scholarly journals Intraosseous Injection of Calcium Phosphate Polymer-Induced Liquid Precursor Increases Bone Density and Improves Early Implant Osseointegration in Ovariectomized Rats

2021 ◽  
Vol Volume 16 ◽  
pp. 6217-6229
Author(s):  
Yanyan Zhou ◽  
Zihe Hu ◽  
Mingjie Ge ◽  
Wenjing Jin ◽  
Ruikang Tang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Density ◽  
Ovariectomized Rats ◽  
Liquid Precursor ◽  
Intraosseous Injection

scholarly journals Protective effect ofGlycyrrhiza glabraroots extract on bone mineral density of ovariectomized rats

BioMedicine ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 8 ◽  
Author(s):  
Dimitrios Galanis ◽  
Konstantinos Soultanis ◽  
Pavlos Lelovas ◽  
Alexandros Zervas ◽  
Panagiotis Papadopoulos ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Density ◽  
Protective Effect ◽  
Bone Mineral ◽  
Proximal Tibia ◽  
Glycyrrhiza Glabra ◽  
Ovariectomized Rats ◽  
Mineral Density ◽  
Three Point Bending ◽  
Significant Difference

Objective: The aim of this study was to evaluate the potential effect of the methanolic extract of plantGlycyrrhiza glabraroots on bone mineral density and femoral bone strength of ovariectomized rats.Methods: Thirty 10-month-old Wistar rats were randomly separated into three groups of ten, Control, Ovariectomy and Ovariectomy-plus-Glycyrrhiza in their drinking water. Total and proximal tibial bone mineral density was measured in all groups before ovariectomy (baseline) and after 3 and 6 months post ovariectomy. Three-point-bending of the femurs and uterine weight and histology were examined at the end of the study.Results: No significant difference was noted in bone density percentage change of total tibia from baseline to 3 months between Control and Ovariectomy-plus-Glycyrrhiza groups (+5.31% ± 4.75 and +3.30% ± 6.31 respectively,P = non significant), and of proximal tibia accordingly (+5.58% ± 6.92 and +2.61% ± 13.62,P = non significant) demonstrating a strong osteoprotective effect. There was notable difference in percentage change of total tibia from baseline to 6 months between groups Ovariectomy and Ovariectomy-plus-Glycyrrhiza (−13.03% ± 5.11 and −0.84% ± 7.63 respectively,P < 0.005), and of proximal tibia accordingly (−27.9% ± 3.69 and −0.81% ± 14.85 respectively,P < 0.001), confirming the protective effect ofGlycyrrhiza glabraextract in preserving bone density of the Ovariectomy-plus-Glycyrrhiza group. Three-point-bending did not reveal any statistically significant difference between Ovariectomy and Ovariectomy-plus-Glycyrrhiza groups. Uterine weights of the Ovariectomy-plus-Glycyrrhiza group ranged between the other two groups with no statistically significant difference to each.Conclusions:Glycyrrhiza glabraroot extract notably protected tibial bone mineral density loss in Ovariectomy-plus-Glycyrrhiza rats in comparison with ovariectomized rats, but did not improve biomechanical strength.

scholarly journals OPG and PTH-(1–34) Have Additive Effects on Bone Density and Mechanical Strength in Osteopenic Ovariectomized Rats

Endocrinology ◽  
2001 ◽  
Vol 142 (10) ◽  
pp. 4295-4304 ◽  
Author(s):  
Paul J. Kostenuik ◽  
Casey Capparelli ◽  
Sean Morony ◽  
Stephen Adamu ◽  
Grant Shimamoto ◽  
...  
Keyword(s):  
Bone Density ◽  
Mechanical Strength ◽  
Ovariectomized Rats ◽  
Additive Effects

Moderate Alcohol Consumption Does Not Augment Bone Density in Ovariectomized Rats

1997 ◽  
Vol 21 (7) ◽  
pp. 1165-1168 ◽  
Author(s):  
H. Wayne Sampson ◽  
Debra Shipley
Keyword(s):  
Alcohol Consumption ◽  
Bone Density ◽  
Ovariectomized Rats ◽  
Moderate Alcohol Consumption

