scholarly journals Features of cytokine balance with the progression of structural changes in the gastric mucosa in patients with atrophic gastritis

2021 ◽  
Vol 55 (2) ◽  
pp. 67-73
Author(s):  
L.M. Mosyichuk ◽  
O.M. Tatarchuk ◽  
O.V. Simonova ◽  
O.P. Petishko
Keyword(s):  
Gastric Mucosa ◽  
Blood Serum ◽  
Atrophic Gastritis ◽  
Structural Changes ◽  
Mucosal Atrophy ◽  
Group Iii ◽  
Gastric Mucosal Atrophy ◽  
Cytokine Balance ◽  
Group I ◽  
Mucosal Dysplasia

Background. Until now, the issue of the correlation between the cytokine balance and the progression of structural changes in the gastric mucosa remain completely uncertain. At the same time, the determination of the role of cytokine ba­lance as a component of gastric carcinogenesis will make it possible to substantiate new approaches to managing patients with atrophic gastritis. The purpose was to assess the level of pro- and anti-inflammatory cytokines, vascular endothelial growth factor (VEGF) at the stages of progression of structural changes in the gastric mucosa of patients with atrophic gastritis. Materials and methods. The study included 79 individuals with atrophic gastritis who underwent narrow band imaging endoscopic examination. The patients were divided into groups taking into account the revealed structural changes in the gastric mucosa: group I — 7 people with gastric mucosal atrophy without intestinal metaplasia (IM); group II — 16 individuals with gastric mucosal atrophy with IM limited by the antrum; group III — 45 people with diffuse IM against the background of gastric mucosal atrophy; group IV — 10 individuals with gastric mucosal dysplasia. In all patients, we assessed the level of interleukins (IL-8, IL-10, IL-18), tumor necrosis factor alpha (TNF-α), VEGF. Results. In patients of group IV, the concentration of IL-8 in the blood serum was 18.6 (11.3; 23.9) pg/ml that was significantly higher than in group I (by 5.0 times, p < 0.05), group II (by 3.6 times, p < 0.05) and group III (by 3.4 times, p < 0.05). According to the results of the Kruskal-Wallis test, the probability of a difference in the IL-8 level between the groups was 0.0260. The level of VEGF in the blood serum of patients with gastric mucosal dysplasia was significantly increased compared to that in people with gastric mucosal atrophy without IM (by 1.8 times, p < 0.05) and those with gastric mucosal atrophy with IM (by 1.7 times, p < 0.05). Changes in the cytokine balance towards proinflammatory cytokines were most pronounced in patients of groups III and IV; according to the results of the Kruskal-Wallis test, the probability of a difference in the IL-8/IL-10 ratio between the groups was 0.0207. Conclusions. With the progression of structural changes in the gastric mucosa of patients with atrophic gastritis, an increase in the level of proinflammatory cytokines (IL-8, IL-18 and TNF-α) in the blood serum does not induce the secretion of anti-inflammatory cytokines (IL-10). According to the results of the ROC analysis, the diagnostic criteria for the formation of the risk group for detecting dysplastic changes in the gastric mucosa are VEGF level of more than 341.4 mU/ml (sensitivity — 90.0 %, specificity — 77.2 %) and the level of IL-8 above 14.4 pg/ml (sensitivity — 80.0 %, specificity — 78.3 %).

The effect of MgSO4 addition and the increasing doses of calcium and phosphorus during ending drying period on the occurrence of hypocalcaemia and hypophosphataemia in dairy cows

2013 ◽  
Vol 16 (4) ◽  
pp. 655-662 ◽  
Author(s):  
R. Bodarski ◽  
S. Kinal ◽  
J. Preś ◽  
M. Słupczyńska ◽  
J. Twardoń
Keyword(s):  
Blood Serum ◽  
Magnesium Sulphate ◽  
Group Iv ◽  
Dry Period ◽  
Urine Ph ◽  
Inorganic P ◽  
Group Iii ◽  
Group I ◽  
Salt Addition ◽  
Group Ii

