The Genus Glycosmis [Rutaceae]: A Comprehensive Review on its Phytochemical and Pharmacological Perspectives

2019 ◽  
Vol 9 (2) ◽  
pp. 98-124 ◽  
Author(s):  
Mohammad Yasir ◽  
Manish K. Tripathi ◽  
Pushpendra Singh ◽  
Rahul Shrivastava
Keyword(s):  
Complete Information ◽  
Convincing Evidence ◽  
Rich Source ◽  
Biologically Active ◽  
Immunomodulatory Activity ◽  
Anticancer Activities ◽  
Pharmacological Activities ◽  
Lead Compounds ◽  
The Family ◽  
Different Parts

Background:Medicinal plants are rich source of large variety of lead compounds. The plants of genus Glycosmis or its different parts valued for its therapeutic and medicinal qualities. Glycosmis belongs to the family Rutaceae.Objective:The genus Glycosmis is a rich source of pharmacologically and biologically active secondary metabolites, such as alkaloids, flavonoids, phenolic glycosides, quinones, terpenoids, glycerides isolated from different parts of Glycosmis plant. The objectives of this review is to provide updatedand complete information on the distribution, phytochemical, pharmacological, and toxicity research of Glycosmis species.Results:About 233 phytoconstituents are isolated from this genus. Recent interest in this genus has focused on isolating and identifying of different phytoconstituents that exhibit potent antioxidant, antibacterial, antiviral and anticancer activities. They show good cytotoxic activity against various cancer cell lines and also reported for good antiviral and immunomodulatory activity. In this support convincing evidence in experimental animal models are available.Conclusion:This review summarizes information about the isolated compounds their bioactivities related to same compounds present in other plants including pharmacological activities of plant extract of Glycosmis genus.

An Overview on Phytochemical and Pharmacological Profile of Morus alba Linn.

2020 ◽  
Vol 16 ◽  
Author(s):  
Arpita Paul ◽  
Monami Rajiung ◽  
Kamaruz Zaman ◽  
Sushil Kumar Chaudhary ◽  
Hans Raj Bhat ◽  
...  
Keyword(s):  
Traditional Medicine ◽  
Morus Alba ◽  
Biologically Active ◽  
Pharmacological Profile ◽  
Pharmacological Activities ◽  
Significant Information ◽  
The Past ◽  
Comprehensive Information ◽  
The Family ◽  
White Mulberry

Background: Morus alba Linn. commonly known as white mulberry, belongs to the family Moraceae, is a promising traditional medicine. In Asia, besides its use in the preparation of delicacies, every part of this plant is utilized in traditional medicine. Over the past decade, studies related to identification and isolation of biologically active compounds, with flavonoids as the major class of phytoconstituents, from this plant has been reported. These phytoconstituents are not only found to be beneficial for the maintenance of general health but also are associated with a range of potential pharmacological activities such as antioxidant, anti-inflammatory, anti-diabetic, anticancer, hepatoprotective, cardioprotective, neuroprotective to name a few. Objective: This review aims to provide upgraded and comprehensive information regarding the phytochemical, ethnomedicinal use and pharmacological profile of the plant Morus alba Linn. Method: The significant information has been collected through various database viz. PubMed, Scopus, Web of Science, Science Direct based on the recent findings, using different terms of Morus alba. Results: The outcome of the study suggests that Morus alba is a multifunctional plant numerous phytochemicals, and possess a range of pharmacological activities. Conclusion: The data assembled on Morus alba will be beneficial to trigger research in various fields of pharmaceutical and allied science to explore the medicinal importance of this unique plant.

