Effect of Sucrose on Cisplatin-induced Fatigue-like Behavior in Mice: Comparison With Fructose and Glucose

2021 ◽  
Vol 1 (2) ◽  
pp. 95-102
Author(s):  
KAZUMI YOSHIZAWA ◽  
RUKA KURONO ◽  
HARUKA SATO ◽  
ERIKA ISHIJIMA ◽  
HARUKA NASU ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Anticancer Agents ◽  
Saline Control ◽  
Common Symptom ◽  
Antitumor Effects ◽  
Patients With Cancer ◽  
Cancer Related Fatigue ◽  
Running Activity ◽  
Glucose Intake

Background/Aim: Fatigue is the most common symptom in patients with cancer undergoing radiation therapy or cancer chemotherapy. However, cancer-related fatigue remains undertreated and poorly understood. Materials and Methods: Mice were administered a single dose of cisplatin (10 mg/kg, intraperitoneally) or saline (as a control) and then treated with sucrose, fructose, glucose (each at 500 or 5,000 mg/kg, orally), or saline (control) daily for 4 days. cisplatin-induced fatigue-like behavior was investigated by assessment of running activity on a treadmill. The influence of glucose intake on tumor growth was also examined in Lewis lung carcinoma (LLC)-bearing mice. Results: Administration of sucrose and glucose improved cisplatin-induced fatigue-like behavior in mice, whereas administration of fructose showed only slight antifatigue effects. Although glucose-fed mice showed increased tumor growth, this was balanced out by the powerful cytotoxicity of cisplatin. Conclusion: Sucrose, and especially glucose, may improve patient quality of life during treatment with anticancer agents by preventing fatigue without interfering with the antitumor effects of cisplatin.

scholarly journals Insights and Perspectives in the Clinical and Operational Management of Cancer-Related Anemia

2010 ◽  
Vol 8 (Suppl_7) ◽  
pp. S-38-S-55 ◽  
Author(s):  
Jennifer M. Hinkel ◽  
Edward C. Li ◽  
Stephen L. Sherman
Keyword(s):  
Quality Of Life ◽  
Radiation Therapy ◽  
Surgical Interventions ◽  
Patients With Cancer ◽  
Cancer Related Fatigue ◽  
Operational Management ◽  
Life Issues ◽  
Economic Perspectives ◽  
Cancer Related Anemia

Management of anemia in patients with cancer presents challenges from clinical, operational, and economic perspectives. Clinically, anemia in these patients may result from treatment (chemotherapy, radiation therapy, or surgical interventions) or from the malignancy itself. Anemia not only contributes to cancer-related fatigue and other quality of life issues, but also affects prognosis. From the operational perspective, a patient with cancer who is also anemic may consume more laboratory, pharmacy, and clinical resources than other patients with cancer.

scholarly journals An Activity Tracker–Guided Physical Activity Program for Patients Undergoing Radiotherapy: Protocol for a Prospective Phase III Trial (OnkoFit I and II Trials) (Preprint)

2021 ◽  
Author(s):  
Franziska Hauth ◽  
Barbara Gehler ◽  
Andreas Michael Nieß ◽  
Katharina Fischer ◽  
Andreas Toepell ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Functional Assessment ◽  
Exercise Program ◽  
Daily Step ◽  
Patients With Cancer ◽  
Activity Tracker ◽  
Cancer Related Fatigue ◽  
Daily Step Count

