scholarly journals Chromium Coordination Compounds with Antimicrobial Activity: Synthetic Routes, Structural Characteristics, and Antibacterial Activity

2020 ◽  
Vol 14 (1) ◽  
pp. 1-25
Author(s):  
Manolis C. Vlasiou ◽  
Kyriaki S. Pafiti
Keyword(s):  
Public Health ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Transition Metal Complexes ◽  
Coordination Compounds ◽  
Antimicrobial Agents ◽  
Structural Characteristics ◽  
Major Threat ◽  
Synthetic Routes ◽  
New Challenges

A major threat to public health worldwide is that the antimicrobial activity of the established drugs is constantly reduced due to the resistance that bacteria develop throughout the years. Some transition metal complexes show higher antibacterial activity against several bacteria compared to those of clinically used antibiotics. Novel classes of molecules provide new challenges and seem promising to solve the crisis that the overuse of antibiotics has led over the last years. This review discusses the challenges of chromium-based metallodrugs as antimicrobial agents. In particular, the synthetic routes, the structural characteristics, as well as the antimicrobial activity of 32 chromium (III) complexes have been presented.

scholarly journals An In Vitro Study on the Antimicrobial Properties of Essential Oil Modified Resin Composite against Oral Pathogens

Materials ◽  
2020 ◽  
Vol 13 (19) ◽  
pp. 4383
Author(s):  
Barbara Lapinska ◽  
Aleksandra Szram ◽  
Beata Zarzycka ◽  
Janina Grzegorczyk ◽  
Louis Hardan ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Antimicrobial Agents ◽  
Resin Composite ◽  
Antimicrobial Properties ◽  
In Vitro Study ◽  
Diffusion Method ◽  
Oral Pathogens

Modifying the composition of dental restorative materials with antimicrobial agents might induce their antibacterial potential against cariogenic bacteria, e.g., S.mutans and L.acidophilus, as well as antifungal effect on C.albicans that are major oral pathogens. Essential oils (EOs) are widely known for antimicrobial activity and are successfully used in dental industry. The study aimed at evaluating antibacterial and antifungal activity of EOs and composite resin material (CR) modified with EO against oral pathogens. Ten EOs (i.e., anise, cinnamon, citronella, clove, geranium, lavender, limette, mint, rosemary thyme) were tested using agar diffusion method. Cinnamon and thyme EOs showed significantly highest antibacterial activity against S.mutans and L.acidophilus among all tested EOs. Anise and limette EOs showed no antibacterial activity against S.mutans. All tested EOs exhibited antifungal activity against C.albicans, whereas cinnamon EO showed significantly highest and limette EO significantly lowest activity. Next, 1, 2 or 5 µL of cinnamon EO was introduced into 2 g of CR and microbiologically tested. The modified CR showed higher antimicrobial activity in comparison to unmodified one. CR containing 2 µL of EO showed the best antimicrobial properties against S.mutans and C.albicans, while CR modified with 1 µL of EO showed the best antimicrobial properties against L.acidophilus.

scholarly journals 3-Amino-5-(indol-3-yl)methylene-4-oxo-2-thioxothiazolidine Derivatives as Antimicrobial Agents: Synthesis, Computational and Biological Evaluation

2020 ◽  
Vol 13 (9) ◽  
pp. 229
Author(s):  
Volodymyr Horishny ◽  
Victor Kartsev ◽  
Vasyl Matiychuk ◽  
Athina Geronikaki ◽  
Petrou Anthi ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Antimicrobial Agents ◽  
Biological Evaluation ◽  
Minimal Bactericidal Concentration ◽  
Active Compounds ◽  
Hek 293 ◽  
E Coli ◽  
Thiazolyl Blue Tetrazolium Bromide

