scholarly journals ДОСВІД ТА ПЕРСПЕКТИВИ ЗАСТОСУВАННЯ КАРБОКСІТЕРАПІЇ ПРИ ЦУКРОВОМУ ДІАБЕТІ

2021 ◽  
Vol 78 (4) ◽  
pp. 110-116
Author(s):  
Світлана Дроговоз ◽  
Галина Бєлік ◽  
Катерина Калько ◽  
Станіслав Шевченко ◽  
Людмила Деримедвідь ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Key Words Diabetes Mellitus ◽  
Key Words Diabetes ◽  
Scientific Publications ◽  
Off Label ◽  
Alternative Method ◽  
Physiological Properties ◽  
National University ◽  
Treatment Of Diabetes ◽  
Diabetes Mellitus Treatment

Цукровий діабет (ЦД) є глобальною актуальною соціальною проблемою XXI століття. Метою даного огляду літератури: є аналіз фізіологічних властивостей та фармакотерапевтичних можливостей карбоксітерапії, а також досвіду застосування даного методу для лікування ЦД. Матеріали і методи дослідження. Наукові публікації в зарубіжних та вітчизняних журналах переважно за останні 5 років, інтернет ресурси по карбоксітерапії як методу лікування ЦД. Результати досліджувати і їх обговорення. В результаті аналізу літератури були зіставленні механізми реалізації фармакологічних ефектів карбоксітерапії з окремими ланками патогенезу ЦД. Проаналізовані механізми і ефекти карбоксітерапії як ефективного альтернативного методу лікування ЦД та його ускладнень. Представлені дані свідчать про раціональність застосування карбоксітерапії як альтернативного методу лікування ЦД та його ускладнень. Висновки. З огляду на сучасні можливості фармакотерапії ЦД та більш ніж п’ятдесятирічний досвід застосування карбоксітерапії в практичній медицині дозволяє рекомендувати цей інноваційний метод як альтернативну off-label терапію ЦД. Ключові слова: цукровий діабет, лікування, карбоксітерапія.     EXPERIENCE AND PROSPECTS OF CARBOXYTHERAPY IN DIABETES MELLITUS Drogovoz S. M.1, Belik G. V.1, Kalko К. О.1, Bondariev Ye. V.1, Derymedvid L. V.1, Orlenko І. V.1, Shtroblya А. L.2 National University of Pharmacy, Kharkiv, Ukraine Uzhgorod National University, Uzhgorod, Ukraine   Diabetes mellitus (DM) is a global topical social problem of the XXI century. The aim of this literature review is to analyze the physiological properties and pharmacotherapeutic possibilities of carboxytherapy, as well as the experience of this method for the treatment of diabetes. Materials and methods. Scientific publications in foreign and domestic journals mainly for the last 5 years, online resources on carboxytherapy as a method of DM treating. Results and discussions. As a result of the literature analysis, the mechanisms of implementation of the pharmacological effects with separate links of the pathogenesis of diabetes were compared. The mechanisms and effects of carboxytherapy as an effective alternative method for treating diabetes mellitus and its complications have been analyzed. The presented data indicate the rational use of carboxytherapy as an alternative method for treating diabetes and its complications. Conclusions. Given the current possibilities of pharmacotherapy of diabetes and more than fifty years of experience in the use of carboxytherapy in practical medicine allows us to recommend this innovative method as an alternative to off-label therapy of diabetes. Key words: diabetes mellitus, treatment, carboxytherapy.      