BACKGROUND The positive impact that physical activity has on patients with cancer has been shown in several studies over recent years. However, supervised physical activity programs have several limitations, including costs and availability. Therefore, our study proposes a novel approach for the implementation of a patient-executed, activity tracker–guided exercise program to bridge this gap. OBJECTIVE Our trial aims to investigate the impact that an activity tracker–guided, patient-executed exercise program for patients undergoing radiotherapy has on cancer-related fatigue, health-related quality of life, and preoperative health status. METHODS Patients receiving postoperative radiotherapy for breast cancer (OnkoFit I trial) or neoadjuvant, definitive, or postoperative treatment for other types of solid tumors (OnkoFit II trial) will be randomized (1:1:1) into 3-arm studies. Target accrual is 201 patients in each trial (50 patients per year). After providing informed consent, patients will be randomized into a standard care arm (arm A) or 1 of 2 interventional arms (arms B and C). Patients in arms B and C will wear an activity tracker and record their daily step count in a diary. Patients in arm C will receive personalized weekly targets for their physical activity. No further instructions will be given to patients in arm B. The target daily step goals for patients in arm C will be adjusted weekly and will be increased by 10% of the average daily step count of the past week until they reach a maximum of 6000 steps per day. Patients in arm A will not be provided with an activity tracker. The primary end point of the OnkoFit I trial is cancer-related fatigue at 3 months after the completion of radiotherapy. This will be measured by the Functional Assessment of Chronic Illness Therapy-Fatigue questionnaire. For the OnkoFit II trial, the primary end point is the overall quality of life, which will be assessed with the Functional Assessment of Cancer Therapy-General sum score at 6 months after treatment to allow for recovery after possible surgery. In parallel, blood samples from before, during, and after treatment will be collected in order to assess inflammatory markers. RESULTS Recruitment for both trials started on August 1, 2020, and to date, 49 and 12 patients have been included in the OnkoFit I and OnkoFit II trials, respectively. Both trials were approved by the institutional review board prior to their initiation. CONCLUSIONS The OnkoFit trials test an innovative, personalized approach for the implementation of an activity tracker–guided training program for patients with cancer during radiotherapy. The program requires only a limited amount of resources. CLINICALTRIAL ClinicalTrials.gov NCT04506476; https://clinicaltrials.gov/ct2/show/NCT04506476. ClinicalTrials.gov NCT04517019; https://clinicaltrials.gov/ct2/show/NCT04517019. INTERNATIONAL REGISTERED REPORT DERR1-10.2196/28524

The effects of androgen deprivation therapy and radiation therapy on cancer-related fatigue.

2019 ◽  
Vol 37 (31_suppl) ◽  
pp. 10-10
Author(s):  
Leorey Saligan
Keyword(s):  
Prostate Cancer ◽  
Androgen Deprivation Therapy ◽  
Wheel Running ◽  
Androgen Deprivation ◽  
Common Symptom ◽  
Cancer Related Fatigue ◽  
Running Activity ◽  
Fatigue Development ◽  
Wheel Running Activity ◽  
Significant Difference

10 Background: Fatigue is a common symptom characterized by incapacitating tiredness. Androgen deprivation therapy (ADT) in combination with radiotherapy (RT) is one of the standard treatments for prostate cancer. Fatigue often worsens during RT with concomitant ADT and it persists long after treatment completion. The purpose of this study is to examine the effects of combined ADT and RT on fatigue in prostate cancer men and in a fatigue mouse model. Methods: 64 participants were recruited and followed at baseline, midpoint, completion, and 1 year post-RT. Two cohorts of men: +ADT cotinued after RT (n=27), +ADT during RT only (n=20), and -ADT (n=17). Fatigue was measured using FACT-F. Male C57BI/6 mice (n=55) were randomly placed into 2 groups: +ADT and –ADT (control). Mice were further subdivided into +RT and –RT (sham) groups. Voluntary Wheel Running Activity (VWRA) data from all mice were recorded for 6 days post-irradiation and the total average of all 6 days was used for analysis. Results: Fatigue (n=64) worsened during RT ( p=.02 at midpoint, p=.04 at completion). ADT significantly affected fatigue development over time (F3,42 = 3.80, p=.02) with the most significant difference occurring at midpoint ( p<.001) and completion of RT ( p<0.001). VWRA significantly decreased in mice that received the combination of ADT and irradiation, compared to those that received only ADT + sham radiation ( p=.001) and no ADT + sham radiation ( p=.004). Transcription factor A, mitochondrial (TFAM) in brain cortical samples was significantly reduced in irradiated mice compared to control mice ( p=.014). Glucose transported type 4 (GLUT4) in brain cortices was significantly reduced in irradiated mice compared to non-irradiated mice ( p=.0057). GLUT4 was also significantly reduced in irradiated mice receiving ADT compared to control mice receiving sham RT ( p=.043). Conclusions: There is a significant combined effect of ADT and RT on fatigue in both humans and mice. Mitochondrial function/neuronal bioenergetic markers were altered in the cortices of irradiated mice that received concomitant ADT. These findings suggest that fatigue experienced by subjects who receive ADT + RT could be attributable to impaired cortical energy production.