Serum Mineral Status and Long Bone Morphometry of Ovariectomized Rats Fed a Nano-Calcium Phosphate Diet

2019 ◽  
Vol 18 (11) ◽  
pp. 1058-1067
Author(s):  
Neng Nenden Mulyanings ◽  
Ariadne Lakshmidevi Juwono ◽  
Djarwani Soeharso Soejoko ◽  
Dewi Apri Astuti
Keyword(s):  
Calcium Phosphate ◽  
Ovariectomized Rats ◽  
Long Bone ◽  
Bone Morphometry ◽  
Mineral Status

scholarly journals Functionalized DNA nanostructures as scaffolds for guided mineralization

2019 ◽  
Vol 10 (45) ◽  
pp. 10537-10542 ◽  
Author(s):  
Francesca Kim ◽  
Tong Chen ◽  
Trevor Burgess ◽  
Prakash Rasie ◽  
Tim Luca Selinger ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Dna Nanostructures ◽  
Polyaspartic Acid ◽  
Liquid Precursor

Nanopatterned DNA–polyaspartic acid (pAsp) conjugates guide the growth of calcium phosphate minerals in the polymer-induced liquid precursor (PILP) method.

Intraosseous Injection of rhBMP-2/Calcium Phosphate Matrix Improves Bone Structure and Strength in the Proximal Aspect of the Femur in Chronic Ovariectomized Nonhuman Primates

2013 ◽  
Vol 95 (1) ◽  
pp. 36-47 ◽  
Author(s):  
Howard J Seeherman ◽  
X Jian Li ◽  
Erica Smith ◽  
Jascha Parkington ◽  
Rebecca Li ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Nonhuman Primates ◽  
Bone Structure ◽  
Intraosseous Injection

Calcium Phosphate Cements Improve Bone Density When Used in Osteoporotic Sternums

2009 ◽  
Vol 88 (5) ◽  
pp. 1658-1661 ◽  
Author(s):  
Derek D. Muehrcke ◽  
Will M. Shimp ◽  
Rafael Aponte-Lopez
Keyword(s):  
Calcium Phosphate ◽  
Bone Density ◽  
Calcium Phosphate Cements

scholarly journals The Combination of High Calcium Milk with Citrus maxima Peels Ethanolic Extract Increased Bone Density of Ovariectomized Rats

2017 ◽  
Vol 6 (2) ◽  
pp. 42
Author(s):  
Ragil S. Dianingati ◽  
Annisa Novarina ◽  
Amanita K. Hana ◽  
Laeli Muntafi'ah ◽  
Endang Lukitaningsih
Keyword(s):  
Estrogen Receptor ◽  
Bone Density ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Menopausal Woman ◽  
Good Prospect ◽  
Sprague Dawley ◽  
Docking Score ◽  
High Calcium ◽  
Citrus Maxima

Osteoporosis is a common problem in menopause woman. The main cause is lack of estrogen hormone. Commonly, prevention therapy is by consuming high calcium milk, but it is not effective. Bali orange’s peel (Citrus maxima Merr.) is a waste material but known contains phytoestrogen according to previous study. Considering of this result, fortification of high calcium milk and Bali orange’s peel is expected to be an effective solution for osteoporosis in menopause woman. This research began with extraction of Bali orange’s peel (BPE) using ethanol 70% by maceration method. Ovariectomized Sprague Dawley female rats as the model of post menopausal woman were treated by BPE for 28 days. The doses of BPE was given to rats is 500 and 1000 mg/KgBW combined with high calcium milk. Bone density was determined using digital microradiography, the profile showed the increase of bone density in group that treated with combination of BPE 1000 mg/Kg BW and high calcium milk compare to control and given only milk groups. Docking molecular showed that BPE’s active compound which are hesperidin and naringin have interaction with estrogen receptor α and β. Docking score of naringin with ER α and β are -19,97; -18,99 respectively. Meanwhile the docking score of hesperidin with ER α and β are -19,98; +49,92 respectively. Overall, the result of this research showed that fortification of BPE with high calcium milk has good prospect to develop as effective therapy of osteoporosis.Keywords : Citrus maxima Merr., phytoestrogen, osteoporosis, high calcium milk, estrogen receptor 