The role of antioxidants in the treatment of diabetes

2020 ◽  
Vol 04 (05) ◽  
pp. 12-16
Author(s):  
Afag Ulduz Kazimova ◽  
◽  
Elnura Musa Musayeva ◽  
Gulbaniz Asif Huseynova ◽  
Rashida Musa Abdullayeva ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Free Radicals ◽  
Therapeutic Strategy ◽  
High Reactivity ◽  
Key Words Diabetes Mellitus ◽  
Key Words Diabetes ◽  
Oxygen Species ◽  
Treatment Of Diabetes

Oxidative stress is a major cause of various types of tissue damage, especially endothelial dysfunction, which occurs in diabetes mellitus. In a healthy organism the formation of ROS occurs under the strict control of the biological system, on the contrary, under severe stress, many diseases, as well as diabetes, the production of ROS increases curtly. Due to its high reactivity, an increase in the amount of SOR leads to oxidative stress, which disturb the balance between the antioxidant and prooxidant systems. The main prin-ciple of the therapeutic strategy to reduce oxidative stress in diabetes mellitus is to inhibit the formation of free radicals. The results of clinical and experimental experiments demonstrate the administration of antioxidants, especially vitamin E, insulin resistance and therapeutic effect in diabetic conditions. Recently, the use of synthetic, as well as herbal antioxidants, along with other drugs in the pharmacotherapeutic correction of a number of pathologies in medical practice has become widespread. The development of a more effective pharmacotherapeutic strategy for diabetes with antioxidants and the synthesis of potent agents are promising for further research. Key words: diabetes mellitus, antioxidant, oxidative stress, reactive oxygen species (ROS), free radicals

Evaluation of complications of the late postoperative period in patients with diabetes mellitus after drainage surgery of neovascular glaucoma

2021 ◽  
pp. 10-12
Author(s):  
V.A. Biletskaya ◽  
◽  
D.V. Lipatov ◽  
M.A. Frolov ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Postoperative Period ◽  
Pain Syndrome ◽  
Neovascular Glaucoma ◽  
Research Centre ◽  
Federal State ◽  
Key Words Diabetes Mellitus ◽  
Key Words Diabetes ◽  
Surgical Methods

Today diabetes mellitus (DM) is one of the leading medical and social problems. Its complications lead to terrible concomitant pathologies that qualitatively affect the lives of patients. At the end of 2019, there were more than 463 million people with diabetes in the world and this number is increasing every year. Diabetic retinopathy (DR) is one of the most severe complications of DM on the organ of vision. Secondary neovascular glaucoma (NG) is a manifestation of the end-stage proliferative DR. This is a relatively rare but difficult-to-treat pathology that often leads working-age patients to disability and impaired social adaptation. The main objective of treatment for NG is to compensate for intraocular pressure (IOP), but conservative (drug) therapy is often ineffective. Therefore, doctors are forced to use surgical methods of treatment. At the same time, do not forget about the multiple complications during the operation, as well as in the early and late postoperative periods. A special feature of the course of NG in patients with DM is its combination with the failure of the ligamentous-capsular apparatus of the lens, iris bombage, anterior and posterior synechiae, traction retinal detachment and various hemorrhagic complications. All this allows us to talk about the so-called diabetic glaucoma (DG). Currently, drainage devices have become the standard in the treatment of refractory NG. The effectiveness of such operations according to various sources is about 70-80% of success. Purpose. To assess the condition of patients with DM in the late (10-15 years) postoperative period after performing NG drainage surgery, to analyze the effectiveness of the intervention by studying the dynamics of IOP, the presence or absence of pain syndrome and various intraocular complications. Material and methods. During the period 2006-2020, 150 patients with NG and DM were operated on in the Department of Diabetic Retinopathy of the Federal State Budgetary Institution «Endocrinology Research Centre» of the Ministry of Health of the Russian Federation. Results. In 100% of the postoperative period, the pain syndrome was stopped. And also, in 59.7% of cases, the presence of late complications: vascular thorn, EED, subatrophy and anophthalmos. Conclusion. Despite the presence of complications, drainage surgery in patients with DM continues to be an effective method of choosing surgical treatment for patients with uncompensated NG. Key words: diabetes mellitus; diabetic retinopathy; neovascular glaucoma; drainage surgery.

scholarly journals The Role of Natural Products on Diabetes Mellitus Treatment: A Systematic Review of Randomized Controlled Trials

