scholarly journals Biochemical status of blood of dogs with atopic dermatitis in the conditions of private veterinary clinic “Alfa vet” m. Konotop

2021 ◽  
pp. 29-31
Author(s):  
Olga Stotska ◽  
Oksana Shkromada ◽  
Aleksandr Stockiy
Keyword(s):  
Atopic Dermatitis ◽  
Reference Values ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Skin Diseases ◽  
Clinical Manifestations ◽  
Metabolic Changes ◽  
The Body ◽  
Veterinary Clinic ◽  
Gamma Glutamyltransferase

Metabolic changes in the body of dogs with atopic dermatitis and the causes of its occurrence still remain poorly understood. This study confirms the need for biochemical blood tests for the differential diagnosis of skin diseases in animals. The aim of the research. To identify metabolic changes in dogs with atopic dermatitis. Methods. Serum samples from five ill animals and five intact animals were tested. The diagnosis of the nosological form of skin lesions was established based on the results of anamnesis and clinical manifestations of the disease. Additionally, biochemical studies of the serum of sick animals were performed. Blood of dogs (n=5) was taken from the anterior subcutaneous vein of the forearm or the lateral subcutaneous vein of the tibia into blood tubes. Results. In the study of mineral metabolism, it was found that the concentration of inorganic phosphorus in the serum of sick animals is reduced by only 0.01 mmol/l, but the concentration of total calcium by 10.0 %. The concentration of cholesterol increases 1.3 times and exceeds the reference values by 0.16 mmol/l. In the blood of sick animals, the activity of alanine aminotransferase is significantly reduced by 21.0 % and aspartate aminotransferase – by 20.0 % compared to intact animals. The enzyme gamma-glutamyltransferase probably increases by 1.51 times (P<0.05) in sick dogs, but does not exceed the reference values. Conclusions. It was found that in atopic dermatitis in the serum of dogs decreases the activity of alanine aminotransferase by 21.0 % and aspartate aminotransferase – by 20.0 %, while the activity of gamma-glutamyltransferase increases 1.51 times. The results show the toxic effect of an allergic agent on animals, especially on the liver, which confirms the previous diagnosis – atopic dermatitis.

scholarly journals Establishment of Reference Values of Gamma-Glutamyl-Transferase and Plasma Aminotransferases in Young Congolese

2021 ◽  
Vol 11 (9) ◽  
pp. 259-264
Author(s):  
Linel Darrel Ngokana ◽  
Fylla Onanga Koumou ◽  
Landry Aymar Loukanou Mbouaka
Keyword(s):  
Reference Values ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyltransferase ◽  
Plasma Enzymes ◽  
Reference Limits ◽  
Biological Criteria ◽  
Serum Biochemical ◽  
Glutamyl Transferase

Objectives: Our goal was to contribute to the production of reference values ​​of plasma or serum biochemical markers by determining the reference values ​​of gamma-glutamyltransferase (GGT), aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT) in young Congolese presumed to be healthy. Methods: 250 young Congolese presumed to be healthy (125 boys and 125 girls) aged 15 to 25 participated in the study. They were selected according to anamnestic and clinico-biological criteria. Samples were taken on a tube containing EDTA and the resulting plasma was stored at -20 ° C. The KENZA MAX spectrophotometer was used to analyze GGT, ASAT and ALAT. The median and the 2.5-97.5 percentiles were used to set the reference limits for each enzyme. The benchmarks determined were compared with those reported by other Africans, Europeans, Indians and Americans. Results: The established reference values ​​were: GGT 12.15-61.85 IU/L for boys and 7-51.95 IU / l for girls (p˂0.0001); ASAT 21.60-94.85 IU/L for boys and 17-84.85 IU/L for girls (p = 0.0003); ALAT 8.30-74.40 IU/L for boys and 8-53.85 IU/L for girls (p˂0.0001). In addition, the comparison between our values ​​and those of other populations showed significant differences. Conclusion: Our results underline the importance of establishing reference values ​​for plasma enzymes specific to the Congolese population. The use of the values ​​established in the ’other populations could induce errors of judgment by excess or by default. Key words: Gamma-glutamyltransferase, Aspartate aminotransferase, Alanine aminotransferase, Reference values, Congo.

