Selection of local antiseptic for treatment and prevention of wound infection

Treatment And Prevention ◽

Octenidine Dihydrochloride ◽

The advantages and disadvantages of modern antiseptics for local treatment and prevention of wound infections are considered. On the basis of data of comparative clinical studies the advantages of topical drugs based on octenidine dihydrochloride in combination with phenoxyethanol are presented. The advantages of octenidine dihydrochloride/ phenoxyethanol as a local antiseptic for treatment and prevention of wound infections in case of wound defects, burns are described.

Therapeutic potential of sulfathiazole silver for topical treatment of wound infection

Ambulatory surgery hospital-replacing technologies ◽

10.21518/1995-14772018-1-2-42-51 ◽

2018 ◽

pp. 42-51

Author(s):

A. V. Rodin ◽

V. V. Privolnev ◽

A. N. Barsukov

Keyword(s):

Wound Infection ◽

Topical Treatment ◽

Clinical Studies ◽

Therapeutic Potential ◽

Topical Agent ◽

Wound Infections ◽

Silver Compound

This article discusses the advantages and disadvantages of using silver compound-based preparations for topical treatment of wound infections. Comparative clinical studies showed the advantages of topical silver preparations that were used to treat the wound process. It also describes the advantages of sulfathiazole silver as a topical agent for the topical treatment of wound infections.

Advances in Rodent Models for Breast Cancer Formation, Progression, and Therapeutic Testing

Frontiers in Oncology ◽

10.3389/fonc.2021.593337 ◽

2021 ◽

Vol 11 ◽

Author(s):

Chong Liu ◽

Pei Wu ◽

Ailin Zhang ◽

Xiaoyun Mao

Keyword(s):

Breast Cancer ◽

Cancer Progression ◽

Rodent Model ◽

Rodent Models ◽

Clinical Therapeutics ◽

Treatment And Prevention ◽

Mechanism Of Carcinogenesis ◽

Prevention Of Breast Cancer ◽

Breast cancer is a highly complicated disease. Advancement in the treatment and prevention of breast cancer lies in elucidation of the mechanism of carcinogenesis and progression. Rodent models of breast cancer have developed into premier tools for investigating the mechanisms and genetic pathways in breast cancer progression and metastasis and for developing and evaluating clinical therapeutics. Every rodent model has advantages and disadvantages, and the selection of appropriate rodent models with which to investigate breast cancer is a key decision in research. Design of a suitable rodent model for a specific research purpose is based on the integration of the advantages and disadvantages of different models. Our purpose in writing this review is to elaborate on various rodent models for breast cancer formation, progression, and therapeutic testing.

Trends in Diagnosis for Active Tuberculosis Using Nanomaterials

Current Medicinal Chemistry ◽

10.2174/0929867325666180912105617 ◽

2019 ◽

Vol 26 (11) ◽

pp. 1946-1959 ◽

Cited By ~ 3

Author(s):

Le Minh Tu Phan ◽

Lemma Teshome Tufa ◽

Hwa-Jung Kim ◽

Jaebeom Lee ◽

Tae Jung Park

Keyword(s):

Sensitivity And Specificity ◽

High Efficiency ◽

Point Of Care ◽

High Sensitivity ◽

Signs And Symptoms ◽

Diagnostic Methods ◽

Treatment And Prevention ◽

Clinical Tools ◽

Diagnostic Applications

Background:Tuberculosis (TB), one of the leading causes of death worldwide, is difficult to diagnose based only on signs and symptoms. Methods for TB detection are continuously being researched to design novel effective clinical tools for the diagnosis of TB.Objective:This article reviews the methods to diagnose TB at the latent and active stages and to recognize prospective TB diagnostic methods based on nanomaterials.Methods:The current methods for TB diagnosis were reviewed by evaluating their advantages and disadvantages. Furthermore, the trends in TB detection using nanomaterials were discussed regarding their performance capacity for clinical diagnostic applications.Results:Current methods such as microscopy, culture, and tuberculin skin test are still being employed to diagnose TB, however, a highly sensitive point of care tool without false results is still needed. The utilization of nanomaterials to detect the specific TB biomarkers with high sensitivity and specificity can provide a possible strategy to rapidly diagnose TB. Although it is challenging for nanodiagnostic platforms to be assessed in clinical trials, active TB diagnosis using nanomaterials is highly expected to achieve clinical significance for regular application. In addition, aspects and future directions in developing the high-efficiency tools to diagnose active TB using advanced nanomaterials are expounded.Conclusion:This review suggests that nanomaterials have high potential as rapid, costeffective tools to enhance the diagnostic sensitivity and specificity for the accurate diagnosis, treatment, and prevention of TB. Hence, portable nanobiosensors can be alternative effective tests to be exploited globally after clinical trial execution.

