scholarly journals Features of the use of topical preparations of framycetin sulfate in the treatment of rhinosinusitis

2021 ◽  
pp. 158-164
Author(s):  
S. A. Eremin ◽  
I. M. Dyakov ◽  
S. S. Pavlova
Keyword(s):  
Nasal Cavity ◽  
Antibacterial Therapy ◽  
Control Group ◽  
Acute Rhinosinusitis ◽  
The World ◽  
Structural Differences ◽  
Topical Antibacterial ◽  
Group A ◽  
Viral Nature ◽  
Experimental Group

Introduction. Acute rhinosinusitis is one of the most common infectious diseases in the world. But despite their predominantly viral nature, the activation of their own microflora occurring during the disease, the addition of pathogenic and the associated risks of rhinogenic complications lead to the widespread use of antibacterial therapy for this pathology. Local antiseptics, such as framycetin sulfate in the form of nasal spray, play an important role in the multicomponent structure of rhinosinusitis therapy.The aim of the study was to evaluate the effect of an aerosol preparation of framycetin sulfate of domestic and imported production on the activity of the atrial fibrillation of the nasal cavity as topical antibacterial therapy in acute rhinosinusitis.Materials and methods. The study included 30 adult patients diagnosed with acute rhinosinusitis. The patients were randomized into 2 equal groups and received standard therapy for this disease, according to clinical recommendations. The differences in the groups concerned only topical antibacterial therapy. The 1st experimental group used a drug of domestic production, the 2nd group - a control group, used an imported framycetin spray.Results. Data were obtained not only comparing the clinical picture depending on the treatment, but also information about the effect of the drug on the activity of the atrial epithelium of the nasal cavity, the distribution of the substance in the nasal cavity, and even considered the structural differences of the vials that affect the distribution of the drug during injection. Conclusion. Topical antibacterial therapy with framycetin sulphate is an effective method in complex treatment of acute rhinosinusitis. Innovative technologies for the creation of an aerosol of framicetin solution allow to achieve stable dosage of the drug during use.

Optimization of postoperative management of patients undergoing functional endoscopic sinus surgery

2018 ◽  
pp. 26-31
Author(s):  
Sergey Bezshapochny ◽  
Andrey Loburets ◽  
Valery Loburets
Keyword(s):  
Nasal Cavity ◽  
Postoperative Period ◽  
Sodium Hyaluronate ◽  
Sinus Surgery ◽  
Control Group ◽  
Nasal Breathing ◽  
Traditional Therapy ◽  
Significant Difference ◽  
Water Salt ◽  
Experimental Group

Topicality: The result of surgical treatment depends largely on the chosen method of management of the postoperative period, the main purpose of which is to reduce the effects of surgical trauma. Despite the wide variety of drugs for local and systemic use, the question of pharmacotherapy of the operated sinus remains open to this day. The main properties that a modern drug should possess are safety and high clinical efficacy. Aim: to study the clinical efficacy of topical application of a complex preparation based on a saline solution containing sodium hyaluronate and dexpanthenol in patients with chronic sinusitis after functional endoscopic sinus surgery (FESS). Materials and Methods: Clinical and laboratory studies were conducted on 47 patients with chronic rhinosinusitis who underwent surgery using the FESS technique. Patients were divided into 2 groups according to the principle of the postoperative period. Patients of research group (n=21), except for traditional therapy, was used locally NASOMER (a preparation based on a water-salt solution containing sodium hyaluronate and dexpanthenol); to the control group (n=26) patients entered, in the postoperative period received traditional therapy. Traditional therapy included a toilet of the nasal cavity, the use of short-course topical decongestants, irrigation of the nasal cavity with water-salt solutions. Criteria of clinical effectiveness: data of endoscopy of the nasal cavity, rhinomanometry, activity of the mucociliary transport system. The effectiveness of functional research methods in the postoperative period was determined on the 7th and 14th day of treatment. Results: On the 3rd day of the study, an increase in the swelling of the nasal cavity was observed in patients of both clinical groups, correlated with difficulty in nasal breathing. On the 7th day, a decrease in edema was observed in patients of both groups, but in the experimental group, the index of nasal breathing, according to rhinomanometry, was significantly (p<0.05) different from the control group, and was respectively 1.54±0.14 and 2.04±0.19 kPa/l*s. On the 14th day of the study, no significant difference was observed between these indicators. When studying the activity of the ciliated epithelium of the mucous membrane of the nasal cavity, it was proved that patients of the experimental group on day 7 after surgery showed a statistically significant difference in this indicator compared to the control group (17.8±1.0 and 22.7±2.1 min. respectively). Conclusions: The use of NASOMER after surgical intervention in patients with chronic rhinosinusitis contributes to more effective treatment compared with traditional therapy, as evidenced by the rapid recovery of the main functional parameters according to active posterior rhinomanometry and mucociliary clearance. Based on the results of the studies performed, the use of NASOMER for pharmacotherapy in the postoperative period is recommended for patients who have undergone rhinosurgical interventions with the aim of reducing the period of postoperative rehabilitation as an effective anti-inflammatory and wound-healing agent.