Herein we report the design, synthesis, computational, and experimental evaluation of the antimicrobial activity of fourteen new 3-amino-5-(indol-3-yl) methylene-4-oxo-2-thioxothiazolidine derivatives. The structures were designed, and their antimicrobial activity and toxicity were predicted in silico. All synthesized compounds exhibited antibacterial activity against eight Gram-positive and Gram-negative bacteria. Their activity exceeded those of ampicillin and (for the majority of compounds) streptomycin. The most sensitive bacterium was S. aureus (American Type Culture Collection ATCC 6538), while L. monocytogenes (NCTC 7973) was the most resistant. The best antibacterial activity was observed for compound 5d (Z)-N-(5-((1H-indol-3-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)-4-hydroxybenzamide (Minimal inhibitory concentration, MIC at 37.9–113.8 μM, and Minimal bactericidal concentration MBC at 57.8–118.3 μM). Three most active compounds 5d, 5g, and 5k being evaluated against three resistant strains, Methicillin resistant Staphilococcus aureus (MRSA), P. aeruginosa, and E. coli, were more potent against MRSA than ampicillin (MIC at 248–372 μM, MBC at 372–1240 μM). At the same time, streptomycin (MIC at 43–172 μM, MBC at 86–344 μM) did not show bactericidal activity at all. The compound 5d was also more active than ampicillin towards resistant P. aeruginosa strain. Antifungal activity of all compounds exceeded those of the reference antifungal agents bifonazole (MIC at 480–640 μM, and MFC at 640–800 μM) and ketoconazole (MIC 285–475 μM and MFC 380–950 μM). The best activity was exhibited by compound 5g. The most sensitive fungal was T. viride (IAM 5061), while A. fumigatus (human isolate) was the most resistant. Low cytotoxicity against HEK-293 human embryonic kidney cell line and reasonable selectivity indices were shown for the most active compounds 5d, 5g, 5k, 7c using thiazolyl blue tetrazolium bromide MTT assay. The docking studies indicated a probable involvement of E. coli Mur B inhibition in the antibacterial action, while CYP51 inhibition is likely responsible for the antifungal activity of the tested compounds.

scholarly journals Аntibacterial inorganic agents: efficiency of using multicomponent systems

2020 ◽  
Vol 10 (4) ◽  
pp. 639-654
Author(s):  
А. A. Meleshko ◽  
A. G. Afinogenova ◽  
G. E. Afinogenov ◽  
A. A. Spiridonova ◽  
V. P. Tolstoy
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antimicrobial Agents ◽  
Metal Oxide Nanoparticles ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Nanoscale Systems ◽  
Gram Negative ◽  
Low Toxicity

Metal and metal oxide nanoparticles (NPs) are promising antibacterial agents. They have a broad antimicrobial activity against both Gram-positive and Gram-negative bacteria, viruses, and protozoans. The use of NPs reduces the possibility of the microbial resistance development. This review briefly shows the general mechanisms and the main factors of antibacterial activity of NPs. In this article, a comprehensive review of the recent researches in the field of new antimicrobial agents with superior long-term bactericidal activity and low toxicity is provided. The review gives the examples of synthesis of double and triple nanocomposites based on following oxides: CuO, ZnO, Fe3O4, Ag2O, MnO2, etc. including metal and nonmetal doped nanocomposites (for example with Ag, Ce, Cr, Mn, Nd, Co, Sn, Fe, N, F, etc.). Compared with bactericidal action of individual oxides, the nanocomposites demonstrate superior antibacterial activity and have synergistic effects. For example, the antimicrobial activity of ZnO against both Gram-positive and Gram-negative bacteria was increased by -100% by formation of triple nanocomposites ZnO—MnO2—Cu2O or ZnO—Ag2O—Ag2S. Similar effect was showed for Ce-doped ZnO and Zn-doped CuO. The present article also provides the examples of nanocomposites containing NPs and organic (chitosan, cellulose, polyvinylpyrrolidone, biopolymers, etc.) or inorganic materials with special structure (graphene oxide, TiO2 nanotubes, silica) which demonstrate controlled release and longterm antibacterial activity. All of the considered nanocomposites and their combinations have a pronounced long-term antimicrobial effect including against antibiotic-resistant strains. They are able to prevent the formation of microbial biofilms on biotic and abiotic surfaces, have low toxicity to eukaryotic cells, demonstrate anti-inflammatory and woundhealing properties in compositions with polymers (sodium alginate, collagen, polyvinylpyrrolidone, etc.). The use of nanoscale systems can solve several important practical problems at the same time: saving of long-term antimicrobial activities while reducing the number of compounds, creation of new antimicrobial agents with low toxicity and reduced environmental impact, development of new biocidal materials, including new coatings for effective antimicrobial protection of medical devices.

scholarly journals Evaluation of antimicrobial activity of the fixed oil of Bowdichia virgilioides Kunth (Fabaceae) seeds

Gaia Scientia ◽  
2016 ◽  
Vol 10 (4) ◽  
pp. 681-689
Author(s):  
Filipe Gutierre Carvalho de Lima ◽  
Maria Arlene Pessoa da Silva ◽  
Beatriz Tupinambá Freitas ◽  
José Carlos Marques Freitas ◽  
Claudener de Souza Teixeira ◽  
...  
Keyword(s):  
Public Health ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antibiotic Resistance ◽  
Bacterial Resistance ◽  
Public Health Problem ◽  
Biologically Active ◽  
Major Public Health Problem ◽  
Gram Negative ◽  
The Family

