scholarly journals Ultra Flexible Nanocarrier for Enhanced the Ocular Delivery of Quercetin in Management of Macular Edema

2021 ◽  
Vol 3 (1) ◽  
pp. p9
Author(s):  
Sahu Seema ◽  
Shah Gulab Chand ◽  
Manigauha Ashish ◽  
Gupta Vandana
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Macular Edema ◽  
Cell Lines ◽  
Cancer Cell ◽  
Drug Delivery Systems ◽  
Present Review ◽  
Plant Parts ◽  
Related Drug ◽  
Therapeutic Properties

Quercetin (Que) and its derivatives are naturally taking place phytochemicals with promising bioactive belongings. The antidiabetic, anti-inflammatory, antioxidant, antimicrobial, anti-Alzheimer’s, antiarthritic, cardiovascular, and wound-healing possessions of Que have been extensively investigated, as well as its anticancer commotion against different cancer cell lines has been newly reported. Que and its derivatives are found predominantly in the Western starve yourself, and people might benefit from their defensive effect just by taking them via diets or as a food enhancement. Bioavailability-related drug-delivery systems of Que have also been markedly exploited, and Que nanoparticles become visible as a promising proposal to enhance their bioavailability. The present review aims to make available a brief overview of the therapeutic things, new insights, and forthcoming perspectives of Que. Plants and plant parts are used for its aroma, flavor, or therapeutic properties. There are a number of recompense associated with using plants and plant phytoconstituents as contrasting to pharmaceutical merchandise.

Comprehensive Review on Hydrogels

2021 ◽  
Vol 18 ◽  
Author(s):  
Hitesh Chopra ◽  
Inderbir Singh ◽  
Sandeep Kumar ◽  
Tanima Bhattacharya ◽  
Md. Habibur Rahman ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Controlled Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Bone Engineering ◽  
Comprehensive Review ◽  
Therapeutic Benefits ◽  
Conventional Drug ◽  
Repeated Dosing

: The conventional drug delivery systems have a long list of issues of repeated dosing and toxicity arising due to it. The hydrogels are the answer to them and offer a result that minimizes such activities and optimizes therapeutic benefits. The hydrogels proffer tunable properties that can withstand degradation, metabolism, and controlled release moieties. Some of the areas of applications of hydrogels involve wound healing, ocular systems, vaginal gels, scaffolds for tissue, bone engineering, etc. They consist of about 90% of the water that makes them suitable bio-mimic moiety. Here, we present a birds-eye view of various perspectives of hydrogels, along with their applications.

Integration of polymers in the pore space of mesoporous nanocarriers for drug delivery

2017 ◽  
Vol 5 (45) ◽  
pp. 8891-8903 ◽  
Author(s):  
Jixi Zhang ◽  
Kaiyong Cai
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Pore Space ◽  
Delivery Systems ◽  
Related Drug

The construction of carrier-polymer–drug hybrids in confined nanopore space is reviewed for advancing related drug delivery systems.

scholarly journals GASTRORETENTIVE DRUG DELIVERY SYSTEMS: FROM CONCEPTION TO COMMERCIAL SUCCESS

2017 ◽  
Vol 4 (2) ◽  
pp. 10 ◽  
Author(s):  
Harshil P. Shah ◽  
Shailesh T. Prajapati ◽  
C. N. Patel
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Oral Route ◽  
Delivery Systems ◽  
Present Review ◽  
Gastric Residence Time ◽  
In Vivo Characterization ◽  
Absorption Window

Despite the extensive advancements in the field of drug delivery, the oral route remains the favorable route for administration of therapeutic actives. A success of oral controlled drug delivery systems is associated with reduced dosing frequency, decreased fluctuation in plasma drug concentration profile along with improved patient compliance. However, they are also associated with challenges like shorter gastric residence time, unpredictable gastric emptying and poor bioavailability for some molecules. This has initiated tremendous advancements in the field of gastro-retention to achieve controlled release of drugs along with improved bioavailability of drugs with narrow absorption window as well as localized action in the stomach and upper part of GIT. In present review, efforts have been envisaged to summarize our current understanding in the field of gastro-retention and their in vitro as well as in vivo characterization. Present review also highlights commercially utilized gastro-retentive technologies and some recently granted US patents in the field of GRDDS.