Wound Infections of Snakebites from the Venomous Protobothrops mucrosquamatus and Viridovipera stejnegeri in Taiwan: Bacteriology, Antibiotic Susceptibility, and Predicting the Need for Antibiotics—A BITE Study

Toxins ◽

10.3390/toxins12090575 ◽

2020 ◽

Vol 12 (9) ◽

pp. 575 ◽

Cited By ~ 1

Author(s):

Chih-Chuan Lin ◽

Yen-Chia Chen ◽

Zhong Ning Leonard Goh ◽

Chen-Ken Seak ◽

Joanna Chen-Yeen Seak ◽

...

Keyword(s):

Wound Infection ◽

Roc Curve ◽

Predictive Performance ◽

Antibiotic Usage ◽

Emergency Department Visits ◽

Treatment Modalities ◽

Wound Infections ◽

Neutrophil Lymphocyte Ratio ◽

Cell Counts ◽

Freeze Dried

Snakebites from Taiwan habus (Protobothrops mucrosquamatus) and green bamboo vipers (Viridovipera stejnegeri) account for two-thirds of all venomous snakebites in Taiwan. While there has been ongoing optimization of antivenin therapy, the proper management of superimposed bacterial wound infections is not well studied. In this Bacteriology of Infections in Taiwanese snake Envenomation (BITE) study, we investigated the prevalence of wound infection, bacteriology, and corresponding antibiotic usage in patients presenting with snakebites from these two snakes. We further developed a BITE score to evaluate the probability of wound infections and guide antibiotic usage in this patient population. All snakebite victims who presented to the emergency departments of seven training and research hospitals and received at least one vial of freeze-dried hemorrhagic antivenin between January 2001 and January 2017 were identified. Patient biodata, laboratory investigation results, and treatment modalities were retrieved. We developed our BITE score via univariate and multiple logistic regression analyses. The receiver operating characteristic (ROC) curve was plotted to evaluate the predictive performance of the BITE score. Out of 8,295,497 emergency department visits, 726 patients presented with snakebites from a Taiwan habu or a green bamboo viper. The wound infection rate was 22.45%, with seven positive wound cultures, including six polymicrobial infections. Morganella morganii, Enterococcus spp., Bacteroides fragilis, and Aeromonas hydrophila were most frequently cultured. There were no positive blood cultures. A total of 33.0% (n = 106) of snakebite patients who received prophylactic antibiotics nevertheless developed wound infections, while 44.8% (n = 73) of wound infection patients were satisfactorily treated with one of the following antibiotics: amoxicillin/clavulanic acid, oxacillin, cefazolin, and ampicillin/sulbactam. With the addition of gentamicin, the success of antibiotic therapy increased by up to 66.54%. The prognostic factors for the secondary bacterial infection of snakebites were white blood cell counts, the neutrophil lymphocyte ratio, and the need for hospital admission. The area under the ROC curve for the BITE score was 0.839. At the optimal cut-off point of 5, the BITE score had a 79.58% accuracy, 82.31% sensitivity, and 79.71% specificity when predicting infection in snakebite patients. Our BITE score may help with antibiotic stewardship by guiding appropriate antibiotic use in patients presenting with snakebites. It may also be employed in further studies into antibiotic prophylaxis in snakebite patients for the prevention of superimposed bacterial wound infections.

A Systematic Literature Review of Multi-Criteria Decision-Making Methods for Sustainable Selection of Insulation Materials in Buildings

Sustainability ◽

10.3390/su13020737 ◽

2021 ◽

Vol 13 (2) ◽

pp. 737

Author(s):

Indre Siksnelyte-Butkiene ◽

Dalia Streimikiene ◽

Tomas Balezentis ◽

Virgilijus Skulskis

Keyword(s):

