Natural Bioactive Cyclopeptides from Microbes as Promising Anticancer Drug Leads: A Mini-review

2021 ◽  
pp. 291-303
Author(s):  
Linda Sukmarini
Keyword(s):  
Natural Products ◽  
Cyclic Peptides ◽  
Recent Decade ◽  
Bioactive Molecules ◽  
Marine Cyanobacteria ◽  
Anticancer Activities ◽  
Natural Sources ◽  
Naturally Occurring ◽  
Lead Candidate ◽  
Drug Leads

Natural products from microbes are a rich source of bioactive molecules to serve as drug leads, predominantly in cancer therapy. Peptides are among the essential nature-derived biomolecules. Owing to their great diversity and favorable characteristics, cyclic peptides (cyclopeptides) from natural sources have become a propitious lead candidate for the development of therapeutics, including anticancer drugs. This present mini-review highlights cyclopeptides from microbial-derived natural products that have demonstrated significant cytotoxicity or anticancer activities. Moreover, this mini-review also provides a look into the mode of action of anticancer cyclopeptides. Selected examples are given for the potent anticancer cyclopeptides isolated in the recent decade from fungi and bacteria from both terrestrial and marine origins. Naturally occurring cyclopeptides with canonical and non-canonical amino acids isolated from fungi, myxobacteria, actinomycetes, marine cyanobacteria, and microbes associated with marine organisms and their anticancer activity are featured herein.

scholarly journals Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 2080 ◽  
Author(s):  
Muna Abdalla ◽  
Lyndy McGaw
Keyword(s):  
Drug Discovery ◽  
Cyclic Peptides ◽  
Cyclic Peptide ◽  
Pharmacological Properties ◽  
Biological Processes ◽  
Peptide Antibiotics ◽  
Natural Sources ◽  
Biological Targets ◽  
Naturally Occurring ◽  
Wide Range

Peptides are important biomolecules which facilitate the understanding of complex biological processes, which in turn could be serendipitous biological targets for future drugs. They are classified as a unique therapeutic niche and will play an important role as fascinating agents in the pharmaceutical landscape. Until now, more than 40 cyclic peptide drugs are currently in the market, and approximately one new cyclopeptide drug enters the market annually on average. Interestingly, the majority of clinically approved cyclic peptides are derived from natural sources, such as peptide antibiotics and human peptide hormones. In this report, the importance of cyclic peptides is discussed, and their role in drug discovery as interesting therapeutic biomolecules will be highlighted. Recently isolated naturally occurring cyclic peptides from microorganisms, sponges, and other sources with a wide range of pharmacological properties are reviewed herein.

Naturally occurring and synthetic polyyne glycosides

2009 ◽  
Vol 87 (11) ◽  
pp. 1565-1582 ◽  
Author(s):  
Yanqing Pan ◽  
Todd L. Lowary ◽  
Rik R. Tykwinski
Keyword(s):  
Natural Products ◽  
Marine Algae ◽  
Biological Activities ◽  
Terrestrial Plants ◽  
Natural Sources ◽  
Naturally Occurring

Polyyne glycosides are a class of natural products that have been found in terrestrial plants, fungi, and marine algae. Many display interesting and potentially useful biological activities, which in some cases has initiated synthetic efforts toward their formation. This review provides a comprehensive report of polyyne glycosides isolated from natural sources, as well as the synthesis of these molecules and their analogues.

scholarly journals Bioprospecting for antituberculosis natural products – A review

2021 ◽  
Vol 19 (1) ◽  
pp. 1074-1088
Author(s):  
Olabisi Flora Davies-Bolorunduro ◽  
Abraham Ajayi ◽  
Isaac Adeyemi Adeleye ◽  
Alfinda Novi Kristanti ◽  
Nanik Siti Aminah
Keyword(s):  
Natural Products ◽  
Mycobacterium Tuberculosis ◽  
High Throughput Screening ◽  
Antitubercular Drug ◽  
Natural Sources ◽  
Resource Limited ◽  
Novel Drugs ◽  
Mdr Tb ◽  
Drug Leads ◽  
Novel Antibiotics

Abstract There has been an increase in the reported cases of tuberculosis, a disease caused by Mycobacterium tuberculosis, which is still currently affecting most of the world’s population, especially in resource-limited countries. The search for novel antitubercular chemotherapeutics from underexplored natural sources is therefore of paramount importance. The renewed interest in studies related to natural products, driven partly by the growing incidence of MDR-TB, has increased the prospects of discovering new antitubercular drug leads. This is because most of the currently available chemotherapeutics such as rifampicin and capreomycin used in the treatment of TB were derived from natural products, which are proven to be an abundant source of novel drugs used to treat many diseases. To meet the global need for novel antibiotics from natural sources, various strategies for high-throughput screening have been designed and implemented. This review highlights the current antitubercular drug discovery strategies from natural sources.

scholarly journals Applications of Virtual Screening in Bioprospecting: Facts, Shifts, and Perspectives to Explore the Chemo-Structural Diversity of Natural Products

2021 ◽  
Vol 9 ◽  
Author(s):  
Kauê Santana ◽  
Lidiane Diniz do Nascimento ◽  
Anderson Lima e Lima ◽  
Vinícius Damasceno ◽  
Claudio Nahum ◽  
...  
Keyword(s):  
Natural Products ◽  
Virtual Screening ◽  
Bioactive Compounds ◽  
Chemical Space ◽  
Structural Diversity ◽  
Industrial Applications ◽  
Bioactive Molecules ◽  
Natural Sources ◽  
Compound Libraries ◽  
Pharmacokinetic Properties

