scholarly journals Bioresorbable Metals for Cardiovascular and Fracture Repair Implants

2021 ◽  
pp. 134-155
Keyword(s):  
Clinical Trials ◽  
Cardiovascular Diseases ◽  
Medical Devices ◽  
Biomedical Applications ◽  
Fracture Repair ◽  
Iron And Zinc ◽  
Bioresorbable Implants

The potential of bioresorbable metals to revolutionize current and future medical devices fascinates researchers. Magnesium, iron, and zinc have been thoroughly studied for the treatment of cardiovascular diseases or to repair fractures. Iron was the first type of metal being researched and introduced in biomedical applications. Magnesium is the most studied one, it has been tested by clinical trials and commercially available products have been already developed. The interest in zinc has recently emerged and is continuously growing. This chapter offers an overview of the role that Mg, Fe, and Zn are playing advancing the evolution of bioresorbable implants.

scholarly journals An Overview of the Use of Equine Collagen as Emerging Material for Biomedical Applications

2020 ◽  
Vol 11 (4) ◽  
pp. 79
Author(s):  
Nunzia Gallo ◽  
Maria Lucia Natali ◽  
Alessandro Sannino ◽  
Luca Salvatore
Keyword(s):  
Immune Response ◽  
Clinical Trials ◽  
Medical Devices ◽  
Biomedical Applications ◽  
Life Science ◽  
Type I Collagen ◽  
Experimental Studies ◽  
Attractive Alternative ◽  
Type I ◽  
Implantable Medical Devices

Type I collagen has always aroused great interest in the field of life-science and bioengineering, thanks to its favorable structural properties and bioactivity. For this reason, in the last five decades it has been widely studied and employed as biomaterial for the manufacture of implantable medical devices. Commonly used sources of collagen are represented by bovine and swine but their applications are limited because of the zoonosis transmission risks, the immune response and the religious constrains. Thus, type-I collagen isolated from horse tendon has recently gained increasing interest as an attractive alternative, so that, although bovine and porcine derived collagens still remain the most common ones, more and more companies started to bring to market a various range of equine collagen-based products. In this context, this work aims to overview the properties of equine collagen making it particularly appealing in medicine, cosmetics and pharmaceuticals, as well as its main biomedical applications and the currently approved equine collagen-based medical devices, focusing on experimental studies and clinical trials of the last 15 years. To the best of our knowledge, this is the first review focusing on the use of equine collagen, as well as on equine collagen-based marketed products for healthcare.

scholarly journals In silico imaging clinical trials: cheaper, faster, better, safer, and more scalable

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Aldo Badano
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Medical Devices ◽  
In Silico ◽  
Lessons Learned ◽  
Patient Access ◽  
High Quality ◽  
Virtual Imaging ◽  
Regulatory Evaluation

AbstractImaging clinical trials can be burdensome and often delay patient access to novel, high-quality medical devices. Tools for in silico imaging trials have significantly improved in sophistication and availability. Here, I describe some of the principal advantages of in silico imaging trials and enumerate five lessons learned during the design and execution of the first all-in silico virtual imaging clinical trial for regulatory evaluation (the VICTRE study).

scholarly journals An Outline for Public Registration of Clinical Trials Evaluating Medical Devices

2006 ◽  
Vol 47 (8) ◽  
pp. 1518-1521 ◽  
Author(s):  
Richard L. Popp ◽  
Beverly H. Lorell ◽  
Gregg W. Stone ◽  
Warren Laskey ◽  
John J. Smith ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Medical Devices

scholarly journals Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4621
Author(s):  
Lucileno Rodrigues Trindade ◽  
Davi Vieira Teixeira da da Silva ◽  
Diego dos Santos Baião ◽  
Vania Margaret Flosi Paschoalin
Keyword(s):  
Clinical Trials ◽  
Cardiovascular Diseases ◽  
Adjuvant Therapy ◽  
Vascular Diseases ◽  
Ppar Γ ◽  
Epidemiological Surveys ◽  
Genes Encoding ◽  
And Oxidative Stress ◽  
Gradual Release ◽  
Inflammatory Action

