scholarly journals Comparation of Antihypertensive Effect of Goldenberry, Cucumber, and Combination Juice Against Systolic Blood Pressure on Rats Induced 8% NaCl

2019 ◽  
Vol 3 (1) ◽  
pp. 43
Author(s):  
Fiki Husna ◽  
Amilia Yuni Damayanti ◽  
Dianti Desita Sari
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Mean Difference ◽  
Group Method ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Before And After ◽  
Post Test ◽  
The Mean ◽  
Post Hoc

<p><em>This study was</em><em> a</em><em> </em><em>true e</em><em>xperimental study </em><em>using the </em><em>randomized controlled group method with a </em><em>pre</em><em>-</em><em>post test</em><em> design</em><em>. </em><em>The </em><em>Sprague-Dawley rats </em><em>were </em><em>divided into 4 groups (5</em><em> rats/</em><em>group</em><em>):</em><em> K (+) Captopril 0</em><em>,</em><em>45 mg/200 g BW, goldenberry juice 1</em><em>,</em><em>8 ml/200 g BW</em><em> (P1)</em><em>, cucumber juice 1</em><em>,</em><em>8 ml/200 g BW</em><em> (P2)</em><em>, and 1</em><em>,</em><em>8 ml/200 g BW (</em><em>P3, </em><em>combination juice 50%:50%). Systolic blood pressure measured by blood pressure analyzer with the tail-cuff method. The result of systolic blood pressure analyzed by Paired t-Test to determine the mean difference of systolic blood pressure before and after 8% NaCl induction. One Way ANOVA test followed by Post Hoc Duncan to determine the mean difference of systolic blood pressure between groups.</em><em> Goldenberry, cucumber, and combination juice have a significant effect of reducing systolic blood pressure in hypertension with p = 0</em><em>,</em><em>000 (&lt;0</em><em>,</em><em>05). Goldenberry juice was </em><em>the </em><em>most effectively on reducing systolic blood pressure in hypertension with 42.21%.</em><em></em></p>

Proximal tubule microvilli remodeling and albuminuria in the Ren2 transgenic rat

2007 ◽  
Vol 292 (2) ◽  
pp. F861-F867 ◽  
Author(s):  
Melvin R. Hayden ◽  
Nazif A. Chowdhury ◽  
Shawna A. Cooper ◽  
Adam Whaley-Connell ◽  
Javad Habibi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Proximal Tubule ◽  
Structural Damage ◽  
Kidney Tissue ◽  
Proximal Tubule Cell ◽  
Ang Ii ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

TG(mRen2)27 (Ren2) transgenic rats overexpress the mouse renin gene, with subsequent elevated tissue ANG II, hypertension, and nephropathy. The proximal tubule cell (PTC) is responsible for the reabsorption of 5–8 g of glomerular filtered albumin each day. Excess filtered albumin may contribute to PTC damage and tubulointerstitial disease. This investigation examined the role of ANG II-induced oxidative stress in PTC structural remodeling: whether such changes could be modified with in vivo treatment with ANG type 1 receptor (AT1R) blockade (valsartan) or SOD/catalase mimetic (tempol). Male Ren2 (6–7 wk old) and age-matched Sprague-Dawley rats were treated with valsartan (30 mg/kg), tempol (1 mmol/l), or placebo for 3 wk. Systolic blood pressure, albuminuria, N-acetyl-β-d-glucosaminidase, and kidney tissue malondialdehyde (MDA) were measured, and ×60,000 transmission electron microscopy images were used to assess PTC microvilli structure. There were significant differences in systolic blood pressure, albuminuria, lipid peroxidation (MDA and nitrotyrosine staining), and PTC structure in Ren2 vs. Sprague-Dawley rats (each P < 0.05). Increased mean diameter of PTC microvilli in the placebo-treated Ren2 rats ( P < 0.05) correlated strongly with albuminuria ( r2 = 0.83) and moderately with MDA ( r2 = 0.49), and there was an increase in the ratio of abnormal forms of microvilli in placebo-treated Ren2 rats compared with Sprague-Dawley control rats ( P < 0.05). AT1R blockade, but not tempol treatment, abrogated albuminuria and N-acetyl-β-d-glucosaminidase; both therapies corrected abnormalities in oxidative stress and PTC microvilli remodeling. These data indicate that PTC structural damage in the Ren2 rat is related to the oxidative stress response to ANG II and/or albuminuria.

