Syntheses, Biological and Material Significance of Dihydro[1,3]oxazine Derivatives: An Overview

2020 ◽  
Vol 24 ◽  
Author(s):  
Ankit Lathwal ◽  
Bijoy P. Mathew ◽  
Mahendra Nath

: Dihydro[1,3]oxazines are an important class of heterocyclic compounds having a wide range of biological and material properties. Medicinally, they possess diverse pharmacological activities such as bactericidal, fungicidal, microbiocidal, antitumor, anti-HIV and anti-inflammatory agents. Apart from being biologically active, they are materially useful for making polybenzoxazines. Polybenzoxazines, a novel class of non-conjugated thermosetting materials that belong to the family of addition-curable phenolic resins. They have lucrative properties such as small shrinkage in curing, low water absorption, good thermal stability, no release of volatile materials during cure, no need for catalyst and inexpensive raw materials. Further, the flexibility in designing a monomer gives polybenzoxazines an additional edge over ordinary phenolic resins. This review briefly describes the syntheses including eco-friendly strategies, biological and material significance of various dihydro[1,3]oxazine derivatives.

2020 ◽  
Vol 16 ◽  
Author(s):  
Arpita Paul ◽  
Monami Rajiung ◽  
Kamaruz Zaman ◽  
Sushil Kumar Chaudhary ◽  
Hans Raj Bhat ◽  
...  

Background: Morus alba Linn. commonly known as white mulberry, belongs to the family Moraceae, is a promising traditional medicine. In Asia, besides its use in the preparation of delicacies, every part of this plant is utilized in traditional medicine. Over the past decade, studies related to identification and isolation of biologically active compounds, with flavonoids as the major class of phytoconstituents, from this plant has been reported. These phytoconstituents are not only found to be beneficial for the maintenance of general health but also are associated with a range of potential pharmacological activities such as antioxidant, anti-inflammatory, anti-diabetic, anticancer, hepatoprotective, cardioprotective, neuroprotective to name a few. Objective: This review aims to provide upgraded and comprehensive information regarding the phytochemical, ethnomedicinal use and pharmacological profile of the plant Morus alba Linn. Method: The significant information has been collected through various database viz. PubMed, Scopus, Web of Science, Science Direct based on the recent findings, using different terms of Morus alba. Results: The outcome of the study suggests that Morus alba is a multifunctional plant numerous phytochemicals, and possess a range of pharmacological activities. Conclusion: The data assembled on Morus alba will be beneficial to trigger research in various fields of pharmaceutical and allied science to explore the medicinal importance of this unique plant.


2021 ◽  
Vol 15 (1) ◽  
Author(s):  
L. Osipova ◽  
O. Radionova ◽  
L. Tkachenko ◽  
T. Abramova

The analysis of the current state of processing of secondary raw materials of wine-making in Ukraine is given. It is proved that the latter is a rich source of biologically active compounds, including phenolic ones, which makes it possible to use it for the production of a wide range of products (raccoon, polyphenol extracts, tartaric acid, beverages, fertilizers, grape oil, cake, vitamin D, animal feed, food powder, abrasives) with high consumer value for various industries: food, pharmaceutical, perfume and cosmetics, chemical, feed, etc. In the light of modern research, the role of phenolic compounds as essential nutrition factors that cannot remain out of the field of view of physiologists, pharmacologists, and food hygiene specialists is shown. However, currently in Ukraine there are no specialized enterprises for complex processing of secondary raw materials of winemaking; traditional technologies are not effective from a technological, economic and environmental point of view, which indicates not rational use of resources and loss of material resources; there are no systematic studies on physical and chemical, microbiological, Toxicological composition in order to determine the optimal direction of its use. A limiting factor is also the lack of comparative analysis of innovative domestic and foreign technologies for processing secondary raw materials of winemaking. In the vast majority of cases, in particular, combs and pomace are taken out of control to agricultural land without special treatment, which leads to acid soil erosion and pollution of the environment with metabolites of micromycetes, increasing one of the global problems of mankind-environmental. At the present stage of technological development, there are a number of innovative developments in the field of processing secondary raw materials, in particular grape pomace, in order to obtain biologically active additives, the limiting factor for the introduction of which is the lack of domestic and expensive imported equipment. A promising way to solve the existing problems is to create a mechanism that will unite the interests of wineries (producers of secondary raw materials of winemaking), processing enterprises (producers of products from secondary raw materials of winemaking), scientists and potential consumers of innovative products. Consolidation of the above-mentioned institutions and enterprises is possible by creating clusters for the development and implementation of innovative technologies and equipment


