scholarly journals A PROSPECTIVE OBSERVATIONAL STUDY ON PATTERN OF ADVERSE DRUG REACTION TO ANTIBIOTICS COMMONLY PRESCRIBED IN THE HOSPITALIZED PEDIATRIC PATIENTS

2018 ◽  
Vol 11 ◽  
Author(s):  
Malarkodi Velraj,
Keyword(s):  
Prospective Observational Study ◽  
Pediatric Patients ◽  
Early Recognition ◽  
Pediatric Population ◽  
Onset Time ◽  
World Health ◽  
Beta Lactams ◽  
Medication Information ◽  
Set Up ◽  
Health Organization

Objective: Antibiotics are the almost usually specified or authorized medication in hospitals, and antibiotics were found to be the almost bothersome classes of drugs providing or endowing to adverse drug reactions (ADRs). Therefore, the present study was conducted to check or regulate the precautions (ADRs) of antibiotics usually specified or authorized in the pediatrics unit. Methods: A potential, experimental, non-interventionist study was conducted or executed in the Department of Pediatrics for a time of 6 months to analyze the ADRs reported spontaneously from the hospital using patient statistics, objective and medication information, data of ADRs, onset time, causal drug details, outcome, and severity. Results: Among 72 ADRs observed, beta-lactams and quinolones were set up to be contributing the highest number of ADRs. The duct or abdominal system was the almost commonly affected organ, followed by respiratory system and the cardiovascular system. The assessment by the World Health Organization causation estimation scale demonstrated that 5.56% ADRs were certain, 55.56% were possible, 30.56% were probable, and 8.33% were unlikely. Conclusion: Thus, the pattern of ADRs occurring in the pediatric population was observed and assessed. Early recognition and management of ADRs are essential to reduce the burden of ADRs

scholarly journals Should pediatric parenteral nutrition be individualized?

2014 ◽  
Vol 32 (4) ◽  
pp. 326-332
Author(s):  
Renata Germano Borges de Oliveira Nascimento Freitas ◽  
Roberto José Negrão Nogueira ◽  
Margareth Lopes Galvão Saron ◽  
Alexandre Esteves Souza Lima ◽  
Gabriel Hessel
Keyword(s):  
Parenteral Nutrition ◽  
Pediatric Patients ◽  
Pediatric Population ◽  
Tertiary Hospital ◽  
Inorganic Phosphorus ◽  
Nutritional State ◽  
World Health ◽  
Blood Levels ◽  
Health Organization ◽  
In The Beginning

INTRODUCTION: Parenteral nutrition (PN) formulations are commonly individualized, since their standardization appears inadequate for the pediatric population. This study aimed to evaluate the nutritional state and the reasons for PN individualization in pediatric patients using PN, hospitalized in a tertiary hospital in Campinas, São Paulo.METHODS: This longitudinal study comprised patients using PN followed by up to 67 days. Nutritional status was classified according to the criteria established by the World Health Organization (WHO) (2006) and WHO (2007). The levels of the following elements in blood were analyzed: sodium, potassium, ionized calcium, chloride, magnesium, inorganic phosphorus, and triglycerides (TGL). Among the criteria for individualization, the following were considered undeniable: significant reduction in blood levels of potassium (<3mEq/L), sodium (<125mEq/L), magnesium (<1mEq/L), phosphorus (<1.5mEq/L), ionic calcium (<1mmol), and chloride (<90mEq/L), or any value above the references.RESULTS: Twelve pediatric patients aged 1 month to 15 years were studied (49 individualizations). Most patients were classified as malnourished. It was observed that 74/254 (29.2%) of examinations demanded individualized PN for indubitable reasons.CONCLUSION: The nutritional state of patients was considered critical in most cases. Thus, the individualization performed in the beginning of PN for energy protein adequacy was indispensable. In addition, the individualized PN was indispensable in at least 29.2% of PN for correction of alterations found in biochemical parameters.

scholarly journals Circulation and Molecular Epidemiology of Enteroviruses in Paralyzed, Immunodeficient and Healthy Individuals in Tunisia, a Country with a Polio-Free Status for Decades

Viruses ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 380
Author(s):  
Anissa Chouikha ◽  
Dorra Rezig ◽  
Nadia Driss ◽  
Ichrak Abdelkhalek ◽  
Ahlem Ben Yahia ◽  
...  
Keyword(s):  
Detection Rate ◽  
Warning System ◽  
World Health ◽  
Clinical Samples ◽  
Nucleotide Sequencing ◽  
Comprehensive Picture ◽  
Set Up ◽  
Health Organization ◽  
Type 3