scholarly journals Parenting Stress and Need Assessment of Families with Disabled Children across Himachal Himalaya

2015 ◽  
Vol 3 (2) ◽  
pp. 38 ◽  
Author(s):  
Randhir S. Ranta ◽  
Vijay Kumar Sharma ◽  
Pankaj Gupta
Keyword(s):  
Parenting Stress ◽  
Assessment Scale ◽  
Control Group ◽  
Disabled Children ◽  
Normal Children ◽  
Need Assessment ◽  
Significant Difference ◽  
Group A ◽  
And Control ◽  
Experimental Group

The study pertains to the parenting stress, which is believed to be the resultant of child disability and further assesses the needs of the families across selected pockets of Himachal Himalaya. Perceived Stress Questionnaire (PSQ) and Need Assessment Scale were used for the purpose. For assessing the stress level among the parents, PQS was administered among two hundred parents having disabled children, herein called experimental group and two hundred parents with normal children, herein called control group. A three point Need assessment scale was used to measure the needs of 200 families on five different parameters. The result of t-test shows the significant difference between experimental and control groups indicating that the parents of disabled children experience more stress than their control counterpart. The study indicates that people need proper guidance and information regarding a child’s disability, nutritional requirements of a child, vocational training and child management. There is a need for proper counselling for parents suffering from stress and creating consciousness among parents of children with disabilities and in the society.

EFFECT OF YOGA ON CARDIOVASCULAR EFFICIENCY

2019 ◽  
pp. 12-16
Author(s):  
Brij Bhushan Singh ◽  
Shubi Mirja ◽  
Samiya Husain
Keyword(s):  
Statistical Technique ◽  
Step Test ◽  
Control Group ◽  
Significant Difference ◽  
Post Test ◽  
Group A ◽  
Cardio Vascular ◽  
Level Of Significance ◽  
Group B ◽  
Experimental Group

The purpose of this study was to investigate the effects of yogic practices on cardio-vascular efficiency. Material and methods: Total Forty (40) subject’s boys/girls were selected as the sample of the study through the random sampling and their age ranged between 20 to 25 years from the Department of Physical Education, Aligarh Muslim University, Aligarh. The subjects were divided into two groups comprising 20 subjects in each group, namely group “A” (the experimental group) performs yogic practices (Asanas, Pranayamas and Kriyas) and group “B” (the control group) served as control. Statistical technique: for the assessment of the cardiovascular efficiency through Harvard step test pre and post-test was conducted and t-test was applied for the analysis. Result: revealed that there exist a significant difference between group A and group B, at .05 level of significance. On the basis of the pre and post-test among experimental and control group, experimental group found better than the control group on cardiovascular efficiency and significant result were found in this study.