Author(s):  
Zahra Zakeri Khatir ◽  
Hamid Irannejad

: 1, 2, 4-Triazine derivatives have received much attention due to their multifunctional nature, especially in diverse pharmacological properties as well as a key fragment in many drug candidates. Introduction of a vicinal 5, 6-diaryl/heteroaryl moiety on the 1, 2, 4-triazine ring has attracted plentiful attention in the field of medicinal chemistry. 5, 6-Diaryl/heteroaryl-3-substituted-1, 2, 4-triazine is as a prominent scaffold in many drug candidates which has shown a wide range of pharmacological activities such as anti-diabetic, antifungal, anti-inflammatory, anticancer, anti-HIV, neuroprotective, anticonvulsant, anti- Alzheimer, anti-Parkinson and antioxidant. In this review, we have discussed synthesis, various pharmacological activities of 5, 6-diaryl/heteroaryl-3-substituted-1, 2, 4-triazines, their structure-activity relationship (SAR), pharmacophoric elements and their mechanism of action reported in the published articles during 2000-2019. Evaluation of compounds by PAINS filtering tool was accomplished and showed that this versatile structure could be considered as a privileged structure. Compilation of the biological data confirmed that the position 3 of the 1,2,4-triazine is a key location to determine the affinity and selectivity of the 5,6-diaryl/heteroaryl-3-substituted-1, 2, 4-triazines towards different biologic targets. Specific geometrical and thermodynamic characters of this motif have prompted it as a frequent hitter.


2020 ◽  
Vol 14 (2) ◽  
Author(s):  
N. Pritulska ◽  
I. Motuzka ◽  
A. Koshelnyk ◽  
M. Jarossová ◽  
A. Lacková

A recent tendency in Ukraine is the changes in the structure of food consumption, which are caused by the reduced consumption of some product groups and by their decreasing quality. A persisting problem is that affordable and easy-to-consume food products made with due consideration of the needs of patients with certain categories of diseases can hardly be found on the domestic market. The products present on the domestic market are all imported, available in a limited assortment, very expensive, and not customised to suit all the specific needs of human metabolism. Approaches to the nutrition of patients with certain types of nutrition-dependent and non-infectious diseases have been analysed. It has been established that аn effective component in the diet of patients with non-infectious diseases can be plant-based milk analogues. It has been determined how important it is to use domestic raw materials: it will contribute to expanding domestic production, will help the gross domestic product growth, and will reduce the product’s costs, thus reducing the costs of diagnostic and treatment procedures. It has been established that the assortment of plant-based milk analogues is constantly expanding. The vegetable raw material conventionally used to make this product group has been analysed. It has been shown that fenugreek seeds can be most effectively used to make special food products (in particular, plant-based milk analogues) for the nutritional support of patients with non-infectious diseases. This is feasible due to the availability of the raw material, simple cultivating conditions, the chemical composition of the product (e. g. a wide range of biologically active substances), low costs of the product when it is made from domestic raw materials, and the simple production technology. It is expected that manufacture of milk analogues from fenugreek seeds will widen the assortment of this product group, and satisfy the target consumers’ needs of safe and high quality products that offer an alternative to imports.


Vestnik ◽  
2021 ◽  
pp. 252-255
Author(s):  
Д.К. Айдарбаев ◽  
А.Ж. Жарқынбек

В статье рассматриваются биологические и экологические особенности цистанхе, а также предусматривается этноботанические исследования, рекомендации по рациональному использованию. Выявлены некоторые значения Cistanchе, которое произрастает в Казахстане. Определена область использования в народной медицине цистанхе из семейства Orobanchaceae. В исследовании показана роль цистанхе, как растения с широким спектром фармакологических свойств. Проведен анализ маршрутно-рекогносцировочных исследований популяции цистанхе, определены распределение, запасы и объемы ежегодных заготовок по основным расположенным флористическим районам. Проведен расчет среднего суммарного объема заготовок сырья, собранных в Прибалхашье Алматинской области. В настоящее время в результате глобального потепления климатические условия меняются, и многие виды растений вымирают. Поэтому защита и эффективное использование растений является одной из самых актуальных проблем. Также важно изучить цистанхе, используемый в народной медицине как лекарственное растение. The article discusses the biological and ecological features of cistanche, as well as provides for ethnobotanical research, recommendations for rational use. Some values of Cistanche, which grows in Kazakhstan, are revealed. The scope of use in folk medicine of cistanha from the family Orobanchaceae is determined. The study shows the role of cistanche as a plant with a wide range of pharmacological properties. Conducted analysis of route-reconnaissance studies of cisterna populations, determined the distribution, stock and volumes of annual preparations for the main floristic areas. Calculated the average total volume of raw materials collected in the Balkhash region of Almaty region. As a result of global warming, climatic conditions are changing and many plant species are dying. Therefore, the protection and efficient use of plants is one of the most pressing problems. It is also important to study the tanks used in folk medicine as a medicinal plant.


