Prognostic and Functional Role of Hyaluronan-binding Protein 1 (HABP1) in Pancreatic Ductal Adenocarcinoma
Abstract Background: Hyaluronan-binding protein 1 (HABP1) is one of molecules that binds to hyaluronan and is involved in a variety of cellular processes including cell proliferation and migration. HABP1 has related to the progression of various cancers however there are few reports on the expression and function of HABP1 in pancreatic ductal adenocarcinoma (PDAC). We examined the expression and functional role of HABP1 in PDAC.Methods: (1) Immunohistochemical analysis of HABP1 protein was done in archival tissues from 105 PDAC patients. (2) We examined the functional effect of HABP1 on proliferation, colony formation, and migration in PDAC cells by knockdown of HABP1. Results: (1) HABP1 was overexpressed in 49(46.2%) of 106 PDAC patients. Overall survival was significantly shorter in patients with high HABP1 expression (median survival time of 12.8 months) than in those with low HABP1 expression (28.5 months) (log-rank test; p = 0.004). (2) Knockdown of HABP1 expression in PDAC cells resulted in decreased cell proliferation, colony formation and migration ability. Conclusion: HABP1 may serve as a prognosis factor in PDAC and could be a new therapeutic target.