Abstract The aim of the presented study was the estimation of optimal Ca and P levels applied before calving together with anionic salt addition, as an element of hypocalcaemia and hypophosphataemia prevention. The experiment was carried out during the dry period on 48 cows with similar milk yield in the previous lactation. Cows were divided into four groups. In group I (control) the amount of minerals was in accordance to NRC standards. In experimental groups (groups II-IV), two weeks before calving, cows received 140 g/day/head of hydrated magnesium sulphate to achieve dietary cation- anion difference at the level of about 50 mEq/kg DM. In groups II and III cows received calcium carbonate (100 g/day) 10 days a.p. (antepartum) (group II), or 5 days a.p. (group III), while cows in IV group received dicalcium phosphate (100 g/day) for 5 days a.p. Application of MgSO4 × 7H2O significantly affected the urine pH of cows from group III and IV 4-5 d. before calving - 6.45 and 6.81, respectively. The acidification of urine was observed after calving in group IV (7.13). In cows from group II (100 CaCO3 10 days a.p.) urine pH decline was not found (7.97-7.75). In that group the incidences of hypophosphatemia were noted (blood serum inorganic P level 1.41-1.46 mmol/l). Addition of magnesium sulphate prevented hypocalcaemia occurrence - 4-5 d. before calving the concentration of ionized Ca in blood serum was 1.11, 1.13 and 1.16 mmol/l (respectively for group II, III and IV). Reproductive functions were significantly improved after the application of CaCO3 and CaHPO4 for 5 days a.p. in comparison with control and group II - progesterone concentration in the blood serum on the 45th day of lactation was 1.396 - 1.409 vs 0.799 - 0.401. The correlation between progesterone and inorganic P level in serum was almost significant. Based on the obtained results a treatment optimal in prevention of hypocalcaemia and hypophosphataemia is the application of 50 g CaCO3 and 50 g of CaHPO4 for the last 5 days of the dry period together with MgSO4 × 7H2O given for 14 days a.p.

scholarly journals Effect of organic and mineral selenium sources on production performance and selected physiological indicators in swine

2017 ◽  
Vol 73 (12) ◽  
pp. 756-763
Author(s):  
Anna Szuba-Trznadel ◽  
Tomasz Hikawczuk ◽  
Adam Ciura ◽  
Bogusław Fuchs
Keyword(s):  
Amino Acid ◽  
Blood Serum ◽  
Production Performance ◽  
Control Group ◽  
Lactation Period ◽  
Feed Conversion ◽  
Group Iii ◽  
Group I ◽  
Acid Chelate ◽  
Group Ii

The study was conducted on sows (hybrids of wbp × pbz breeds) and their offspring (until day 75 of life) kept on a farm. The aim of the experiment was to compare the effects of different sources of selenium (Se) on the production performance of the animals, Se content in their blood, the level of Se in sow’s colostrum, as well as Gpx, haptoglobin and immunoglobulin levels in the serum of sows and their offspring. Experimental feed mixtures for pregnant sows (LP), lactating sows (LK) and piglets (prestarter and starter) in each treatment had an identical basic composition, differing only in the type of selenium forms. Group I received a mineral form of Se in an amount of 0.2 mg/kg; group II received a mixture of a Se amino acid chelate and the mineral form of Se (0.1 mg/kg of each); group III received a Se amino acid chelate (0.2 mg/kg), and group IV received Se-enriched yeasts (0.2 mg/kg). Beneficial effects of the organic forms of Se were evident already in the lactation period. Sows, especially those from group II receiving 0.2 mg/kg of organic Se, had a higher feed intake, which was related to a higher milk production during lactation. As a result, on the weaning day, piglets from this group were significantly heavier than the other piglets. After weaning, as well, the piglets in this group were significantly heavier. These results were confirmed by parameters of blood serum and whey colostrum. Selenium as a chelate was more available than the mineral and enriched yeast forms. For this reason, the animals receiving the chelate were healthier (fewer inflammations were noted). The animals in this group also showed a better feed conversion compared with the others. The Gpx level in sows’ serum varied depending on the treatment. The highest level of this parameter was determined in sows from group III (receiving 0.2 mg/kg of organic Se), and it differed significantly from its value in the control group. The results showed that the Gpx level was related to the Se concentration in blood serum, which was also confirmed by a higher production of selenocysteine (a part of Gpx). Cells of the animals from this group were better protected against free radicals. Administration of 0.1 mg/kg of organic Se positively affects the performance of animals, but the recommended level in feed is 0.2 mg/kg of a selenium-containing amino acid....

scholarly journals Formation features of humoral immunity in newborn calves in case of including haylage with bio-preservative into the diet of cows