2020 ◽  
Vol 8 (1) ◽  
pp. 4-28
Author(s):  
Е. V. Zvezdina ◽  
J. V. Dayronas ◽  
I. I. Bochkareva ◽  
I. N. Zilfikarov ◽  
E. Yu. Babaeva ◽  
...  

The aim of this work is to review and analyze the data published in the modern scientific literature obtained in pharmacological, pharmacognostic and pharmacotechnological studies of various types of raw materials obtained from members of the family Lamiaceae L., which were sources of biologically active substances, pharmaceutical substances, total extracts and the drugs – with a neurotropic activity.Materials and methods. For the review, we used the information of scientific literature from open and accessible sources of the last twenty years, located in the scientific and technical libraries of institutions, as well as in electronic databases: Elibrary, PubMed, Scopus, Cyberleninka, GoogleAcademy, J-Stage. The search inquiries were: the species of the family Lamiaceae (Russian and Latin), the samples of medicinal plant materials based on them as well as the names of the drugs and biologically active substances obtained from these raw materials.Results. When working with the sources of scientific information, the main attention was paid to pharmacologic tests performed during the studies on laboratory animals and proving the presence of neurotropic activity in the studied objects – essential oils and extracts from plant raw materials: aqueous, aqueous alcoholic, and methanol ones. It has been established that the potential of the therapeutic and preventive application of pharmaceutical substances and drugs based on the medicinal plant materials obtained from 30 genera members of the Lamiaceae family, remains unrealized despite the close attention of various researchers.Conclusion. This review comprised 71 species from 30 genera. Despite the significant level of the previous study presented in the analysis of this publication, an enormous potential of this family’s species remains unexplored. In the future, they can be of both – pharmacognostic and practical interest, in particular, in creation of new medicinal preparations of the neurotropic action based on them.


2020 ◽  
Vol 1 (337) ◽  
pp. 33-40
Author(s):  
Yedilova A.K. ◽  
Inelova Z.A.

The article provides an overview of the structural features of the natural populations of Humulus lupulus L. in the world and in Kazakhstan. Currently, the use in medicine of natural products, medicines and biologically active substances of plant origin is increasing. Significant parts of the medicinal raw materials are wild plants. The need for medicinal plant raw materials (medicinal plants) is not decreasing; the technology of its procurement and reproduction in natural conditions wants significant perfection. It is known that they have a milder, more complex effect on the human body and are used in the treatment of many chronic diseases. The growing anthropogenic impact on populations of valuable medicinal plants is decreasing their stocks of raw materials. In this regard, the study of biological characteristics and the development of scientifically based agricultural techniques for the cultivation of many medicinal plants are becoming relevant. Humulus lupulus L. (common hop) is a valuable medicinal plant. They are used as painkillers, sedatives, hypnotics for increased nervous irritability, sleep distur-bances, neuralgia, vegetovascular dystonia, mild coronary spasms, tachycardia, and in the early stages of hyper-tension. According to the classification of medicinal plant resources, Humulus lupulus L. is a plant with a wide range, but with a limited supply of raw materials. In places of growth of Humulus lupulus L. does not form large thickets [1]. Recently, a comprehensive approach has been applied in the study of natural plant populations, including ontomorphological and population-ecological studies. This makes it possible to objectively assess the state of the species in the cenosis and predict its future behavior. In this regard, a comprehensive study of the natural populations of Humulus lupulus L. is of great relevance. Hops (Humulus lupulus L.) is an important crop worldwide, known as the main flavor ingredient in beer. A diversified brewing industry requires a variety of flavors, superior technological properties and sustainable agro-nomy, which are the center of advanced molecular breeding efforts in hops. Hop breeders have been limited in their ability to create strains with desirable traits, however, due to unusual and unpredictable inheritance patterns and the associated non-Mendelian segregation of genetic markers [2]. The use of hops has recently been undergoing a new change, driven by a growing international preference for more intensely flavored beer, supported by the craft-brewing sector. This movement led to the introduction of much more hops at various stages of beer production and to an ever-growing search for new flavors. Some hop varieties have thus received particular attention, including several older typical hops mostly used to date, although an intensive search for new varieties dubbed "Green Gold" has also taken place. A large number of new exquisite varieties have been described and are increasingly appreciated in the market. Global hop growing areas have increased over the past 5 years, although total world beer production has declined over the same period, confirming the trend of using more hops per liter of beer. In addition, a wide range of pharmacological properties have been described for hops and its derivatives, namely antioxidant, anti-inflammatory and antitumor properties, which are of great importance for the pharmaceutical industry. The bioactivity of beer can depend on the use of hops, which can become an important tool for brewers aiming to develop functional products. Taken together, the compounds isolated from Humulus lupulus L. have a wide range of biological activity, such as anti-inflammatory action, antimicrobial action, antioxidant action, antiproliferative effects, cytochrome P450 effects, glucose metabolism effects, hormonal effects, lipid effects and sedative / hypnotic effects. Therefore, the purpose of this Chapter is to describe the importance of hops in this new direction of beer production, market overview of hops, varieties, forms and methods of use, composition, value in bioactivity of beer and new discoveries in research hops [3].