scholarly journals Progress of Traditional Chinese Medicine Treatment for Cancer-Related Fatigue in Patients with Colorectal Cancer

2021 ◽  
Vol 5 (5) ◽  
pp. 15-18
Author(s):  
Yuexin Wang ◽  
Tao Yu
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Chinese Medicine ◽  
Common Symptom ◽  
Curative Effect ◽  
Cancer Related Fatigue ◽  
High Incidence ◽  
Colorectal Cancer Patients ◽  
Chinese Medicine Treatment

Cancer-related fatigue, which is a common symptom among colorectal cancer patients, has a high incidence and it affects the quality of life of these patients. Western medicine still lacks effective treatment means. However, with various methods of intervention and treatment, Chinese medicine has made certain progress in this area, where it has good curative effect in improving fatigue and the quality of life of patients. This article briefly summarizes the main TCM treatment methods for cancer-related fatigue in patients with colorectal cancer in order to provide reference and suggestions for clinical practice.

scholarly journals An Activity Tracker–Guided Physical Activity Program for Patients Undergoing Radiotherapy: Protocol for a Prospective Phase III Trial (OnkoFit I and II Trials)

10.2196/28524 ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. e28524
Author(s):  
Franziska Hauth ◽  
Barbara Gehler ◽  
Andreas Michael Nieß ◽  
Katharina Fischer ◽  
Andreas Toepell ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Functional Assessment ◽  
Exercise Program ◽  
Daily Step ◽  
Patients With Cancer ◽  
Activity Tracker ◽  
Cancer Related Fatigue ◽  
Daily Step Count

Background The positive impact that physical activity has on patients with cancer has been shown in several studies over recent years. However, supervised physical activity programs have several limitations, including costs and availability. Therefore, our study proposes a novel approach for the implementation of a patient-executed, activity tracker–guided exercise program to bridge this gap. Objective Our trial aims to investigate the impact that an activity tracker–guided, patient-executed exercise program for patients undergoing radiotherapy has on cancer-related fatigue, health-related quality of life, and preoperative health status. Methods Patients receiving postoperative radiotherapy for breast cancer (OnkoFit I trial) or neoadjuvant, definitive, or postoperative treatment for other types of solid tumors (OnkoFit II trial) will be randomized (1:1:1) into 3-arm studies. Target accrual is 201 patients in each trial (50 patients per year). After providing informed consent, patients will be randomized into a standard care arm (arm A) or 1 of 2 interventional arms (arms B and C). Patients in arms B and C will wear an activity tracker and record their daily step count in a diary. Patients in arm C will receive personalized weekly targets for their physical activity. No further instructions will be given to patients in arm B. The target daily step goals for patients in arm C will be adjusted weekly and will be increased by 10% of the average daily step count of the past week until they reach a maximum of 6000 steps per day. Patients in arm A will not be provided with an activity tracker. The primary end point of the OnkoFit I trial is cancer-related fatigue at 3 months after the completion of radiotherapy. This will be measured by the Functional Assessment of Chronic Illness Therapy-Fatigue questionnaire. For the OnkoFit II trial, the primary end point is the overall quality of life, which will be assessed with the Functional Assessment of Cancer Therapy-General sum score at 6 months after treatment to allow for recovery after possible surgery. In parallel, blood samples from before, during, and after treatment will be collected in order to assess inflammatory markers. Results Recruitment for both trials started on August 1, 2020, and to date, 49 and 12 patients have been included in the OnkoFit I and OnkoFit II trials, respectively. Both trials were approved by the institutional review board prior to their initiation. Conclusions The OnkoFit trials test an innovative, personalized approach for the implementation of an activity tracker–guided training program for patients with cancer during radiotherapy. The program requires only a limited amount of resources. Trial Registration ClinicalTrials.gov NCT04506476; https://clinicaltrials.gov/ct2/show/NCT04506476. ClinicalTrials.gov NCT04517019; https://clinicaltrials.gov/ct2/show/NCT04517019. International Registered Report Identifier (IRRID) DERR1-10.2196/28524