scholarly journals PENGARUH THERAPY BEKAM BASAH TERHADAP TEKANAN DARAH PASIEN HIPERTENSI

2018 ◽  
Vol 6 (2) ◽  
pp. 102-105
Author(s):  
Leli Mulyati
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Cupping Therapy ◽  
Control Group ◽  
Pressure Measurements ◽  
Hypertensive Patients ◽  
Average Systolic Blood Pressure ◽  
Before And After ◽  
Post Test ◽  
Quasi Experimental

This study aims to determined the effected of wet cupping therapy on blood pressure in hypertensive patients. The study used a quasi-experimental method with one group pre-test and post-test without a control group. The study subjects total 30 respondents consisting of patients with hypertension. All subjects are given wet cupping treatment twice with an interval of 2 weeks. Blood pressure measurements made ​​before and after wet cupping. The results of analysis used a t-dependent, decrease in average systolic blood pressure was 13 333 ± 12 042 wet cupping mmHg and diastolic 4667 ± 3294 mmHg. At week 2 a decrease in average systolic blood pressure mmHg while the 8667 ± 8308 6667 ± 5525 mmHg diastolic. Decrease in average systolic and diastolic blood pressure there were significant differences (p <0.05) in the first wet cupping and second wet cupping. This shows that wet cupping therapy affects blood pressure in hypertension patients.

scholarly journals Khat (Catha Edulis) as a Risk Factor for Cardiovascular Disorders: Systematic Review and Meta-Analysis

2017 ◽  
Vol 11 (1) ◽  
pp. 146-155 ◽  
Author(s):  
Teshale Ayele Mega ◽  
Nikodimos Eshetu Dabe
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Systolic Blood Pressure ◽  
Cardiovascular System ◽  
Meta Analysis ◽  
Conclusive Evidence ◽  
Mean Difference ◽  
Cardiovascular Disorders ◽  
Khat Chewing ◽  
The Mean

Background:About 20 million people worldwide are believed to be using khat. Although some studies reported that khat chewing might result in cardiovascular disorders, conclusive evidence is limited.Method:The objective of this review was to synthesize the best available evidence for the effect of khat on the cardiovascular system. Databases searched were PubMed, Cochrane database of systematic reviews, CINAHL, poplin, LILACS, MedNar and Scopus. All papers included in the review were subjected to rigorous appraisal using the Joanna Briggs Institute (JBI) standardized critical appraisal tool. Review Manager Software (Revman 5.3) was used for meta-analysis and effect size and the 95% confidence interval (CI) was calculated.Result:Data was extracted from 10 articles. Our meta-analysis included 9,207 subjects, (2123 chewers and 7084 non-chewers, respectively) to elucidate the effect of khat on heart rate, diastolic and systolic blood pressure. The mean diastolic and systolic blood pressure of khat chewers was higher than the non-chewers with a mean difference of 5.1 mmHg, 95%CI [2.7,7.5] and 7.9 mmHg, 95%CI [2.65, 13.18], respectively. Similarly, the heart rate of the chewers remained consistently higher, making the mean difference of 6.9 beats/min, 95%CI [0.5, 13.3]. In addition, khat was found to have either a causative or worsening effect on stroke, myocardial infarction and heart failure.Conclusion:We showed that khat chewing could significantly affect the cardiovascular system through its effect on heart rate and blood pressure. Therefore, health promotion should be aimed to encourage quitting khat chewing.