2021 ◽  
Vol 273 ◽  
pp. 02008
Author(s):  
Anna Karamaeva ◽  
Larisa Bakaeva ◽  
Natalia Soboleva ◽  
Sergey Karamaev
Keyword(s):  
Blood Serum ◽  
Milk Yield ◽  
Humoral Immunity ◽  
Immune Status ◽  
The Body ◽  
Group Iii ◽  
First Feeding ◽  
Group I ◽  
Newborn Calves ◽  
Group Ii

The peculiarities of the formation of colostrum in the udder of cows and the immune status in the body of calves in the first hours and days after birth, when included in the diet of cows, haylage from eastern goat’s rue prepared with the use of bio-preservatives “Silostan” (group II) and “GreenGrass 3 × 3”(Group III). The study of colostrum of the first milk yield showed that feeding cows with silage with the bio-preservative “Silostan” contributed to an increase in the content of immunoglobulins by 4.0% (Р<0,001), with bio-preservative “GreenGras 3 × 3” - by 5.3% (Р<0,001). After drinking the first portion of colostrum, immunoglobulins appear in the blood serum of calves after 2 hours. After 6 hours, the content of immunoglobulins in the blood serum of calves of group II was 21.9% higher than in group I (haylage without preservative) (P < 0.05), group III - by 27.1% (P <0.001). The proportion of calves with an immunoglobulin content 6 hours after the first feeding with colostrum not more than 6.0 mg / ml, decreased in group II by 12.0%, in group III - by 20.0%.

Comparative Study on the Effect of Adipose tissue derived Mesenchymal Stem Cells versus Metformin on Age-related Structural Changes of the Cerebellum in Albino Rat

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
M. M Doaa Karem ◽  
Soheir K Ahmed ◽  
Hanan A Saleh ◽  
Ghada Galal Hamam
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Purkinje Cells ◽  
Structural Changes ◽  
Female Rats ◽  
Group Iii ◽  
Age Related ◽  
Group I ◽  
Group Ii

Abstract Introduction Aging is a normal physiological process that affects all organs in the body including the cerebellum. Metformin is an anti-diabetic drug that is used in some age-related diseases. Regenerative medicine using adipose tissue derived mesenchymal stem cells (ADMSCs) is an emerging promising strategy. Aim to compare between the role of ADMSCs and metformin on the age-related structural changes of the cerebellum in female albino rats. Materials and methods Fifty-five female rats of different ages (4, 12 and 24 months) were included in this study. They were divided into three groups according to their ages: Group I (Adult rats), Group II (Old rats) and Group III (Senile rats). Group II and Group III were subdivided into three subgroups, Subgroup a: rats were left without treatment, Subgroup b: rats were given a single dose of 1X106 ADMSCs via tail vein. Subgroup c: Rats received300 mg/kg metformin/day orally. Rats were sacrificed after four weeks. The cerebellum was collected and processed for H&E, Toluidine blue and immuno-histochemical reaction using glial fibrillary acidic protein (GFAP). Results Histological examination of the cerebellum of the subgroups IIa and IIIa revealed age-related structural changes in comparison to group I. Purkinje cells appeared distorted with irregular outline. Some Purkinje cells were seen shrunken while others appeared ballooned. Focal loss of Purkinje cells was also noticed. Granular layer contained small widely separated granule cells. GFAP reaction revealed an apparent decrease in number of astrocytes and their processes. The structural changes were more obvious in subgroup IIIa. In ADMSCs treated subgroups (IIbandIIIb); more noticeable improvement of these changes was noticed compared to the corresponding metformin treated subgroups (IIc and IIIc). Conclusion ADMSCs was more effective than metformin in preventing some age-related structural changes of the cerebellum.

scholarly journals The Correlation of PPARαActivity and Cardiomyocyte Metabolism and Structure in Idiopathic Dilated Cardiomyopathy during Heart Failure Progression

PPAR Research ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
E. Czarnowska ◽  
D. Domal-Kwiatkowska ◽  
E. Reichman-Warmusz ◽  
J. B. Bierla ◽  
A. Sowinska ◽  
...  
Keyword(s):  
Structural Changes ◽  
Time Window ◽  
Structural Characteristics ◽  
Cardiac Metabolism ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Entire Study ◽  
Glycogen Accumulation ◽  
Group Iii ◽  
Group I ◽  
Group Ii