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 101
Author(s):  
Lucía Vivó-Barrachina ◽  
María José Rojas-Chacón ◽  
Rocío Navarro-Salazar ◽  
Victoria Belda-Sanchis ◽  
Javier Pérez-Murillo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Natural Products ◽  
Promising Therapeutic Target ◽  
Prevalent Disease ◽  
Bibliographic Search ◽  
Treatment Of Diabetes ◽  
Definition Of ◽  
Diabetes Mellitus Treatment

The present study was carried out to relate the role of natural products in the metabolism of an increasingly prevalent disease, type 2 diabetes mellitus. At present, in addition to the pharmacological resources, an attempt is being made to treat diabetes mellitus with natural products. We carried out a systematic review of studies focusing on the role of natural products on diabetes mellitus treatment. The bibliographic search was done through Medline (Pubmed) and Web of Science. From 193 records, the title and summary of each were examined according to the criteria and whether they met the selection criteria. A total of 15 articles were included; after reviewing the literature, it is apparent that the concept of natural products is ambiguous as no clear boundary has been established between what is natural and what is synthetic, therefore we feel that a more explicit definition of the concept of “natural product” is needed. Gut microbiota is a promising therapeutic target in the treatment of diabetes. Therefore, it would be necessary to work on the relationship between the microbiome and the benefits in the treatment of diabetes mellitus. Treatment based solely on these natural products is not currently recommended as more studies are needed.

scholarly journals PROVIDING THE BEST PREVENTION AND TREATMENT FOR DIABETES PATIENTS

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Khaled M. Hassan
Keyword(s):  
Type 2 Diabetes ◽  
Diabetes Prevention Program ◽  
Evidence Base ◽  
Control Group ◽  
Key Words Diabetes Mellitus ◽  
Key Words Diabetes ◽  
Intervention Protocol ◽  
Drastic Increase ◽  
Diabetes Mellitus Treatment

Diabetes is one of the main threats to human health in this century. The drastic increase in incidence of diabetes worldwide has been attributed to distinct changes in human behavior and lifestyle during the last century. To prevent the personal and socio-economic burden of diabetes effort to prevent the disease needs to start before the onset of diabetes and address all susceptibility factors. Four recent studies have shown that prevention of type 2 diabetes is possible and that reinforced lifestyle interventions / modification can significantly reduce the onset of the disease. The studies repeatedly showed that for about 60% of the persons with increased diabetes risk, compared to a control group, the diabetes was prevented from developing. Early pharmacologic preventive strategies have yielded 25-30%. These studies have convincingly demonstrated that the primary aim in prevention of type 2 diabetes is the stabilization of glucose tolerance due to improvement of insulin resistance. Based on the studies intervention protocol focuses on achieving 5 core goals. With respect to the world wide burden of diabetes this studies offer a compelling evidence-base for the important translation of the research findings into community-based prevention strategies a development of a National Diabetes Prevention Program. Key words: Diabetes Mellitus, Treatment, Prevention

Glucose Control

2020 ◽  
Author(s):  
Timothy P. Graham ◽  
Erich N. Marks ◽  
Joshua J. Sebranek ◽  
Douglas B. Coursin
Keyword(s):  
Diabetes Mellitus ◽  
Critically Ill ◽  
Glucose Control ◽  
Cost Of Care ◽  
Hospital Length Of Stay ◽  
Glucose Measurement ◽  
Key Words Diabetes Mellitus ◽  
Key Words Diabetes ◽  
Adult Intensive Care Unit ◽  
Patients With Diabetes

