Recent Advances in Theranostic Applications of Nanomaterials in Cancer

: Early detection and accurate monitoring are two critical factors affecting the outcome of anticancer therapy. However, both these factors are affected by the limitations of conventional approaches of diagnosis and treatment. Nanomedicine has progressively offered a scientific solution in improved delivery and better diagnosis of various cancers, thus providing a targeted treatment approach. With the advances in the field, simultaneous delivery and diagnosis are becoming a reality. The present manuscript discusses various drug delivery challenges, provides the scope for theranostic nanomaterials in the diagnosis and treatment of cancer. The clinical and translational potential of theranostic nanomedicine and the future directions for further research are also presented in the manuscript.

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Smart Organic-Inorganic Nanogels for Activatable Theranostics

Current Medicinal Chemistry ◽

10.2174/0929867324666170920164614 ◽

2019 ◽

Vol 26 (8) ◽

pp. 1366-1376 ◽

Cited By ~ 6

Author(s):

Fangyuan Li ◽

Zeyu Liang ◽

Daishun Ling

Keyword(s):

Drug Delivery ◽

Controlled Drug Release ◽

The Other ◽

Stimuli Responsive ◽

Chemical Methods ◽

Future Directions ◽

Inorganic Hybrid ◽

Inorganic Nanomaterials ◽

Theranostic Applications ◽

Physical And Chemical

Intelligent polymeric nanogels, with the rationally designed stimuli-responsive drug delivery and controlled drug release, have attracted considerable attention as an ideal nanoplatform for activatable therapy. On the other hand, functional inorganic nanomaterials are widely used as medical imaging agents due to their unique magnetic or optical properties. The construction of stimuli-responsive polymeric nanogels incorporating with functional inorganic nanomaterials inherits the excellent properties of both polymers and inorganic nanomaterials, consequently, the resulted organic-inorganic hybrid nanogels naturally exhibit stimuli-responsive multi-functionalities for both imaging and therapy. In this review, we summarize the recent advances of stimuli-responsive organic-inorganic hybrid nanogels. Firstly, we discuss the physical and chemical methods thus far developed for the integration of polymeric nanogels and inorganic nanomaterials, and then we show the typical examples of activatable theranostic applications using organic-inorganic hybrid nanogels. In the end, the existing challenges and future directions are briefly discussed.

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Skin Permeation of Nanoparticles: Mechanisms Involved and Critical Factors Governing Topical Drug Delivery

Current Pharmaceutical Design ◽

10.2174/1381612826666200701204010 ◽

2020 ◽

Vol 26 (36) ◽

pp. 4601-4614

Author(s):

Taha Umair Wani ◽

Roohi Mohi-ud-Din ◽

Asmat Majeed ◽

Shabnam Kawoosa ◽

Faheem Hyder Pottoo

Keyword(s):

Drug Delivery ◽

Skin Permeation ◽

Complex Structure ◽

Osmotic Gradient ◽

Critical Factors ◽

Permeation Enhancers ◽

Vast Number ◽

Factors Affecting ◽

Chemical Permeation Enhancers ◽

Chemical Permeation

Transdermal route has been an ever sought-after means of drug administration, regarded as being the most convenient and patient compliant. However, skin poses a great barrier to the entry of the external particles including bacteria, viruses, allergens, and drugs as well (mostly hydrophilic or high molecular weight drugs), consequent to its complex structure and composition. Among the various means of enhancing drug permeation through the skin, e.g. chemical permeation enhancers, electroporation, thermophoresis, etc. drug delivery through nanoparticles has been of great interest. Current literature reports a vast number of nanoparticles that have been implicated for drug delivery through the skin. However, a precise account of critical factors involved in drug delivery and mechanisms concerning the permeation of nanoparticles through the skin is necessary. The purpose of this review is to enumerate the factors crucial in governing the prospect of drug delivery through skin and classify the skin permeation mechanisms of nanoparticles. Among the various mechanisms discussed are the ones governed by principles of kinetics, osmotic gradient, adhesion, hydration, diffusion, occlusion, electrostatic interaction, thermodynamics, etc. Among the most common factors affecting skin permeation of nanoparticles that are discussed include size, shape, surface charge density, composition of nanoparticles, mechanical stress, pH, etc.

