scholarly journals Alterations of Lipid profile levels in 7,12-Dimethylbenz(a)anthracene induced ulcerative colitis rat model.

2017 ◽  
Vol 10 (4) ◽  
pp. 352
Author(s):  
Geetha Palaniswamy ◽  
Lakshman Kumar B ◽  
Indra U ◽  
Pavithra Sheetal B
Keyword(s):  
Ulcerative Colitis ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Intestinal Inflammation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Significant Difference

Objective: Ulcerative colitis is a type of inflammatory bowel disease is a chronic gastrointestinal disorder characterized by intestinal inflammation and mucosal tissue damage. We examined the lipid profile levels in murine model of 7,12 Dimethylbenz(a)anthracene induced ulcerative colitis.Methods: Serum was separated from whole blood and was used to determine the lipid profile such as total cholesterol (TC), phospholipids (PL), triglycerides (TG), free fatty acids, high density lipoprotein (HDL-C) and low density lipoprotein (HDL-C).Results: Ulcerative colitis rats exhibit low level of low density lipoprotein cholesterol and total cholesterol. No significant difference was observed in high density lipoprotein and triglycerides and significant difference was observed in phospholipids and free fatty acid serum levels. This communication highlights the lipid profile that occurs in ulcerative colitis.Conclusion: This study, thus, provides valuable information about the disturbances in the lipids and lipoproteins occur in ulcerative colitis.Keywords: Ulcerative colitis, 7,12-Dimethylbenz(a)anthracene, Lipoprotein, Low-density lipoprotein, Phospholipids.

scholarly journals Uji Toksisitas Ekstrak Metanolik Kombinasi Daun Benalu Teh Dan Daun Benalu Mangga Terhadap Profil Lipid Tikus Betina (Rattus norvegicus) pada Paparan Sub-Kronik 28 Hari

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Tengku Anggun Lestari ◽  
Nour Athiroh ◽  
Nurul Jadid Mubarakati
Keyword(s):  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Rattus Norvegicus ◽  
Toxicity Test ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
One Way Anova