Decision Making ◽

Literature Review ◽

Systematic Literature Review ◽

Energy Demand ◽

Energy Performance ◽

Future Research ◽

Multi Criteria Decision Making ◽

Insulation Materials ◽

The European Commission has recently adopted the Renovation Wave Strategy, aiming at the improvement of the energy performance of buildings. The strategy aims to at least double renovation rates in the next ten years and make sure that renovations lead to higher energy and resource efficiency. The choice of appropriate thermal insulation materials is one of the simplest and, at the same time, the most popular strategies that effectively reduce the energy demand of buildings. Today, the spectrum of insulation materials is quite wide, and each material has its own specific characteristics. It is recognized that the selection of materials is one of the most challenging and difficult steps of a building project. This paper aims to give an in-depth view of existing multi-criteria decision-making (MCDM) applications for the selection of insulation materials and to provide major insights in order to simplify the process of methods and criteria selection for future research. A systematic literature review is performed based on the Search, Appraisal, Synthesis and Analysis (SALSA) framework and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. In order to determine which MCDM method is the most appropriate for different questions, the main advantages and disadvantages of different methods are provided.

Aspergillus flavus costochondritis following coronary artery bypass grafting: a case report and a brief review of literature

Asian Cardiovascular and Thoracic Annals ◽

10.1177/0218492320988458 ◽

2021 ◽

pp. 021849232098845

Author(s):

Aamir Mohammad ◽

Santhosh Regini Benjamin ◽

Sameer Mallampati ◽

Birla Roy Gnanamuthu ◽

Anne Jennifer Prabhu ◽

...

Keyword(s):

Cardiac Surgery ◽

Wound Infection ◽

Artery Bypass ◽

Correct Diagnosis ◽

Relevant Literature ◽

Specific Treatment ◽

Wound Infections ◽

Sternal Wound Infection ◽

Review Of Literature ◽

Sternal Wound Infections

Bacterial sternal wound infections following cardiac surgery are not uncommon. However, sternal wound infection by a fungus is a rarity, and it warrants a correct diagnosis followed by specific treatment. We report a case of Aspergillus sternal wound infection with costochondritis following cardiac surgery, and briefly review the relevant literature.

Management of Deep Spinal Wound Infections Following Instrumentation Surgery with Subfascial Negative Pressure Wound Therapy

Journal of Neurological Surgery Part A Central European Neurosurgery ◽

10.1055/s-0040-1720999 ◽

2021 ◽

Author(s):

Marcus Rickert ◽

Michael Rauschmann ◽

Nizar Latif-Richter ◽

Mohammad Arabmotlagh ◽

Tamin Rahim ◽

...

Keyword(s):

Risk Factors ◽

Wound Healing ◽

Wound Infection ◽

Spinal Fusion ◽

Negative Pressure Wound Therapy ◽

Wound Infections ◽

Wound Therapy ◽

Postoperative Wound ◽

Deep Wound ◽

The Impact

Abstract Background and Study Aims The treatment of infections following a spine surgery continues to be a challenge. Negative pressure wound therapy (NPWT) has been an effective method in the context of infection therapy, and its use has gained popularity in recent decades. This study aims to analyze the impact of known risk factors for postoperative wound infection on the efficiency and length of NPWT therapy until healing. Patients and Methods We analyzed 50 cases of NPWT treatment for deep wound infection after posterior and posteroanterior spinal fusion from March 2010 to July 2014 retrospectively. We included 32 women and 18 men with a mean age of 69 years (range, 36–87 years). Individual risk factors for postoperative infection, such as age, gender, obesity, diabetes, immunosuppression, duration of surgery, intraoperative blood loss, and previous surgeries, as well as type and onset (early vs. late) of the infection were analyzed. We assessed the associations between these risk factors and the number of revisions until wound healing. Results In 42 patients (84%), bacterial pathogens were successfully detected by means of intraoperative swabs and tissue samples during first revision. A total of 19 different pathogens could be identified with a preponderance of Staphylococcus epidermidis (21.4%) and S. aureus (19.0%). Methicillin-resistant S. aureus (MRSA) was recorded in two patients (2.6%). An average of four NPWT revisions was required until the infection was cured. Patients with infections caused by mixed pathogens required a significantly higher number of revisions (5.3 vs. 3.3; p < 0.01) until definitive wound healing. For the risk factors, no significant differences in the number of revisions could be demonstrated when compared with the patients without the respective risk factor. Conclusion NPWT was an effective therapy for the treatment of wound infections after spinal fusion. All patients in the study had their infections successfully cured, and all spinal implants could be retained. The number of revisions was similar to those reported in the published literature. The present study provides insights regarding the effectiveness of NPWT for the treatment of deep wound infection after spinal fusion. Further investigations on the impact of potential risk factors for postoperative wound healing disorders are required. Better knowledge on the impact of specific risk factors will contribute to a higher effectiveness of prophylaxis for postoperative wound infections considering the patient-specific situation.

