Research and Application Progress of Insect Antimicrobial Peptides on Food Industry

2010 ◽  
Vol 6 (6) ◽  
Author(s):  
Wei Zhao ◽  
Lixin Lu ◽  
Yali Tang
Keyword(s):  
Antimicrobial Peptides ◽  
Crucial Role ◽  
Food Industry ◽  
Eukaryotic Cells ◽  
Food Preservatives ◽  
Significant Group ◽  
Antimicrobial Spectrum ◽  
Existing Problems ◽  
Low Toxicity ◽  
Heat Tolerant

With several desirable properties, such as heat-tolerant, relatively broad antimicrobial spectrum and low toxicity to eukaryotic cells, antimicrobial peptides (AMPs)—especially the “food-derived antimicrobial peptides”—may serve as a potentially significant group of food preservatives. Insects produce a variety of AMPs that play a crucial role in protecting them from invading microorganisms. This article overviews research and application progress of insect antimicrobial peptides on food industry, especially the existing problems for AMPs, which might be contributive in designing new and promising antimicrobial peptides for food preservatives.

scholarly journals Varied-shaped gold nanoparticles with nanogram killing efficiency as potential antimicrobial surface coatings for the medical devices

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ewelina Piktel ◽  
Łukasz Suprewicz ◽  
Joanna Depciuch ◽  
Sylwia Chmielewska ◽  
Karol Skłodowski ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Medical Devices ◽  
Multidrug Resistant ◽  
Resistance Mechanisms ◽  
Antimicrobial Spectrum ◽  
Antimicrobial Coatings ◽  
Low Toxicity ◽  
Spherical Gold Nanoparticles ◽  
Cost Efficient ◽  
Bactericidal Efficiency

AbstractMedical device-associated infections are a serious medical threat, particularly for patients with impaired mobility and/or advanced age. Despite a variety of antimicrobial coatings for medical devices being explored to date, only a limited number have been introduced for clinical use. Research into new bactericidal agents with the ability to eradicate pathogens, limit biofilm formation, and exhibit satisfactory biocompatibility, is therefore necessary and urgent. In this study, a series of varied-morphology gold nanoparticles in shapes of rods, peanuts, stars and spherical-like, porous ones with potent antibacterial activity were synthesized and thoroughly tested against spectrum of Candida albicans, Pseudomonas aeruginosa, Staphylococcus aureus clinical strains, as well as spectrum of uropathogenic Escherichia coli isolates. The optimization of gold nanoparticles synthesis allowed to develop nanomaterials, which are proved to be significantly more potent against tested microbes compared with the gold nanoformulations reported to date. Notably, their antimicrobial spectrum includes strains with different drug resistance mechanisms. Facile and cost-efficient synthesis of gold nanoparticles, remarkable bactericidal efficiency at nanogram doses, and low toxicity, underline their potential for development as a new coatings, as indicated by the example of urological catheters. The presented research fills a gap in microbial studies of non-spherical gold nanoparticles for the development of antimicrobial coatings targeting multidrug-resistant pathogens responsible for device-associated nosocomial infections.

scholarly journals Mitochondrial Protein Network: From Biogenesis to Bioenergetics in Health and Disease

2020 ◽  
Vol 22 (1) ◽  
pp. 1
Author(s):  
Alessandra Ferramosca
Keyword(s):  
Crucial Role ◽  
Mitochondrial Protein ◽  
Protein Network ◽  
Eukaryotic Cells ◽  
Double Membrane ◽  
Health And Disease ◽  
Membrane Bound

Mitochondria are double membrane-bound organelles which are essential for the viability of eukaryotic cells, because they play a crucial role in bioenergetics, metabolism and signaling [...]

Antimicrobial peptides of the genus Bacillus: a new era for antibiotics

2015 ◽  
Vol 61 (2) ◽  
pp. 93-103 ◽  
Author(s):  
Chandra Datta Sumi ◽  
Byung Wook Yang ◽  
In-Cheol Yeo ◽  
Young Tae Hahm
Keyword(s):  
Antimicrobial Peptides ◽  
Well Being ◽  
Rapid Onset ◽  
Antibacterial Drug ◽  
Genus Bacillus ◽  
Antimicrobial Drugs ◽  
Food Preservatives ◽  
New Era ◽  
Peptide Biosynthesis ◽  
Conventional Antibiotics

The rapid onset of resistance reduces the efficacy of most conventional antimicrobial drugs and is a general cause of concern for human well-being. Thus, there is great demand for a continuous supply of novel antibiotics to combat this problem. Bacteria-derived antimicrobial peptides (AMPs) have long been used as food preservatives; moreover, prior to the development of conventional antibiotics, these AMPs served as an efficient source of antibiotics. Recently, peptides produced by members of the genus Bacillus were shown to have a broad spectrum of antimicrobial activity against pathogenic microbes. Bacillus-derived AMPs can be synthesized both ribosomally and nonribosomally and can be classified according to peptide biosynthesis, structure, and molecular weight. The precise mechanism of action of these AMPs is not yet clear; however, one proposed mechanism is that these AMPs kill bacteria by forming channels in and (or) disrupting the bacterial cell wall. Bacillus-derived AMPs have potential in the pharmaceutical industry, as well as the food and agricultural sectors. Here, we focus on Bacillus-derived AMPs as a novel alternative approach to antibacterial drug development. We also provide an overview of the biosynthesis, mechanisms of action, applications, and effectiveness of different AMPs produced by members of the Bacillus genus, including several recently identified novel AMPs.

scholarly journals Biological activities of basil essential oil: a review of the current evidence