Syntheses, Biological and Material Significance of Dihydro[1,3]oxazine Derivatives: An Overview

2020 ◽  
Vol 24 ◽  
Author(s):  
Ankit Lathwal ◽  
Bijoy P. Mathew ◽  
Mahendra Nath
Keyword(s):  
Raw Materials ◽  
Biologically Active ◽  
Pharmacological Activities ◽  
Phenolic Resins ◽  
Good Thermal Stability ◽  
Wide Range ◽  
The Family ◽  
Anti Hiv ◽  
Volatile Materials ◽  
Oxazine Derivatives

: Dihydro[1,3]oxazines are an important class of heterocyclic compounds having a wide range of biological and material properties. Medicinally, they possess diverse pharmacological activities such as bactericidal, fungicidal, microbiocidal, antitumor, anti-HIV and anti-inflammatory agents. Apart from being biologically active, they are materially useful for making polybenzoxazines. Polybenzoxazines, a novel class of non-conjugated thermosetting materials that belong to the family of addition-curable phenolic resins. They have lucrative properties such as small shrinkage in curing, low water absorption, good thermal stability, no release of volatile materials during cure, no need for catalyst and inexpensive raw materials. Further, the flexibility in designing a monomer gives polybenzoxazines an additional edge over ordinary phenolic resins. This review briefly describes the syntheses including eco-friendly strategies, biological and material significance of various dihydro[1,3]oxazine derivatives.

Phytopharmaceutical potential of Anthocephalus cadamba (Roxb.)

2021 ◽  
Vol 16 (12) ◽  
pp. 150-160
Author(s):  
T. Sharma ◽  
V. Khandelwal
Keyword(s):  
Skin Diseases ◽  
Biologically Active ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Tropical Regions ◽  
The Family ◽  
Ancient Times ◽  
Herbal Formulations ◽  
Anthocephalus Cadamba

Ever since ancient times, medicinal plants served as a great source of herbal formulations which can confer human civilization with preferential quality of life. Among them, some plants secured their position in mythologies, also highlighting Anthocephalus cadamba, a religious medicinal plant, belonging to the family Rubiaceae, mostly cultivated in tropical regions. Conventional medicinal system of India provides evidences regarding folk medicinal uses for the treatment of various ailments like inflammation, skin diseases, uterine complaints, blood disease and diarrhea etc. Phytochemical investigations revealed the presence of some biologically active compounds like flavonoids, alkaloids, coumarins, terpenoids, diterpenoids, triterpenes, glycosides, sterols, amides and fatty acids and these compounds were found to be accountable for various pharmacological activities such as antimicrobial, antipyretic, anti-inflammatory, analgesic, anticancerous, antidibetic, hypolipidemic, antihepatotoxic, antidiarrhoel, diuretic, laxative, antioxidant, immunomodulatory, wound healing etc.

scholarly journals Traditional uses, phytochemistry, and pharmacological activities of Cochlospermum tinctorium A. Rich (Cochlospermaceae): a review

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Mubarak Hussaini Ahmad ◽  
Abubakar Ibrahim Jatau ◽  
Garba M. Khalid ◽  
Omar Yahya Alshargi
Keyword(s):  
Liver Diseases ◽  
Bioactive Molecules ◽  
Pharmacological Activities ◽  
Main Text ◽  
Traditional Uses ◽  
Comprehensive Information ◽  
The Family ◽  
Arjunolic Acid ◽  
Ethnomedicinal Uses ◽  
Different Parts

Abstract Background The plant Cochlospermum tinctorium A. Rich is a sub-shrub that belongs to the family Cochlospermaceae. The plant has been used in traditional medicine for the treatment of malaria, rickets, stomachache, diarrhea, gastric ulcer, parasitic infestations, liver diseases, fever, pain, inflammation, infectious diseases, epilepsy, snake bite, burns, orchitis, labour, menstrual problems, and many other diseases. This review summarizes the traditional uses, phytochemistry, and pharmacological activities of Cochlospermum tinctorium. Main text To date, few bioactive molecules have been identified and isolated from the plant such as 7,3-dimethyldihydroquercelin, 5,4-dimethylquercelin, cochloxanthine, dihydrocochloxanthine, arjunolic acid, 3-O-E-p-coumaroylalphitolic acid, alphitolic acid, 1-hydroxytetradecan-3-one, 3-bisabolen, 2-tridecanone, 3-hexadecanone, 1-dodecanol, l-tetradecanol, 2-pentdecanone, 3-octadecanone, 1-hydroxy-3-hexadecanone, 1-nonadecanol, l-O-acetyl-3-hexadecanone, and l-hydroxy-3-oetadecanone. The literature related some of the reported ethnomedicinal uses of the plant to these compounds found in the different parts of the plant. Conclusion The comprehensive information documented in this review about the importance of the C. tinctorium may provide an opportunity for research advancement in drug discovery and a better understanding of the medicinal benefits of the plant.

