Inulin as a Delivery Vehicle for Targeting Colon-Specific Cancer

2020 ◽  
Vol 17 (8) ◽  
pp. 651-674
Author(s):  
Swati Chadha ◽  
Arun Kumar ◽  
Shambhavi Ashwini Srivastava ◽  
Tapan Behl ◽  
Rishu Ranjan
Keyword(s):  
Colon Cancer ◽  
Colonic Cancer ◽  
Well Being ◽  
Therapeutic Agents ◽  
Cancer Targeting ◽  
Delivery Vehicle ◽  
The Past ◽  
Colon Delivery ◽  
Beneficial Uses ◽  
Specific Cancer

Natural polysaccharides, as well as biopolymers, are now days widely developed for targeting colon cancer using various drug delivery systems. Currently, healing conformations are being explored that can efficiently play a multipurpose role. Owing to the capability of extravagance colonic diseases with the least adverse effects, biopolymers for site specific colon delivery have developed an increased curiosity over the past decades. Inulin (INU) was explored for its probable application as an entrapment material concerning its degradation by enzymes in the colonic microflora and its drug release behavior in a sustained and controlled manner. INU is a polysaccharide and it consists of 2 to 1 linkage having an extensive array of beneficial uses such as a carrier for delivery of therapeutic agents as an indicative/investigative utensil or as a dietary fiber with added well-being aids. In the main, limited research, as well as information, is available on the delivery of therapeutic agents using inulin specifically for colon cancer because of its capability to subsist in the stomach’s acidic medium. This exceptional steadiness and robustness properties are exploited in numerous patterns to target drugs securely for the management of colonic cancer, where they effectively act and kills colonic tumor cells easily. In this review article, recent efforts and inulin-based nano-technological approaches for colon cancer targeting are presented and discussed.

Enabling Community Well-being Self-Monitoring in the Context of Mining: The Naskapi Nation of Kawawachikamach

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Robert Klinck ◽  
Ben Bradshaw ◽  
Ruby Sandy ◽  
Silas Nabinacaboo ◽  
Mannie Mameanskum ◽  
...  
Keyword(s):  
Indigenous Peoples ◽  
Well Being ◽  
Aboriginal Community ◽  
Self Monitoring ◽  
Community Engaged Research ◽  
The Past ◽  
Mineral Development ◽  
Iron Deposits ◽  
Term Monitoring

The Naskapi Nation of Kawawachikamach is an Aboriginal community located in northern Quebec near the Labrador Border. Given the region’s rich iron deposits, the Naskapi Nation has considerable experience with major mineral development, first in the 1950s to the 1980s, and again in the past decade as companies implement plans for further extraction. This has raised concerns regarding a range of environmental and socio-economic impacts that may be caused by renewed development. These concerns have led to an interest among the Naskapi to develop a means to track community well-being over time using indicators of their own design. Exemplifying community-engaged research, this paper describes the beginning development of such a tool in fall 2012—the creation of a baseline of community well-being against which mining-induced change can be identified. Its development owes much to the remarkable and sustained contribution of many key members of the Naskapi Nation. If on-going surveying is completed based on the chosen indicators, the Nation will be better positioned to recognize shifts in its well-being and to communicate these shifts to its partners. In addition, long-term monitoring will allow the Naskapi Nation to contribute to more universal understanding of the impacts of mining for Indigenous peoples.

Bridging the Gap of Drug Delivery in Colon Cancer: The Role of Chitosan and Pectin Based Nanocarriers System

2020 ◽  
Vol 17 (10) ◽  
pp. 911-924
Author(s):  
Rohitas Deshmukh
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Therapeutic Agent ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Target Tissue ◽  
Polymer Carriers

Colon cancer is one of the most prevalent diseases, and traditional chemotherapy has not been proven beneficial in its treatment. It ranks second in terms of mortality due to all cancers for all ages. Lack of selectivity and poor biodistribution are the biggest challenges in developing potential therapeutic agents for the treatment of colon cancer. Nanoparticles hold enormous prospects as an effective drug delivery system. The delivery systems employing the use of polymers, such as chitosan and pectin as carrier molecules, ensure the maximum absorption of the drug, reduce unwanted side effects and also offer protection to the therapeutic agent from quick clearance or degradation, thus allowing an increased amount of the drug to reach the target tissue or cells. In this systematic review of published literature, the author aimed to assess the role of chitosan and pectin as polymer-carriers in colon targeted delivery of drugs in colon cancer therapy. This review summarizes the various studies employing the use of chitosan and pectin in colon targeted drug delivery systems.