Tea Benalu (Scurrula atropurpurea [Bl.] Dans.) and Mango Benalu (Dendrophthoe pentandra L. miq.) containssecondary metabolites with potential antioxidant potential. Antioxidants can inhibit the oxidation process and reduce Total Cholesterol, Triglycerides, Low-Density Lipoprotein (LDL) and increase High-Density Lipoprotein (HDL). The safety of the preparations for the combination of parasites of tea and mango leaves was tested to obtain toxic effects after repeated treatment tests over some time. The purpose of this study was to determine the toxic effects of a combination of methanolic extracts of a combination of tea parasites and mangoes in female rats (Rattus norvegicus) subchronically for 28 days by looking at the results of the clinical biochemical examination on lipid profiles, namely total cholesterol levels, triglycerides, high-density lipoproteins (28%). HDL), and Low-Density Lipoprotein (LDL). The method of this study was experimental with a combination dose of methanol extract of tea parasite leaves and mango parasite leaves at a dose of 250 mg / KgBB, 500 mg / KgBB and 1000 mg / KgBB with 5x replications each treatment. The subjects used white rats (Rattus norvegicus) female Wistar strains aged 6-8 weeks with a minimum body weight of 100 grams. The treatment in this study was in the form of each dose given 5 times a week for 28 days (subchronic toxicity test) orally. Lipid profile levels were analyzed using the one-way ANOVA test. The results showed that the level of control blood lipid profile with a treatment dose of 250 mg / KgBW, 500 mg / KgBW, and 1000 mg / KgBW was not significantly different. The toxicity test of combined extracts of tea leaves and mango parasite leaves of female rat Rattus novergicus on subchronic exposure 28 days with those doses showed no difference tangible between treatments of controls. This means it is safe and does not cause toxic properties in the lipid profile of female wistar rats.Keywords: Lipid Profile, Scurrula atropurpurea, Dendophthoe pentandra, Sub-Chronic Toxicity, Rattus norvegicus ABSTRAKBenalu Teh (Scurrula atropurpurea [Bl.] Dans.) dan  Benalu Mangga (Dendrophthoe pentandra L. miq.) mengandung metabolit sekunder berpotensi sebagai antioksidan. Antioksidan dapat memperhambat proses oksidasi dan menurunkan Cholesterol Total, Trigliserida, Low Density Lipoprotein (LDL) dan menaikkan High Density Lipoprotein (HDL). Keamanan sediaan kombinasi daun benalu teh dan mangga diuji memperoleh tentang efek toksik setelah uji perlakuan berulang dalam jangka waktu tertentu. Tujuan dari penelitian ini untuk mengetahui efek toksik kombinasi ekstrak metanolik kombinasi daun benalu teh dan mangga pada tikus betina (Rattus norvegicus) secara subkronik selama 28 hari dengan melihat hasil pemeriksaan biokimia klinis pada profil lipid, yaitu kadar Cholesterol Total, Trigliserida, High Density Lipoprotein (HDL), dan Low Density Lipoprotein (LDL). Metode penelitian ini adalah eksperimental dengan perlakuan dosis kombinasi ekstrak metanol daun benalu teh dan daun benalu mangga dosis 250 mg/KgBB, 500 mg/KgBB dan 1000 mg/KgBB dengan ulangan 5x tiap perlakuan. Subjek menggunakan tikus putih (Rattus norvegicus) betina strain wistar yang berumur 6-8 minggu dengan berat badan minimal 100 gram. Perlakuan dalam penelitian ini berupa setiap dosis  diberikan 5 kali seminggu selama 28 hari (uji toksisitas subkronik) secara per-oral. Kadar profil lipid dianalisis menggunakan uji One-way ANOVA. Hasil penelitian menunjukkan bahwa kadar profil lipid darah kontrol dengan perlakuan dosis 250 mg/KgBB, 500 mg/KgBB dan 1000 mg/KgBB tidak berbeda nyata. Uji”toksisitas”ekstrak kombinasi daun benalu teh dan daun benalu mangga  tikus betina Rattus novergicus pada paparan subkronik 28 hari dengan”dosis”tersebut menunjukkan hasil tidak”beda”nyata antara perlakuan terhadap”kontrol. ”Hal ini berarti aman dan tidak menimbulkan sifat toksik pada profil lipid tikus wistar betina.Kata Kunci : Profil Lipid, Scurrula atropurpurea, Dendophthoe pentandra, Subkronik, Rattus norvegicus

scholarly journals Status of Lipid Profile among the Hypertensive Patients in Bangladesh

2014 ◽  
Vol 9 (1) ◽  
pp. 13-17 ◽  
Author(s):  
CM Reza ◽  
ASMA Kabir ◽  
Tuhin Biswas ◽  
Kamrun Nahar Choudhury ◽  
Md Zahidur Rahman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Hypertensive Patients

Back ground: Hypertension and dyslipidemia are associated with oxidative stress and are major causes of cardiovascular disease amounting to 30% of global death rate. It is widely accepted that cardiovascular disease is associated with hypertension and increased blood levels of low-density lipoprotein (LDL), total cholesterol (TC), and triglycerides. In contrast, a low level of high density lipoprotein (HDL) is a risk factor for mortality from cardiovascular disease. Hypertension is a major public health problem in developed and developing countries. Methods: This study was a cross sectional study in which 159 diagnosed hypertensive patient and 75 with normal blood pressure (normotensive) were enrolled. These patients sought a through health cheek up including blood pressure assessment between May 2012 to April 2013 in Tairunnessa Memorial Medical College and Hospital. Lipid parameter total cholesterol (TC), triglyceride (TG), low density lipoprotein ( LDLc) and high density lipoprotein (HDLc) were estimated by enzymatic colorimetric test. Results: The mean of Systolic blood pressure and Diastolic blood pressure of hypertensive were higher than normotensive (p<0.001). The serum levels of total cholesterol, triglyceride and LDL-C in hypertensive subject were higher than normotensive and statistically significant (p<0.001). Serum HDL-C was significantly lower (p<0.001) in hypertensive patients than in normotensive. Conclusion: Analytical results of the study revealed that hypertensive patients have been found to have close association with dyslipidemia. Hypertension and dyslipidemia can be modified either by proper life style changes or medical management or by the combination of the both. This study suggests that hypertensive patients need measurement of blood pressure and lipid profile at regular interval to prevent heart diseases and stroke. DOI: http://dx.doi.org/10.3329/uhj.v9i1.19505 University Heart Journal Vol. 9, No. 1, January 2013; 13-17