EFFECT OF ACCUPRESSURE PEN ON DISTANCE VARIABLE IN SCIATICA PATIENTS -A RANDOMIZED CONTROL TRIAL

2021 ◽  
pp. 28-31
Author(s):  
Urja S. Vaidya ◽  
Roshani S. Patel
Keyword(s):  
Randomized Control Trial ◽  
Stride Length ◽  
Step Length ◽  
Control Group ◽  
Exclusion Criteria ◽  
Parametric Test ◽  
Group A ◽  
Randomized Control ◽  
Experimental Group ◽  
Distance Variable

Background: Sciatica is a radiating pain which is treated with manual accupressure and after a time electro accupressure came into introduction. Aim And Objective: Aim: To nd out the effectiveness of accupressure pen to improve the distance variable To nd out the effect of Objective: accupressure pen on pain and distance variable in sciatica patient To compare the experimental group to the control group On the basis of Method: inclusion and exclusion criteria 30 participants were selected. They were treated with electro accupressure pen for 3 alternative days / week for 3 weeks, after that re-assessment was taken with NPRS, Slump and Distance variables. The data was analyzed using SPSS Version Results: 21.Parametric test was used .In Group A improvement was seen Accupressure Conclusions: pen is effective to reduce pain and improve step length and stride length in Sciatica Patients

Effect of deoxynivalenol on the levels of toll-like receptors 2 and 9 and their mRNA expression in enterocytes in the porcine large intestine: a preliminary study

2017 ◽  
Vol 20 (2) ◽  
pp. 213-220 ◽  
Author(s):  
M. Dąbrowski ◽  
E. Jakimiuk ◽  
M. Gajęcka ◽  
M.T. Gajęcki ◽  
Ł. Zielonka
Keyword(s):  
Mrna Expression ◽  
Large Intestine ◽  
Control Group ◽  
Local Immune Response ◽  
Ascending Colon ◽  
Immune Disorders ◽  
The World ◽  
Preliminary Study ◽  
Experimental Group ◽  
Tlr2 Mrna

Abstract Deoxynivalenol (DON), one of the most prevalent mycotoxins in the world, and is capable of inducing immune disorders in humans and animals. The aim of this study was to determine the effect of feed contaminated with DON on the number of TLR2- and TLR9-positive cells and their mRNA expression in the porcine large intestine. The experiment was conducted on two equal groups of pigs (n=4). The experimental group (E) was administered feed contaminated with DON (1008 μg/kg of feed) for 6 weeks, and the control group (C) was administered non-contaminated feed over the same period of time. A decrease in the expression of TLR2 mRNA was noted in the cecum. The percentage of TLR9-positive enterocytes increased in the ascending colon and decreased in the cecum. The results of this study indicate that DON can modify the local immune response by changing the expression of TLRs.

scholarly journals Ameliorative effects of Spinacia oleracea on sperm morphology, count, and motility by normalizing the obesity-induced oxidative stress in Sprague Dawley rats

2020 ◽  
Vol 14 (03) ◽  
pp. 124-127
Author(s):  
Somia Iqbal ◽  
Noman Sadiq ◽  
Saad Siddiqui ◽  
Hira Iqbal
Keyword(s):  
Sperm Concentration ◽  
Treated Group ◽  
Sperm Parameters ◽  
Control Group ◽  
Sprague Dawley ◽  
Normal Morphology ◽  
Sprague Dawley Rats ◽  
Group A ◽  
Group B ◽  
Experimental Group