Polyphenols play a therapeutic role in vascular diseases, acting in inherent illness-associate conditions such as inflammation, diabetes, dyslipidemia, hypertension, and oxidative stress, as demonstrated by clinical trials and epidemiological surveys. The main polyphenol cardioprotective mechanisms rely on increased nitric oxide, decreased asymmetric dimethylarginine levels, upregulation of genes encoding antioxidant enzymes via the Nrf2-ARE pathway and anti-inflammatory action through the redox-sensitive transcription factor NF-κB and PPAR-γ receptor. However, poor polyphenol bioavailability and extensive metabolization restrict their applicability. Polyphenols carried by nanoparticles circumvent these limitations providing controlled release and better solubility, chemical protection, and target achievement. Nano-encapsulate polyphenols loaded in food grade polymers and lipids appear to be safe, gaining resistance in the enteric route for intestinal absorption, in which the mucoadhesiveness ensures their increased uptake, achieving high systemic levels in non-metabolized forms. Nano-capsules confer a gradual release to these compounds, as well as longer half-lives and cell and whole organism permanence, reinforcing their effectiveness, as demonstrated in pre-clinical trials, enabling their application as an adjuvant therapy against cardiovascular diseases. Polyphenol entrapment in nanoparticles should be encouraged in nutraceutical manufacturing for the fortification of foods and beverages. This study discusses pre-clinical trials evaluating how nano-encapsulate polyphenols following oral administration can aid in cardiovascular performance.

Biocompatible succinic acid-based polyesters for potential biomedical applications: fungal biofilm inhibition and mesenchymal stem cell growth

RSC Advances ◽  
2015 ◽  
Vol 5 (104) ◽  
pp. 85756-85766 ◽  
Author(s):  
E. Jäger ◽  
R. K. Donato ◽  
M. Perchacz ◽  
A. Jäger ◽  
F. Surman ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Stem Cell ◽  
Cell Growth ◽  
Mesenchymal Stem Cell ◽  
Medical Devices ◽  
Biomedical Applications ◽  
Growth Promotion ◽  
Intrinsic Properties ◽  
Biofilm Inhibition

Poly(alkene succinates) are promising materials for specialized medical devices and tissue engineering, presenting intrinsic properties, such as; fungal biofilm inhibition, biocompatibility and stem cells controlled growth promotion.

scholarly journals Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease

Antioxidants ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 907 ◽  
Author(s):  
Man Liu ◽  
Samuel C. Dudley
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Heart Failure ◽  
Cardiovascular Disease ◽  
Clinical Trials ◽  
Cardiovascular Diseases ◽  
Serum Magnesium ◽  
Mg Deficiency ◽  
All Cause Mortality ◽  
Low Serum

Hypomagnesemia is commonly observed in heart failure, diabetes mellitus, hypertension, and cardiovascular diseases. Low serum magnesium (Mg) is a predictor for cardiovascular and all-cause mortality and treating Mg deficiency may help prevent cardiovascular disease. In this review, we discuss the possible mechanisms by which Mg deficiency plays detrimental roles in cardiovascular diseases and review the results of clinical trials of Mg supplementation for heart failure, arrhythmias and other cardiovascular diseases.

Wearable and Implantable Sensors for Biomedical Applications

2018 ◽  
Vol 11 (1) ◽  
pp. 127-146 ◽  
Author(s):  
Hatice Ceylan Koydemir ◽  
Aydogan Ozcan
Keyword(s):  
Mobile Health ◽  
Medical Devices ◽  
Biomedical Applications ◽  
Health Management ◽  
Great Promise ◽  
Implantable Sensors ◽  
Implantable Medical Devices ◽  
Health Technologies ◽  
Materials Used ◽  
Improving Patient Care

Mobile health technologies offer great promise for reducing healthcare costs and improving patient care. Wearable and implantable technologies are contributing to a transformation in the mobile health era in terms of improving healthcare and health outcomes and providing real-time guidance on improved health management and tracking. In this article, we review the biomedical applications of wearable and implantable medical devices and sensors, ranging from monitoring to prevention of diseases, as well as the materials used in the fabrication of these devices and the standards for wireless medical devices and mobile applications. We conclude by discussing some of the technical challenges in wearable and implantable technology and possible solutions for overcoming these difficulties.

scholarly journals Improving clinical trials for cardiovascular diseases: a position paper from the Cardiovascular Round Table of the European Society of Cardiology

2015 ◽  
Vol 37 (9) ◽  
pp. 747-754 ◽  
Author(s):  
Neville Jackson ◽  
Dan Atar ◽  
Maria Borentain ◽  
Günter Breithardt ◽  
Martin van Eickels ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Cardiovascular Diseases ◽  
European Society ◽  
Round Table ◽  
Position Paper ◽  
European Society Of Cardiology
Sign in / Sign up

Export Citation Format

Share Document