This study aimed to define relationship between PPARαexpression and metabolic-structural characteristics during HF progression in hearts with DCM phenotype. Tissue endomyocardial biopsy samples divided into three groups according to LVEF ((I) 45–50%,n=10; (II) 30–40%,n=15; (III) <30%,n=15; and control (donor hearts, >60%,n=6)) were investigated. The PPARαmRNA expression in the failing hearts was low in Group (I), high in Group (II), and comparable to that of the control in Group (III). There were analogous changes in the expression of FAT/CD36 and CPT-1 mRNA in contrast to continuous overexpression of GLUT-4 mRNA and significant increase of PDK-4 mRNA in Group (II). In addition, significant structural changes of cardiomyocytes with glycogen accumulation were accompanied by increased expression of PPARα. For the entire study population with HF levels of FAT/CD36 mRNA showed a strong tendency of negative correlation with LVEF. In conclusion, PPARαelevated levels may be a direct cause of adverse remodeling, both metabolic and structural. Thus, there is limited time window for therapy modulating cardiac metabolism and protecting cardiomyocyte structure in failing heart.

scholarly journals PECULIARITIES OF STRUCTURAL CHANGES IN BRAIN OF PATIENTS WITH HYPERTENSION, HYPOTHYROIDISM AND DURING THE COMORBID COURSE OF THESE TWO DISEASES

2020 ◽  
Vol 20 (4) ◽  
pp. 67-71
Author(s):  
M.I. Lesiv ◽  
V.A. Hryb
Keyword(s):  
Frontal Lobe ◽  
Gray Matter ◽  
Structural Changes ◽  
Structural Parameters ◽  
Control Group ◽  
Group Iii ◽  
Average Value ◽  
Group I ◽  
Significant Difference ◽  
The Brain

This article presents the investigation of structural parameters of the brain in 67 patients aged 47.23 ± 2.64 years, whose duration of the disease was 13.27 ± 0.75 (from 2 to 19) years. The control group included 18 healthy individuals of the same age (47.84 ± 0.36 years), whose selection was carried out based on the anamnesis and the absence of hypothyroidism and hypertension. According to the data we discussed in our previous publications, during neuropsychological testing we registered memory deterioration in patients with hypertension assessed by the test for learning 10 words according to the method proposed by A.R. Luria (p <0.05), as well as serial counting by the Matisse scale (p <0.05). The patients with hypothyroidism were found as demonstrating attention deficiency (p <0.05) by applying the method of "Selectivity of attention" (G. Munsterberg test). For more detailed assessment, we used Schulte tables, the result of which demonstrates the state of the domain of the patient's executive functions and proves the instability of attention. The analysis of the results showed that taking into account the interaction between hypertension and hypothyroidism, the most affected cognitive domains were memory and attention, respectively (p <0.05). To diagnose cognitive and mnestic disorders of all groups, we used MR imaging, measured the transverse dimensions of the medial, lateral (temporal horn) and vertical perihippocampal spaces, and evaluated the volume of gray matter (cortex) of the frontal lobe of the brain in 3 zones. The measurements were performed in the right and left hemispheres. There was a significant increase in the indices of the medial and upper perihippocampal right and left in the patients in group III compared with the groups I and II. The lateral perihypocampal index did not differ significantly in the three groups (p> 0.05). Thus, taking into account the interaction of factors (hypertension and hypothyroidism), the patients were found to have an increase in perihippocampal indices (p> 0.05). Based on the data in table 2, in the patients of group I the average value of the frontal lobe was 634.06 ± 10.92. In the patients of group II, the average value of the frontal lobe was 638.6 ± 7.82, and in the patients of group III, the average value of the frontal lobe was 601.3 ± 3,325. There was no statistically significant difference between groups I and II (p = 0.05). But groups I and III demonstrated statistically significant difference between the indicators (p <0.05). We also found a statistically significant difference between groups II and III (p <0.05). Thus, in patients with hypertension, hypothyroidism and hypertension with concomitant hypothyroidism, an increase in perihippocampal indices, a decrease in the volume of gray matter (cortex) of the frontal lobe of the brain (right and left), significantly exceeded possible (involutional or otherwise). Thus, the results of the study indicate that in cases of isolated hypertension, hypothyroidism, and in the comorbidity of hypertension and hypothyroidism, there has been detected a significant acceleration of atrophic processes.