scholarly journals Dyslipidemia in Psoriasis: A Case - Controlled Study

2021 ◽  
Vol 19 (2) ◽  
pp. 39-43
Author(s):  
Monique Kafle ◽  
Madhu Gyawlee ◽  
Amit Amatya ◽  
Bhaskar Mohan Meher Kayastha ◽  
Smarika Upadhyaya
Keyword(s):  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Controlled Study ◽  
Control Group ◽  
Low Density ◽  
Chronic Inflammatory Condition

INTRODUCTION:  Psoriasis is a chronic inflammatory condition of skin which can be associated with other ailments including dyslipidemia which is an abnormal serum lipid profile. OBJECTIVE: The aim of present study was to determine correlation between dyslipidemia and Psoriasis of patients visiting the Out-patient Department of Patan Hospital METHODS: Ninety patients were selected for study. Among them 30 patients with psoriasis were taken as cases and 60 patients that matched for age and sex with Psoriasis patients were taken as controls. The lipid profile that comprised four parameters: serum High-density Lipoprotein, Low-density Lipoprotein, Total Cholesterol and Triglyceride were determined and compared for both case and control groups. RESULTS: More than 95% of the psoriatic patients had dyslipidemia. The odds of dyslipidemia among Psoriatic patients were 1.709 times higher compared to control group (p <0.001). Among the parameters, results showed High-density lipoprotein was significantly lower while Triglyceride was significantly higher among the cases compared to controls with p value of 0.012 and 0.001 respectively. The risk factors like smoking and alcohol were present in higher proportions among the patients with dyslipidemia but it failed to reach statistical significance. With increase in duration of Psoriasis and PASI scores, lipid parameters i.e., Total cholesterol, triglyceride and Low-density lipoprotein increased while High density lipoprotein decreased but this correlation was insignificant. CONCLUSION: This study showed Dyslipidemia is significantly higher among patients with Psoriasis especially lipid profile parameters Triglyceride and total cholesterol. Thus, timely screening and management of dyslipidemia among Psoriatic patients might be helpful in prevention of future cardiovascular events.

scholarly journals Lipid Profile in Postmenopausal Diabetic Female.

2021 ◽  
Vol 18 (1) ◽  
pp. 45-48
Author(s):  
Rabindra Simkhada ◽  
Sanjay Singh KC ◽  
Dharma Nath Yadav ◽  
Ravi Sahi
Keyword(s):  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Blood Sugar ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Cross Sectional ◽  
Increased Risk

Background and Aims: Postmenopausal diabetic female are at increased risk of cardiovascular disease. The objective of this study was to study their lipid profile and prevalence of dyslipidemia and assess relation of control of lipid components with various risk factors. Methods: A cross sectional prospective study conducted at Shahid Gangalal National Heart Centre from 15th July 2020 to 14th October 2020 including 109 postmenopausal diabetic female. Detailed history along with clinical examination were conducted. Fasting lipid profile and other relevant investigations were obtained. Results: Mean age of participants was 63.48±9.26 years. Mean age of menopause was 48.59±1.88 years. A total of 37 (33.9%) were hypertensive, 17 (15.6%) were smoker, 67 (61.5%) were physically inactive. A total of 91 (83.5%) were non-vegetarian. Thirty eight (34.9%) had their blood sugar controlled with hemoglobin A1c of <7%. The mean total cholesterol and high density lipoprotein were 5.21±0.97 mmol/l and 1.02±0.13 mmol/l. Similarly mean triglyceride and low density lipoprotein were 2.24±0.75 mmol/l and 3.04±0.12 mmol/l. Dyslipidemia was present in 82.6%. Significant correlation of control of blood sugar with total cholesterol control status (R=0.28, P=0.01), low density lipoprotein control status (R=0.38, P=0.01), high density lipoprotein control status (R=0.36, P=0.04) and triglyceride control status (R=0.30, P=0.04) were seen. Conclusion: Dyslipidemia was common in post menopausal diabetic female. Blood sugar control status showed significant correlation with lipid profile parameters. A good sugar control and evaluation for lipid abnormalities is recommended in postmenopausal diabetic female.

