scholarly journals Cold urticaria and your risk of anaphylaxis

2021 ◽  
Vol 11 (2) ◽  
pp. 18-23
Author(s):  
Paulo Eduardo Silva Belluco ◽  
Bárbara Garcia Sifuentes ◽  
Maurício Domingues Ferreira
Keyword(s):  
High Risk ◽  
Medical History ◽  
Health Professionals ◽  
Thermal Sensation ◽  
Strong Relationship ◽  
Stimulation Test ◽  
Cold Weather ◽  
Cold Urticaria ◽  
Systemic Reactions ◽  
Made In

Cold urticaria (CU) is characterized by the appearance of wheals or angioedema after exposure to cold. It presents with mild to severe symptoms and can even lead to anaphylaxis. The risk of systemic reactions is high. We discuss this important pathology and show its strong relationship with anaphylaxis. Cold weather is one of the most common triggers for the onset of symptoms, with variables including humidity and thermal sensation. It is divided into acquired or familial forms. The diagnosis is made in patients with a medical history suggestive of the disease and should be confirmed with a stimulation test. The central aspect of treatment is to avoid cold stimuli. The prescription of self-injectable epinephrine for groups that are at high risk of systemic reactions is ideal. In conclusion, health professionals should be aware of CU in order to recognize the risk of anaphylaxis in these patients.

scholarly journals Evaluation of saliva sampling procedures for SARS-CoV-2 diagnostics reveals differential sensitivity and association with viral load

2020 ◽  
Author(s):  
Pieter Mestdagh ◽  
Michel Gillard ◽  
Marc Arbyn ◽  
Jean-Paul Pirnay ◽  
Jeroen Poels ◽  
...  
Keyword(s):  
Viral Load ◽  
High Risk ◽  
Health Professionals ◽  
High Viral Load ◽  
Sampling Procedure ◽  
Differential Sensitivity ◽  
Collection Method ◽  
Viral Loads ◽  
Saliva Collection ◽  
Sampling Procedures

AbstractNasopharyngeal sampling has been the preferential collection method for SARS-CoV-2 diagnostics. Alternative sampling procedures that are less invasive and do not require a healthcare professional would be more preferable for patients and health professionals. Saliva collection has been proposed as such a possible alternative sampling procedure. We evaluated the sensitivity of SARS-CoV-2 testing on two different saliva collection devices (spitting versus swabbing) compared to nasopharyngeal swabs in over 2500 individuals that were either symptomatic or had high-risk contacts with infected individuals. We observed an overall poor sensitivity in saliva for SARS-CoV-2 detection (30.8% and 22.4% for spitting and swabbing, respectively). However, when focusing on individuals with medium to high viral load, sensitivity increased substantially (97.0% and 76.7% for spitting and swabbing, respectively), irrespective of symptomatic status. Our results suggest that saliva cannot readily replace nasopharyngeal sampling for SARS-CoV-2 diagnostics but may enable identification of cases with medium to high viral loads.

scholarly journals Assessing The Thermal Comfort Conditions In Open Spaces: A Transversal Field Survey On The University Campus In India

2021 ◽  
Vol 8 (3) ◽  
pp. 77-92
Author(s):  
Pardeep Kumar ◽  
Amit Sharma
Keyword(s):  
Thermal Comfort ◽  
Air Temperature ◽  
Arid Regions ◽  
Thermal Sensation ◽  
Probit Analysis ◽  
Outdoor Thermal Comfort ◽  
Cold Weather ◽  
Open Spaces ◽  
Physiological Equivalent Temperature ◽  
Preferred Temperature

Outdoor thermal comfort (OTC) promotes the usage frequency of public places, recreational activities, and people's wellbeing. Despite the increased interest in OTC research in the past decade, less attention has been paid to OTC research in cold weather, especially in arid regions. The present study investigates the OTC conditions in open spaces at the campus area in the arid region. The study was conducted by using subjective surveys(questionnaire) and onsite monitoring (microclimate parameters). The study was conducted at the Deenbandhu Chhotu Ram University of Science and Technology, Murthal, Haryana-India campus during the cold season of 2019. The timings of surveys were between 9:00 and 17:00 hours. The authors processed the 185 valid questionnaire responses of the respondents to analyze OTC conditions. Only 8.6% of the respondents marked their perceived sensation "Neutral." Regression analysis was applied between respondents' thermal sensations and microclimate parameters to develop the empirical thermal sensation model. The air temperature was the most dominant parameter affecting the sensations of the respondents. The empirical model indicated that by increasing air temperature, relative humidity, and solar radiation, the thermal sensations also increased while wind speed had an opposite effect. Physiological equivalent temperature (PET) was applied for assessing the OTC conditions; the neutral PET range was found to be 18.42-25.37°C with a neutral temperature of 21.89°C. The preferred temperature was 21.99 °C by applying Probit analysis. The study's findings could provide valuable information in designing and planning outdoor spaces for educational institutions in India's arid regions