Bacterial resistance to current drugs is a major public health problem worldwide. The search for biologically active compounds that act synergistically with antibiotics for their use at lower concentrations would be of great help in overcoming bacterial resistance. Bowdichia virgilioides Kunth, also known as sucupira-preta or sucupira-do-cerrado, is a species of the family LeguminosaePapilionoidea that occurs in both primary and secondary formations, always in fast-draining areas. The objective of this study was to evaluate of antibiotic modulation through of the fixed oil from the seeds of B. virgiloides activity. . The seeds showed a considerable amount of oil, with a yield of approximately 11%. The oil did not inhibit bacterial growth, but its combination with the antibiotics tested produced growth inhibition. Our data indicated that the oil extracted from B. virgiloides seeds has no antibacterial activity at clinically relevant concentrations, but when combined with aminoglycoside antibiotics, it showed modulatory activity, lowering the antibiotic resistance of Gram-negative strains.

scholarly journals Ag/H-ZIF-8 Nanocomposite as an Effective Antibacterial Agent Against Pathogenic Bacteria

Nanomaterials ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1579 ◽  
Author(s):  
Yanmei Zhang ◽  
Xin Zhang ◽  
Jie Song ◽  
Liming Jin ◽  
Xiaotong Wang ◽  
...  
Keyword(s):  
Public Health ◽  
Antibacterial Activity ◽  
Ag Nanoparticles ◽  
Antibacterial Agent ◽  
Pathogenic Bacteria ◽  
Reduction Method ◽  
Antibacterial Activities ◽  
Narrow Size Distribution ◽  
New Approach ◽  
Major Threat

Development of antimicrobial nanomaterials is one of the most attractive strategies for eliminating the major threat of pathogenic bacteria to public health. In this work, we developed a simple impregnation-reduction method for the synthesis of Ag-doped hierarchical ZIF-8 (Ag/H-ZIF-8) nanocomposite. The nanocomposite was characterized by several techniques and its antibacterial activity was investigated. The Ag nanoparticles are uniformly dispersed in the porous ZIF-8 with narrow size distribution. Consequently, the resulting Ag/H-ZIF-8 nanocomposite showed significantly enhanced antibacterial activities compared to the single ZIF-8 or Ag nanoparticles. Furthermore, the composite is biocompatible, because no obvious toxicity was observed on Hepatic epithelial cells. This study offers a new approach for the design of hybrid antimicrobial nanomaterials that have great potentials in practical disinfections

scholarly journals Novel 2,4,6-Trimethylbenzenesulfonyl Hydrazones with Antibacterial Activity: Synthesis and In Vitro Study

Materials ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 2723
Author(s):  
Łukasz Popiołek ◽  
Sylwia Szeremeta ◽  
Anna Biernasiuk ◽  
Monika Wujec
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Potential Application ◽  
Antimicrobial Agents ◽  
Inhibitory Concentration ◽  
Condensation Reaction ◽  
In Vitro Study ◽  
In Vitro Bioactivity ◽  
Bacterial Strains

This research describes the synthesis and in vitro antimicrobial activity study of a series of 2,4,6-trimethylbenzenesulfonyl hydrazones. Twenty-five hydrazones (2–26) were synthesized on the basis of condensation reaction. The in vitro bioactivity study confirmed the potential application of obtained derivatives as antimicrobial agents. Among the tested compounds, the highest activity was discovered for derivative 24, which possessed minimal inhibitory concentration (MIC) ranging from 7.81 to 15.62 µg/mL against Gram-positive reference bacterial strains. Synthesized benzenesulfonyl hydrazones can be applied as potential ligands for the synthesis of bioactive metal complexes.

scholarly journals Synthesis and biological evaluation of some new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as antimicrobial agents

2022 ◽  
Vol 11 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Iryna Myrko ◽  
Taras Chaban ◽  
Vasyl Matiychuk
Keyword(s):  
Mass Spectrometry ◽  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antimicrobial Agents ◽  
Biological Evaluation ◽  
Bacterial Strains ◽  
Synthesis And Biological Evaluation

A series of some new pyrazole-substituted 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines was synthesized in this study. The structures of target substances were confirmed by using 1H and 13С NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds have been evaluated for antimicrobial activity against five bacterial strains (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus) and two fungal strains (Candida albicans and Cryptococcus neoformans). The antimicrobial screening studies of synthesized substances established that 2 of 12 compounds show pronounced antibacterial activity against the strain Staphylococcus aureus.

scholarly journals ANTIMICROBIAL ACTIVITY AND PHYTOCHEMICAL STUDY OF PLANT PARTS OF BUTEA MONOSPERMA

2019 ◽  
Vol 9 (4-A) ◽  
pp. 344-348
Author(s):  
KRUTIBEN MUKESHBHAI DAVE ◽  
Parth Pankaj Darji ◽  
Fenie Ritesh Gandhi
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antimicrobial Agents ◽  
Herbal Medicines ◽  
Host Cells ◽  
Phytochemical Study ◽  
Chemical Test ◽  
Medicinal Uses ◽  
Butea Monosperma