The effects of ethanol (0.75 g/kg body weight) on the activities of selected enzymes in sera of healthy young adults: 1. Intermediate-term effects.

1977 ◽  
Vol 23 (5) ◽  
pp. 830-834 ◽  
Author(s):  
D E Freer ◽  
B E Statland
Keyword(s):  
Young Adults ◽  
Body Weight ◽  
Enzyme Activity ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Ethanol Ingestion ◽  
Similar Time ◽  
Gamma Glutamyltransferase ◽  
Time Courses ◽  
Apparently Healthy

Abstract We report the intermediate-term effects of three consecutive evenings of moderate ethanol ingestion (0.75 g/kg body weight each evening) on activity values for alkaline phosphatase, gamma-glutamyltransferase, creatine kinase, aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase in sera of nine apparently healthy young adults. We define "intermediate-term" effects as those occurring between 10 h and 100 h after completion of the ethanol consumption schedule. The most pronounced changes in enzyme activity for the group of volunteers were: gamma-glutamyltransferase, +25% at 60 h after ethanol ingestion; alanine aminotransferase, +12% at 60 h after ethanol; and aspartate aminotransferase,--12% at 60 h after ethanol. All three enzymes exhibited similar time courses, i.e., mean peak activity changes were observed at 60 h, and all three mean enzyme activity values returned to near baseline by 100 h. The possible explanations for the observed changes and the clinical significance are discussed.

scholarly journals Association between Alanine Aminotransferase/Aspartate Aminotransferase Ratio (AST/ALT Ratio) and Coronary Artery Injury in Children with Kawasaki Disease

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Jinxin Wang ◽  
Jiawen Li ◽  
Yue Ren ◽  
Hongying Shi ◽  
Xing Rong ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Laboratory Data ◽  
Clinical Manifestations ◽  
Resistance Rate ◽  
Thrombin Time ◽  
Illness Onset ◽  
Ivig Resistance

Objective. To investigate the association between the aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AST/ALT ratio, AAR) and intravenous immunoglobulin (IVIG) resistance, coronary artery lesions (CAL), and coronary artery aneurysms (CAA) in children with Kawasaki disease (KD). Design. We retrospectively studied 2678 children with KD and divided them into two groups: a low-AAR group and a high-AAR group with a median AAR of 1.13 as the cut-off point. The differences in laboratory data, clinical manifestations, and coronary artery damage rates were compared between the two groups. Results. The incidence of CAL was higher in the low-AAR group than in the high-AAR group at 2 and 3-4 weeks after illness onset (p<0.001, respectively). The IVIG resistance rate was significantly higher in the low-AAR group than in the high-AAR group (29.94% vs 21.71%, p<0.001). The levels of C-reactive protein, erythrocyte sedimentation rate, white blood cell count, bilirubin, fibrinogen, thrombin time, D-dimer, and brain natriuretic peptide were also significantly higher in the low-AAR group compared with the high-AAR group. The levels of albumin and IgG were significantly lower in the low-AAR group compared with those of the high-AAR group. The proportion of typical KD cases in the low-AAR group was significantly higher than that in the high-AAR group. Low-AAR correlated with the risk of coronary artery damage and IVIG resistance. Conclusion. Children with KD who had low-AAR value were more likely to develop coronary artery damage and IVIG resistance. Low AAR is a risk factor for CAL, CAA, and IVIG resistance in KD.

scholarly journals The role of nutrition in the prevention and therapy of selected skin diseases

2021 ◽  
Vol 10 (4) ◽  
pp. 175-179
Author(s):  
Magdalena Daszkiewicz ◽  
Keyword(s):  
Atopic Dermatitis ◽  
Skin Diseases ◽  
The Body ◽  
Unhealthy Lifestyle ◽  
Dermatological Diseases ◽  
Poor Diet ◽  
Current State ◽  
Prevention And Therapy

Nowadays it is known that many dermatological diseases are associated with a poor diet and unhealthy lifestyle. Some nutrients can exacerbate the disease, while others aid in their treatment. The aim of the study was to present the current state of knowledge on the influence of nutrients on the course of skin diseases such as acne, atopic dermatitis and urticaria. Providing the body with the necessary ingredients and eliminating those that favor the development or worsening of symptoms are an important element in the treatment of many skin diseases.