Background: Obesity is a prevailing metabolic disorder that affects the functioning of the male reproductive system. Excessive adipose tissue enhances reactive oxygen species generation and is linked with male infertility. Spinach has demonstrated antioxidant effects. The present study was conducted to determine the antioxidant effects of spinach on sperm parameters in obese Sprague Dawley rats. Subjects and methods: This randomized control study was conducted at the animal house of the National Institute of Health Islamabad, Islamic International Medical College, Cosmesurge International Hospital, Rawalpindi, and Apollo lab, Islamabad, Pakistan from April 2016 to March 2017. Forty male Sprague Dawley rats having an age of 8 weeks and weight 160-200g were tagged from number 1 to 40. Every third rat was randomly allocated to control Group A (n=13) and remaining into the Experimental group (n=27). Rats of control Group A was given a standard diet while a high-fat diet was given to Experimental group rats to induce obesity for the duration of six weeks. Weight (g) was measured weekly and obesity was confirmed when rats attain more than 20% weight when compared with that of rats of control Group A. Then, after obesity induction, the experimental group was alienated into the obesity control group (Group B) and spinach treated group (Group C). For sample, rats of Group A and Group B were sacrificed, and the cauda epididymis of each rat was placed in a Petri dish containing normal saline and cut into pieces to allow the release of sperm and then sperm parameters (sperms concentration, motility, and morphology) were recorded under the microscope. Then, spinach (5% hot water extract) along with the persistence of fat diet was administered to Group C for 4 weeks and finally, sperm parameters were measured in this group. Results: Sperm concentration/ml, motility (%), and normal morphology (%) of Group B rats were significantly decreased as compared to Group A rats. However, sperm concentration/ml, motility (%), and normal morphology (%) of Group C (spinach treated group) rats was significantly increased (p<0.001) as compared to Group B (obesity control group) rats after administering spinach. Conclusion: The addition of Spinach in a normal diet regimen restores normal sperm morphology, improves sperm motility and concentration.

scholarly journals Peningkatan Keterampilan Sosial dan Motorik Halus Anak Melalui Pembelajaran Berbasis Proyek

2021 ◽  
Vol 1 (1) ◽  
pp. 14-33
Author(s):  
Wuni Arum Sekar Sari
Keyword(s):  
Emotional Development ◽  
Project Based Learning ◽  
Fine Motor ◽  
Control Group ◽  
Social Emotional Development ◽  
Social Emotional ◽  
Control Group Design ◽  
Post Test ◽  
Group A ◽  
Experimental Group

This study examines the effect of project-based learning on children’s social-emotional development and children’s fine motoric development. This study uses a Quasi-Experimental Design. Control-Group Design (Pre-test and Post Test) or Nonequivalent [Pretest and Post Test] Control-Group Design, the experimental group (A) and the control group (B), were selected without a random assignment procedure. In these two groups, both pretest and posttest were carried out. Only the experimental group (A) was treated. This research was conducted at RA Uniform Debit and RA Kusuma Mulia, Ngino, Plemahan, Kediri. Data were collected using observation sheets, descriptive statistical data analysis, and paired t-test with alpha <0.05.  Based on the results of different tests with the Paired t-test, the Sig. As much as 0.000, where this value is less than 0.05, reject H1 and accept H0, there are differences in social-emotional development and fine motor skills between before (pretest) and after (posttest) getting project-based learning the experimental group and the control group. The average value shows that the social-emotional development after being given the Project-Based learning was more significant than the social-emotional development, namely 26.03> 20.44 in the experimental group and 22.10> 20.23 in the control group. Likewise, fine motor development before being given the Project-Based learning, namely 14.97> 11.84 in the experimental group and 13.03> 11.97 in the control group. This means that the project-based learning given to RA students in Plemahan, Kediri is more effective than learning in the control group.

scholarly journals Comparison of a novel herbal skin care ointment with regular ointments to treat skin around the abdominal stoma: A clinical trial study

2019 ◽  
Author(s):  
Maryam Hajikari ◽  
Soheila Mojdeh ◽  
Mohsen Shariari
Keyword(s):  
Data Collection ◽  
Herbal Product ◽  
Gastric Ulcers ◽  
Control Group ◽  
Skin Ulcers ◽  
Significant Difference ◽  
Group A ◽  
The Mean ◽  
Experimental Group