This report is an overview of enterovirus (EV) detection in Tunisian polio-suspected paralytic cases (acute flaccid paralysis (AFP) cases), healthy contacts and patients with primary immunodeficiencies (PID) during an 11-year period. A total of 2735 clinical samples were analyzed for EV isolation and type identification, according to the recommended protocols of the World Health Organization. Three poliovirus (PV) serotypes and 28 different nonpolio enteroviruses (NPEVs) were detected. The NPEV detection rate was 4.3%, 2.8% and 12.4% in AFP cases, healthy contacts and PID patients, respectively. The predominant species was EV-B, and the circulation of viruses from species EV-A was noted since 2011. All PVs detected were of Sabin origin. The PV detection rate was higher in PID patients compared to AFP cases and contacts (6.8%, 1.5% and 1.3% respectively). PV2 was not detected since 2015. Using nucleotide sequencing of the entire VP1 region, 61 strains were characterized as Sabin-like. Among them, six strains of types 1 and 3 PV were identified as pre-vaccine-derived polioviruses (VDPVs). Five type 2 PV, four strains belonging to type 1 PV and two strains belonging to type 3 PV, were classified as iVDPVs. The data presented provide a comprehensive picture of EVs circulating in Tunisia over an 11-year period, reveal changes in their epidemiology as compared to previous studies and highlight the need to set up a warning system to avoid unnoticed PVs.

scholarly journals Knowledge of HIV and benefits of male medical circumcision amongst clients in an urban area

2014 ◽  
Vol 6 (1) ◽  
Author(s):  
Abidemi Faleye
Keyword(s):  
Urban Area ◽  
Hiv Transmission ◽  
World Health ◽  
Routine Practice ◽  
Cross Sectional ◽  
Innovative Methods ◽  
Validated Questionnaire ◽  
Preventative Strategy ◽  
Set Up ◽  
Health Organization

Background: Male medical circumcision (MMC) has been shown to reduce the risk of HIV transmission in circumcised men by up to 60%. Following recommendations from the World Health Organization, South Africa adopted MMC as a preventative strategy against HIV in 2010 and set up circumcision camps across the country. Concerns have been raised about condom avoidance following MMC because of a mistaken belief about the benefits of MMC.Aim and setting: The aim of this study was to describe the profile and knowledge about HIV and circumcision amongst men presenting for MMC in an urban area in KwaZulu-Natal.Methods: This was a cross-sectional descriptive study of 394 clients over the age of 18 years who presented to two MMC sites in Durban between November 2012 and March 2013. A validated questionnaire was used to collect data.Results: The mean age of clients presenting for MMC was 28 years. Most clients were black, single, unemployed and sexually active. The majority presented for MMC because they believed that MMC would reduce their risk of acquiring HIV infection. Knowledge about HIV transmission was very good and 86.3% of clients were aware that risky sexual behaviour suchas condom avoidance could reverse the benefits of MMC.Conclusion: The knowledge of HIV and benefits of MMC was very good amongst those presenting for MMC. However as MMC is primarily a preventative strategy, innovative methods to promote MMC prior to first sexual encounter need to be explored. Further research is needed to determine whether the benefits of MMC on the reduction of HIV transmission aresustained in routine practice. [Full text article to follow]

INTERNATIONAL DEVELOPMENT ISSUES

PEDIATRICS ◽  
1982 ◽  
Vol 70 (3) ◽  
pp. 395-395
Author(s):  
Keyword(s):  
International Development ◽  
Low Income ◽  
Development Aid ◽  
Military Expenditure ◽  
World Health ◽  
Low Income Countries ◽  
River Blindness ◽  
Eradication Programme ◽  
Set Up ◽  
Health Organization

The annual military bill is now approaching 450 billion US dollars, while official development aid accounts for less than 5 per cent of this figure. Four examples: 1. The military expenditure of only half a day would suffice to finance the whole malaria eradication programme of the World Health Organization, and less would be needed to conquer river-blindness, which is still the scourge of millions. 2. A modern tank costs about one million dollars; that amount could improve storage facilities for 100,000 tons of rice and thus save 4000 tons or more annually; one person can live on just over a pound of rice a day. The same sum of money could provide 1000 classrooms for 30,000 children. 3. For the price of one jet fighter (20 million dollars) one could set up about 40,000 village pharmacies. 4. One-half of one per cent of one year's world military expenditure would pay for all the farm equipment needed to increase food production and approach self-sufficiency in food-deficit low-income countries by 1990.

scholarly journals Oral treprostinil in transition or as add-on therapy in pediatric pulmonary arterial hypertension

2019 ◽  
Vol 9 (3) ◽  
pp. 204589401985647 ◽  
Author(s):  
D. Dunbar Ivy ◽  
Jeffrey A. Feinstein ◽  
Delphine Yung ◽  
Mary P. Mullen ◽  
Edward C. Kirkpatrick ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Pediatric Patients ◽  
Cardiopulmonary Exercise Testing ◽  
Functional Class ◽  
World Health ◽  
Walk Distance ◽  
Pulmonary Arterial ◽  
Health Organization