scholarly journals A Pilot Study of a Mindfulness-Based Stress Reduction Programme in Patients Suffering from Atopic Dermatitis

Psych ◽  
2021 ◽  
Vol 3 (4) ◽  
pp. 663-672
Author(s):  
Martin Offenbächer ◽  
Michael Seitlinger ◽  
Daniela Münch ◽  
Christina Schnopp ◽  
Ulf Darsow ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Pilot Study ◽  
Stress Reduction ◽  
Skin Diseases ◽  
Life Quality ◽  
The Body ◽  
Atopic Dermatitis Patient ◽  
Qualitative Feedback ◽  
Mindfulness Based Stress Reduction

Introduction: Patients with atopic dermatitis (AD) have several potential stressors including the symptoms of the disease itself, the stigmatization due to their appearance, and emotional and psychological strain. Psychological factors and stress can trigger and exacerbate the symptoms of skin diseases and there is evidence that stress has a relevant clinical effect on the function of skin cells in vivo. Our objective was to evaluate in a pilot study the feasibility, acceptance, and effectiveness of a Mindfulness-Based Stress Reduction (MBSR) programme in AD patients in a clinical setting. Methods: 10 patients took part in an 8-week MBSR programme, which included, e.g., mindful and conscious awareness of the body and bodywork, and seated meditation. We assessed sociodemographics and disease related variables with standardized measures at predefined time points including Score of Atopic Dermatitis, Patient Oriented Eczema Measure, Dermatology Life Quality Index, Perceived Stress Questionnaire, Freiburg Mindfulness Inventory (FMI), and others. Participants also gave qualitative feedback regarding the effects of the intervention. Results: The mean age was 53.10 years (SD = 15.04), seven patients were female, and disease duration was 36.6 years (SD = 25.5). Calculating pre-post effect sizes (Cohen’s d), the FMI indicated significant improvement in the ‘”presence” and ‘”acceptance” subscales. There was also tendency for less stress. This was confirmed by the qualitative statements of the participants. Conclusions: The MBSR programme is feasible and acceptable for AD patients. Considering the long disease history and the severity of disease burden, the effects of this intervention seem promising as an adjunct to conventional treatments for patients with AD.

scholarly journals The main aspects of the immunopathogenesis of atopic dermatitis in children

2021 ◽  
pp. 27-34
Author(s):  
Olga Olegovna Pobezhimova ◽  
Alexander Viktorovich Zhestkov
Keyword(s):  
Atopic Dermatitis ◽  
Rural Areas ◽  
Skin Diseases ◽  
Secondary Infection ◽  
Allergic Diseases ◽  
Developed Countries ◽  
Severe Form ◽  
Pathological Process ◽  
The Body ◽  
Social Adaptation

Research objective Atopic dermatitis (AtD) is the earliest and most frequent manifestation of the body’s hypersensitivity reaction to environmental allergens. Often manifested in severe form, affecting the skin, can occur in early infancy, childhood. The disease is genetically determined and is chronic. AtD is one of the most common skin diseases (from 20 to 40% in the structure of skin diseases), which occurs in all countries in people of both sexes. In recent years, there has been an increase in the incidence of AtD throughout the world. The disease is more common in highly developed countries and cities (less commonly in rural areas). AtD significantly reduces the quality of life of children, causing psychological discomfort and disrupting their social adaptation. AtD in children is a risk factor for the «atopic march» — the further sequential development of other allergic diseases: allergic rhinitis, pollinosis, allergic conjunctivitis, bronchial asthma. With a reduced immune response of the body, AtD in children can be complicated by the addition of a secondary infection (bacterial, viral, fungal). Such a high incidence rate, a debut in early childhood, a frequently recurring course of the pathological process, and a tendency towards an increase in the forms of the disease resistant to traditional therapy make the details of the pathogenesis of AtD particularly relevant. One of the main roles in the pathogenesis of AtD belongs to the cells of the immune system. The purpose of this article: to systematize the information available today on the immunopathogenesis of atopic dermatitis.