Introduction The incidence of gastric ulcers in patients with abdominal stoma is high and affects the quality of patients’ life. Aim To evaluate the effect of Adib herbal ointment containing chamomile rose, black nightshade origin versus Comfeel and Conveen ointments on the skin of abdominal stoma. Material and methods This is a clinical study in which the volunteers were stoma patients. Study group consisted of 52 qualified subjects, 26 were included in the experimental group and 26 in the control group. A 2-part questionnaire was used for the data collection. The 1st part was demographic information. The 2nd part of the data collection was evaluated according to the pressure ulcer scale for healing (PUSH) tool, which used for examining skin ulcers around the stoma. P ≤ 0.05 was considered as a significant. Results and discussion The results of the Mann–Whitney test showed that between the mean score of the total score of the wound before intervention (P = 0.92) and on the 3rd day (P = 0.476), 6th (P = 0.222), 9th (P = 0.11) and 12th (P = 0.418), there was no significant difference between the control and test groups. Also, the Friedman test (intra-group) also showed that between the mean score of the total score of the wound before the intervention and the 3rd, 6th, 9th and 12th days in the control group (P = 0.0001) and in the experimental group (P = 0.0001) There was a significant statistical difference. Conclusions Based on the study, Adib herbal ointment could be recommended for the treatment of stoma to the skin as an herbal product as other common treatments.

Effectiveness of Peer Tutoring Program on Students’ Academic Performance for Engineering Course

2021 ◽  
Vol 6 (1) ◽  
pp. 71
Author(s):  
Fei Ha Chiew ◽  
Clotilda Petrus ◽  
Siti Zaidah Othman ◽  
Joe Davylyn Nyuin ◽  
Ung Hua Lau
Keyword(s):  
Peer Tutoring ◽  
Intervention Program ◽  
Solid Mechanics ◽  
Practical Significance ◽  
Control Group ◽  
Tutoring Program ◽  
Significant Difference ◽  
Group A ◽  
And Control ◽  
Experimental Group

This study investigated the effectiveness of a peer tutoring program that was implemented for Basic Solid Mechanics course, as an intervention program to improve students’ performance in the course. Ten tutors were chosen to provide tutoring services to an experimental group of 36 tutees. Tutees were required to answer an entry test before the intervention program, and another exit test after the program. A control group which shared the same instructor in their lecture classes was included in the study. Comparison between the performances for entry and exit tests of both experimental and control groups were made. Analyses showed an increase in the percentage of students that passed the exit test from the experimental group. The average marks for the experimental group in the exit test also increased, compared to their marks in the entry test. A Mann- Whitney U test conducted indicated a significant difference between the gain scores of the experimental group and control group. A further metaanalysis revealed a large effect size, signaling the practical significance of the results. The findings demonstrated the effectiveness of the peer tutoring intervention program on students’ performance of the course.

An importance of matrix-metalloprotease determination in urine of patients with bladder cancer

2021 ◽  
Vol 1 (1) ◽  
pp. 30-32
Author(s):  
Vladimir N. Tkachuk ◽  
Adel S. Al-Shukri ◽  
Dmitriy I. Danilchenko
Keyword(s):  
Bladder Cancer ◽  
Control Group ◽  
Depth Of Invasion ◽  
Matrix Metalloprotease ◽  
Cancer Occurrence ◽  
Bladder Diseases ◽  
Neoplastic Process ◽  
Group A ◽  
Experimental Group

The aimof this work is to estimate an influence of a depth and an extent of differentiation of neoplastic process on 2 and 9 matrix-metalloprotease levels in urine of patients with bladder cancer. Patients and methods.71 patients with bladder cancer have been investigated. 14 patients with chronic cystitis were included in an experimental group and 45 patients without bladder diseases were included in a control group, patients without urinary tract obstructions and infections were included in a control group. A level of metalloprotease was identified by a cimographic method. Results.It has been proved that enzymes MMP-2 and MMP-9 of urine proteolysis are high sensitive markers of bladder cancer occurrence and their concentration depends on a depth of invasion and an extent of tumor differentiation, and shows a disease course prognosis. Conclusion.It is reasonably to identify MMP-2 and MMP-9 of urine by the cimographic method for diagnostics and noninvasive determination of a depth of invasion and an extent of bladder cancer differentiation.

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