Parathyroidectomy significantly decreases hypertension in spontaneously hypertensive and deoxycorticosterone plus saline treated rats

1982 ◽  
Vol 60 (2) ◽  
pp. 208-212 ◽  
Author(s):  
Alexis Gairard ◽  
Alain Berthelot ◽  
René Schleiffer ◽  
Fanny Pernot
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Systolic Blood Pressure ◽  
Normal Serum ◽  
Male Rats ◽  
Shr Rats ◽  
Sprague Dawley ◽  
Spontaneously Hypertensive ◽  
Sprague Dawley Rats ◽  
Normal Serum Calcium

In male Sprague–Dawley rats, hypertensive development was diminished for 10 weeks when parathyroidectomy (PTX) was performed 1 week before deoxycorticosterone plus saline (DOCA + NaCl) treatment. In young spontaneously hypertensive male rats (SHR, Okamoto strain) parathyroidectomy performed after weaning lessened hypertensive levels and lowered heart rate for 24 weeks. When mineralocorticoid or genetic hypertension was established, parathyroidectomy did not significantly change blood pressure levels. High dietary calcium in PTX–SHR rats reestablished normal serum calcium but not systolic blood pressure to the level of sham SHR. From our present and previously reported results, it appears that the parathyroid gland is necessary for the total development of hypertension in both models.

scholarly journals Increased Blood Pressure Variability and the Risk of Probable Dementia or Mild Cognitive Impairment: A Post Hoc Analysis of the SPRINT MIND Trial

2021 ◽  
Author(s):  
Adam de Havenon ◽  
Mohammad Anadani ◽  
Shyam Prabhakaran ◽  
Ka‐Ho Wong ◽  
Shadi Yaghi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Systolic Blood Pressure ◽  
Blood Pressure Variability ◽  
Pressure Control ◽  
Post Hoc Analysis ◽  
The Mean ◽  
Post Hoc

Background Increased systolic blood pressure variability (BPV) is associated with stroke, cardiovascular disease, and dementia and mild cognitive impairment. However, prior studies assessing the relationship between BPV and dementia or mild cognitive impairment had infrequent measurement of blood pressure or suboptimal blood pressure control. Methods and Results We performed a post hoc analysis of the SPRINT (Systolic Blood Pressure Intervention Trial) MIND (Memory and Cognition in Decreased Hypertension) trial. The primary outcome was probable dementia during follow‐up. We defined our exposure period, during which blood pressures were collected, as the first 600 days of the trial, and outcomes were ascertained during the subsequent follow‐up. BPV was measured as tertiles of systolic blood pressure standard deviation. We fit Cox proportional hazards models to our outcome. We included 8379 patients. The mean follow‐up was 3.2±1.4 years, during which 316 (3.8%) patients developed dementia. The mean number of blood pressure measurements was 7.8, and in the tertiles of BPV, the SD was 6.3±1.6, 10.3±1.1, and 16.3±3.6 mm Hg, respectively. The rate of dementia was 2.4%, 3.6%, and 5.4% by ascending tertile, respectively ( P <0.001). In the Cox models, compared with the lowest tertile of BPV, the highest tertile of BPV increased the risk of dementia in both unadjusted (hazard ratio [HR], 2.36; 95% CI, 1.77–3.15) and adjusted (HR, 1.69; 95% CI, 1.25–2.28) models. Conclusions In a post hoc analysis of the SPRINT MIND trial, we found that higher BPV was associated with the development of probable dementia despite excellent blood pressure control. Additional research is needed to understand how to reduce BPV and if its reduction lowers the risk of cognitive impairment and dementia.

scholarly journals TERAPI TERTAWA DAN PERUBAHAN TEKANAN DARAH PADA MAHASISWA DI UNIVERSITAS ADVENT INDONESIA

2016 ◽  
Vol 2 (2) ◽  
pp. 187
Author(s):  
Tawarina Surbakti ◽  
Gilny Aileen Joan ◽  
Denny Ricky
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Normal Blood ◽  
Test Design ◽  
Normal Blood Pressure ◽  
Purposive Sampling ◽  
Average Value ◽  
Before And After ◽  
Post Test