scholarly journals CHRONIC GASTRITIS CLINICAL FEATURES AND STOMACH FUNCTIONAL STATE DURING NONSTEROIDAL ANTI-INFLAMMATORY DRUGS ADMINISTRATION IN PATIENTS WITH OSTEOARTHRITIS

2016 ◽  
Vol 5 ◽  
pp. 17-22
Author(s):  
Maxim Zak ◽  
Lyudmila Pasiyeshvili
Keyword(s):  
Protective Factors ◽  
Atrophic Gastritis ◽  
Clinical Features ◽  
Chronic Gastritis ◽  
Group Iii ◽  
Group I ◽  
Gastric Contents ◽  
Inflammatory Drugs ◽  
Group Ii ◽  
Selective Nsaid

Aim. Determination of chronic gastritis clinical features and stomach functional state during nonsteroidal anti-inflammatory drugs (NSAID) administration in patients with osteoarthritis (OA). Materials and methods. 122 patients with OA and verified chronic gastritis (CG) (50 males and 72 females) aged 42 to 64 years (mean age – 49.65±3.51) were observed. Depending on gastritis morphological form, patients were divided into 2 groups: 54 patients with OA in combination with non-atrophic gastritis (NAG) were included into the group I, 68 patients with OA in combination with atrophic gastritis (AG) – into group II. 40 patients with OA without concomitant gastroduodenal pathology in anamnesis were included into the group III. All patients obtained selective NSAID for OA treatment: Meloxicam 15 mg daily or Nimesulide 200 mg daily. The control group was formed by 20 persons, which were found to be healthy after a complex examination. Stomach acid-forming function was investigated using esophageal pH monitoring. In the gastric contents, which obtained by aspiration, concentration of sialic acids glycoproteins, fucose, and hexosamines was determined. Results. Clinical picture of NSAID gastropathy at NAG characterized by abdominal pain of varying intensity and not associated with eating, but in patients with AG severity and discomfort symptoms dominated over weakly expressed pain syndrome. As a result of NSAID, in the group I dyspepsia developed in 31 (57.4 %), and erosive gastropathy developed in 9 (16.7 %) patients. In the group II, erosive gastropathy and dyspepsia were observed in 15 (22.1%) and in 35 (51.5 %) patients, respectively. In the group III, erosive gastropathy was observed 3.3 times (c2=84.33; р=0.009) and 4.4 times (c2=36.78; р=0.002) less than in groups I and II, respectively. In 25% patients of the group I after NSAID therapy intragastric pH increased from normacid to hyperacid status. In the group II, NSAID administration led to stomach mucosal (SM) protective factors depletion, which was observed in 73.3 % and in 28.6 % of patients with erosive gastropathy and NSAID-associated dyspepsia, respectively. At AG with erosive gastropathy, unlike NAG, several protective factors simultaneous reduction was observed. Coonclusion. In anamnesis, CG factor at selective NSAID administration (Meloxicam and Nimesulide) in relation to OA significantly increases the risk of erosive gastropathy, compared with patients without CG in anamnesis. At OA NSAID administration in patients with NAG led to gastric contents acidification and in patients with AG – to SM protective factors depletion (glycoprotein, fucose, and hexosamine).

Risk factors of gastric carcinogenesis in underlying gastric mucosal atrophy.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 28-28
Author(s):  
Ji Hyun Song ◽  
Sang Gyun Kim ◽  
Eun Hyo Jin ◽  
Joo Hyun Lim ◽  
Sun Young Yang
Keyword(s):  
Risk Factors ◽  
Atrophic Gastritis ◽  
Intestinal Metaplasia ◽  
Alcohol Intake ◽  
Salt Intake ◽  
Gastric Carcinogenesis ◽  
Gastric Neoplasm ◽  
Mucosal Atrophy ◽  
Gastric Mucosal Atrophy