scholarly journals Analisis Profil Lipid Ikan Gelodok (Periophthalmodon schlosseri) di Desa Tanipah dan Desa Kuala Lupak Kalimantan Selatan

2020 ◽  
Vol 7 (2) ◽  
pp. 89
Author(s):  
Gusti Maharani ◽  
Hidayaturrahmah Hidayaturrahmah
Keyword(s):  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Density ◽  
The Body ◽  
Low Density ◽  
Purposive Sampling

Lipid adalah kelompok molekul alami yang berperan penting sebagai bahan bakar metabolisme, stabilitas membran sel dan komponen penting pada struktur sel didalam tubuh. Penelitian profil lipid ikan gelodok dilakukan dengan pemeriksaan kolesterol total, trigliserida, High Density Lipoprotein (HDL), dan Low Density Lipoprotein (LDL). Penelitian ini bertujuan untuk mengetahui dan menganalisa profil lipid yang ada pada ikan gelodok (Periothalmodon schlosseri) di perairan desa Kuala Lupak dan desa Tanipah, Kalimantan Selatan. Rancangan penelitian dilakukan secara eksploratif dengan menentukan lokasi pengambilan sampel. Teknik pengambilan sampel yang dilakukan adalah purposive sampling atau pengambilan sampel secara isidental berdasarkan pertimbangan heterogenitas lokasi sampel. Pemeriksaan profil lipid dilakukan dengan metode enzimatik. Hasil yang diperoleh pada penelitian ini yaitu profil lipid ikan timpakul pada perairan desa Tanipah mengandung kolesterol total sebanyak 101.17±36.06 mg/dL, HDL Kolesterol 26.5±7.06 mg/dL, LDL Kolesterol 50±26.9 mg/dL dan trigliserida sebanyak 134.8±146.07 mg/dL, sedangkan hasil profil lipid pada desa Kuala Lupak mengandung kolesterol total sebanyak 76.09±25.7 mg/dL, HDL Kolesterol 24±11.3 mg/dL, LDL Kolesterol 27.8±16.2 mg/dL, dan trigliserida 97.3±90.2 mg/dL, berdasarkan hasil yang didapatkan mengindikasikan bahwa kadar profil lipid pada ikan gelodok memiliki nilai yang lebih rendah dibandingkan dengan nilai kadar normal ikan pada umumnya.Lipids are a group of natural molecules that important role as fuel metabolism, cell membrane stability and important components of cell structure in the body. The research of lipid fish lipid profiles was carried out by examining total cholesterol, triglycerides, High Density Lipoprotein (HDL), and Low Density Lipoprotein (LDL). This research aims to determine and analyze the existing lipid profile in the gelodok (Periothalmodon schlosseri) in the waters of Kuala Lupak and Tanipah villages, South Kalimantan. The research design was carried out exploratively by determining the location of sampling. The sampling technique used was purposive sampling based on consideration of heterogeneity of sample locations. Lipid profile examination was carried out using an enzymatic method. The results obtained in this study are the lipid profile of the lead fish in the waters of Tanipah village containing total cholesterol as much as 101.17 ± 36.06 mg / dL, HDL Cholesterol 26.5 ± 7.06 mg / dL, LDL Cholesterol 50 ± 26.9 mg / dL and triglycerides as much as 134.8 ± 146.07 mg / dL, while the results of the lipid profile in Kuala Lupak village contained 76.09 ± 25.7 mg / dL total cholesterol, HDL Cholesterol 24 ± 11.3 mg / dL, Cholesterol LDL 27.8 ± 16.2 mg / dL, and triglycerides 97.3 ± 90.2 mg / dL, based on the results obtained indicate that the lipid profile level in the mackerel fish has a lower value than the normal value of fish in general.Keywords: lipid, Perithalmodon schlosseri, total cholesterol, Lipoprotein, Triglycerides

scholarly journals Status of Lipid Profile among the Hypertensive Patients in Bangladesh

2015 ◽  
Vol 10 (2) ◽  
pp. 73-77
Author(s):  
CM Reza Qureshi Forhad ◽  
Asma Kabir ◽  
Tuhin Biswas ◽  
Kamrun Nahar Choudhury ◽  
Md Zahidur Rahman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Hypertensive Patients