ABSTRAK Penelitian ini dilatarbelakangi hasil penelitian Ramdhani (2013) yang menunjukan adanya perubahan penurunan tekanan darah yaitu setelah dilakukan terapi tertawa selama dua minggu sebanyak enam kali pemberian. Maka peneliti merasa perlu dilakukan uji ulang pemberian terapi tertawa pada tekanan darah normal dengan satu kali pemberian. Tujuan penelitian untuk menganalisis perbedaan tekanan darah sebelum dan sesudah pemberian terapi tertawa pada mahasiswa di Universitas Advent Indonesia. Desain penelitian yang digunakan dalam penelitian ini adalah penelitian eksperimen yang menggunakan One Group Pre-Test and Post-Test Design dengan melibatkan satu kelompok subjek. Intervensi dalam penelitian yang dilakukan ini adalah pemberian terapi tertawa selama 20 menit. Subjek penelitian ini berjumlah 30 orang mahasiswi di Universitas Advent Indonesia. Pengambilan sampel dilakukan dengan teknik purposive sampling. Hasil penelitian ini menunjukan bahwa nilai rata-rata tekanan darah pada mahasiswi di Universitas Advent Indonesia sebelum pemberian terapi tertawa yaitu dengan nilai tekanan darah sistolik adalah  115.6 mmHg dan nilai tekanan darah diastolik 75.0 mmHg. Nilai rata-rata tekanan darah sistolik sesudah pemberian terapi tertawa adalah  110.8 mmHg dan tekanan darah diastolik 73.8  mmHg. Nilai tekanan darah sebelum dan sesudah pemberian terapi tertawa mempunyai nilai yang signifikan pada nilai uji-t pada tekanan sistolik. Tekanan diastolik tidak terjadi perubahan yang signifikan.   Kata kunci: Tekanan darah normal, Terapi tertawa   ABSTRACT This research is based on the writing of Ramdhani (2013) showing that there is a change in blood pressure after given six times laughter therapy for two weeks. Researchers find it necessary to repeat the laugh therapy on person with normal blood pressure with one provision. The purpose of this research is to identify changes in blood pressure before and after given laugh therapy. The research design used in this study is One Group Pre-Test and Post-Test Design experimental research that uses. Intervention conducted in this research is laughing therapy for 20 minutes. Subjects of this research were 30 students of Adventist University of Indonesia. That were by purposive sampling technique. The results of this research showed that the average value of blood pressure in students of Universitas Advent Indonesia before given laugh therapy with a systolic blood pressure value of 115.6 mm Hg and diastolic blood pressure value of 75.0 mmHg. The average value of systolic blood pressure after the administration of laughter therapy was 110.8 mmHg and a diastolic blood pressure value of 73.8 mmHg. Systolic blood pressure values before and after administration of laughter therapy has a significant change but not with the diastolic. Keywords: Normal blood pressure value, Laugh therapy

Sodium—Potassium Pump Activity in Mineralocorticoid- and Glucocorticoid-Induced Hypertension

1982 ◽  
Vol 63 (s8) ◽  
pp. 69s-72s ◽  
Author(s):  
G. Wambach ◽  
A. Helber ◽  
W. Kaufmann
Keyword(s):  
Blood Pressure ◽  
Atpase Activity ◽  
Systolic Blood Pressure ◽  
Heart Tissue ◽  
Control Group ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Induced Hypertension ◽  
Pump Activity ◽  
Kidney Liver