Some Pain, Some Gain: Reflections on the Past Two Decades of Neonatal Pain Research and Treatment

2002 ◽  
Vol 21 (5) ◽  
pp. 37-41 ◽  
Author(s):  
Linda Franck
Keyword(s):  
Health Professionals ◽  
Future Research ◽  
Pain Research ◽  
Attitudes And Practices ◽  
Neonatal Pain ◽  
The Past ◽  
New Directions ◽  
Infant Pain ◽  
Made In

This review reflects back on the progress that has been made in infant pain research over the past 20 years and how the research has influenced (or has failed to influence) the attitudes and practices of health professionals about infant pain. Progress in understanding of infant pain neurobiology, treatment, and measurement are discussed, and new directions for future research are proposed.

scholarly journals MacchiariniGate: The Fall from Grace of Stem Cell Healer, Paolo Macchiarini, and Clues and Concerns from the Early Literature that Cast Ethical Doubts

2018 ◽  
Vol 9 (1) ◽  
pp. 1-12
Author(s):  
Jaime A. Teixeira Da Silva
Keyword(s):  
Lung Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
High Risk ◽  
Domino Effect ◽  
Nobel Committee ◽  
Tracheal Surgery ◽  
High Profile ◽  
Ethical Approval ◽  
Made In

After a long and successful career in tracheal surgery and lung cancer, Paolo Macchiarini became very famous in 2008 with the transplantation of a trachea from a cadaver that then apparently used the patient’s own stem cells to supposedly regenerate new trachea, i.e., tissue-engineered tracheae. Among the nine patients that received this revolutionary treatment, using biological or artificial tracheae, under Macchiarini’s supervision, six have reportedly died. Although several critics had expressed concerns with the procedures, allegations of misconduct against Macchiarini first arose in August of 2014 by four Karolinska Institutet (KI) colleagues, and an independent investigation was called for by KI based on claims made in seven published papers. Among the claims were the fact that the procedure constituted a high risk, information on the patients was incomplete and that there was no or incomplete ethical approval, thus constituting misconduct. His CV was also shown to contain inaccuracies. By September 10, 2016, most of these claims have now proved to be true, and Macchiarini was found guilty of misconduct by KI. This paper looks primarily at earlier published papers by Macchiarini and his collaborators in a search for clues to better understand the evolution of altruism, or narcissism. An assessment of the controversial papers, and of letters written by critics and skeptics like Pierre R. Delaere, indicate that insufficient experimental evidence was presented for several case studies, and that claims made about the success of the procedures exceeded what was shown by the evidence. A domino effect of personal and professional tragedies ensued, in rapid succession, between 2014 and 2016. The effect on the field of stem cell research has been chilling, and the side-effects have taken their toll, with several high-profile resignations, primarily at KI, within the Swedish education system and in the Nobel Committee. This case has mesmerized the bioethics and biomedical communities for years.   

The Dynamics of Failing Service Delivery in Nigeria and Ghana

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Mary S Mangai
Keyword(s):  
Service Delivery ◽  
Public Service ◽  
Public Services ◽  
Strong Relationship ◽  
Government Performance ◽  
Public Service Delivery ◽  
Sub Saharan ◽  
Donor Agencies ◽  
Made In

This article compares the quality of service delivery in Nigeria and Ghana in the areas of healthcare, food provision and access to clean water and sanitation. Its first finding is that public service delivery in the two countries has been perceived as inadequate and deteriorating for over a decade. Therefore, this paper concludes that Nigeria and Ghana are lagging behind in the provision of basic public services for their citizens and need to re-orient their service delivery. Governments in sub-Saharan countries are working with donor agencies at the forefront of combating poverty through a number of interventions to improve the delivery of public services. Notwithstanding these good intentions, few results have been achieved so far, especially considering the massive investment made in attempts to reduce poverty in this region. The outcomes of this research suggest a strong relationship between household satisfaction and problems experienced in service delivery in these areas. They also show that satisfaction with public service delivery involves more than government performance. Political, geographical and demographic factors are also important predictors.