scholarly journals Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A Review

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1803
Author(s):  
Vivek Puri ◽  
Ameya Sharma ◽  
Pradeep Kumar ◽  
Inderbir Singh
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Efficient Method ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Review Article ◽  
Present Review ◽  
Tabular Form ◽  
Thiolated Polymers ◽  
Drug Delivery Applications

Biopolymers are extensively used for developing drug delivery systems as they are easily available, economical, readily modified, nontoxic, biodegradable and biocompatible. Thiolation is a well reported approach for enhancing mucoadhesive and mechanical properties of polymers. In the present review article, for the modification of biopolymers different thiolation methods and evaluation/characterization techniques have been discussed in detail. Reported literature on thiolated biopolymers with enhanced mechanical and mucoadhesive properties has been presented conspicuously in text as well as in tabular form. Patents filed by researchers on thiolated polymers have also been presented. In conclusion, thiolation is an easily reproducible and efficient method for customization of mucoadhesive and mechanical properties of biopolymers for drug delivery applications.

Functionalized Carbon Nano-scale Drug Delivery Systems From Biowaste Sago Bark For Cancer Cell Imaging

2017 ◽  
Vol 14 (8) ◽  
Author(s):  
Shoriya Aruni Abdul Manaf ◽  
Gurumurthy Hegde ◽  
Uttam Kumar Mandal ◽  
Wong Tin Wui ◽  
Partha Roy
Keyword(s):  
Drug Delivery ◽  
Cancer Cell ◽  
Drug Delivery Systems ◽  
Cell Imaging ◽  
Delivery Systems ◽  
Nano Scale ◽  
Cancer Cell Imaging ◽  
Sago Bark

scholarly journals In VitroAntibacterial, Antioxidant, and Cytotoxic Activities ofParthenium hysterophorusand Characterization of Extracts by LC-MS Analysis

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Shashank Kumar ◽  
Sanjay Pandey ◽  
Abhay K. Pandey
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Biological Activities ◽  
Beta Carotene ◽  
Cancer Cell Lines ◽  
Salmonella Typhi ◽  
Cytotoxic Activities ◽  
Plant Parts ◽  
Colon Cancer Cell Lines

Present work reports the biological activities ofP. hysterophorusleaf, stem, flower, and root. Dried samples were sequentially extracted with many solvents. Hexane (HX), benzene (BZ), and chloroform (CH) extracts of leaf showed considerable antibacterial activity againstStreptococcus mutans(MTCC 497),Proteus vulgaris(MTCC 7299), andSalmonella typhi(MTCC 3917). Flower extracts exhibited presence of higher amount of flavonoids (13.9–59.6 μgQE/mg) followed by leaf, stem, and root. Stem (HX, BZ, and CH), leaf ethanol (ET), and root (HX, BZ, and CH) fractions showed noticeable antioxidant capacity in phosphomolybdate assay. Most of the extracts demonstrated beta carotene bleaching inhibition capability. BZ, ethyl acetate (EA), and ET fractions of leaves, stem aqueous (AQ), and flower EA extracts showed membrane protective activities (40–55%). Middle fractions of the plant parts displayed moderate antihemolytic potential. Most of the flower extracts exhibited cytotoxic activity (80–100%) against lung and colon cancer cell lines. Root (HX and ET) and leaf ET extracts showed considerable inhibition (90–99%) of colon and ovary cancer cell lines. The LC-MS scan demonstrated presence of different compounds showing 3–20 min retention time. The study revealed considerable antibacterial, antioxidant, lipo-protective, antihemolytic, and anticancer potential in all parts ofP. hysterophorus.