1. The activity of ouabain-sensitive Na+,K+-dependent ATPase and ouabain-sensitive ATPase was measured in the microsomal fractions of kidney, liver and heart tissue of Sprague-Dawley rats treated with DOCA (10 mg day−1 kg−1 for 6 days, systolic blood pressure 143 ± 13 mmHg, n = 9) or 6 α-methylprednisolone (100 mg day−1 kg−1 for 6 days, systolic blood pressure 140 ± 19 mmHg, n = 9) and of a control group (systolic blood pressure 124 ± 12 mmHg, n = 9). 2. In the kidney, the ouabain-sensitive Na+,K+-ATPase activity (μmol of phosphate h−1 mg−1 of protein) was increased in the DOCA-treated (33.0 ± 6.9) and in the prednisolone-treated groups (30.8 ± 6.9) compared with that in the control group (26.4 ± 3.4) (P < 0.05). In the liver, the ouabain-sensitive Na+,K+-ATPase activity was elevated in the prednisolone-treated animals only (4.8 ± 1.3 vs 3.1 ± 0.8 in the controls, P < 0.025). The ouabain-sensitive Na+,K+-ATPase activity in heart tissue was similar in all three groups. The ouabain-insensitive ATPase activity was not altered by DOCA or prednisolone in the tissues studied. 3. In a separate study, the activity of the ouabain-sensitive Na+,K+-ATPase in erythrocyte ghosts was found to be elevated in 10 patients with Cushing's syndrome (0.91 ± 0.35 μmol of phosphate h−1 mg−1 of protein) compared with five patients with primary aldosteronism and compared with 12 normotensive control subjects (0.38 ± 0.08) (P < 0.005). 4. These data demonstrate an increased Na-K pump activity in the kidney in mineralocorticoid-induced hypertension. Glucocorticoids in addition activate the Na-K pump in a variety of other tissues. This could partially explain the redistribution of volume from the intracellular to the extracellular space.

scholarly journals Pemberian Bisphenol A (BPA) Oral Menurunkan Kadar Superoksida Dismutase dan Meningkatkan Kadar F2-isoprostan pada Tikus Putih (Rattus norvegicus) Jantan Galur Sprague Dawley

2017 ◽  
Vol 9 (3) ◽  
Author(s):  
Yogie Sulaiman ◽  
IGM Aman ◽  
Wimpie Pangkahila
Keyword(s):  
Superoxide Dismutase ◽  
Bisphenol A ◽  
Rattus Norvegicus ◽  
Control Group ◽  
Sprague Dawley ◽  
Control Group Design ◽  
Group Design ◽  
Sprague Dawley Rats ◽  
Before And After ◽  
The Mean

Abstract: Bisphenol A (BPA), commonly found in plastic packaging and cans, can induce oxidative stress. This study was aimed to prove that oral BPA could decrease superoxide dismutase (SOD) and increase F2-isoprostan levels in male Sprague Dawley rats. This was an experimental study using randomized pretest-posttest control group design. There were 14 rats (Rattus norvegicus), male, Sprague Dawley strain, 8-10 weeks old, as subjects. Rats were divided into two groups with 7 rats each. The control group (P0) was treated with placebo for 21 days and the treatment group (P1) was treated with oral BPA dose of 400mg/kg for 21 days. Before and after treatment for 21 days, blood was drained through the canthus medial sinus orbital and urine was collected as pretest and posttest data. SOD and F2-isoprostan levels were then examined by using ELISA. The results showed that before treatment (pretest), the mean SOD level in P0 group was 42.51±3.127 U/mL and in P1 group was 41.87±2.477 U/mL (P > 0.05). The mean F2-isoprostane level in P0 group was 3.18±0.599 ng/ml and in P1 group was 3.22±0.489 ng/ml (P > 0.05). However, after treatment for 21 days (posttest), the mean level of SOD in P0 group was 43.52±3.472 U/mL and in P1 group was 31.84±2.563 U/mL (P <0.01). The mean level of F2-isoprostane in P0 group was 2.94±0.500 ng/ml and in P1 group was 4.47±0.241 ng/ml (P < 0.01). The analysis of the treatment effect showed significant decreased level of SOD and increased level of F2-isoprostane in P1 group (P < 0.01). Conclusion: Oral bisphenol A could decrease superoxide dismutase (SOD) and increase F2-isoprostan levels in male Sprague dawley rats.Keywords: bisphenol A (BPA), SOD, F2-isoprostane, Sprague Dawley ratsAbstrak: Bisphenol A (BPA) banyak ditemukan dalam kemasan plastik dan kaleng dan dapat menyebabkan peningkatan radikal bebas. Penelitian ini bertujuan untuk membuktikan pemberian BPA oral dapat menurunkan kadar superoksida dismutase (SOD) dan meningkatkan kadar F2-isoprostan pada tikus (Rattus norvegicus) jantan galur Sprague Dawley. Jenis penelitian ialah eksperimental dengan randomized pretest-postest control group design yang menggunakan 14 ekor tikus (Rattus norvegicus) jantan, galur Sprague Dawley, berumur 8-10 minggu, yang terbagi menjadi 2 (dua) kelompok masing-masing berjumlah 7 ekor tikus. Kelompok kontrol (P0) diberikan plasebo selama 21 hari dan kelompok perlakuan (P1) diberikan BPA dosis 400mg/kgBB selama 21 hari. Sebelum dan sesudah perlakuan selama 21 hari, darah diambil melalui chantus medial orbitalis dan urin dikumpulkan untuk pemeriksaan pretest dan postest. Kadar SOD dan F2-isoprostan diperiksa dengan metode ELISA. Hasil penelitian menunjukkan bahwa sebelum perlakuan (pretest), rerata kadar SOD kelompok P0 42,51±3,127 U/mL dan kelompok P1 41,87±2,477 U/mL (P > 0,05). Rerata kadar F2-isoprostan kelompok P0 3,18±0,599 ng/ml dan kelompok P1 3,22±0,489 ng/ml (P > 0,05). Setelah perlakuan selama 21 hari (posttest), rerata kadar SOD kelompok P0 43,52±3,472 U/mL dan kelompok P1 31,84±2,563 U/mL (P < 0,01). Rerata kadar F2-isoprostan kelompok P0 2,94±0,500 ng/ml dan kelompok P1 4,47±0,241 ng/ml (P < 0,01). Analisis efek perlakuan menunjukkan terjadi penurunan kadar SOD dan peningkatan kadar F2-isoprostan yang bermakna pada kelompok P1 (P < 0,01). Simpulan: Bisphenol A oral dapat menurunkan kadar superoksida dismutase dan meningkatkan kadar F2-isoprostan pada tikus galur Sprague Dawley jantan.Kata kunci: BPA, SOD, F2-Isoprostan, tikus Sprague Dawley