28 Background: Atrophic gastritis and intestinal metaplasia were considered as premalignant lesions. The prevalence of chronic atrophic gastritis is very high in Korea. The aims of this study were to evaluate the risk factors of gastric carcinogenesis in underlying gastric mucosal atrophy. Methods: A total of 10187 subjects underwent upper gastrointestinal endoscopy for health checkup between 2003 and 2004 were enrolled in this retrospective cohort study. Follow-up endoscopy was performed between 2005 and 2014. Atrophic gastritis and intestinal metaplasia were assessed according to the Kimura-Takemoto classification by endoscopy. Helicobacter pylori (Hp) was evaluated by serum IgG antibody. Results: The number of atrophic gastritis was 3716 (36.5%) in baseline endoscopy, and 2146 were undergone follow-up endoscopy (82.8±38.3month); 1139 showed aggravation of atrophy and 1007 showed no change. A total of 71 subjects were diagnosed as gastric neoplasms (34 adenoma, 37 carcinoma). Age (HR = 1.019, 95%CI 1.010-1.028), alcohol intake (HR = 1.002, 95%CI 1.001-1.002), Salt intake (HR = 1.295, 95%CI 1.038-1.617) and Hp infection (HR = 1.584, 95%CI 1.220-2.057) were associated with aggravation of mucosal atrophy. The risk factors for gastric neoplasm in underlying mucosal atrophy were age (HR = 1.041, 95%CI 1.004-1.079), alcohol intake (HR = 1.003, 95% CI 1.001-1.005), Salt intake (HR = 2.553, 95% CI 1.141-5.712), Extent of mucosal atrophy (HR = 2.375, 95% CI 1.201-4.695 in C3-O1; HR = 4.255, 95% CI 1.612-11.229 in O2-O3), and intestinal metaplasia (HR = 2.599, 95% CI 1.286-5.251). Conclusions: Hp was a risk factor for aggravation of atrophy, but not for gastric neoplasm. Salt intake, extent of mucosal atrophy, and intestinal metaplasia were important risk factors for gastric neoplasm.

scholarly journals Increasing efficiency of preterm birth prediction

2021 ◽  
Keyword(s):  
Preterm Birth ◽  
Confidence Interval ◽  
Blood Serum ◽  
Preterm Labor ◽  
Group Iii ◽  
Healthy Pregnancy ◽  
Group I ◽  
Combined Use ◽  
Group Ii ◽  
Plgf Ratio

Abstract. The disturbed placentation in a certain way plays an important role in the pathogenesis of great obstetric syndromes. Therefore, the possibility of using biochemical indicators of the level of placental growth factor (PlGF) and fms-like tyrosine kinase (sFlt-1) for predicting preterm labor is of great interest. The aim of the study was developing criteria for predicting preterm labor based on the combined use of ultrasound cervicometry and the concentration of PlGF and sFlt-1. Materials and methods. A total of 227 pregnant women were examined, 190 of whom had preterm birth. Group I included 48 women whose pregnancy completed at 23 to 27 weeks. In group II, 142 women with prematurity in terms of 28 to 36 weeks were observed. Group III included 37 women with a healthy pregnancy, which completed at 38–41 weeks. All patients involved in the study underwent ultrasound cervicometry on a Voluson 730 (GE Healthcare, USA) at 16 weeks, and also the concentration of PlGF and sFlt-1 in blood serum by electrochemiluminescence immunoassay using a Cobas e411 analyzer was studied (Roche diagnostics, Switzerland). Results. The study revealed a significant (p < 0.001) decrease in the average concentration of PlGF in the blood serum by 65 % associated with an increased level of sFlt-1 by 93% in women with early termination of pregnancy – 23–27 weeks (group I) in relation to women with a healthy pregnancy. In women with preterm birth at 28–36 weeks of gestation (group II), a similar trend of changes was observed: the PlGF level significantly (p = 0.014) decreased on average by 68 % in relation to women with a healthy pregnancy. In women of group I, the value of the sFlt-1 / PlGF ratio exceeded (p < 0.001) the values of patients in group III by 14 times. But an even more pronounced imbalance of angiogenic factors was observed in women of group II – on average 16 times. Two main markers were used to predict premature birth: shortening of the cervix according to ultrasound cervicometry data of less than 30 mm, as well as the sFlt-1/PlGF ratio of more than 50 conv. units. The odds ratio (OR) of preterm birth in the case of using only the length of the cervix was 34,133 (95 % confidence interval – 12.308–94.660). OR in the case of combined use of cervicometry data and angiogenesis variables was 148.750 (95 % confidence interval – 33.243–665.593). Conclusion. Thus, the use of an additional biochemical marker significantly improved the accuracy of preterm labor prediction.

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