An importance of matrix-metalloprotease determination in urine of patients with bladder cancer
The aimof this work is to estimate an influence of a depth and an extent of differentiation of neoplastic process on 2 and 9 matrix-metalloprotease levels in urine of patients with bladder cancer. Patients and methods.71 patients with bladder cancer have been investigated. 14 patients with chronic cystitis were included in an experimental group and 45 patients without bladder diseases were included in a control group, patients without urinary tract obstructions and infections were included in a control group. A level of metalloprotease was identified by a cimographic method. Results.It has been proved that enzymes MMP-2 and MMP-9 of urine proteolysis are high sensitive markers of bladder cancer occurrence and their concentration depends on a depth of invasion and an extent of tumor differentiation, and shows a disease course prognosis. Conclusion.It is reasonably to identify MMP-2 and MMP-9 of urine by the cimographic method for diagnostics and noninvasive determination of a depth of invasion and an extent of bladder cancer differentiation.