The role of general surgery in the palliative care of patients with cancer

2015 ◽  
Author(s):  
Brian Badgwell ◽  
Robert S. Krouse
Keyword(s):  
Quality Of Life ◽  
Treatment Options ◽  
Symptom Control ◽  
Palliative Surgery ◽  
Common Symptom ◽  
Life Outcomes ◽  
Patients With Cancer ◽  
Increased Risk ◽  
Patient Reported

Palliative surgery is defined as surgical intervention in patients with incurable malignancy for symptoms attributable to their cancer. A considerable percentage of consultations at major cancer centres are palliative in nature, resulting in 13-21% of all operations meeting the criteria for palliative surgery. Common symptom groups for evaluation include gastrointestinal obstruction, wound problems/infections, gastrointestinal bleeding, and obstructive jaundice. This chapter outlines the indications, treatment options, and outcomes for these diagnoses and a few less common indications for surgical consultation. Clinical trials are infrequent in this population and there is a paucity of prospective studies with quality of life outcomes measures. Most studies focus on morbidity and mortality as palliative surgery has long been recognized as having increased risk for complications, although recent studies suggest an improvement in this regard. The benefits of palliative surgery should focus on quality of life, symptom control, and symptom prevention. Future studies will be needed to determine the definitions of success and hopefully include patient-reported outcomes assessment.

Cancer-related fatigue: light therapy: updated meta-analysis of randomised controlled trials

2021 ◽  
pp. bmjspcare-2021-003135
Author(s):  
Chao-Ming Hung ◽  
Bing-Yan Zeng ◽  
Bing-Syuan Zeng ◽  
Cheuk-Kwan Sun ◽  
Yu-Shian Cheng ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Light Therapy ◽  
Controlled Trials ◽  
Patients With Cancer ◽  
Cancer Related Fatigue ◽  
Fatigue Severity ◽  
Randomised Controlled

BackgroundModerate-to-severe cancer-related fatigue occurs in 45% of patients with cancer and interferes with many aspects of quality of life. Although physical exercise has level 1 evidence for improvement of cancer-related fatigue, it has a relatively high behavioural demand compared with other non-pharmacological interventions. The aim of this updated meta-analysis was to address the efficacy of light therapy in improving cancer-related fatigue in patients with cancer.MethodsWe included randomised controlled trials investigating the efficacy of bright white light (BWL) therapy in ameliorating cancer-related fatigue in patients with cancer. This meta-analysis was conducted using a random-effects model. The target outcomes were changes in cancer-related fatigue associated with BWL or dim red light (DRL).ResultsThere were 9 articles with 231 participants included. The main results revealed that daily morning BWL for 30 min was associated with significantly better improvement in fatigue severity compared with DRL (k=5, Hedges’ g=−0.414, 95% CI −0.740 to −0.087, p=0.013). The subgroup without psychiatric comorbidities (k=4, Hedges’ g=−0.479, 95% CI −0.801 to −0.156, p=0.004) was associated with significantly better improvement in fatigue severity with BWL than with DRL. In contrary, BWL was not associated with significantly different changes in depression severity or quality of life compared with DRL. Finally, BWL was associated with similar acceptability (ie, dropout rate) and safety profile (ie, any discomfort) as those of DRL.ConclusionsThis meta-analysis provides an updated evidence on the rationale for application of BWL in ameliorating cancer-related fatigue in patients with different types of cancer.Trial registration numberINPLASY202140090.

Cancer-Related Fatigue

2007 ◽  
Vol 5 (10) ◽  
pp. 1054 ◽  
Author(s):  
_ _
Keyword(s):  
Bone Marrow ◽  
Radiation Therapy ◽  
Cytotoxic Chemotherapy ◽  
Common Symptom ◽  
Patients With Cancer ◽  
Cancer Related Fatigue ◽  
Biologic Response ◽  
Dose Dense ◽  
Recent Version ◽  
Prevalence Of Cancer

Fatigue is a common symptom in patients with cancer and is nearly universal in those undergoing cytotoxic chemotherapy, radiation therapy, bone marrow transplantation, or treatment with biologic response modifiers. The problem, which affects 70% to 100% of cancer patients, has been exacerbated by the increased use of fatigue-inducing multimodal treatments and dose-dense, dose-intense protocols. In patients with metastatic disease, the prevalence of cancer-related fatigue exceeds 75%, and cancer survivors report that fatigue is a disruptive symptom months or even years after treatment ends. Patients perceive fatigue to be the most distressing symptom associated with cancer and its treatment, more distressing even than pain or nausea and vomiting, which, for most patients, can generally be managed with medications. For the most recent version of the guidelines, please visit NCCN.org

scholarly journals Factors Associated to Cancer Related Fatigue: A Literature Review