scholarly journals Serum clinical biochemical markers of Hy-Line W-36 laying hens under the influence of increased stocking densities in cages of multilevel batteries

2021 ◽  
Vol 12 (3) ◽  
pp. 425-429
Author(s):  
Y. V. Osadcha ◽  
M. I. Sakhatsky ◽  
R. O. Kulibaba
Keyword(s):  
Lactate Dehydrogenase ◽  
Chronic Stress ◽  
Aspartate Aminotransferase ◽  
High Performance ◽  
Laying Hens ◽  
Stocking Density ◽  
The Body ◽  
Gamma Glutamyltransferase ◽  
Calcium And Phosphorus

Today, the organism of hens is constantly exposed to numerous technological stressors in the conditions of industrial poultry farming, the least studied of which are long-term, which can cause the development of chronic stress. One of such stressors is the increased stocking density of hens, which is also a way of saving resources in egg poultry and is often used by producers to obtain more eggs per 1 m2 of poultry area. The aim of this study was to examine the effect of overcrowding, as a factor of chronic stress development, on the body of hens of a modern high-performance cross, which is necessary to select the best ways to keep them. Four groups of hens were formed for this purpose, which were kept at different stocking densities, according to European standards, Ukrainian standards and with increasing overcrowding. In this way, the gradually increasing intensity of the technological stressor was modeled. Long-term keeping of laying hens at high stocking density did not affect the content in the serum of total protein, albumin, urea and cholesterol, which were within the physiological norm. It was found that the increase in the stocking density of hens to Ukrainian standards, compared to the European, was accompanied by an increase in the activity of lactate dehydrogenase in the serum of their blood. With an increase in stocking density above European and Ukrainian standards, namely to 25.3 birds/m2, there was an increase in the activity of three enzymes – lactate dehydrogenase, aspartate aminotransferase and gamma-glutamyltransferase. It is proved that further overcompaction of hens to 26.7 birds/m2 is accompanied by an increase in serum glucose, creatinine, as well as a decrease in the ratio of calcium and phosphorus, which was confirmed by an increase in alkaline phosphatase activity. Also, increased activity of aspartate aminotransferase, lactate dehydrogenase and gamma-glutamyltransferase was observed. Thus, the main effects of chronic stress caused by prolonged keeping of hens at high stocking densities are reflected in the biochemical parameters of their serum, namely in the increase of glucose, creatinine, enzyme activity, as well as the violation of the ratio of calcium and phosphorus.

scholarly journals CLINICAL AND DIAGNOSTIC VALUE OF DETERMINATION OF NEOPTERIN IN ATOPIC DERMATITIS IN CHILDREN

2018 ◽  
Vol 25 (3) ◽  
pp. 24-27
Author(s):  
M. M. BEN ◽  
E. YU. YANCHEVSKAYA ◽  
O. A. MESNYANKINA
Keyword(s):  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Secondary Infection ◽  
Clinical Manifestations ◽  
Diagnostic Value ◽  
Laboratory Method ◽  
Control Group ◽  
Allergic Skin ◽  
Monitoring And Forecasting

Aim. To improve the diagnosis of allergic skin diseases in childrenMaterials and methods. 135 children aged from 2 to 6 with atopic dermatitis were examined during exacerbation. They were on inpatient treatment in the skin and venereologic department of the Regional skin and venereologic dispensary and the Department of Allergology of the Regional children's clinical hospital. At the same time, 103 people (the main group) had uncomplicated course of the disease, 32 patients had complications of atopic dermatitis in the form of secondary infection. The control group consisted of 29 children aged 2 to 6. Neopterin in serum was determined by enzyme-linked immunosorbent analysis using test kits "Neopterin ELISA" (Germany). Statistical reliability of the obtained data was evaluated using The Student's test.Results. Atopic dermatitis in children, regardless of clinical manifestations, is accompanied by an increase in the content of neopterin in serum. The nature of the increase in the level of neopterin is determined by the duration of the disease, while its highest values are characteristic of the prolonged course of the process (over 4 years).Conclusion. The determination of neopterin in children with atopic dermatitis is a promising laboratory method for assessing the severity of dermatosis, monitoring and forecasting the further course of the process, as well as evaluating the effectiveness of therapeutic measures.

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