scholarly journals Comparative Effect of Atorvastatin and Rosuvastatin on 25-hydroxy-Vitamin D Levels in Non-diabetic Patients with Dyslipidaemia: A Prospective Randomized Open-label Pilot Study

2014 ◽  
Vol 8 (1) ◽  
pp. 55-60 ◽  
Author(s):  
Panagiotis Anagnostis ◽  
Fotini Adamidou ◽  
Aristidis Slavakis ◽  
Stergios A Polyzos ◽  
Despina Selalmatzidou ◽  
...  
Keyword(s):  
Vitamin D ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Diabetic Patients ◽  
Open Label ◽  
Open Label Study ◽  
Reactive Protein ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D

Aims: Low 25-hydroxy-vitamin D [25(ΟΗ)D] levels have been associated with increased risk for cardiovascular disease. Conflicting data exist regarding the effect of statins on [25(OH)D] levels. The aim of this study was to compare the effect of atorvastatin and rosuvastatin on 25(OH)D levels in non-diabetic patients with dyslipidaemia. Methods: This was a prospective randomized open-label study. Patients were assigned to atorvastatin 20 mg⁄day (n=28, age: 56.1±2.2 years, 22 females) or rosuvastatin 10 mg⁄day (n=24, age: 57.4±1.9 years, 20 females). Total cholesterol (TC), low- (LDL-C) and high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), fasting plasma glucose, insulin, glycosylated haemoglobin A1c (HbA1c) and high sensitivity C-reactive protein (hsCRP) levels were measured, and homeostatic model of assessment insulin resistance (HOMA-IR) was calculated at baseline and 12 weeks post-treatment. Results: There were no within or between group significant differences in 25(OH)D levels (atorvastatin: 21.7±1.9 ng/ml at baseline and 23.5±2.3 ng/ml at week 12; rosuvastatin: 25.3±1.8 and 27.0±2.4 ng/ml, respectively; p=0.172 and p=0.306 for between groups, respectively). Both statins significantly reduced TC, TG and LDL-C levels, with a greater LDL-C reduction being observed by rosuvastatin. Conclusion: Atorvastatin and rosuvastatin did not significantly affect 25(OH)D levels in this study.

Acute-Phase Plasma PCSK9 Levels and Recurrent Cardiovascular Events in a Chinese Acute Myocardial Infarction Cohort

Cardiology ◽  
2018 ◽  
Vol 141 (2) ◽  
pp. 88-97 ◽  
Author(s):  
Yan Gao ◽  
Yan Qiu ◽  
Jihua Wu ◽  
Wei Diao ◽  
Haibo Zhang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Acute Phase ◽  
Recurrent Events ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Female Gender ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Increased Risk

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising target for lowering plasma low-density lipoprotein cholesterol and preventing cardiovascular (CV) disease. Whether plasma PCSK9 measured during the acute phase predicts recurrent CV events in patients with acute myocardial infarction (AMI) remains unresolved. Methods and Results: Plasma PCSK9 levels were measured in 1,646 patients with AMI from the China PEACE-Prospective AMI Study at the acute phase. Additionally, 248 patients were resampled and measured at 1 month post-AMI. Associations of acute-phase PCSK9 tertiles with clinical characteristics and recurrent CV events within 1 year were assessed. Female gender (OR 1.94, 95% CI 1.24–3.03), premature coronary heart disease (CHD; OR 2.12, 95% CI 1.37–3.26), higher high-sensitivity C-reactive protein (OR 1.67, 95% CI 1.44–1.95), and higher triglycerides (OR 1.46, 95% CI 1.03–2.09) were associated with higher baseline PCSK9. Plasma PCSK9 levels in the highest tertile (versus lowest) did not have an increased risk of 1-year recurrent CV events in the AMI cohort (HR 0.78, 95% CI 0.52–1.16) or any subgroup. There was also no association between percentage changes in PCSK9 over the first month and 1-year recurrent events, although there was a trend of differences between patients in the upper versus lower tertiles. Conclusion: Plasma PCSK9 levels measured during the acute phase were associated with high-sensitivity C-reactive protein, triglycerides, premature CHD, and gender in patients with AMI but did not predict recurrent CV events within 1 year. Dynamic changes in PCSK9 suggested a trend yet no significance value in predicting recurrent CV events.