2020 ◽  
Vol 4 (2) ◽  
pp. 1
Author(s):  
Putu Oka Yuli Nurhesti ◽  
Made Adi Yudari ◽  
Ni Luh Lasiani ◽  
Luh Gede Lisnawati ◽  
Nyoman Mariani
Keyword(s):  
Literature Review ◽  
Cancer Patients ◽  
Scientific Evidence ◽  
Cancer Treatments ◽  
Factors Associated ◽  
Patients With Cancer ◽  
Cancer Related Fatigue ◽  
Psychological Pressure ◽  
Pressure Stress

Cancer related fatigue is one of the common problems that occur in patients with cancer. This condition is also experienced by cancer patients who receive chemotherapy, radiation therapy, bone marrow transplantation, or other cancer treatments. Continued of cancer related fatigue can disturb the quality of life of patients so that a good assessment and management of this condition is needed. The purpose of this study is for factors related to fatigue in cancer patients. These factors can be new scientific evidence for the treatment of fatigue in cancer patients. This was literature review study. Research data is collected from books, research results, journals, magazines and articles related to the research objectives. The results show that various factors associated to cancer related fatigue discussed in patients are hemoglobin level, type and amount of therapy, sleep quality, nutritional status, level of physical activity, psychological pressure, stress, infection status and comorbidities. Therapy on fatigue patients can be done by overcoming the causal factors. Index Terms— cancer, cancer related fatigue, factors associated

Occurrence, severity, and impact of cancer-related fatigue in Taiwanese patients with cancer: A national survey.

2015 ◽  
Vol 33 (29_suppl) ◽  
pp. 77-77
Author(s):  
Ruey Kuen Hsieh ◽  
Shiow-Ching Shun ◽  
Kun-Ming Rau ◽  
Tzeon-Jye Chiou ◽  
Yung-Chuan Sung ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
National Survey ◽  
Well Being ◽  
Common Symptom ◽  
Cancer Related Fatigue ◽  
General Fatigue ◽  
Icd 10 ◽  
The Mean

77 Background: Cancer-related fatigue (CRF) is common symptom in cancer patients. However, there is no study related to occurrence, severity and impact of CRF in Taiwan. The aim of this study was to report the occurrence and severity of CRF, and its impact on quality of life in cancer inpatients and outpatients in Taiwan. Methods: A national survey with cross-sectional study design was used. Patients were recruited from 20 hospitals with inpatients unit (n = 574) and outpatients clinics (n = 633) in Taiwan. The structured questionnaire was used to assess patients’ demographic, clinical, and CRF characteristics among Taiwanese cancer patients. The CRF were assessed by International Classification of Diseases 10th Revision (ICD-10) and Brief Fatigue Inventory–Taiwan Form (BFI-T). Quality of life (QOL) was assessed by FACT-general. Descriptive statistics and bivariate correlations were used to compare the occurrence, severity, and impacts on quality of life of CRF between cancer inpatients and outpatients. Results: Overall, the occurrence was 23.36% based on ICD-10 CRF criteria and 31.9% and 15.6 for inpatients and outpatients, respectively. About94.4% of inpatients and 89.7% of outpatients experienced fatigue. Inpatients had significant higher fatigue severity (current fatigue, general fatigue, and worst fatigue) during the past 24 hours compared to the outpatients. Enjoyment of life was the most interfered by fatigue in both inpatients and outpatients. The mean levels of current fatigue, general fatigue and worst fatigue were moderate in inpatients, and they were mild to moderate in outpatients. The mean score of FACT-general was 17.57 in overall with the lowest level of functional well-being, and 15.68 and 19.29 in inpatients and outpatients. Conclusions: The occurrence based on the ICD-10 CRF criteria was relative low compared to self-report. Fatigue interfered patients’ enjoyment of life and the patients had the lowest level of quality of life in functional well-being. Healthcare providers should pay attention on how to decrease cancer patients’ fatigue in order to improve their QOL, especially in inpatients.

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