Supplementation with extract of pumpkin seeds exerts estrogenic effects upon the uterine, serum lipids, mammary glands, and bone density in ovariectomized rats

2019 ◽  
Vol 33 (4) ◽  
pp. 891-900
Author(s):  
Beni Lestari ◽  
Ziana Walidah ◽  
Rohmad Yudi Utomo ◽  
Retno Murwanti ◽  
Edy Meiyanto
Keyword(s):  
Bone Density ◽  
Serum Lipids ◽  
Mammary Glands ◽  
Ovariectomized Rats ◽  
Estrogenic Effects ◽  
Pumpkin Seeds

scholarly journals Osteoprotective Effects in Postmenopausal Osteoporosis Rat Model: Oral Tocotrienol vs. Intraosseous Injection of Tocotrienol-Poly Lactic-Co-Glycolic Acid Combination

2021 ◽  
Vol 12 ◽  
Author(s):  
Nurul ‘Izzah Ibrahim ◽  
Hasnul ‘Iffah Mohd Noor ◽  
Ahmad Naqib Shuid ◽  
Sharlina Mohamad ◽  
Mohd Maaruf Abdul Malik ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Postmenopausal Osteoporosis ◽  
Bone Strength ◽  
Oral Delivery ◽  
Glycolic Acid ◽  
Antioxidant Activities ◽  
Bone Microarchitecture ◽  
Ovariectomized Rats ◽  
Increased Risk ◽  
Intraosseous Injection

Osteoporosis, the most common bone disease, is associated with compromised bone strength and increased risk of fracture. Previous studies have shown that oxidative stress contributes to the progression of osteoporosis. Specifically, for postmenopausal osteoporosis, the reduction in estrogen levels leads to increased oxidative stress in bone remodeling. Tocotrienol, a member of vitamin E that exhibits antioxidant activities, has shown potential as an agent for the treatment of osteoporosis. Most studies on the osteoprotective effects of tocotrienols had used the oral form of tocotrienols, despite their low bioavailability due the lack of transfer proteins and high metabolism in the liver. Several bone studies have utilized tocotrienol combined with a nanocarrier to produce a controlled release of tocotrienol particles into the system. However, the potential of delivering tocotrienol–nanocarrier combination through the intraosseous route has never been explored. In this study, tocotrienol was combined with a nanocarrier, poly lactic-co-glycolic acid (PLGA), and injected intraosseously into the bones of ovariectomized rats to produce targeted and controlled delivery of tocotrienol into the bone microenvironment. This new form of tocotrienol delivery was compared with the conventional oral delivery in terms of their effects on bone parameters. Forty Sprague–Dawley rats were divided into five groups. The first group was sham operated, while other groups were ovariectomized (OVX). Following 2 months, the right tibiae of all the rats were drilled at the metaphysis region to provide access for intraosseous injection. The estrogen group (OVX + ESTO) and tocotrienol group (OVX + TTO) were given daily oral gavages of Premarin (64.5 mg/kg) and annatto-tocotrienol (60 mg/kg), respectively. The locally administered tocotrienol group (OVX + TTL) was given a single intraosseous injection of tocotrienol–PLGA combination. After 8 weeks of treatment, both OVX + TTO and OVX + TTL groups have significantly lower bone markers and higher bone mineral content than the OVX group. In terms of bone microarchitecture, both groups demonstrated significantly higher trabecular separation and connectivity density than the OVX group (p &lt; 0.05). Both groups also showed improvement in bone strength by the significantly higher stress, strain, stiffness, and Young’s modulus parameters. In conclusion, daily oral tocotrienol and one-time intraosseous injection of tocotrienol–PLGA combination were equally effective in offering protection against ovariectomy-induced bone changes.

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