scholarly journals The Correlation between Vitamin D and Clinical Implications for Obesity-Related Type 2 Diabetes Mellitus

2020 ◽  
Vol 14 (1) ◽  
pp. 39-45
Author(s):  
Noor Thair Tahir ◽  
Hind SH. Ahmed ◽  
Rasha K. Hashim ◽  
Teba D. Soluiman
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Density Lipoprotein ◽  
Obese Group ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Clinical Implications ◽  
Vitamin D Levels

Background: Obesity and type 2 diabetes have both rapidly raised during the last periods and are ongoing to increase at a disturbing rate universal. Several clinical and epidemiological researches demonstrated a reverse association between circulating vitamin D levels, central adiposity and the progress of insulin resistance and diabetes. Objective: The target of this work was to elucidate the complex role of vitamin D and the clinical implications of diabetes on metabolic defects related with obesity. Subjects and Methods: This study encompassed 90 diabetic patients (45 obese and 45 non obese) who were attending the National Diabetic Center/ Al-Mustansiriyah University during the period from June 2019 to January 2020; their age range was (35-60) years. All participant underwent clinical and biochemical examinations. Results: A substantial rise (p= 0.01) in waist/hip ratio, body mass index, fasting serum glucose, total cholesterol, triacylglycerol, and low density lipoprotein cholesterol in obese diabetic patients as paralleled to non-obese group. Moreover, there was an elevation in glycated hemoglobin, serum insulin, and homeostasis model assessment for insulin resistance in obese group, but it was not significant. A substantial decrease (p= 0.01) in serum high density lipoprotein cholesterol and vitamin D3 were detected in obese diabetic patients as paralleled to non-obese group.       Also, obese diabetic patients had the higher percent (61%) of D3 deficiency as paralleled to non-obese patients. Conclusions: In the present study, it is found that there is significant increase in blood sugar in the individuals with decreased vitamin D levels, which was related with insulin resistance, decreased β-cell function, and obesity.  

Vitamin D Treatment Effect on Serum Endocan and High-Sensitivity C-Reactive Protein Levels in Renal Transplant Patients

2016 ◽  
Vol 26 (4) ◽  
pp. 335-339 ◽  
Author(s):  
Omer Atis ◽  
Mustafa Keles ◽  
Erdem Cankaya ◽  
Hasan Dogan ◽  
Hulya Aksoy ◽  
...  
Keyword(s):  
Vitamin D ◽  
Endothelial Dysfunction ◽  
Renal Transplant ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Transplant Patients ◽  
Vitamin D Levels ◽  
Hs Crp ◽  
25 Oh Vitamin D

Context: Endocan is a marker showing endothelial dysfunction and inflammation. Significantly increased endocan levels have been observed in serum of patients with sepsis and cancer. Objective: Our aim was to investigate the relationship between vitamin D treatment and serum endocan and high-sensitivity C-reactive protein (hs-CRP) levels as inflammatory markers in transplant patients. Design: Prospective. Setting: Nephrology clinic. Patients: Thirty-eight renal transplant patients with serum 25-hydroxy-vitamin D (25-OH-vitamin D) levels below 20 ng/mL and transplanted at least 12 months. Intervention: One-time oral dose of 300 000 IU vitamin D3. Main Outcome Measures: Before and after vitamin D treatment, serum endocan, hs-CRP, calcium, phosphorus, and parathyroid hormone (PTH) levels were measured. Results: Median serum endocan and PTH values before vitamin D were significantly higher than those of after treatment values ( P = .001 and P < .001, respectively). On the other hand, serum total calcium and phosphorus levels before vitamin D treatment were lower than the values obtained after vitamin D treatment ( P = .0013 and P < .001, respectively). Serum hs-CRP was lower after vitamin D therapy than before, but the difference was not statistically significant ( P = .06). A moderate negative correlation was determined between endocan and 25-OH-vitamin D levels after treatment with vitamin D ( r = −.36, P = .02). Conclusion: This study has revealed that vitamin D treatment reduced markers of endothelial dysfunction in patients with renal transplantation and vitamin D deficiency.