Temporal Focus

2020 ◽  
Author(s):  
Abbie J. Shipp
Keyword(s):  
Well Being ◽  
Psychology Research ◽  
The Past ◽  
Research Areas ◽  
The Future ◽  
Behavior Based ◽  
The Individual ◽  
And Behavior ◽  
Temporal Focus

Temporal focus is the individual tendency to characteristically think more or less about the past, present, and future. Although originally rooted in early work from psychology, research on temporal focus has been steadily growing in a number of research areas, particularly since Zimbardo and Boyd’s (1999) influential article on the topic. This chapter will review temporal focus research from the past to the present, including how temporal focus has been conceptualized and measured, and which correlates and outcomes have been tested in terms of well-being and behavior. Based on this review, an agenda for research is created to direct temporal focus research in the future.

scholarly journals Himalayan perceptions: Environmental change and the well-being of mountain peoples

1970 ◽  
Vol 2 (3) ◽  
pp. 17-19 ◽  
Author(s):  
Jack D Ives
Keyword(s):  
New York ◽  
Environmental Change ◽  
Environmental Degradation ◽  
Full Text ◽  
Armed Conflict ◽  
Well Being ◽  
Government Agencies ◽  
The Past ◽  
Highland Forests ◽  
Development Paradigm

Preview of Himalayan perceptions: Environmental change and the well-being of mountain peoples by JD Ives Routledge, London and New York To be published in August 2004 Himalayan Perspectives returns to the enormously popular development paradigm that Ives dubbed the ‘Theory of Himalayan Degradation’. According to this seductive construct, poverty and overpopulation in the Himalayas was leading to degradation of highland forests, erosion, and downstream flooding. In the ‘Himalayan Dilemma’, Ives and Messerli exposed this “Theory” as a dangerous collection of assumptions and misrepresentations. While most scholars in the field promptly conceded Ives and Messerli’s points, the Theory has somehow survived as the guiding myth of development planners and many government agencies. In his new book, Ives returns to drive a stake through the heart of this revenant. His book not only reviews the research that, over the past 15 years, has confirmed the arguments of the ‘Himalayan Dilemma’; it also takes a close look at all those destructive factors that were overlooked by the conveniently simplistic ‘Theory of Himalayan Environmental Degradation’: government mismanagement, oppression of mountain minorities, armed conflict, and inappropriate tourism development. Himalayan Journal of Sciences 2(3): 17-19, 2004 The full text is of this article is available at the Himalayan Journal of Sciences website

Sexual harassment and psychological complaints: student- and class-level associations

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
S Brolin Låftman ◽  
Y Bjereld ◽  
B Modin ◽  
P Löfstedt
Keyword(s):  
School Climate ◽  
Sexual Harassment ◽  
Linear Regression Analysis ◽  
Well Being ◽  
Negative Effects ◽  
School Class ◽  
School Aged Children ◽  
The Past ◽  
Class Level ◽  
Using Data

Abstract Background Students who are subjected to sexual harassment at school report lower psychological well-being than those who are not exposed. Yet, it is possible that the occurrence of sexual harassment in the school class is stressful also for those who are not directly targeted, with potential negative effects on well-being for all students. The aim was to examine whether sexual harassment at the student- and at the class-level was associated with students' psychological complaints. Methods Data from the Swedish Health Behaviour in School-aged Children (HBSC) of 2017/18 was used, with information from students aged 11, 13 and 15 years (n = 3,720 distributed across 209 classes). Psychological complaints were constructed as a summative index of four items capturing how often the student had felt low, felt irritable or bad tempered, felt nervous, or had difficulties to fall asleep, during the past six months (Cronbach's alpha=0.78). Sexual harassment at the student-level was measured by one item concerning bullying at school: “Other students have exposed me to sexual jokes”. Students who reported that this had happened at least “2 or 3 times a month” were classified as exposed to sexual harassment at school. Sexual harassment at the class-level was defined as the school class proportion of students exposed to sexual harassment, reported in per cent. Two-level linear regression analysis was applied. Results Students who had been exposed to sexual harassment had higher levels of psychological complaints (b = 2.74, p < 0.001). The proportion of students in the school class who had been exposed to sexual harassment was also associated with higher levels of psychological complaints, even when adjusting for sexual harassment at the student-level, gender and grade (b = 0.03, p = 0.015). Conclusions Sexual harassment is harmful for those who are exposed, but may also affect other students negatively. Thus, a school climate free from sexual harassment will profit all students. Key messages Using data collected among students aged 11, 13 and 15 years, this study showed that sexual harassment at the student- and class-level was associated with higher levels of psychological complaints. Sexual harassment is harmful for those who are exposed, but may also affect other students negatively. Thus, a school climate free from sexual harassment will profit all students.

Evaluation of 99mTc-labeled glutathione as a colon cancer targeting probe

2021 ◽  
Vol 327 (2) ◽  
pp. 673-689
Author(s):  
Sumeera Sidiq ◽  
Ravi Ranjan Kumar ◽  
Neelima D. Passi ◽  
D. K. Dhawan ◽  
Jaya Shukla ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Targeting

“So Quick Bright Things Come to Confusion”

1987 ◽  
Vol 13 (2-3) ◽  
pp. 169-187
Author(s):  
Alexander Morgan Capron
Keyword(s):  
Homo Sapiens ◽  
Care Delivery ◽  
Well Being ◽  
Workplace Safety ◽  
Selective Abortion ◽  
Self Identity ◽  
The Past ◽  
Adverse Impacts ◽  
The Rich ◽  
Insurance Discrimination