Internet Use by Patients with Lymphoma and Caregivers.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 5532-5532
Author(s):  
Antonia A. Garcia-Nieto ◽  
Soledad S. Duran ◽  
Maria Carmen M.C. Fernandez-Valle ◽  
Eduardo E. Rios ◽  
Juan Nicolas J.N. Rodriguez ◽  
...  
Keyword(s):  
Information Search ◽  
Health Professionals ◽  
Internet Use ◽  
Spanish Language ◽  
Second Opinion ◽  
The Internet ◽  
Important Resource ◽  
Health And Illness ◽  
Use Of Internet ◽  
Made In

Abstract The Internet is changing the way that people learn about health and illness. At present do not exist data of the use of Internet by patients of lymphoma and her caregivers in Spain. OBJECTIVE: To investigate the distribution and patterns of Internet use by patients with lymphoma and her caregivers. PATIENTS AND METHODS: 585 subjects (258 patients, 264 relatives and 63 health professionals), 228 male and 357 female, they have responded a questionnaire on diverse aspects of the use of Internet. RESULTS: Two hundred fifty (42,7%) subjects use Internet, although only 27% make to obtain data on lymphoma. With respect to the group of patients 31% recognize to use Internet, but only the 23,3% do it by questions related to their disease. The main reasons for Internet use are to obtain information about treatments (74.7%) or second opinion medical (9.3%). The 77,6% have been using Internet for more than 3 years; the 47,2% have university studies and the 58,4% have between 33–50 years. Mainly the information search is made in Spanish language and through the Google finder. They consider that Information on lymphoma is acceptable (44.9%) or of enough quality (43.7%), trustworthy (50.6%) or of enough reliability (33.5%) and useful (45.6%) or quite useful (37.3%). COMMENTARIES: This study contributes data on the use of Internet by patients with lymphoma and her caregivers in Spain. Oncologists should be familiar with this important resource to help patients access appropriate material.

Evaluation of the prognostic value of guanylyl cyclase C (GCC) lymph node (LN) classification in patients with stage II colon cancer: A pooled analysis.

2012 ◽  
Vol 30 (4_suppl) ◽  
pp. 443-443
Author(s):  
Daniel J. Sargent ◽  
Qian Shi ◽  
Murray B. Resnick ◽  
Stephen Lyle ◽  
Michael O. Meyers ◽  
...  
Keyword(s):  
Colon Cancer ◽  
High Risk ◽  
Clinical Outcomes ◽  
Prognostic Value ◽  
Disease Free Survival ◽  
Strong Relationship ◽  
Low Risk ◽  
Stage Ii ◽  
Risk Status ◽  
Cox Models

443 Background: Identification of a sensitive and specific prognostic marker would aid in the management of patients (pts) with standard histopathology node negative colon cancer (CC). We conducted a pooled individual pt data analysis to confirm the prognostic value of GCC for disease recurrence in untreated stage II CC. Methods: GCC mRNA was quantified by RT-qPCR using formalin-fixed LN from 310 stage II pts diagnosed from 1991-2006 enrolled in two studies (Sargent 2011 [study1] and Haince 2009 [study2]). Patients were classified by GCC LN ratio (LNR) (high risk: LNR ≥ 0.1; low risk: LNR < 0.1), with LNR defined as number of GCC positive LN divided by number of informative LNs. Clinical outcomes included time to recurrence (TTR), overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS). Stratified log-rank tests and multivariate Cox models assessed the association between clinical outcomes and GCC LN status. Results: The 5-year recurrence rate in study 1 (n=241) was 15.8%, 24.9% in study 2 (n=69). GCC LNR high risk pts had significantly higher risk of TTR, OS, DSS and DFS, which remained after adjusting for age, T stage, grade, number of LNs examined, and presence of lymphovascular invasion ( Table ). In a secondary analysis of low risk stage II pts (T3, ≥12 LNs examined, and negative surgical margins, n=241), a strong relationship between GCC LNR and each endpoint remained (TTR HR=4.34, 95% CI=2.07 – 9.13, p<0.001). Conclusions: Pts with GCC LNR high risk status have significantly poorer outcomes compared to pts with low risk status, particularly among those traditionally considered to be low risk. [Table: see text]

Sign in / Sign up

Export Citation Format

Share Document