Back ground: Hypertension and dyslipidemia are associated with oxidative stress and are major causes of cardiovascular disease amounting to 30% of global death rate. It is widely accepted that cardiovascular disease is associated with hypertension and increased blood levels of low-density lipoprotein (LDL), total cholesterol (TC), and triglycerides. In contrast, a low level of high density lipoprotein (HDL) is a risk factor for mortality from cardiovascular disease. Hypertension is a major public health problem in developed and developing countries. Methods: This study was a cross sectional study in which 159 diagnosed hypertensive patient and 75 with normal blood pressure (normotensive) were enrolled for compare. These patients sought a through health cheek up including blood pressure assessment between May 2012 to April 2013 in Tairunnessa Memorial Medical College and Hospital. Lipid parameters total cholesterol (TC), triglyceride (TG), low density lipoprotein ( LDLc) and high density lipoprotein (HDLc) were estimated by enzymatic colorimetric test. Results: The mean of Systolic blood pressure and Diastolic blood pressure of hypertensive were higher than normotensive (p<0.001). The serum levels of total cholesterol, triglyceride and LDL-C in hypertensive subject were higher than normotensive and statistically significant (p<0.001). Serum HDL-C was significantly lower (p<0.001) in hypertensive patients than in normotensive. Age, waist circumference (WC), body mass index (BMI) showed significant association with hypertensive patients (p<0.001) than in normotensive subjects.The logistic regression analysis indicates hypertensive were 1.2 times higher total cholesterol, 1.3 times higher triglyceride and 1.2 times higher LDL-C than normotensive and was statistically significant (p<0.001). HDL-C was 1.08 times lower in hypertensive than normotensive and statistically significant p<0.001). Conclusion: Analytical results of the study revealed that hypertensive patients have been found to have close association with dyslipidemia. Hypertension and dyslipidemia can be modified either by proper life style changes or medical management or by the combination of the both. This study suggests that hypertensive patients need measurement of blood pressure and lipid profile at regular interval to prevent heart diseases and stroke.University Heart Journal Vol. 10, No. 2, July 2014; 73-77

scholarly journals Hubungan indeks massa tubuh dengan profil lipid pada pasien diabetes melitus tipe 2

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Pradika H. Koampa ◽  
Karel Pandelaki ◽  
Marthen C.P. Wongkar
Keyword(s):  
Body Mass Index ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Body Mass ◽  
Pearson Correlation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Diabetes Melitus

Abstract: Body Mass Index (BMI) is a measurement of nutritional status by calculating the ratio of height and weight. Type 2 Diabetes Mellitus (T2DM) is more common in a person with a BMI of more than normal. In patients with T2DM, there is lipid metabolism disorder, dyslipidaemia. Changes in lipid profiles consist of increased levels of total cholesterol, Low Density Lipoprotein (LDL), and triglycerides, and decreased levels of High Density Lipoprotein (HDL). This study aimed to obtain the correlation between body mass index and lipid profile in T2DM patients in Prof. Dr. R. D. Kandou Hospital Manado. This was a descriptive analytical study using patients’ medical record in Endocrine Clinic Prof. Dr. R. D. Kandou Hospital Manado from September to November 2015. The Pearson correlation test showed correlations between BMI and total cholesterol levels with r=0.037and p=0.763; between BMI and HDL levels with r=-0.249 and p=0.039; between BMI and LDL levels with r=0.091 and p=0,455; and between BMI and triglyceride levels with r=0.179 and p=0.142. Conclusion: Among T2DM patients, there were no significant correlations between body mass index and total cholesterol, LDL cholesterol, as wello as triglyceride levels. However, there was a significant correlation between body mass index and HDL levels. Keywords: body mass index, total cholesterol, HDL, LDL, triglycerides, T2DM Abstrak: Indeks Massa Tubuh (IMT) merupakan salah satu pengukuran status gizi dengan menghitung perbandingan tinggi badan dan berat badan. Diabetes Melitus Tipe 2 (DMT2) lebih sering terjadi pada individu dengan IMT lebih dari normal. Pada pasien DMT2 terjadi gangguan metabolisme lipid yaitu dislipidemia. Perubahan profil lipid yang terjadi yaitu peningkatan kadar Kolesterol Total, Low Density Lipoprotein (LDL), dan trigliserida, serta penurunan kadar High Density Lipoprotein (HDL). Penelitian ini bertujuan untuk mengetahui hubungan antara IMT dengan profil lipid pada pasien DMT2di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ini deskriptif analitik dengan menggunakan data rekam medik pasien di Poliklinik Endokrin Bagian/SMF Ilmu Penyakit Dalam RSUP. Prof. Dr. R. D. Kandou Manado periode September – November 2015. Hasil uji korelasi Pearson memperlihatkan nilai hubungan antara IMT dan kadar kolesterol total r = 0,037 dan p = 0,763 ; nilai hubungan antara IMT dan kadar HDL r = -0,249 dan p = 0,039 ; nilai hubungan antara IMT dan kadar LDL r = 0,091 dan p = 0,455; serta nilai hubungan antara IMT dan kadar trigliserida r = 0,179 dan p = 0,142. Simpulan: Pada pasien DMT2 tidak dijumpai hubungan bermakna antara IMT dengan kadar kolesterol total, kadar LDL, dan kadar trigliserida, namun terdapat hubungan bermakna antara IMT dengan kadar HDL.Kata kunci: IMT, kolesterol total, HDL, LDL, trigliserida, DMT2

