyword(s):  
Quality Of Life ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Leisure Activity ◽  
Inpatient Rehabilitation ◽  
Functional Score ◽  
Major Health Problem ◽  
Physician Visits

Abstract Background: Stroke is a major health problem leading to chronic disability and a negative impact on the quality of life (QoL). This study aimed to investigate QoL and its related factors 1-year after discharge from post-stroke inpatient rehabilitation. Methods: This longitudinal study was performed among 9 rehabilitation centres. QoL of stroke patients was evaluated using the WHOQOL-BREF. Its score ranged from 26-130, with a higher score representing better QoL. Factors related to QoL were analysed using univariate and multiple linear regression. Results: One hundred and ninety-seven patients were recruited, with a mean age of 62.3 years. The majority of patients were male (57.4%). The mean score of QoL score of patients with stroke at 1-year was significantly lower than the score at discharge period. In multiple linear regression analysis, 5 factors were associated with QoL, including having a leisure activity, modified Barthel Index at follow-up period, need caregiver, anxiety, and depression score with regression coefficient (b) of 6.29 (95%CI: 2.23, 10.35), 0.63 (95%CI: 0.07, 1.20), -7.72 (95%CI: -12.04, -3.40), -0.78 (95%CI: -1.40, -0.17), and -1.14 (95% CI: -1.72, -0.57). Conclusion: At 1 year, patients with stroke had poorer QoL compared to discharge period. Factors strongly related to QoL included having leisure activity, no need for caregiver, and no depression. The other factor were high functional score at follow-up period and no anxiety. Further study with adequate sample size and consider physician visits to patients who fail to follow-up should be performed in order to strengthen the integrity of these findings. Trial registration: TCTR20180531006 (Retrospectively registered). Date 31 May 2018 Keywords: Stroke, quality of life, rehabilitation, WHOQOL-BREF

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