A Comprehensive Review on Pharmacological Properties of Abrus precatorius L.

2020 ◽  
Vol 10 (5) ◽  
pp. 543-549
Author(s):  
Vijay Chopra ◽  
Aishwarya Shriwastva ◽  
Gopal L. Khatik ◽  
Manish Vyas ◽  
Pramod Yadav ◽  
...  
Keyword(s):  
Chemotherapeutic Agent ◽  
Anthelmintic Activity ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Poisonous Plant ◽  
Comprehensive Review ◽  
Active Constituents ◽  
Abrus Precatorius ◽  
The Family ◽  
Different Parts

Background: Abrus precatorius L. (A. precatorius) is a valuable plant from the family Fabaceae which is a pea family. It is commonly known as Gunja or Jequirity, significantly found throughout India mainly Himalaya to Southern India and Ceylon. It is considered a poisonous plant due to the presence of abrin. Objective: A. precatorius has many pharmacological and biologically active constituents, such as alkaloids, glycosides and flavonoids situated in different parts of the plant. The objective of this review is to provide a retrospective study based on its anticancer potential. Results: Recent studies of A. precatorius are based on the isolation, characterization, and pharmacological evaluation of different secondary metabolites. These constituents possess significant cytotoxic properties against various cancer cell lines including breast, lung, liver, ovarian, prostate and leukaemia. A. precatorius is also reported to have anti-diabetic, anti-microbial, abortifacient, antioxidant, anthelmintic activity, antifertility, nephroprotective, and immunomodulatory activities. Conclusion: The present review summarizes the anticancer potential of A. precatorius and its constituents. However, extensive research is required to establish it as a potent chemotherapeutic agent.

scholarly journals Tetracarpidium conophorum (African walnut) Hutch. & Dalziel: Ethnomedicinal uses and its therapeutic activities

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Ayeni E. Ayodeji ◽  
Nuhu Aliyu
Keyword(s):  
Medicinal Plants ◽  
Healthcare Management ◽  
African Countries ◽  
Pharmacological Activities ◽  
The Family ◽  
The World ◽  
Edible Seed ◽  
Therapeutic Activities ◽  
Ethnomedicinal Uses ◽  
Different Parts

The use of medicinal plants to cure many ailments has been a tradition in different parts of the world. Tetracarpidium conophorum (African walnut) belongs to the family Euphorbiaceae. It is an edible seed that is widely cultivated for its delicacy. All parts of the plant have been used ethnomedically. This article reviewed the ethnomedicinal, nutritional, phytochemical and some pharmacological activities of T. conophorum, because medicinal plants are our hope in achieving sustainable global statutory of health for all and a last resort in healthcare management in African countries. This review reveals previous findings and other pharmacological benefits of the African walnut towards its potential as food and drug development.

scholarly journals FivePistaciaspecies (P. vera,P. atlantica,P. terebinthus,P. khinjuk, andP. lentiscus): A Review of Their Traditional Uses, Phytochemistry, and Pharmacology

2013 ◽  
Vol 2013 ◽  
pp. 1-33 ◽  
Author(s):  
Mahbubeh Bozorgi ◽  
Zahra Memariani ◽  
Masumeh Mobli ◽  
Mohammad Hossein Salehi Surmaghi ◽  
Mohammad Reza Shams-Ardekani ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Flowering Plants ◽  
Gastrointestinal Disorders ◽  
Pharmacological Activities ◽  
Beneficial Effects ◽  
Comprehensive Information ◽  
The Family ◽  
Phytochemical Constituents ◽  
Ethnomedicinal Uses ◽  
Different Parts

Pistacia, a genus of flowering plants from the family Anacardiaceae, contains about twenty species, among them five are more popular includingP. vera, P. atlantica, P. terebinthus, P. khinjuk,andP. lentiscus. Different parts of these species have been used in traditional medicine for various purposes like tonic, aphrodisiac, antiseptic, antihypertensive and management of dental, gastrointestinal, liver, urinary tract, and respiratory tract disorders. Scientific findings also revealed the wide pharmacological activities from various parts of these species, such as antioxidant, antimicrobial, antiviral, anticholinesterase, anti-inflammatory, antinociceptive, antidiabetic, antitumor, antihyperlipidemic, antiatherosclerotic, and hepatoprotective activities and also their beneficial effects in gastrointestinal disorders. Various types of phytochemical constituents like terpenoids, phenolic compounds, fatty acids, and sterols have also been isolated and identified from different parts ofPistaciaspecies. The present review summarizes comprehensive information concerning ethnomedicinal uses, phytochemistry, and pharmacological activities of the five mentionedPistaciaspecies.