2021 ◽  
Vol 10 (12) ◽  
pp. e363101220409
Author(s):  
Mayara Zagoto ◽  
Gabriel Fernando Esteves Cardia ◽  
Edvalkia Magna Teobaldo da Rocha ◽  
Kathia Socorro Mathias Mourão ◽  
Vanderly Janeiro ◽  
...  
Keyword(s):  
Essential Oil ◽  
Biological Activities ◽  
Current Evidence ◽  
Future Research ◽  
Existing Problems ◽  
Treatment And Prevention ◽  
Low Toxicity ◽  
Pharmacological Potential ◽  
Clinical Conditions ◽  
Insight Into

Currently, natural products are being used as a therapeutic alternative in the treatment and prevention of several diseases due to their low toxicity and relevant pharmacological potential. Thus, we can highlight basil (Ocimum basilicum L), one of the most used aromatic plants worldwide. Therefore, we provide some current evidence and insight into the potential therapeutic effect of basil essential oil to expand the available knowledge. A narrative review was carried out by searching electronic databases, providing a comprehensive analysis of the literature, where it was possible to identify existing problems and gaps to facilitate future research on basil essential oil. The available literature on basil essential oil presents us with several important pharmacological activities, such as: antioxidant, antiviral, antimicrobial, analgesic, anti-inflammatory, and analgesic and diuretic properties, among others. However, further research must be carried out to increase knowledge about this plant with enormous potential and determine its effectiveness and use in clinical conditions.

scholarly journals Mini Review on Antimicrobial Peptides, Sources, Mechanism and Recent Applications

2019 ◽  
Vol 27 (1) ◽  
pp. 4-16 ◽  
Author(s):  
Jaspreet Kaur Boparai ◽  
Pushpender Kumar Sharma
Keyword(s):  
Antimicrobial Peptides ◽  
Biological Diversity ◽  
Therapeutic Potential ◽  
High Specificity ◽  
New Era ◽  
Therapeutic Drugs ◽  
Therapeutic Peptides ◽  
Low Toxicity ◽  
Pharmaceutical Industries ◽  
Micro Organisms

Antimicrobial peptides in recent years have gained increased interest among scientists, health professionals and the pharmaceutical companies owing to their therapeutic potential. These are low molecular weight proteins with broad range antimicrobial and immuno modulatory activities against infectious bacteria (Gram positive and Gram negative), viruses and fungi. Inability of micro-organisms to develop resistance against most of the antimicrobial peptide has made them as an efficient product which can greatly impact the new era of antimicrobials. In addition to this these peptides also demonstrates increased efficacy, high specificity, decreased drug interaction, low toxicity, biological diversity and direct attacking properties. Pharmaceutical industries are therefore conducting appropriate clinical trials to develop these peptides as potential therapeutic drugs. More than 60 peptide drugs have already reached the market and several hundreds of novel therapeutic peptides are in preclinical and clinical development. Rational designing can be used further to modify the chemical and physical properties of existing peptides. This mini review will discuss the sources, mechanism and recent therapeutic applications of antimicrobial peptides in treatment of infectious diseases.

Clinical Applications of Antimicrobial Peptides (AMPs): Where do we Stand Now?

2020 ◽  
Vol 27 (2) ◽  
pp. 120-134 ◽  
Author(s):  
Mithoor Divyashree ◽  
Madhu K. Mani ◽  
Dhanasekhar Reddy ◽  
Ranjith Kumavath ◽  
Preetam Ghosh ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Molecular Mechanisms ◽  
Metabolic Diseases ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Noncommunicable Diseases ◽  
Multi Drug Resistance ◽  
Food Preservatives ◽  
Pharmaceutical Industries

: In this era of multi-drug resistance (MDR), antimicrobial peptides (AMPs) are one of the most promising classes of potential drug candidates to combat communicable as well as noncommunicable diseases such as cancers and diabetes. AMPs show a wide spectrum of biological activities which include antiviral, antifungal, anti-mitogenic, anticancer, and anti-inflammatory properties. Apart from these prospective therapeutic potentials, the AMPs can act as food preservatives and immune modulators. Therefore, AMPs have the potential to replace conventional drugs and may gain a significant global drug market share. Although several AMPs have shown therapeutic potential in vitro or in vivo, in most cases they have failed the clinical trial owing to various issues. In this review, we discuss in brief (i) molecular mechanisms of AMPs in various diseases, (ii) importance of AMPs in pharmaceutical industries, (iii) the challenges in using AMPs as therapeutics and how to overcome, (iv) available AMP therapeutics in market, and (v) AMPs under clinical trials. Here, we specifically focus on the therapeutic AMPs in the areas of dermatology, surgery, oncology and metabolic diseases.

Anaflex and noxyflex: low-toxicity antiseptics

1970 ◽  
Vol 8 (20) ◽  
pp. 79-80
Keyword(s):  
Organic Material ◽  
Systemic Administration ◽  
The Body ◽  
Antibacterial Action ◽  
Hypersensitivity Reactions ◽  
Antimicrobial Spectrum ◽  
Antibiotic Resistant ◽  
Low Toxicity

The use of antibiotics on the surface of the body or in its cavities is often undesirable because of the risks of encouraging the emergence of antibiotic-resistant organisms and of causing hypersensitivity reactions. Antiseptics, substances with an antibacterial action but not suitable for systemic administration, are therefore useful if they have a very broad antimicrobial spectrum, negligible tissue toxicity and allergenicity, and high and rapid activity in the presence of excess organic material. A group of hydroxymethylurea antiseptics, represented by polynoxylin and noxytiolin, possess many of these properties.

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