scholarly journals ANTI-PYRETIC AND ANTI-INFLAMMATORY ACTIVITY OF AQUEOUS EXTRACT OFSOLANUM XANTHOCARPUM BERRIES IN SUITABLE ANIMAL MODELS

2021 ◽  
Vol 9 (11) ◽  
pp. 954-959
Author(s):  
Leisangthem Tarinita Devi ◽  
◽  
Mayanglambam Medhabati Devi ◽  
Florence Lalvarmawi ◽  
Swagata Datta ◽  
...  
Keyword(s):  
Animal Models ◽  
Aqueous Extract ◽  
Inflammatory Activity ◽  
Active Principle ◽  
Traditional Medicines ◽  
Control Drug ◽  
Paw Oedema ◽  
Study Results ◽  
Anti Inflammatory ◽  
Solanum Xanthocarpum

Background: Use of traditional medicines for treating various diseases have become a topic of global importance because of their safety, less side effects and cost-effectiveness. The present study was undertaken to evaluate the anti-pyretic and anti-inflammatory activity of aqueous extract of Solanum xanthocarpum berries (SXB) in suitable animal models. Methods: Anti-pyretic activity was assessed by dried yeast induced pyrexia in rats. Anti-inflammatory activity was evaluated using carrageenan induced paw oedema in rats. Three doses of the plant extract (500, 1000 and 1500 mg/kg) prepared by dissolving the drugs in 2% gum acacia were used. Paracetamol 33 mg/kg and aspirin 100 mg/kg were used as standard drugs for anti-pyretic and anti-inflammatory activity respectively. Vehicle served as a control drug. Results: Acute toxicity study results demonstrated no mortality of animals after 24 hours. The aqueous extract of the plant significantly decreased the rectal temperature of the rats and significantly prevented increase in volume of paw oedema. Conclusion: The aqueous extract of Solanum xanthocarpum berries exerts its anti-pyretic and anti-inflammatory activity activity. However, further studies with the plant are required to evaluate the dose dependent activity and also to determine the active principle responsible for exact mechanism for both antipyretic and anti-inflammatory activity.

scholarly journals EVALUATION OF EFFECT OF AQUEOUS EXTRACT OF PORTULACA OLERACEA LINN. LEAVES IN ACUTE INFLAMMATION

2020 ◽  
pp. 1-2
Author(s):  
M. Medhabati ◽  
L. Babycha ◽  
L. Tarinita ◽  
Bikram Tewari ◽  
Saumya Kanti Sinha
Keyword(s):  
Aqueous Extract ◽  
Acute Inflammation ◽  
Portulaca Oleracea ◽  
Inflammatory Activity ◽  
Albino Rats ◽  
Standard Drug ◽  
Paw Oedema ◽  
The Mean ◽  
Anti Inflammatory ◽  
Inflammatory Action

In the present study, the anti-inflammatory activity of aqueous extract of Portulaca oleracea (POE 200, 400 and 600mg/kg) was studied using carrageenan induced paw oedema in albino rats. The mean increase in paw volume was recorded. POE produced significant (p<,0.01) anti-inflammatory activity when compared to the control. The anti-inflammatory action of POEcan be attributed to its flavonoid contents which are known to act through inhibition of prostaglandin biosynthesis. However, the test drug at maximum dose (600mg/kg) was found to be less effective than the standard drug, aspirin (100mg/Kg).

scholarly journals ANTI-INFLAMMATORY ACTIVITY OF AQUEOUS EXTRACTS OF GRACILARIA

2017 ◽  
pp. 17-19
Author(s):  
CHALINI K. ◽  
JOHNSON M. ◽  
ADAIKALARAJ G. ◽  
VIDYARANI GEORGE ◽  
RAMAKRISHNAN P.
Keyword(s):  
Gracilaria Verrucosa ◽  
Inflammatory Activity ◽  
Active Principle ◽  
Aqueous Extracts ◽  
Gracilaria Edulis ◽  
Gracilaria Corticata ◽  
Study Results ◽  
Anti Inflammatory ◽  
Semi Solid ◽  
Dose Dependent

