Research on: Cell printer using light irradiation Coral reef regeneration & restoration using biomedical techniques

Impact ◽  
2020 ◽  
Vol 2020 (3) ◽  
pp. 54-56
Author(s):  
Masato Ueda
Keyword(s):  
Coral Reef ◽  
Communication Channels ◽  
Basic Research ◽  
Light Irradiation ◽  
University Faculty ◽  
Research Projects ◽  
Know How ◽  
Essential Components ◽  
A Cell ◽  
The Right

In research it can be hard to know how one discovery can be used in unrelated fields. This is why basic research and collaboration are such essential components of science. Without a constant well of ideas and knowledge to draw from and the necessary communication channels to pass on these ideas many advances simply would not be possible. These channels rely on institutions that encourage collaboration and place their researchers in positions to build networks and work together, but they also require the right individuals who are able to follow the trail of their work into new areas. These individuals, who are not afraid to try new things, work with new partners and jump through the doors that open throughout their careers are the backbones of large, multi-disciplinary research projects. Professor Masato Ueda, based at the Kansai University Faculty of Chemistry, Materials and Bioengineering is one such individual. Ueda is currently involved in two research projects; one developing a cell printer that relies on light irradiation and the second focused on exploring coral reef regeneration and restoration using biomedical techniques.

Lysosome Targeting Chimeras (LYTACs) for the Degradation of Secreted and Membrane Proteins

2019 ◽  
Author(s):  
Steven Banik ◽  
Kayvon Pedram ◽  
Simon Wisnovsky ◽  
Nicholas Riley ◽  
Carolyn Bertozzi
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Membrane Proteins ◽  
Growth Factor Receptor ◽  
Basic Research ◽  
Biochemical Pathway ◽  
Programmed Death Ligand 1 ◽  
Programmed Death ◽  
A Cell ◽  
Epidermal Growth ◽  
Powerful Strategy

<p>Targeted protein degradation is a powerful strategy to address the canonically undruggable proteome. However, current technologies are limited to targets with cytosolically-accessible and ligandable domains. Here, we designed and synthesized conjugates capable of binding both a cell surface lysosome targeting receptor and the extracellular domain of a target protein. These lysosome targeting chimeras (LYTACs) consist of an antibody fused to agonist glycopeptide ligands for the cation-independent mannose-6-phosphate receptor (CI-M6PR). LYTACs enabled a CRISPRi knockdown screen revealing the biochemical pathway for CI-M6PR-mediated cargo internalization. We demonstrated that LYTACs mediate efficient degradation of Apolipoprotein-E4, epidermal growth factor receptor (EGFR), CD71, and programmed death-ligand 1 (PD-L1). LYTACs represent a modular strategy for directing secreted and membrane proteins for degradation in the context of both basic research and therapy. <b></b></p>

The Right to Information in India Implementation and Impact

2015 ◽  
Vol 2 (1) ◽  
pp. 17
Author(s):  
_______ Naveen ◽  
_____ Priti
Keyword(s):  
Public Life ◽  
Public Authorities ◽  
The Public ◽  
Know How ◽  
The People ◽  
The Government ◽  
Right To Information ◽  
The Right ◽  
The Impact

The Right to Information Act 2005 was passed by the UPA (United Progressive Alliance) Government with a sense of pride. It flaunted the Act as a milestone in India’s democratic journey. It is five years since the RTI was passed; the performance on the implementation frontis far from perfect. Consequently, the impact on the attitude, mindset and behaviour patterns of the public authorities and the people is not as it was expected to be. Most of the people are still not aware of their newly acquired power. Among those who are aware, a major chunk either does not know how to wield it or lacks the guts and gumption to invoke the RTI. A little more stimulation by the Government, NGOs and other enlightened and empowered citizens can augment the benefits of this Act manifold. RTI will help not only in mitigating corruption in public life but also in alleviating poverty- the two monstrous maladies of India.

Common Sense Propositions

Philosophy ◽  
1973 ◽  
Vol 48 (186) ◽  
pp. 363-379
Author(s):  
A. C. Ewing
Keyword(s):  
Common Sense ◽  
Religious Beliefs ◽  
Physical Object ◽  
Human Beings ◽  
Vast Number ◽  
Know How ◽  
Justified Belief ◽  
The Past ◽  
The Right ◽  
Past Experiences