scholarly journals The Effect of Pilates Training on Body Composition, Lipid Profile, and Serum 25-Hydroxy Vitamin D Levels in Inactive Overweight Women

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Mojdeh Khajehlandi ◽  
Robabeh Mohammadi
Keyword(s):  
Vitamin D ◽  
Body Composition ◽  
Exercise Training ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Training Group ◽  
Control Group ◽  
Overweight Women ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D

Background: The increasing prevalence of overweight and related diseases has gained more scientific attention. Overweight and obesity are known as a threat to health, and low serum 25-hydroxy vitamin D levels is associated with obesity. Objectives: Therefore, we examined the effect of Pilates training on body composition, lipid profile, and serum 25-hydroxy vitamin D levels in inactive overweight women. Methods: In this clinical study, 28 overweight women were randomly divided into a training group (n = 14) and a control group (n = 14). Pilates training was performed three 60-min sessions during 12 weeks. In two stages, blood samples were collected 48 hours before and after the last protocol exercise training session. During the 12 weeks, the control group had no exercise training. For analyzing within- and between-group changes, paired t-test and ANCOVA with the significant level of P < 0.05 were used, respectively. Results: After 12 weeks of Pilates training in the training group compared to the control group, there was a significant decrease in the body mass index (P = 0.005), cholesterol (P = 0.001) and triglyceride (P = 0.001) values, and serum 25-hydroxy vitamin D levels (P = 0.005), while high-density lipoprotein (P = 0.028) increased significantly. However, no significant change was observed in low-density lipoprotein levels (P = 0.435). Conclusions: According to the results, it can be indicated that 12 weeks of Pilates training have improved serum 25-hydroxy vitamin D levels, changed anthropometry, and lipid profile in inactive overweight women.

Abstract P070: Dyslipidemic Adolescent and Adult African Americans Have Similar Cardio-Metabolic Risk

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Puneet K Tung ◽  
Samuel Gidding ◽  
Scott W Keith ◽  
Stephanie DeLoach ◽  
Bonita Falkner
Keyword(s):  
African Americans ◽  
Age Groups ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Age Difference ◽  
Metabolic Risk ◽  
High Group ◽  
Reactive Protein ◽  
Increased Risk ◽  
Adolescents And Adults

Background: African Americans (AA) are at increased risk for developing diabetes mellitus. However, they are known to have lower triglycerides (TG) and higher high density lipoprotein-cholesterol (HDL-C) than other ethnic groups. Among AA, it is thought that adolescents are at lower cardiovascular risk and have lower levels of metabolic co-variants than adults, but there are no studies directly comparing adolescents and adults. Objective: To compare AA adolescents to adults with regard to the relationships of adiposity-related lipid risk markers (TG/HDL ratio and non HDL-C) with body mass index (BMI), waist circumference (WC), homeostasis model of insulin resistance (HOMA), and serum high sensitivity C-Reactive Protein (hsCRP). Methods: Healthy AAs (283 adolescents, 484 adults) were recruited from the same urban community. To create TG/HDL strata, adult tertiles were established. Non HDL-C strata were based on ATP III/NHLBI expert guidelines. Adolescents and adults in the low, middle and high strata were compared with regard to BMI, WC, HOMA, and hsCRP. Results: As both TG/HDL ratio and non HDL-C strata increased, BMI, WC, HOMA, and hsCRP increased in both adolescents and adults (Tables). Among 16% (44/283) of adolescents and 33% (161/484) of adults having a TG/HDL ratio above 2.028 (High group), BMI, WC, and hsCRP were similar in both age groups (Table 1). In 8% (22/283) of adolescents and 12% (60/484) of adults having an elevated non HDL-C (HIgh group), BMI, WC, and hsCRP were also similar (Table 2). HOMA was higher in adolescents, but after accounting for this age difference, was significantly associated with the high TG/HDL ratio and non HDL-C strata. Slopes of these relationships were steeper in adolescents than adults, therefore adolescents in the lower lipid strata had lower BMI, WC, HOMA, and hsCRP. Conclusions: Elevated TG/HDL ratio and non HDL-C are associated with similar levels of metabolic risk in adolescent and adult AAs. The relationship between HOMA and dyslipidemia is stronger in adolescent versus adult AAs.