Objective: In the present investigation an attempt was made to examine the anti-inflammatory potential of aqueous extracts of Gracilaria salicornia C. Ag., Gracilaria edulis (Gmelin) Silva, Gracilaria corticata J. Ag., Gracilaria fergusonii J. Ag.,and Gracilaria verrucosa (Hudson) Papenfus from Mandapam, Gracilaria edulis (Gmelin) Silva., Gracilaria verrucosa (Hudson) Papenfus from Pulicate Lake, Gracilaria fergusonii J. Ag., Gracilaria corticata J. Ag. and Gracilaria corticata J. Ag. var. cylindrica from Tuticorin using heat induced haemolysis of RBC. In addition, the present study is focused to reveal the locality specific anti-inflammatory activities of selected Gracillaria species.Methods: The fresh seaweeds were boiled with distilled water (1:20 W/V) for 2 h. The slurry was filtered through Whatman No. 41 filter paper and condensed. The semi-solid crude extracts were used for anti-inflammatory analysis.Results: An aqueous extracts of studied Gracilaria species were effective in inhibiting the heat induced haemolysis at different concentrations. The results showed the dose dependent protection. The percentage of anti-inflammatory activity of studied Gracillaria was varied from 43.81 to 95.55. The highest percentage (95.55%) of activity was observed in 250 µg/ml of G. edulis aqueous extracts. The anti-inflammatory activity of studied Gracillaria species at 250 µg/ml were as follows G. edulis (Mandabam)>G. corticata (Mandabam)>G. verucosa (Mandabam)>G. salicornia (Mandabam)>G. ferugosonii (Tuticorin)>G. ferugosonii (Mandabam)>G. edulis (Pulicate)>G. corticata (Tuticorin)>G. verucosa (Pulicate)>G. corticata var. cylindrica (Tuticorin).Conclusion: The results of the present study clearly explained the anti-inflammatory potential of the studied Gracillaria species. The aqueous 0extracts of Gracillaria collected from Mandapam showed the highest percentage of protection activity. This study results confirm the existence of active principle responsible for the anti-inflammatory activity. Further studies are required to isolate the active principles without any side effects.

Anti-Inflammatory Activity of the Aqueous Extract of Ficus Deltoidea

2011 ◽  
Vol 14 (1) ◽  
pp. 90-97 ◽  
Author(s):  
Z. A. Zakaria ◽  
M. K. Hussain ◽  
A. S. Mohamad ◽  
F. C. Abdullah ◽  
M. R. Sulaiman
Keyword(s):  
Aqueous Extract ◽  
Formalin Test ◽  
Inflammatory Responses ◽  
Inflammatory Activity ◽  
Second Phase ◽  
Paw Edema ◽  
Ficus Deltoidea ◽  
Inflammatory Models ◽  
Study Results ◽  
Anti Inflammatory

Ficus deltoidea (Family Moraceae) leaves have been used traditionally by the Malays to treat ailments such as wounds, sores, and rheumatism. The aim of the present study was to determine the anti-inflammatory activity of the aqueous extract of F. deltoidea leaf (FDA) using acute and chronic inflammatory models. FDA, in the doses of 30, 100, and 300 mg/kg, was administered intraperitoneally in rats ( n = 6) before the animals were subjected to the carrageenan-induced paw edema test, cotton pellet-induced granuloma test, and formalin test. The first two tests represent acute and chronic models of inflammation, respectively. The first and second phases of the formalin test represent neurogenic pain and inflammatory-mediated pain, respectively; thus, only the second phase was measured in the present study. Results showed that FDA exerted significant ( p < .05) anti-inflammatory activity in all assays, with dose–response effects seen in the paw edema and formalin tests. In conclusion, the leaf of F. deltoidea possesses anti-inflammatory activity against acute and chronic inflammatory responses and against pain-associated inflammatory response. These findings justify the traditional uses of F. deltoidea leaves for treatment of inflammatory-mediated ailments.

scholarly journals Evaluation of Antipyretic and Anti-inflammatory Activity of Aqueous Extract of Leptadenia Reticulata in Animal Models

2016 ◽  
Vol 16 (2) ◽  
pp. 40 ◽  
Author(s):  
Sneha Bherji ◽  
M. Ganga Raju ◽  
Namile Divya
Keyword(s):  
Animal Models ◽  
Acute Toxicity ◽  
Aqueous Extract ◽  
Inflammatory Activity ◽  
Cow Milk ◽  
Albino Rats ◽  
Paw Edema ◽  
Antipyretic Activity ◽  
Toxicity Studies ◽  
Anti Inflammatory