Philosophers have not been sceptical only about metaphysics or religious beliefs. There are a great number of other beliefs generally held which they have had at least as much difficulty in justifying, and in the present article I ask questions as to the right philosophical attitude to these beliefs in cases where to our everyday thought they seem so obvious as to be a matter of the most ordinary common sense. A vast number of propositions go beyond what is merely empirical and cannot be seen to be logically necessary but are still believed by everybody in their daily life. Into this class fall propositions about physical things, other human minds and even propositions about one's own past experiences based on memory, for we are not now ‘observing’ our past. The phenomenalist does not escape the difficulty about physical things, for he reduces physical object propositions, in so far as true, not merely to propositions about his own actual experience but to propositions about the experiences of other human beings in general under certain conditions, and he cannot either observe or logically prove what the experiences of other people are or what even his own would be under conditions which have not yet been fulfilled. What is the philosopher to say about such propositions? Even Moore, who insisted so strongly that we knew them, admitted that we did not know how we knew them. The claim which a religious man makes to a justified belief that is neither a matter of purely empirical perception nor formally provable is indeed by no means peculiar to the religious. It is made de facto by everybody in his senses, whether or not he realizes that he is doing so. There is indeed a difference: while everyone believes in the existence of other human beings and in the possibility of making some probable predictions about the future from the past, not everybody holds religious beliefs, and although this does not necessarily invalidate the claim it obviously weakens it.

scholarly journals Understanding Cell Interactions Using Modular Nanoparticle Libraries

2019 ◽  
Vol 72 (8) ◽  
pp. 595 ◽  
Author(s):  
Georgina K. Such ◽  
Angus P. R. Johnston
Keyword(s):  
Immune Responses ◽  
Small Molecules ◽  
Active Form ◽  
Reticuloendothelial System ◽  
Endosomal Escape ◽  
Biological Interactions ◽  
Nanoparticle Delivery ◽  
A Cell ◽  
Nanoparticle Structure ◽  
The Right

Nanoparticle delivery systems have significant potential to facilitate the delivery of novel therapeutics, such as proteins, DNA or small molecules. However, there are multiple biological barriers that need to be overcome to deliver the cargo in an active form. These challenges include evading clearance by the reticuloendothelial system, minimising adverse immune responses, targeting specific cells and tissues, and trafficking into the right compartment of the cell. In this account, we will discuss how nanoparticle structure can be tuned to optimise biological interactions and thus improve the ability of nanoparticles to overcome these barriers. The focus of this article will be on controlling cell targeting and trafficking within a cell, e.g. endosomal escape.

scholarly journals Goals and Challenges of Stem Cell-Based Therapy for Corneal Blindness Due to Limbal Deficiency

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1483
Author(s):  
Margarita Calonge ◽  
Teresa Nieto-Miguel ◽  
Ana de la Mata ◽  
Sara Galindo ◽  
José M. Herreras ◽  
...  
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Stem Cell Niche ◽  
Basic Research ◽  
Cell Based Therapy ◽  
Novel Approach ◽  
Corneal Blindness ◽  
Limbal Stem Cell ◽  
Cell Niche ◽  
The Right

Corneal failure is a highly prevalent cause of blindness. One special cause of corneal failure occurs due to malfunction or destruction of the limbal stem cell niche, upon which the superficial cornea depends for homeostatic maintenance and wound healing. Failure of the limbal niche is referred to as limbal stem cell deficiency. As the corneal epithelial stem cell niche is easily accessible, limbal stem cell-based therapy and regenerative medicine applied to the ocular surface are among the most highly advanced forms of this novel approach to disease therapy. However, the challenges are still great, including the development of cell-based products and understanding how they work in the patient’s eye. Advances are being made at the molecular, cellular, and tissue levels to alter disease processes and to reduce or eliminate blindness. Efforts must be coordinated from the most basic research to the most clinically oriented projects so that cell-based therapies can become an integrated part of the therapeutic armamentarium to fight corneal blindness. We undoubtedly are progressing along the right path because cell-based therapy for eye diseases is one of the most successful examples of global regenerative medicine.

scholarly journals PENGEMBANGAN BUKU PENGAYAAN BERGAMBAR KETERAMPILAN MENULIS (MERINGKAS) UNTUK SISWA KELAS VII SE-KECAMATAN PEMALANG

2020 ◽  
Vol 7 (2) ◽  
pp. 34-43
Author(s):  
Isya Dina Kamalia
Keyword(s):  
High School Students ◽  
Research And Development ◽  
Junior High School ◽  
Writing Skills ◽  
Learning Activities ◽  
School Students ◽  
Know How ◽  
True Story ◽  
Teachers And Students ◽  
The Right