scholarly journals THE INFLUENCE OF BENSO’S RELAXATION TECHNIQUE IN DECREASING THE BLOOD PRESSURE OF HYPERTENSION PATIENTS AT INTEGRATED COACHING POST FOR NON-COMMUNICABLE DISEASES IN LINGGAJATI VILLAGE, KUNINGAN DISTRICK

2019 ◽  
Vol 6 (1) ◽  
pp. 51-56
Author(s):  
Ating Sutanti ◽  
Jaenudin ◽  
H.Sodikin
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Communicable Diseases ◽  
Relaxation Technique ◽  
P Value ◽  
Relaxation Techniques ◽  
Non Communicable Diseases ◽  
Before And After ◽  
The Mean

In Kuningan District hypertension patients in puskesmas entered diurutan to 5 patterns of disease all age groups (Profile Kab.Kuningan 2016) .The purpose in this research is to identify the influence of Benson’s Relaxation technique in decreasing the blood pressure of hypertension patiens. This research uses quasi experimental design with one group pretest-posttest design model. The sample technique in this study used total sampling which amounted to 32 respondents, research instrument using aneroid spyghmomanometer and stethoscope, data collection using observation. Data analysis using Normality test and paired sample t test. Research location at at integrated coaching post for non-communicable diseases in Linggajati Village, Kuningan District  in June-July 2018. The results showed that the mean systolic blood pressure before and after the Benson relaxation technique was 163,12mmHgbecome 150,47 mmHg, mean diastolic blood pressure before and after relaxation technique Benson was93,28 mmHgbecome 87.19mmHg. The mean systolic blood pressure fell 12.66 mmHg and the diastolic blood pressure was 6.09 mmHg. Value p value 0,000. The conclusion of this research isthe influence of Benson’s Relaxation technique in decreasing the blood pressure of hypertension patiens at integrated coaching post for non-communicable diseases in Linggajati Village, Kuningan District with significance p value 0,000 (<0,005). For people with hypertension is expected to use Benson relaxation techniques to maintain blood pressure stability so as to reduce the use of pharmacological therapy.

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