<strong>Objective:</strong> To study the antipyretic and anti-inflammatory effects of the Aqueous Extract of <em>Leptadenia Reticulata</em> (AELR) in different animal models. <strong>Materials and Methods</strong>: Acute toxicity studies were performed and extract was found to be safe upto 2000 mg/kg. Two doses were selected for the "evaluation of antipyretic and anti-inflammatory activity of aqueous extract of <em>Leptadenia reticulata</em> in animal models" i.e 200 mg/kg and 400 mg/kg b. w. Antipyretic activity was evaluated using baker's yeast induced pyrexia in albino rats and cow milk induced pyrexia in albino rabbits. Anti-inflammatory activity was evaluated using carrageenan induced paw edema and turpentine oil induced paw edema in albino rats. <strong>Results</strong>: In all the animal models AELR at the dose of 200 mg/kg b.w and 400 mg/kg b.w showed significant (P&lt;0.01) antipyretic and anti-inflammatory activity. <strong>Conclusion</strong>: These finding could justify the inclusion of aqueous extract of <em>Leptadenia reticulata</em> in the management of pyrexia and inflammation.

scholarly journals Comparative anti-inflammatory activity of Clerodendrum serratum (Linn) Moon and Solanum xanthocarpum Schrad and Wendl in wistar ablino rats

2016 ◽  
Vol 5 (2) ◽  
pp. 38-44
Author(s):  
Poornima Solapure ◽  
◽  
Pradeep ◽  
Ravi Mundugaru ◽  
Prakash L Hegde ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Albino Rats ◽  
White Pulp ◽  
Tissue Formation ◽  
Paw Oedema ◽  
Anti Inflammatory ◽  
Folk Remedies ◽  
Wistar Albino Rats ◽  
Solanum Xanthocarpum ◽  
Granuloma Tissue

C. serratum and S. xanthocarpum plants are used as folk remedies for inflammations, arthritis, cough, asthma and bronchitis. The present investigation aimed to evaluate the comparative anti-inflammatory activity in Wistar albino rats. The group specific rats were treated for seven consecutive days and subjected to carrageenan induced paw oedema and cotton pellet implanted granuloma tissue formation tests at a dose of 8.64ml/kg (p.o). Both the test drugs have shown reduced paw volume during third and sixth hour readings and a moderate decrease in the granuloma tissue formation. CRP enzyme was found to be reduced significantly and a moderate elevation in white pulp of spleen from both the test groups were observed. The present findings suggest that both the drugs have moderate anti-inflammatory activity as ascertained by the comparative decrease in carrageenan induced paw volume, decreased granuloma tissue formation and normal histological profile of important organs.

In-vivo anti-inflammatory activity and safety assessment of the aqueous extract of Algerian Erica arborea L. (Ericaceae) aerial parts

2021 ◽  
Vol 271 ◽  
pp. 113881
Author(s):  
Djouher Amroun ◽  
Meriem Hamoudi ◽  
Seddik Khennouf ◽  
Sabrina Boutefnouchet ◽  
Daoud Harzallah ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Safety Assessment ◽  
Inflammatory Activity ◽  
Aerial Parts ◽  
Erica Arborea ◽  
Anti Inflammatory

Evaluation of the Anti-inflammatory Activity of Luteolin in Experimental Animal Models

Planta Medica ◽  
2007 ◽  
Vol 73 (3) ◽  
pp. 221-226 ◽  
Author(s):  
Li Ziyan ◽  
Zhou Yongmei ◽  
Zhang Nan ◽  
Tang Ning ◽  
Liu Baolin
Keyword(s):  
Animal Models ◽  
Experimental Animal ◽  
Inflammatory Activity ◽  
Experimental Animal Models ◽  
Anti Inflammatory

scholarly journals EVALUATION OF IN VITRO ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITY OF AQUEOUS AND METHANOLIC SEED EXTRACTS OF CITRULLUS LANATUS