scholarly journals A Comparative Study of Serum 25-Hydroxy Vitamin D Levels in Children with Seizures Receiving Monotherapy and Polytherapy

2021 ◽  
Vol 11 (01) ◽  
pp. e331-e337
Author(s):  
Nazeem Fathima A. ◽  
Radha Kumar ◽  
Dev Kumar V. ◽  
Devanand Gulab Chaudhary
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Tertiary Care ◽  
Hospital Setting ◽  
P Value ◽  
Care Hospital ◽  
Cross Sectional ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D

AbstractThe association between serum 25-hydroxy vitamin D (25(OH)D) antiepileptic drugs (AEDs) and bone health in individuals with epilepsy has been recognized for more than 30 years. Several studies indicate an increased risk for bone loss in patients on antiepileptic medication as well as low levels of serum 25(OH)D. Patients on polytherapy AED are at a higher risk of adverse drug effects compared with those on monotherapy. The present study assessed serum 25(OH)D levels in children receiving AED and compares those children receiving monotherapy versus polytherapy. This is a prospective cross-sectional study conducted in a tertiary care hospital setting on children with seizures receiving AEDs for period of more than 6 months. Participants were enrolled in three groups: 25 children on monotherapy, 25 children on polytherapy, and 25 healthy controls. Serum 25(OH)D level was performed for all children and analyzed. Serum 25(OH)D levels were normal in 52%, insufficient levels in 43.3%, and deficient in 6.7% of children. Vitamin D level was insufficient in 40% of children receiving monotherapy and 52% receiving polytherapy AED. Vitamin D deficiency was present in 4% in monotherapy group and 16% in polytherapy group which was statistically significant (p-value 0.047). Vitamin D deficiency was higher in children receiving AED compared with normal controls. Vitamin D deficiency and insufficiency were higher in children on polytherapy. Our study emphasized the importance of monitoring vitamin D levels in children receiving AED to detect abnormalities in vitamin D levels.

Metabolic Imbalance and Vitamin D Deficiency in Type 1 Diabetes in the Algerian Population

2019 ◽  
Vol 19 (8) ◽  
pp. 1172-1176 ◽  
Author(s):  
Esma Mihoubi ◽  
Rachida Raache ◽  
Habiba Amroun ◽  
Malha Azzouz ◽  
Assia Galleze ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
World Health ◽  
Diabetic Patients ◽  
Algerian Population ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Metabolic Imbalance

Background: We aimed to assess Vitamin D levels in patients with Type 1 Diabetes (T1D) and to investigate the correlation between vitamin D and metabolic imbalance. Material and Methods: For our study, we selected thirty-one patients with T1D without complications and fifty-seven healthy controls. Diabetic patients were diagnosed using the criteria of the World Health Organization/American Diabetes Association. Vitamin D, Parathyroid Hormone (PTH), insulin and C peptide assay were performed using chimilunescence. Glucose level, lipid profile, glycated haemoglobin (HbA1c) and ionogram were also analysed. Results: Vitamin D, HbA1c and Gly levels were found to be significant in T1D patients than in controls (P<0.5). However, for PTH, no significant difference was observed (P > 0. 05) and the results show a non-significant difference of total cholesterol potassium, sodium, phosphor and calcium concentration averages. Conclusion: Our results indicate that the deficiency of VD is associated with an increased risk of T1DM in Algerian population.

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