Patients with diabetes mellitus routinely require management in the adult intensive care unit (ICU). These patients have increased morbidity, mortality, hospital length of stay, cost of care, and frequency of hospital and ICU admission. Glucose control in these patients presents challenges for the clinician. In the critically ill, hyperglycemia does not occur exclusively in patients with diabetes or prediabetes but may be related to stress-induced hyperglycemia or iatrogenic causes. Hyperglycemia can contribute to decreased wound healing and immune function and a host of cellular and molecular dysfunctions and has been linked to increased hospital mortality. Hypoglycemia in the ICU is associated with patients with preexisting diabetes, those receiving insulin and other medications, and septic individuals, among others. Insulin therapy is the mainstay of glucose management in the critically ill. ICU practitioners should be aware that point-of-care glucose meters are not as accurate as core laboratory results. Finally, both hypoglycemia and wide fluctuations in blood glucose during critical illness are also associated with increased mortality, although clear cause-and-effect relationships have not been established. This review contains 1 figure, 8 tables, and 71 references. Key words: Diabetes mellitus, glucose measurement, glucose targets, hyperglycemia, hypoglycemia, insulin

scholarly journals Effect of Fenugreek (Methi) on Cortical Thickness of the Thymus in Streptozotocin-Induced Diabetic Rats

1970 ◽  
Vol 7 (1) ◽  
pp. 37-41
Author(s):  
DK Mondal ◽  
MMA Moinuddin ◽  
MM Saha ◽  
AM Khanom ◽  
BMA Yousuf ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cortical Thickness ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Key Words Diabetes Mellitus ◽  
Key Words Diabetes ◽  
Nondiabetic Control ◽  
The Mean ◽  
Long Evans

Objective: To find out microscopically whether Trigonella foenumgraecum (fenugreek seeds/methi seeds) has got any preventive role against the lowering of cortical thickness of the thymic lobules in diabetes mellitus. Design: An experimental study on Long Evans rats which were divided into three equal groups depending on their different shorts of dietary feeding and drug treatment. Setting: Anatomy department of IPGMR (Institute of Post Graduate Medicine and Research) at present BSMMU (Bangabandhu Sheikh Mujib Medical University) and BIRDEM (Bangladesh Institute of Research and Rehabilitation in diabetes, Endocrine & Metabolic Disorders). Subjects: Fifty eight healthy young Long Evans rats of either sex weighing 72 to 174gm aged between 50 to 60 days were used in this study. Main outcome measures: Variation of cortical thickness of the thymic lobules in different groups of rat. Result: Cortical thickness in the nondiabetic control group, which ranges from 30.17 to 36.99. and the mean was 34.83 ± 0.60. In diabetic control group the cortical thickness ranges from 17.78 to 26.46 and the mean was 21.85 ± 1 On the other hand, in the fenugreek- treated diabetic rats the cortical thickness ranges from 25.71 to 32.95 and mean cortical thickness was 30.49 ± 0.75. Conclusion: Fenugreek showed a tendency of acting against lowering of the cortical thickness of the thymic lobule of Streptozotocin-induced diabetes mellitus. However, further investigations are recommended for establishing fenugreek as a safe, useful effective agent to preserve the cortical thickness improving the diabetic condition by acting as antidiabetogenic agent. Key words: Diabetes mellitus, Differential lymphocyte count, Fenugreek, Thymus   doi: 10.3329/bja.v7i1.3017 Bangladesh Journal of Anatomy January 2009, Vol. 7 No. 1 pp. 37-41

scholarly journals Asociación del control glucémico con la disfunción eréctil en pacientes diabéticos

2017 ◽  
Vol 77 (1) ◽  
Author(s):  
Juan Figueroa García Juan
Keyword(s):  
Diabetes Mellitus ◽  
Erectile Dysfunction ◽  
Glycemic Control ◽  
Odds Ratio ◽  
Glycated Hemoglobin ◽  
Key Words Diabetes Mellitus ◽  
Diabetic Patients ◽  
Key Words Diabetes ◽  
Control Glucémico ◽  
Inadequate Glycemic Control