ABSTRACT: Since ancient times, plants have been model source of medicines as they are a reservoir of chemical agents with therapeutic properties. The general population is increasingly using herbal medicines as dietary supplements to relieve and treat many different human disorders. All parts of the plant, from root to fruit, consisting of a multitude of secondary metabolites which impart an unprecedented variety of medicinal uses to the plant. Studies have shown the presence of different phytochemical constituents in botanical sample responsible for the antimicrobial activity. These antimicrobial agents should be beneficial to host cells and toxic to pathogenic microbes. Hence, the antibacterial activity was examined from the leaf and flower of Butea monosperma. Sample was collected and its crude extract was obtained by using methanol, acetone and water as the extraction solvent. These extract were tested against some pathogenic microorganisms like Staphylococcus aureus , Bacillus cereusa and B. subtilis. The extract of Butea monosperma showed antibacterial activity against Staphylococcus aureus , Bacillus cereusa and B. subtilis. Bio-chemical test for the presence of phytochemicals have shown positive result and these phytochemicals have ability to fight against microorganisms or inhibit the growth of microorganisms. This approach will be an advanced step in the discovery of some herbal drugs. These plant extracts which was proven to be potentially effective can be used as a natural alternative to the chemical preservatives. It could be an ideal way to avoid health hazards that may occur due to chemical antimicrobial agents.

scholarly journals Invitro antibacterial activity of Cassia fistula Linn methanolic leaf extracts

2019 ◽  
Vol 8 (2) ◽  
pp. 270
Author(s):  
Bindhu R. Kamath ◽  
Sabeena Kizhedath
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Antimicrobial Agents ◽  
Diffusion Method ◽  
Bacterial Strains ◽  
Cassia Fistula ◽  
Leaf Extracts ◽  
E Coli

Background: Cassia fistula Linn is a plant which is widely grown in India and is used for medicinal purposes. The study was carried out with an objective to demonstrate the antimicrobial activity of leaves of Cassia fistula Linn. The aim of the study is to assess antibacterial and antifungal activity of methanolic leaf extract of Cassia fistula Linn against selected clinical isolates.Methods: The antimicrobial activity of methanolic extract of Cassia fistula was evaluated using agar well diffusion method and to zone of inhibition of extract was determined. Clinical isolates of Staphyloccocus aureus, MRSA, Pseudomonas aeruginosa, E. coli and Proteus were screened.Results: The methanolic extracts exhibited antibacterial activity against Staphylococcus aureus. The extract was not active against E. coli, Proteus, MRSA, Pseudomonas aeruginosa. The extract also failed to demonstrate antifungal activity against Candida albicans and Aspergillus niger.Conclusions: The global emergence of multidrug resistant bacterial strains is increasing, limiting the effectiveness of current drugs and treatment failure of infections. A novel approach to the prevention of antibiotic resistance of pathogenic species is the use of new compounds that are not based on existing synthetic antimicrobial agents.

scholarly journals Ultraviolet Radiation and Salinity-Induced Physiological Changes and Scytonemin Induction in Cyanobacteria Isolated from Diverse Habitats

2021 ◽  
Vol 12 (3) ◽  
pp. 3590-3606
Keyword(s):  
Antimicrobial Activity ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Antimicrobial Agents ◽  
Free Ligand ◽  
The Novel ◽  
Bacterial Strains ◽  
Resistant Strains ◽  
Antimicrobial And Antifungal Activity

A novel series of transition metal (II) complexes (5a-h) were conveniently synthesized via reaction of important transition metals (Co, Cu, Zn, Ni) with (E)-N-(4-methylbenzylidene)-2-((Z)-(4-methylbenzylidene)amino)benzamide Schiff base (3) which was previously synthesized by reacting 2- aminobenzohydrazide (1) with 4-methylbenzaldehyde (2). The synthesized metal complexes' structure was elucidated by IR, NMR, mass, and elemental analysis. Additionally, we also evaluated the antioxidant, antimicrobial and antifungal activity of the synthesized metal complexes. The bioassay of the novel transition metal complexes envisioned that compounds5eand5c showed better antimicrobial activity than the free ligand, and compounds5g and 5a showed good activity against most bacterial strains. On the other hand, hydrated metal complexes 5b, 5d, 5f, and 5h showed moderate to good antimicrobial activity. In comparison with ascorbic acid, most of the metal complexes showed moderate to good antioxidant activity. The current bioassay was investigated and proved that the compounds 5e and 5c as antimicrobial agents act on highly resistant strains of microbes.

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