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Critical factors affecting the desire to have cosmetic surgery among South Korean women

PsycEXTRA Dataset ◽

10.1037/e645182012-001 ◽

2012 ◽

Author(s):

Eun-Jung Son

Keyword(s):

Cosmetic Surgery ◽

Korean Women ◽

Critical Factors ◽

Factors Affecting ◽

South Korean

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A Study of the Critical Factors Affecting Word-of-Mouth Intention in Use of Hotel Buffet Restaurant

Journal of Korea Service Management Society ◽

10.15706/jksms.2015.16.1.002 ◽

2015 ◽

Vol 16 (1) ◽

pp. 25-45

Author(s):

Lee, Jeonghan ◽

Ryu, Eulsoon ◽

최정일

Keyword(s):

Word Of Mouth ◽

Critical Factors ◽

Factors Affecting

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Green Synthesized Nanomaterials as Theranostic Platforms for Cancer Treatment: Principles, Challenges and the Road Ahead

Current Medicinal Chemistry ◽

10.2174/0929867324666170309124327 ◽

2019 ◽

Vol 26 (8) ◽

pp. 1311-1327 ◽

Cited By ~ 6

Author(s):

Pala Rajasekharreddy ◽

Chao Huang ◽

Siddhardha Busi ◽

Jobina Rajkumari ◽

Ming-Hong Tai ◽

...

Keyword(s):

Nanoparticle Synthesis ◽

Research Field ◽

Synthesis Methods ◽

Synthetic Approach ◽

Future Directions ◽

The Road ◽

New Methods ◽

Recent Developments ◽

Theranostic Applications ◽

Insight Into

With the emergence of nanotechnology, new methods have been developed for engineering various nanoparticles for biomedical applications. Nanotheranostics is a burgeoning research field with tremendous prospects for the improvement of diagnosis and treatment of various cancers. However, the development of biocompatible and efficient drug/gene delivery theranostic systems still remains a challenge. Green synthetic approach of nanoparticles with low capital and operating expenses, reduced environmental pollution and better biocompatibility and stability is a latest and novel field, which is advantageous over chemical or physical nanoparticle synthesis methods. In this article, we summarize the recent research progresses related to green synthesized nanoparticles for cancer theranostic applications, and we also conclude with a look at the current challenges and insight into the future directions based on recent developments in these areas.

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Atherosclerosis and Nanomedicine Potential: Current Advances and Future Opportunities

Current Medicinal Chemistry ◽

10.2174/0929867326666190301143952 ◽

2020 ◽

Vol 27 (21) ◽

pp. 3534-3554 ◽

Cited By ~ 2

Author(s):

Fan Jiang ◽

Yunqi Zhu ◽

Changyang Gong ◽

Xin Wei

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Controlled Drug Delivery ◽

Vascular Wall ◽

Arterial Disease ◽

Diagnosis And Treatment ◽

Antiinflammatory Therapy ◽

Limited Efficacy ◽

Conventional Drug ◽

Diagnostic Modalities

Atherosclerosis is the leading inducement of cardiovascular diseases, which ranks the first cause of global deaths. It is an arterial disease associated with dyslipidemia and changes in the composition of the vascular wall. Besides invasive surgical strategy, the current conservative clinical treatment for atherosclerosis falls into two categories, lipid regulating-based therapy and antiinflammatory therapy. However, the existing strategies based on conventional drug delivery systems have shown limited efficacy against disease development and plenty of side effects. Nanomedicine has great potential in the development of targeted therapy, controlled drug delivery and release, the design of novel specific drugs and diagnostic modalities, and biocompatible scaffolds with multifunctional characteristics, which has led to an evolution in the diagnosis and treatment of atherosclerosis. This paper will focus on the latest nanomedicine strategies for atherosclerosis diagnosis and treatment as well as discussing the potential therapeutic targets during atherosclerosis progress, which could form the basis of development of novel nanoplatform against atherosclerosis.