ANTECEDENTES: la disfunción eréctil es la incapacidad para conseguir y mantener una erección que permita una penetración sexual satisfactoria en 50% de las veces, en un periodo de tres meses. Entre las causas orgánicas, la diabetes mellitus representa 30%. A pesar de esta relación la prevalencia es poco conocida en nuestro medio.OBJETIVO: determinar la asociación entre el control glucémico y la disfunción eréctil en diabéticos.MATERIALES Y MÉTODOS: estudio observacional, transversal y analítico al que se incluyeron pacientes que no refirieron complicaciones al momento del estudio. A todos se les aplicó el cuestionario IIFE-5 (Índice Internacional de la Función Eréctil) para detectar si padecían o no disfunción eréctil, se compararon las concentraciones de hemoglobina glucosilada (HbA1c), y se analizó su asociación mediante la aplicación de la razón de momios.RESULTADOS: en 362 pacientes se encontró una prevalencia de disfunción eréctil de 72.3% (n=272), de estos 80.9% (n=212) estaban en descontrol glucémico, con una razón de momios de 6.92 (IC95%: 4.16 a 11.50).CONCLUSIONES: en los pacientes diabéticos existe una relación 7:1 de probabilidad de disfunción eréctil versus pacientes con adecuado control glucémico.PALABRAS CLAVE: diabetes mellitus, disfunción eréctil, hemoglobina glucosilada, control glucémico.  AbstractBACKGROUND: Erectile dysfunction is the inability to achieve and maintain an erection that enables satisfactory sexual penetration 50% of the time, within a 3-month period. Diabetes mellitus is the organic cause in 30% of cases, but despite this relation, the prevalence of erectile dysfunction is not well known in Mexico.OBJECTIVE: To determine the association between glycemic control and erectile dysfunction in diabetic patients.MATERIALS AND METHODS: An observational, cross-sectional, analytic study included diabetic patients that did not complain of complications at the time of the study. The International Index of Erectile Function (IIEF-5) questionnaire was applied to detect whether or not the patients presented with erectile dysfunction. Their glycated hemoglobin (HbA1c) levels were compared and the association with erectile dysfunction was analyzed through the odds ratio.RESULTS: The prevalence of erectile dysfunction in 362 patients was 72.3% (n=272). Of those patients with erectile dysfunction, 80.9% (n=212) had inadequate glycemic control, with an odds ratio of 6.92 (95% CI: 4.16 to 11.50).CONCLUSIONS: The odds ratio of presenting with erectile dysfunction for diabetic men with inadequate glycemic control and patients with adequate glycemic control was 7:1.KEY WORDS: Diabetes mellitus; Erectile dysfunction; Glycated hemoglobin; Glycemic control

THE EFFECT OF HEALTH EDUCATION THROUGH SESSION-HEALTH APPLICATION MEDIA ON BEHAVIOR MANAGEMENT BEHAVIOR OF DIABETES MELITUS IN BENGKULU CITY

2019 ◽  
Vol 8 (2) ◽  
pp. 115-123
Author(s):  
Hanifah Hanifah ◽  
Vike Pebri Giena ◽  
Ruri Maiseptya Sari
Keyword(s):  
Diabetes Mellitus ◽  
Health Education ◽  
Behavior Management ◽  
Sampling Technique ◽  
Diabetic Complication ◽  
Self Management ◽  
Key Words Diabetes Mellitus ◽  
Cluster Sampling ◽  
Key Words Diabetes ◽  
Management Behavior

Background: Diabetes mellitus (DM) is a chronic disease that requires specific self-management behavior for a lifetime, to avoid long-term diabetic complication. Education about diabetes self-management for people with diabetes mellitus and families is absolutely necessary to overcome diabetic complications. The use of smartphones as educational media provides space for people with DM without restrictions on place and time.Objective: The aims of this study was to identify the effect of health education through the Salam-Sehat application media on diabetes self-management behavior.Method: This research is quantitative with pre-experiment design with one group pre-test post-test. The population of this study was all people with DM in Bengkulu City. Sample was selected by using Multi Stages Cluster Sampling technique. The sample size was determined using the Slovin formula which results are 384 respondents. The sample was selected by using proportional random sampling. The Data were analyzed by using the Wilcoxon Signed Rank Test.Result: The results showed that the average DM self-management behavior before being given education through the Salam-Sehat application was 35.42 and the average DM self-management behavior after being given education through the Salam-Sehat application was 65.18. There is significant influence of health education through Salam-Sehat application media for self-management behavior among diabetes mellitus people in Bengkulu City, with Asymp value. Sig (p) = 0.000.Conclusion: It is expected that the research results of the Salam-Sehat application can be used as an online-based health education media that provides convenience in obtaining health information without being limited by space and time for people with DM in Bengkulu City. Key words: Diabetes Mellitus, Self-Management, Application.