2019 ◽  
Vol 9 (2) ◽  
pp. 98-124 ◽  
Author(s):  
Mohammad Yasir ◽  
Manish K. Tripathi ◽  
Pushpendra Singh ◽  
Rahul Shrivastava

Background:Medicinal plants are rich source of large variety of lead compounds. The plants of genus Glycosmis or its different parts valued for its therapeutic and medicinal qualities. Glycosmis belongs to the family Rutaceae.Objective:The genus Glycosmis is a rich source of pharmacologically and biologically active secondary metabolites, such as alkaloids, flavonoids, phenolic glycosides, quinones, terpenoids, glycerides isolated from different parts of Glycosmis plant. The objectives of this review is to provide updatedand complete information on the distribution, phytochemical, pharmacological, and toxicity research of Glycosmis species.Results:About 233 phytoconstituents are isolated from this genus. Recent interest in this genus has focused on isolating and identifying of different phytoconstituents that exhibit potent antioxidant, antibacterial, antiviral and anticancer activities. They show good cytotoxic activity against various cancer cell lines and also reported for good antiviral and immunomodulatory activity. In this support convincing evidence in experimental animal models are available.Conclusion:This review summarizes information about the isolated compounds their bioactivities related to same compounds present in other plants including pharmacological activities of plant extract of Glycosmis genus.


2021 ◽  
Vol 16 (12) ◽  
pp. 150-160
Author(s):  
T. Sharma ◽  
V. Khandelwal

Ever since ancient times, medicinal plants served as a great source of herbal formulations which can confer human civilization with preferential quality of life. Among them, some plants secured their position in mythologies, also highlighting Anthocephalus cadamba, a religious medicinal plant, belonging to the family Rubiaceae, mostly cultivated in tropical regions. Conventional medicinal system of India provides evidences regarding folk medicinal uses for the treatment of various ailments like inflammation, skin diseases, uterine complaints, blood disease and diarrhea etc. Phytochemical investigations revealed the presence of some biologically active compounds like flavonoids, alkaloids, coumarins, terpenoids, diterpenoids, triterpenes, glycosides, sterols, amides and fatty acids and these compounds were found to be accountable for various pharmacological activities such as antimicrobial, antipyretic, anti-inflammatory, analgesic, anticancerous, antidibetic, hypolipidemic, antihepatotoxic, antidiarrhoel, diuretic, laxative, antioxidant, immunomodulatory, wound healing etc.


2018 ◽  
pp. 99-105
Author(s):  
Светлана (Svetlana) Галимулловна (Galimullovna) Денисова (Denisova) ◽  
Антонина (Аntonina) Анатольевна (Аnatol'evna) Реут (Reut) ◽  
Кира (Kira) Александровна (Aleksandrovna) Пупыкина (Pupykina)

The results of phytochemical studies of various types of raw materials (flowers, leaves, stems, roots) of some taxa of the genus Chrysanthemum (the family Asteraceae Dumort.): two species – Chrysanthemum coronarium, Ch. segetum and four varieties Ch. × hortorum Bailey – "Kupava", "Doch' Rozetty", "Oranzhevyj Zakat", "Vechernie Ogni". As the object of comparison Tanacetum vulgare L. was used. Quantitative characteristics of amino acids, macro- and microelements have been determined. The high ability of leaves to accumulate elements such as sodium (0.30–0.41%), calcium (1.24–2.13%), manganese (317.76–651.83 mg/kg), iodine (0.18–0.32 mg/kg), zinc (80.55–115.44 mg/kg), as well as amino acids (8.97–15.38 mg%). Roots contain as much as possible phosphorus (0.18–0.92%), copper (4.61–20.18 mg/kg) and iron (507.48–1234.71 mg/kg); in the stems – potassium (0.80–1.63%). Varying the studied indicators reflects the different biological value of the objects of research. The analysis of elemental and amino acid composition of various types of raw materials of some taxa of chrysanthemum showed that the studied cultivars are promising sources of amino acids, macro- and microelements. As alternative sources of biologically active substances, further studies have been proposed Ch. coronarium, Ch. segetum, Ch. × hortorum "Oranzhevyj Zakat" and "Vechernie Ogni".


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