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Cancer Nanotheranostics: A Nanomedicinal Approach for Cancer Therapy and Diagnosis

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520619666190820145930 ◽

2020 ◽

Vol 20 (11) ◽

pp. 1288-1299

Author(s):

Paromita Kundu ◽

Deepika Singh ◽

Abhalaxmi Singh ◽

Sanjeeb K. Sahoo

Keyword(s):

Drug Delivery ◽

Side Effects ◽

Cancer Diagnosis ◽

Specific Drug ◽

Novel Therapies ◽

Future Directions ◽

Normal Tissues ◽

Cancer Management ◽

Single Probe ◽

Therapy And Diagnosis

The panorama of cancer treatment has taken a considerable leap over the last decade with the advancement in the upcoming novel therapies combined with modern diagnostics. Nanotheranostics is an emerging science that holds tremendous potential as a contrivance by integrating therapy and imaging in a single probe for cancer diagnosis and treatment thus offering the advantage like tumor-specific drug delivery and at the same time reduced side effects to normal tissues. The recent surge in nanomedicine research has also paved the way for multimodal theranostic nanoprobe towards personalized therapy through interaction with a specific biological system. This review presents an overview of the nano theranostics approach in cancer management and a series of different nanomaterials used in theranostics and the possible challenges with future directions.

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An overview of Osmotic Drug Delivery System: An update review

International Journal of Bioassays ◽

10.21746/ijbio.2017.07.001 ◽

2017 ◽

Vol 6 (7) ◽

pp. 5426 ◽

Cited By ~ 2

Author(s):

Hiren J. Patel ◽

Vaishnavi P. Parikh

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Life Cycle Management ◽

Delivery Systems ◽

Osmotic Pump ◽

Factors Affecting ◽

Advantages And Disadvantages ◽

New Chemical Entities ◽

History Of ◽

Novel Drug

The pharmaceutical industry has faced several marked challenges in order to bring new chemical entities (NCEs) into the market over the past few decades. Various novel drug delivery approaches have been used as a part of life cycle management from which Osmotic drug delivery systems look the most promising one. After discussing the history of osmotic pump development, this article looks at the principles, advantages and disadvantages of osmotic drug delivery systems. Then, the basic components of osmotic pump and factors affecting the design of oral osmotic drug delivery systems are discussed in detail. In the later part of the manuscript, various types of osmotic pumps available in the market and evaluation methods for osmotic drug delivery systems are discussed in detail.

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Nanoparticles as Drug Delivery Systems of RNAi in Cancer Therapy

Molecules ◽

10.3390/molecules26082380 ◽

2021 ◽

Vol 26 (8) ◽

pp. 2380

Author(s):

Diedie Li ◽

Chengzhi Gao ◽

Meiyan Kuang ◽

Minhao Xu ◽

Ben Wang ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Therapeutic Strategy ◽

Target Gene ◽

Treatment Approach ◽

Systemic Delivery ◽

Efficient Delivery ◽

Rnai Therapeutics ◽

Cellular Machinery ◽

Tumor Delivery

RNA interference (RNAi) can mediate gene-silencing by knocking down the expression of a target gene via cellular machinery with much higher efficiency in contrast to other antisense-based approaches which represents an emerging therapeutic strategy for combating cancer. Distinct characters of nanoparticles, such as distinctive size, are fundamental for the efficient delivery of RNAi therapeutics, allowing for higher targeting and safety. In this review, we present the mechanism of RNAi and briefly describe the hurdles and concerns of RNAi as a cancer treatment approach in systemic delivery. Furthermore, the current nanovectors for effective tumor delivery of RNAi therapeutics are classified, and the characteristics of different nanocarriers are summarized.

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