Total arterial myocardial revascularization using bilateral internal mammary arteries and the role of postoperative sternal stabilization to reduce wound infections in a large cohort study

Interactive CardioVascular and Thoracic Surgery ◽

10.1093/icvts/ivz088 ◽

2019 ◽

Vol 29 (2) ◽

pp. 224-229 ◽

Cited By ~ 1

Author(s):

Marc Albert ◽

Ragi Nagib ◽

Adrian Ursulescu ◽

Ulrich F W Franke

Keyword(s):

Retrospective Study ◽

Wound Infection ◽

Internal Mammary Artery ◽

Wound Closure ◽

Myocardial Revascularization ◽

Wound Complications ◽

Wound Infections ◽

Term Survival ◽

Mammary Arteries ◽

Internal Mammary

Abstract OBJECTIVES Total arterial myocardial revascularization using bilateral internal mammary arteries shows improved results for mortality, long-term survival and superior graft patency. It has become the standard technique according to recent guidelines. However, these patients may have an increased risk of developing sternal wound infections, especially obese patients or those with diabetes. One reason for the wound complications may be early sternum instability. This situation could be avoided by using a thorax support vest (e.g. Posthorax® vest). This retrospective study compared the wound complications after bilateral internal mammary artery grafting including the use of a Posthorax vest. METHODS Between April 2015 and May 2017, 1613 patients received total arterial myocardial revascularization using bilateral internal mammary artery via a median sternotomy. The Posthorax support vest was used from the second postoperative day. We compared those patients with 1667 patients operated on via the same access in the preceding 26 months. The end points were the incidence of wound infections, when the wound infection occurred and how many wound revisions were needed until wound closure. RESULTS The demographic data of both groups were similar. A significant advantage for the use of a thorax support vest could be seen regarding the incidence of wound infections (P = 0.036) and the length of hospital stay when a wound complication did occur (P = 0.018). CONCLUSIONS As seen in this retrospective study, the early perioperative use of a thorax stabilization vest, such as the Posthorax vest, can reduce the incidence of sternal wound complications significantly. Furthermore, when a wound infection occurred, and the patient returned to the hospital for wound revision, patients who were given the Posthorax vest postoperatively had a significantly shorter length of stay until wound closure.

Determination and Selection of the Optimum Number of Sites and Patients for Clinical Studies

Journal of Dental Research ◽

10.1177/00220345920710081001 ◽

1992 ◽

Vol 71 (8) ◽

pp. 1516-1521 ◽

Cited By ~ 6

Author(s):

P.P. Hujoel ◽

T.A. DeRouen

Keyword(s):

Clinical Studies ◽

Optimum Number ◽

The selection of the main axis and the forming plane in automatic profiling and stamping lines

10.33920/pro-2-2107-04 ◽

2021 ◽

pp. 44-48

Author(s):

O.M. Koryagina

Keyword(s):

Main Axis ◽

Labor Costs ◽

Simple Shape ◽

Small Thickness ◽

The Third ◽

Large Length ◽

Straight Lines ◽

Light Profiles ◽

The article defines the main axis and the profiling plane in automatic profiling and stamping lines. Specific recommendations are given for choosing the position of the main axis and the profiling plane, depending on the configuration of the manufactured parts of the roll-formed section. Under the general name of profiling in the practice of stamping works, it is meant to obtain rigid and light profiles of large length and various configurations from sheet blanks. Profiling is carried out in four ways: in dies on crank presses, in dies on special bending presses, on universal bending machines (edging machines), on profiling roller machines. The first method, profiling on crank presses, is used for complex semi-closed and open profiles of relatively small length, if there are no special bending presses or profiling machines. The second method, profiling on special bending presses, is used for open and semiclosed profiles up to 5 mm long. The advantage of such presses is the possibility of using simple, and therefore cheap, tools in the manufacture. The third method, profiling on universal bending machines (edging machines), is used for bending parts (profiles of a simple shape in straight lines with different coupling radii determined by the radius of the machine ruler, for which the latter has a set of rulers). Bending machines allow bending materials of small thickness. Low productivity and the need for physical labor costs limit the use of these machines. The fourth method, profiling on roller machines, is used for open, semi-closed and closed profiles. The essence of the profiling process is to gradually change the profile drawing of a flat belt to a given profile when it is moved sequentially through several pairs of shaped rollers arranged sequentially one after the other in the same plane and rotating at the same speed. The article describes in detail the fourth method; the advantages and disadvantages are noted.