Preoperative Assessment of the Patient with Diabetes Mellitus

2019 ◽  
Author(s):  
Sean A. Josephs ◽  
Gretchen A. Lemmink
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Diabetic Ketoacidosis ◽  
Preoperative Assessment ◽  
Major Surgery ◽  
Key Words Diabetes Mellitus ◽  
Diabetic Patients ◽  
Key Words Diabetes ◽  
Hyperglycemic Hyperosmolar State ◽  
Patients With Diabetes

Diabetes mellitus is a major cause of morbidity and mortality.  Nearly 30 million Americans have diabetes, more than 25% of which are undiagnosed. Patients with diabetes have multiple problems that should be addressed prior to surgery. They often have uncontrolled glucose levels that should be treated preoperatively. Current studies suggest that outcomes may be improved if perioperative glycemic control is optimized. Patients with diabetes develop end-organ dysfunction that can complicate perioperative management. Preoperative assessment of cardiac, neurologic, vascular, and renal function is necessary for all patients with diabetes that undergo major surgery. Optimization of cardiac disease in particular can reduce major adverse cardiac events for patients with risk factors such as diabetes. Diabetic patients can occasionally present for major surgery with hyperglycemic emergencies such as diabetic ketoacidosis and hyperglycemic hyperosmolar state. These conditions require urgent treatment to prevent mortality regardless of the need for surgery. This article reviews the preoperative assessment and management of these issues. This review contains 1 figure, 4 tables, and 37 references. Key Words: diabetes mellitus (DM), end-organ damage, hyperglycemia, polyuria, polydipsia, polyphagia, perioperative glycemic management, diabetic ketoacidosis (DKA), hyperglycemic hyperosmolar state (HHS), perioperative cardiac risk factors

The method of viscodissection with contrast enhancement of posterior hyaloid membrane for proliferative diabetic retinopathy surgery

2021 ◽  
pp. 127-129
Author(s):  
D.V. Petrachkov ◽  
◽  
A.G. Matyuschenko ◽  
L. Alkharki ◽  
A.L. Sidamonidze ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Contrast Enhancement ◽  
Proliferative Diabetic Retinopathy ◽  
Vitreoretinal Surgery ◽  
Key Words Diabetes Mellitus ◽  
Key Words Diabetes ◽  
Posterior Hyaloid ◽  
Retinal Breaks

Purpose. Study is to evaluate the efficacy of the method of viscodissection with contrast enhancement of posterior hyaloid membrane in PDR surgery. Material and methods. The study involved 26 patients with type 1 diabetes mellitus and severe PDR with the presence of tractional retinal detachment (TRD). All patients received treatment in the volume of lensectomy and IOL implantation, microinvasive vitrectomy, viscodissection with contrasting of epiretinal structures was performed, followed by segmentation and removal of membranes, endolaser coagulation followed by tamponade with sterile air of the vitreous cavity. Results. In all patients included in the study, with dynamic observation, there was a positive dynamics of morphofunctional indicators - best corrected visual acuity (BCVA) from 32.5-16.1 to 62.2-15.7 and central retinal thickness (CRT) according to optical coherence tomography (OCT) from 775.9-78.4 to 492.1-73.8 µm. Conclusion. The method of viscodissection with simultaneous contrast of the posterior hyaloid membrane facilitates the assessment of the quality of the separation of pathological membranes and improves the quality of visual control over the process of their separation, which reduces the risks of iatrogenic retinal breaks. Key words: diabetes mellitus, proliferative diabetic retinopathy, vitreoretinal surgery, viscodissection.

Sign in / Sign up

Export Citation Format

Share Document