scholarly journals COMPARISON OF SDLDL-C ANALYSIS USING SRISAWASDI METHOD AND HOMOGENEOUS ENZYMATIC ASSAY METHOD ON HYPERTRIGLYCERIDEMIA CONDITION (Perbandingan Analisa sdLDL-C metode Srisawasdi dan Homogeneous Enzymatic Assay di Kondisi Hipertrigliseridemia)

2018 ◽  
Vol 23 (1) ◽  
pp. 74
Author(s):  
Gilang Nugraha ◽  
Soebagijo Poegoeh Edijanto ◽  
Edhi Rianto
Keyword(s):  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Enzymatic Assay ◽  
Assay Method ◽  
Low Density

Small Dense Low Density Lipoprotein (sdLDL) merupakan fraksi terkecil dari partikel Low Density Lipoprotein (LDL) yang memilikidiameter ≤25,5 nm. Partikel sdLDL merupakan lipoprotein sangat aterogenik bahkan telah dilaporkan meningkatkan kebahayaanPenyakit Jantung Koroner (PJK) hingga tiga kali lipat. Pengukuran sdLDL dilakukan dengan alat dan teknik yang rumit sehinggakurang cocok diterapkan dalam praktek klinis sehari-hari. Tahun 2011, Srisawasdi dkk mengembangkan teknik pengukuran perkiraansdLDL-cholesterol (sdLDL-C) menggunakan persamaan dengan menghitung profil lipid rutin. Dilaporkan bahwa peningkatan kepekatantrigliserida (TG) menurunkan kenasaban perkiraan sdLDL-C Srisawasdi. Penurunan nilai kenasaban dapat mempengaruhi ketepatanyang mengakibatkan penurunan mutu pemeriksaan laboratorium. Diambil 88 sampel yang dilakukan pengukuran Total Cholesterol(TC), TG, high density lipoprotein-cholesetrol (HDL-C) dan direk low density lipoprotein-cholesetrol (dLDL-C) di RSUD Dr. Soetomo,sdLDL-C metode homogeneous enzymatic assay dilakukan di Laboratorium Parahita Dharmawangsa. Hasil analisis menunjukkan, tidakada perbedaan hasil periksaan sdLDL-C formula Srisawasdi dkk dengan metode homogeneous enzymatic assay (P=0,000). Penurunannilai kenasaban ditemukan di kelompok kepekatan TG <100 mg/dL sampai dengan kelompok kepekatan TG 200-299 mg/dL. Perbedaannilai kenasaban di setiap kelompok TG tidak mempengaruhi ketepatan pemeriksaan sdLDL-C formula Srisawasdi (P=0,720) hinggakepekatan TG <400 mg/dL, dengan nilai bias pada seluruh sampel yaitu 34,15%. Keterbatasan sdLDL-C formula Srisawasdi dkk hanyadapat digunakan di kepekatan TG kurang dari 200 mg/dL dengan pemantapan mutu intralaboratorium yang terkendali baik. Saranpenelitian, perlu diteliti lebih lanjut untuk menentukan nilai normal sdLDL-C formula Srisawasdi.