2017 ◽  
Vol 9 (5) ◽  
pp. 29
Author(s):  
Iswariya S. ◽  
Uma T. S.
Keyword(s):  
Antimicrobial Activity ◽  
Bacillus Subtilis ◽  
Aqueous Extract ◽  
Seed Extract ◽  
Inflammatory Activity ◽  
Diffusion Method ◽  
Klebsiella Pneumonia ◽  
Anti Inflammatory ◽  
Seed Extracts

Objective: The present study was designed to identify the bioactive phytochemicals and its antibacterial and in vitro anti-inflammatory potential of aqueous and methanolic seed extract of Citrullus lanatus.Methods: The phytochemical screening of both the aqueous and methanolic seed extract was carried out qualitatively to identify the major Phyto-constituents present in the extracts. The antimicrobial activity of the extracts was evaluated against six pathogenic bacterial strains by agar well diffusion method and the Minimum inhibitory concentration (MIC) was determined by broth dilution method. In vitro anti-inflammatory activity of C. lanatus seed extracts was evaluated by using human red blood cell (HRBC) membrane stabilization and inhibition of albumin denaturation method.Results: The results of the study indicated that both the extracts of the seed having antimicrobial activity, while the methanolic extract showed more significant activity against the tested organism than aqueous extract. Methanol extract had the lowest MIC of 1.562 mg/ml against Escherichia coli, Staphylococcus aureus, Klebsiella pneumonia, Pseudomonas aeruginosa and Bacillus subtilis, whereas in aqueous extract was highly sensitive to Bacillus subtilis, E. coli and Klebsiella pneumonia with MIC of 3.125 and 6.25 mg/ml, respectively. Methanolic extracts exerted comparative higher anti-inflammatory activity than aqueous extract.Conclusion: Present study provides a firm evidence to support that the synergistic effect of C. lanatus seed extracts having potent anti-inflammatory and antimicrobial property, which might serve as an effective drug for various microbial infections and inflammatory disorders.

scholarly journals Anti-Inflammatory Activity of Pleurotus ostreatus, a Culinary Medicinal Mushroom, in Wistar Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
W. J. A. Banukie N. Jayasuriya ◽  
Shiroma M. Handunnetti ◽  
Chandanie A. Wanigatunge ◽  
Gita H. Fernando ◽  
D. Thusitha U. Abeytunga ◽  
...  
Keyword(s):  
Pleurotus Ostreatus ◽  
Inflammatory Activity ◽  
No Production ◽  
Protective Effects ◽  
Paw Oedema ◽  
Freeze Dried ◽  
Anti Inflammatory ◽  
Rat Paw ◽  
Rat Paw Oedema

Context. Pleurotus ostreatus (P.o) is a culinary mushroom which is commonly called as “oyster mushroom” belonging to the Basidiomycetous fungi of the order Agaricales and family Pleurotaceae. Objectives. The present study investigates the anti-inflammatory potential of P.o and the underlying mechanisms of activity. Materials and Methods. Anti-inflammatory activity was evaluated using suspensions of freeze-dried and powdered (SFDP) P.o and acetone extract (AE) of P.o in normal and alloxan-induced diabetic rats using the carrageenan-induced rat paw oedema model. The mechanisms by which P.o is mediating the anti-inflammatory activity were studied using in vivo and in vitro assays. Results. At doses of 500–1000 mg/kg, the SFDP of P.o showed long-lasting activity at both early and late phases of carrageenan-induced rat paw oedema. The dose of 750 mg/kg showed the most potent inhibitory activity (92% inhibition) in healthy rats. The AE of P.o showed maximum inhibition of oedema of 87%. P.o exerted protective effects on the inflammatory pathologies in rats with diabetes. The possible mechanisms by which P.o mediates the anti-inflammatory activity were antihistamine activity (52.1%), inhibition of cell migration to the site of inflammation (45.4%), in vitro membrane stabilizing activity (52.6%), and inhibition of nitric oxide (NO) production (91.2%) (P<0.05). Dose-dependent inhibition of NO production was seen with in vitro treatment of rat peritoneal cells with AE of P.o (r = 0.95; P<0.05). Discussion and Conclusion. The promising activity of culinary mushroom P.o against inflammation suggests its potential application as a functional food during inflammatory conditions.

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