Abstrak: Siswa kelas VII SMP idelanya sudah bisa menghasilkan ringkasan cerita yang baik. Akan tetapi sebagaian besar siswa kelas VII SMP di Kecamatan Pemalang masih kesulitan dan tidak tahu cara meringkas cerita yang benar. Selain buku paket dan LKS, sekolah belum menyediakan buku lain untuk mendukung kegiatan belajar siswa dalam memahami pembelajaran meringkas cerita. Penyebab siswa belum tahu tentang cara meringkas yang benar adalah karena buku yang memuat tentang cara meringkas cerita belum ada. masalah tersebut berpengaruh terhadap keterampilan menulis siswa dalam mengembangkan ringkasan yang baik. Tujuan penelitian ini adalah (1) menganalisis kebutuhan guru dan siswa terhadap buku pengayaan keterampilan menulis (meringkas) bergambar, (2) menyusun prototipe buku pengayaan keterampilan menulis (meringkas) bergambar, (3) mendeskripsikan hasil uji validasi ahli pengembangan buku pengayaan keterampilan menulis (meringkas) bergambar. Penelitian ini menggunakan pendekatan Research and Development (R&D).Hasil penelitian ini berupa buku pengayaan bergambar keterampilan menulis (meringkas) yang berjudul Wasis Ngringkes Crita. Kata kunci: buku pengayaan, keterampilan meringkas Abstract: The seventh grade junior high school students have been able to produce a good summary of the story. But most of the VII grade students of SMP in Pemalang Subdistrict are still having difficulties and do not know how to summarize the true story. In addition to textbooks and LKS, schools have not provided other books to support student learning activities in understanding learning to summarize stories. The reason for students not knowing about how to summarize the right one is because the book that contains how to summarize the story does not yet exist. the problem affects students' writing skills in developing good summaries. The objectives of this study are (1) to analyze the needs of teachers and students for illustrative illustrative writing enrichment books, (2) to compile prototypes of enrichment writing (summarizing) illustrative books, (3) to describe the results of expert validation test writing skills enrichment books ( summarize) pictorial. This research uses a Research and Development (R & D) approach. The results of this study are in the form of a book enriching writing skills (summarizing) pictorial entitled Wasis Ngringkes Crita. Keywords: enrichment books, summarizing skills  

scholarly journals Article 33: The Right to Protection from Illicit Use of Narcotic Drugs and Psychotropic Substances

2022 ◽  
pp. 237-244
Author(s):  
Damon Barrett ◽  
Ziba Vaghri
Keyword(s):  
Asia Pacific ◽  
Know How ◽  
Psychotropic Substances ◽  
Illicit Use ◽  
The Right ◽  
Narcotic Drugs

AbstractSchools have courses for students and communities to understand well the consequences of harmful drug and know how to deal with the activities of drug trading. (Asia-Pacific)

scholarly journals Consumer Protection on Nonofficial Drugs Case in Indonesia: How Far the Legal Protection is?

2021 ◽  
Vol 7 (4) ◽  
pp. 459-472
Author(s):  
Chatrin Intan Sari
Keyword(s):  
Consumer Protection ◽  
Research Method ◽  
Legal Protection ◽  
Illegal Drugs ◽  
Know How ◽  
Consumer Law ◽  
Consumer Rights ◽  
The Government ◽  
The Right

The purpose of this study is to know how the legal protection for consumers on the circulation of illegal drugs and how the accountability of business actors on the circulation of illegal drugs. By using normative juridical research method this study found that the legal protection to consumers on the circulation of illegal drugs conducted by the government through the Agency of Drugs and Food. The Agency highlighted that the attention that the government has run its supervision. In addition, the protection of consumer law arising from the existence of rights and obligations set forth in Article 4 letters a and c, article 7 letters a and d, article 8 paragraph 1 letter a, d and e of Law Number 8 Year 1999 concerning Consumer Protection. The fulfilment of consumer rights over security, the right to be heard, the correct, clear, and honest information regulated in the UUPK is still not fulfilled. Article 98 paragraph 2, Article 106 paragraph 1 and 2 of Law Number 36 Year 2009 on Health. The business actor is responsible as the manufacturer of the goods because the importer of the goods is not an agent or official importer. The business actor who is an individual shall be liable for the losses incurred even if only as an importer not as a producer of the goods. 

scholarly journals Oxygen transport and release of adenosine triphosphate in micro-channels

2015 ◽  
Author(s):  
Terry Moschandreou
Keyword(s):  
Oxygen Transport ◽  
Rapid Change ◽  
Microfluidic Channel ◽  
Permeable Membrane ◽  
Micro Channels ◽  
Free Region ◽  
Method Of Solution ◽  
Channel Tube ◽  
A Cell ◽  
The Right

The governing nonlinear steady equations for oxygen transport in a microfluidic channel are solved analytically. The Lagrange inversion theorem is used which admits complete integrable solutions in the channel. Considering a cell-rich and cell free region with RBCs and blood plasma, we obtain results showing clearly that there is a significant decrease in oxygen tension in the vicinity of an oxygen permeable membrane placed on the upper channel/tube wall and to the right side of it in the downstream field. The purpose of the membrane is to cause a rapid change in oxygen saturation as RBC’s flow through channel/tube. To the right of the membrane downstream the greatest amount of ATP is released. The method of solution is compared to numerical results. The analytical results obtained could prove useful for the corresponding time dependent problem in future studies.

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