Biocompatible titanate nanotubes with high loading capacity of genistein: cytotoxicity study and anti-migratory effect on U87-MG cancer cell lines

RSC Advances ◽  
2016 ◽  
Vol 6 (103) ◽  
pp. 101688-101696 ◽  
Author(s):  
Tarek Baati ◽  
Bochra Bejaoui Kefi ◽  
Aicha Aouane ◽  
Leila Njim ◽  
Florence Chaspoul ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cellular Uptake ◽  
Direct Consequence ◽  
Titanate Nanotubes ◽  
Loading Capacity ◽  
Potential Candidate ◽  
Surface Change ◽  
Tubular Shape

Titanate nanotubes (Ti-Nts) have proved to be a potential candidate for drug delivery due to their large surface change and higher cellular uptake as a direct consequence of their tubular shape.

scholarly journals The Effective Combination between 3D Cancer Models and Stimuli-Responsive Nanoscale Drug Delivery Systems

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3295
Author(s):  
Federica Foglietta ◽  
Loredana Serpe ◽  
Roberto Canaparo
Keyword(s):  
Drug Delivery ◽  
Cancer Cell ◽  
Cell Cultures ◽  
Drug Delivery Systems ◽  
In Vitro Models ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Cancer Models

Stimuli-responsive drug-delivery systems (DDSs) have emerged as a potential tool for applications in healthcare, mainly in the treatment of cancer where versatile nanocarriers are co-triggered by endogenous and exogenous stimuli. Two-dimensional (2D) cell cultures are the most important in vitro model used to evaluate the anticancer activity of these stimuli-responsive DDSs due to their easy manipulation and versatility. However, some limitations suggest that these in vitro models poorly predict the outcome of in vivo studies. One of the main drawbacks of 2D cell cultures is their inadequate representation of the 3D environment’s physiological complexity, which sees cells interact with each other and the extracellular matrix (ECM) according to their specific cellular organization. In this regard, 3D cancer models are a promising approach that can overcome the main shortcomings of 2D cancer cell cultures, as these in vitro models possess many peculiarities by which they mimic in vivo tumors, including physiologically relevant cell–cell and cell–ECM interactions. This is, in our opinion, even more relevant when a stimuli-responsive DDS is being investigated. In this review, we therefore report and discuss endogenous and exogenous stimuli-responsive DDSs whose effectiveness has been tested using 3D cancer cell cultures.

scholarly journals Evolution of Nanotechnology in Delivering Drugs to Eyes, Skin and Wounds via Topical Route

2020 ◽  
Vol 13 (8) ◽  
pp. 167 ◽  
Author(s):  
Pratheeksha Koppa Raghu ◽  
Kuldeep K. Bansal ◽  
Pradip Thakor ◽  
Valamla Bhavana ◽  
Jitender Madan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Drug Delivery Systems ◽  
Complex Structure ◽  
Topical Administration ◽  
Dosage Forms ◽  
Improve Patient Compliance ◽  
Improve Patient ◽  
Drug Localization ◽  
Exogenous Substances

The topical route is the most preferred one for administering drugs to eyes, skin and wounds for reaching enhanced efficacy and to improve patient compliance. Topical administration of drugs via conventional dosage forms such as solutions, creams and so forth to the eyes is associated with very low bioavailability (less than 5%) and hence, we cannot rely on these for delivering drugs to eyes more efficiently. An intravitreal injection is another popular drug delivery regime but is associated with complications like intravitreal hemorrhage, retinal detachment, endophthalmitis, and cataracts. The skin has a complex structure that serves as numerous physiological barriers to the entry of exogenous substances. Drug localization is an important aspect of some dermal diseases and requires directed delivery of the active substance to the diseased cells, which is challenging with current approaches. Existing therapies used for wound healing are costly, and they involve long-lasting treatments with 70% chance of recurrence of ulcers. Nanotechnology is a novel and highly potential technology for designing formulations that would improve the efficiency of delivering drugs via the topical route. This review involves a discussion about how nanotechnology-driven drug delivery systems have evolved, and their potential in overcoming the natural barriers for delivering drugs to eyes, skin and wounds.

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