In the past several decades, the problems facing those of us who labor in the vineyards of health policy and ethics have been the problems of success — first medicine's and then, though to a lesser extent, our own. By this I mean that it has been the remarkable fruits of biomedicine, from research to health care delivery, that have produced the rich harvest of ethical, social and legal issues that have drawn our, and society's, attention.In the basic science laboratory, scientists have developed means to splice pieces of DNA together, raising questions from workplace safety to the reengineering of homo sapiens. Of more immediate concern, tests for genetic susceptibility to disease in one's self and one's offspring have been developed, thereby generating questions about employment and insurance discrimination, selective abortion, and adverse impacts on self-identity and well-being.

scholarly journals The Science of Ageism: Two Steps Forward, One Step Back

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 646-646
Author(s):  
Jerin Lee ◽  
Natalie Shook
Keyword(s):  
Psychological Health ◽  
Well Being ◽  
Census Bureau ◽  
Complex Nature ◽  
The Past ◽  
Growing Pains ◽  
Research Findings ◽  
One Step ◽  
Prejudicial Attitudes ◽  
The Impact

Abstract The past two decades have been marked by a rapidly aging population in the U.S. (U.S. Census Bureau, 2018), making prejudicial attitudes toward older adults (i.e., ageism) and the impact of such attitudes more relevant. As such, ageism researchers have worked tirelessly to not only understand this normalized and insidious form of bias, but also develop efforts to combat it. This symposium will feature four ageism researchers who will showcase both the growing pains and novel contributions of ageism research, ranging from the impact of ageism on psychological health to ageism interventions to issues related to the measurement of ageism. Specifically, Dr. Ayalon will present findings regarding difficulties with the assessment of exposure to ageism and the consequences of ageism for psychological well-being. Dr. Horhota will share research demonstrating challenges associated with confronting ageism. Dr. Levy will present a model showcasing factors associated with the reduction of ageism. Ms. Lee will discuss research findings examining the construct validity of several ageism measures. These talks highlight theoretical and real-world implications associated with the complex nature of ageism, providing important directions for enriching ageism research going forward.

scholarly journals The Past, Present and Future of Flow Cytometry in Central Nervous System Malignancies

2021 ◽  
Vol 4 (1) ◽  
pp. 11
Author(s):  
Evrysthenis Vartholomatos ◽  
George Vartholomatos ◽  
George A. Alexiou ◽  
Georgios S. Markopoulos
Keyword(s):  
Central Nervous System ◽  
Flow Cytometry ◽  
Nervous System ◽  
Therapeutic Agents ◽  
Phenotypic Characterization ◽  
Cell Phenotype ◽  
Analytical Technique ◽  
The Past ◽  
Current Review

Central nervous system malignancies (CNSMs) are categorized among the most aggressive and deadly types of cancer. The low median survival in patients with CNSMs is partly explained by the objective difficulties of brain surgeries as well as by the acquired chemoresistance of CNSM cells. Flow Cytometry is an analytical technique with the ability to quantify cell phenotype and to categorize cell populations on the basis of their characteristics. In the current review, we summarize the Flow Cytometry methodologies that have been used to study different phenotypic aspects of CNSMs. These include DNA content analysis for the determination of malignancy status and phenotypic characterization, as well as the methodologies used during the development of novel therapeutic agents. We conclude with the historical and current utility of Flow Cytometry in the field, and we propose how we can exploit current and possible future methodologies in the battle against this dreadful type of malignancy.

A randomised controlled trial to test a non-metallic deodorant used during a course of radiotherapy

2000 ◽  
Vol 1 (4) ◽  
pp. 205-212 ◽  
Author(s):  
A. Gee ◽  
D. Moffitt ◽  
M. Churn ◽  
R.D. Errington
Keyword(s):  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Well Being ◽  
Psychological Benefits ◽  
Weekly Basis ◽  
Skin Reactions ◽  
Treated Area ◽  
The Past ◽  
Randomised Controlled ◽  
Larger Sample

Background: Radiotherapy skin reactions have been well documented in the past. Until recently, washing of the treated area and the use of perfumed products that contain metals has not been advocated during treatment. The aims of this study were to assess the skin reactions of patients using a non-metallic deodorant and to see whether there were any psychological benefits from being able to use the deodorant.Method: 41 women attending for radiotherapy to either the breast or breast and axilla were recruited into the trial. They were randomised into one of two groups. Complete data was obtained for 36 patients. 20 patients used the deodorant and 16 did not. Any skin reactions noted were recorded on a weekly basis. Patients were also asked to complete a questionnaire relating to feelings and activities and to comment on the deodorant if they had used it.Results: Skin reactions did seem to be slightly worse in the patients using deodorant, and it was only in this group of patients that axillary reactions were noted. However, neither of these results were statistically significant. The use of the deodorant did not have any impact on the psychological well being of the patients, but patients using it had found it pleasant to use and the majority said that they would use it again.Conclusion: Further study is indicated to look at skin reactions using the deodorant with a larger sample of patients.

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