Natural products are continually explored in the development of new bioactive compounds with industrial applications, attracting the attention of scientific research efforts due to their pharmacophore-like structures, pharmacokinetic properties, and unique chemical space. The systematic search for natural sources to obtain valuable molecules to develop products with commercial value and industrial purposes remains the most challenging task in bioprospecting. Virtual screening strategies have innovated the discovery of novel bioactive molecules assessing in silico large compound libraries, favoring the analysis of their chemical space, pharmacodynamics, and their pharmacokinetic properties, thus leading to the reduction of financial efforts, infrastructure, and time involved in the process of discovering new chemical entities. Herein, we discuss the computational approaches and methods developed to explore the chemo-structural diversity of natural products, focusing on the main paradigms involved in the discovery and screening of bioactive compounds from natural sources, placing particular emphasis on artificial intelligence, cheminformatics methods, and big data analyses.

A comprehensive review on pyranoindole-containing agents

2021 ◽  
Vol 28 ◽  
Author(s):  
Alessia Catalano ◽  
Domenico Iacopetta ◽  
Jessica Ceramella ◽  
Carmela Saturnino ◽  
Maria Stefania Sinicropi
Keyword(s):  
Natural Products ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Therapeutic Agents ◽  
Biologically Active ◽  
Bioactive Molecules ◽  
Structural Motif ◽  
Huge Number ◽  
Naturally Occurring ◽  
Active Natural

: A huge number of nitrogen-containing heterocyclic compounds are ubiquitous in natural products, pharmaceuticals, and bioactive molecules. Among these, the pyranoindole represents an important structural motif, as it constitutes the central subunit in both the biologically active natural products and therapeutic agents. Talathermophilins, notoamides, norgeamides, carneamides, and versicamides are examples of naturally occurring pyranoindoles, while the well-known etodolac and pemedolac are a tetrahydropyrano[3,4-b]indole deriving from synthetic procedures. Besides the well-known antiinflammatory and fibrinolytic activity, molecules comprising the pyranoindole framework have been demonstrated to exhibit various biological activities, such as antiulcer, antidepressant, analgesic, and antiproliferative. Herein, we report the most common natural and synthetic products bearing a pyranoindole nucleus, their syntheses, and biological activities.

Discovery and applications of naturally occurring cyclic peptides

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
D Craik ◽  
A Poth ◽  
M Colgrave ◽  
M Akcan ◽  
B Oku ◽  
...  
Keyword(s):  
Cyclic Peptides ◽  
Naturally Occurring

Nutraceuticals from Marine Bionetworks

2019 ◽  
Vol 15 (4) ◽  
pp. 338-344
Author(s):  
Abhitav Tiwari ◽  
Shambhawi Pritam ◽  
Keerti Mishra ◽  
Mehshara Khan ◽  
Neeraj Upmanyu ◽  
...  
Keyword(s):  
Dietary Supplements ◽  
Bioactive Compounds ◽  
Daily Basis ◽  
Marine Organisms ◽  
Bioactive Molecules ◽  
Natural Sources ◽  
Nutraceutical Compounds ◽  
Potential Sources ◽  
Immense Potential ◽  
Potential Use

“Nutrition” and “Pharmaceutical” together build up the perception of “Nutraceuticals” that refer to the food or dietary supplements that help to incorporate additional health benefits to the fundamental sustenance accomplished on daily basis. Each nutraceutical contains one or more bioactive molecules that are usually obtained by chemical and/ or biotechnological synthesis or by extraction from natural sources. Among the natural sources, marine bionetwork possess immense potential for the presence of bioactive compounds. Some of these bioactive compounds as isolated from marine sources, have potential use as nutraceuticals. This mini review provides a brief overview of nutraceutical compounds from marine sources that are currently under research and/or have been commercialized. A detailed discussion on the biochemical categories of compounds and the marine organisms that play as potential sources of these bioactive nutraceutical compounds have been included.

Monocyclic Peptides: Types, Synthesis and Applications

2020 ◽  
Vol 22 (1) ◽  
pp. 123-135 ◽  
Author(s):  
Yalda Khazaei-poul ◽  
Shohreh Farhadi ◽  
Sepideh Ghani ◽  
Safar Ali Ahmadizad ◽  
Javad Ranjbari
Keyword(s):  
Drug Delivery ◽  
Cyclic Peptides ◽  
Rational Design ◽  
Bioactive Molecules ◽  
Synthesis Methods ◽  
Targeted Therapeutics ◽  
Diagnostic Agents ◽  
Linear Types ◽  
Microbial Agents ◽  
Structural Classes

: Peptides are considered to be appropriate tools in various biological fields. They can be primarily used for the rational design of bioactive molecules. They can act as ligands in the development of targeted therapeutics as well as diagnostics, can be used in the design of vaccines or can be employed in agriculture. Peptides can be classified in two broad structural classes: linear and cyclic peptides. Monocyclic peptides are a class of polypeptides with one macrocyclic ring that bears advantages, such as more selective binding and uptake by the target receptor, as well as higher potency and stability compared to linear types. This paper provides an overview of the categories, synthesis methods and various applications of cyclic peptides. The various applications of cyclic peptides include their use as pro-apoptotic and anti-microbial agents, their application as targeting ligands in drug delivery and diagnostic agents, as well as agricultural and therapeutics applications that are elaborated and discussed in this paper.

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