The Effects of Low-Density Lipoprotein and High-Density Lipoprotein on Blood Viscosity Correlate with their Association with Risk of Atherosclerosis in Humans

1997 ◽  
Vol 92 (5) ◽  
pp. 473-479 ◽  
Author(s):  
Gregory D. Sloop ◽  
David W. Garber
Keyword(s):  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
High Density Lipoprotein Cholesterol ◽  
Blood Viscosity ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

1. Increased blood or plasma viscosity has been observed in almost all conditions associated with accelerated atherosclerosis. Cognizant of the enlarging body of evidence implicating increased viscosity in atherogenesis, we hypothesize that the effects of low-density lipoprotein and high-density lipoprotein on blood viscosity correlate with their association with risk of atherosclerosis. 2. Blood viscometry was performed on samples from 28 healthy, non-fasting adult volunteers using a capillary viscometer. Data were correlated with haematocrit, fibrinogen, serum viscosity, total cholesterol, high-density lipoprotein-cholesterol, triglycerides and calculated low-density lipoprotein-cholesterol. 3. Low-density lipoprotein-cholesterol was more strongly correlated with blood viscosity than was total cholesterol (r = 0.4149, P = 0.0281, compared with r = 0.2790, P = 0.1505). High-density lipoprotein-cholesterol levels were inversely associated with blood viscosity (r = −0.4018, P = 0.0341). 4. To confirm these effects, viscometry was performed on erythrocytes, suspended in saline, which had been incubated in plasma of various low-density lipoprotein/high-density lipoprotein ratios. Viscosity correlated directly with low-density lipoprotein/high-density lipoprotein ratio (n = 23, r = 0.8561, P < 0.01). 5. Low-density lipoprotein receptor occupancy data suggests that these effects on viscosity are mediated by erythrocyte aggregation. 6. These results demonstrate that the effects of low-density lipoprotein and high-density lipoprotein on blood viscosity in healthy subjects correlate with their association with risk of atherosclerosis. These effects on viscosity may play a role in atherogenesis by modulating the dwell or residence time of atherogenic particles in the vicinity of the endothelium.

scholarly journals Alterations of pancreatic functions and lipid profiles in dairy cows with left displacement of the abomasum

2019 ◽  
Vol 64 (No. 5) ◽  
pp. 204-208
Author(s):  
Z Ismail ◽  
AM Al-Majali ◽  
O Al-Rawashdeh ◽  
M Daradka ◽  
M Mohaffel
Keyword(s):  
High Density Lipoprotein ◽  
Dairy Cows ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Serum Concentrations ◽  
C Reactive Protein ◽  
Reactive Protein

The objectives of this study were to determine the serum activities of the pancreatic enzymes amylase, lipase, trypsinogen 1 and trypsinogen 2, serum concentrations of total cholesterol, high density lipoprotein, low-density lipoprotein and triglycerides and serum inflammatory indicators, namely C-reactive protein and procalcitonin, in Holstein-Friesian dairy cows with left displacement of the abomasum (LDA). A total of 60 cows (30 LDA-affected and 30 healthy) were included in the study. Laboratory analyses were performed using commercially available ELISA kits and chemical reagents according to the manufacturers’ recommendations. There was a significant increase (P ≤ 0.05) in the activities of lipase, trypsinogen 1 and trypsinogen 2 in LDA-affected cows compared to healthy cows. Amylase concentrations, however, remained unchanged. The serum concentrations of total cholesterol and high-density lipoprotein were significantly (P ≤ 0.05) increased in LDA-affected cows while the concentrations of low-density lipoprotein and triglycerides were significantly (P ≤ 0.05) decreased compared to healthy cows. Procalcitonin and C-reactive protein concentrations were significantly (P ≤ 0.05) increased in LDA-affected cows compared to healthy cows. This study indicates that displacement of the abomasum may be associated with significant pathological effects in the pancreas that may affect cows in the post-operative period.

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