A REVIEW ON RECENT ADVANCES IN CHEMISTRY, SYNTHESIS AND BIOLOGICAL APPLICATIONS OF ISATIN DERIVATIVES

2018 ◽  
pp. 16-22
Author(s):  
Shukla PK ◽  
Singh MP ◽  
Patel R
Keyword(s):  
Heterocyclic Compounds ◽  
Biologically Active ◽  
Biological Applications ◽  
Plant Origin ◽  
Recent Past ◽  
Pharmacological Activities ◽  
Naturally Occurring ◽  
Recent Advances ◽  
Biological Aspects ◽  
Isatin Derivatives

Indole and its derivatives have engaged a unique place in the chemistry of nitrogen heterocyclic compounds. The recognition of the plant growthhormone, heteroauxin, the significant amino acids, tryptamine & tryptophan and anti-inflammatory drug, indomethacine are the imperativederivatives of indole which have added stimulus to this review work. Isatin (1H-indole-2,3-dione), an indole derivative of plant origin. Althoughit is a naturally occurring compound, but was synthesized by Erdmann and Laurent in 1840 before it was found in nature. Isatin is a versatileprecursor for many biologically active molecules and its diversified nature makes it a versatile substrate for further modifications. It is concernedin many pharmacological activities like anti-malarial, antiviral, anti-allergic, antimicrobial etc; isatin and its derivatives have been also found todemonstrate promising outcomes against various cancer cell lines. This review provides a brief overview on the recent advances and futureperspectives on chemistry and biological aspects of isatin and its derivatives reported in the recent past.

Privileged Structures in the Design of Potential Drug Candidates for Neglected Diseases

2019 ◽  
Vol 26 (23) ◽  
pp. 4323-4354 ◽  
Author(s):  
Ana Cristina Lima Leite ◽  
José Wanderlan Pontes Espíndola ◽  
Marcos Veríssimo de Oliveira Cardoso ◽  
Gevanio Bezerra de Oliveira Filho
Keyword(s):  
Biologically Active ◽  
Neglected Diseases ◽  
Financial Return ◽  
Drug Candidates ◽  
Lead Compounds ◽  
Wide Range ◽  
Methods Of Synthesis ◽  
Current Therapies ◽  
Resistant Strains ◽  
Privileged Structures

Background: Privileged motifs are recurring in a wide range of biologically active compounds that reach different pharmaceutical targets and pathways and could represent a suitable start point to access potential candidates in the neglected diseases field. The current therapies to treat these diseases are based in drugs that lack of the desired effectiveness, affordable methods of synthesis and allow a way to emergence of resistant strains. Due the lack of financial return, only few pharmaceutical companies have been investing in research for new therapeutics for neglected diseases (ND). Methods: Based on the literature search from 2002 to 2016, we discuss how six privileged motifs, focusing phthalimide, isatin, indole, thiosemicarbazone, thiazole, and thiazolidinone are particularly recurrent in compounds active against some of neglected diseases. Results: It was observed that attention was paid particularly for Chagas disease, malaria, tuberculosis, schistosomiasis, leishmaniasis, dengue, African sleeping sickness (Human African Trypanosomiasis - HAT) and toxoplasmosis. It was possible to verify that, among the ND, antitrypanosomal and antiplasmodial activities were between the most searched. Besides, thiosemicarbazone moiety seems to be the most versatile and frequently explored scaffold. As well, phthalimide, isatin, thiazole, and thiazolidone nucleus have been also explored in the ND field. Conclusion: Some described compounds, appear to be promising drug candidates, while others could represent a valuable inspiration in the research for new lead compounds.

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