Treprostinil, a prostacyclin analogue, is approved for the treatment of pulmonary arterial hypertension (PAH) in adults. Transition from parenteral to oral treprostinil has been successfully accomplished in adults with PAH but not in children. In this multicenter study, pediatric patients treated with parenteral (Cohort 1) or inhaled (Cohort 2) treprostinil were transitioned to oral treprostinil. Prostacyclin-naïve individuals on background oral PAH therapy received oral treprostinil as add-on therapy (Cohort 3). Successful transition was oral treprostinil dose maintenance through week 24. Patients were monitored for adverse events (AEs), 6-min walk distance (6MWD), PAH symptoms, World Health Organization (WHO) Functional Class (FC), cardiac magnetic resonance imaging (cMRI), cardiopulmonary exercise testing (CPET), and quality of life through 24 weeks. A total of 32 patients were enrolled in the study; 23 (72%) were girls (mean age = 12.2 years). All patients were on background oral PAH therapy. Overall, patients (96.9%) maintained transition to oral treprostinil; one patient (Cohort 1) transitioned to oral treprostinil, then back to parenteral after experiencing syncope and WHO FC change from II to III. Cohorts 1, 2, and 3 received a final mean oral treprostinil dose of 5.6, 3.3, and 4.5 mg t.i.d., respectively. All cohorts had variable changes in 6MWD, cMRI, and CPET. Overall, 12 serious AEs were reported. All patients had drug-related AEs including headache (81%), diarrhea (69%), nausea (66%), vomiting (66%), and flushing (56%). Pediatric patients maintained transition to oral treprostinil with preservation of exercise capacity and WHO FC. Prostanoid-related AEs were most common and similar to those reported in adults.

Pediatric Brain Tumors

2017 ◽  
Author(s):  
Vijay Ramaswamy ◽  
Jason T. Huse ◽  
Yasmin Khakoo
Keyword(s):  
Rare Variants ◽  
Pediatric Population ◽  
Pediatric Brain Tumors ◽  
World Health ◽  
Who Grade ◽  
Pilocytic Astrocytomas ◽  
Aggressive Histology ◽  
Malignant Lesions ◽  
Health Organization ◽  
Near Future

Cerebellar astrocytoma of childhood most commonly refers to cerebellar pilocytic astrocytoma, a World health Organization (WHO) Grade I tumor. However, on occasion cerebellar astrocytomas may demonstrate more aggressive histology including fibrillary astrocytomas, pilomyxoid astrocytomas, and rarely malignant lesions. In the near future, the diagnosis of cerebellar astrocytomas will be simplified by molecular analysis for BRAF fusions rather than a purely morphological approach. The emergence of next-generation sequencing can be expected to identify single nucleotide variations and further expand our understanding of both pilocytic astrocytomas as well as rare variants that occur in the cerebellum. Therapies targeting BRAF (B-raf protooncogene) are currently in clinical trial for adult malignancies and will eventually reach the pediatric population, allowing a targeted approach to recurrent and surgically inaccessible cases of pilocytic astrocytomas.

scholarly journals Hypocalcemia following Neridronate Administration in Pediatric Patients with Osteogenesis Imperfecta: A Prospective Observational Study

2020 ◽  
Vol 09 (02) ◽  
pp. 093-100 ◽  
Author(s):  
Evelina Maines ◽  
Elisa Tadiotto ◽  
Grazia Morandi ◽  
Michela Fedrizzi ◽  
Rossella Gaudino ◽  
...  
Keyword(s):  
Vitamin D ◽  
Observational Study ◽  
Osteogenesis Imperfecta ◽  
Prospective Observational Study ◽  
Pediatric Patients ◽  
Pediatric Population ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Vitamin D Levels ◽  
D Values

AbstractThe use of intravenous bisphosphonates has been linked to hypocalcemia both in children and adults with osteogenesis imperfecta (OI). The aims of this study were: (1) to investigate the incidence of hypocalcemia in the first 48 hours (T48) after neridronate infusion in a pediatric population with OI and (2) to assess any correlation between the baseline values of calcium, vitamin D (25-hydroxyvitamin D) and bone turnover markers, and the postinfusion calcium values. We conducted a prospective observational study on 37 pediatric patients. All patients were treated with a single infusion of neridronate at a dose of 1 to 2 mg/kg. The study provided two postinfusion reassessments: 24 hours (T24) and T48 after neridronate administration. Hypocalcemia was observed in 11% of patients at T24 and in 50% of patients at T48 from neridronate infusion. We observed a positive linear correlation between the baseline vitamin D values and postinfusion calcium values, both at baseline and at T24 and T48. Hypocalcemia was mild and asymptomatic in all cases. Postinfusion calcium levels were related to baseline vitamin D levels. Consequently, low vitamin D levels should be considered a significant risk factor for hypocalcemia and should be carefully investigated and treated before neridronate infusion.

Current Problems in the World Health Organization's Program

1952 ◽  
Vol 6 (1) ◽  
pp. 27-50 ◽  
Author(s):  
Charles S. Ascher
Keyword(s):  
New York ◽  
United Nations ◽  
International Organizations ◽  
International Health ◽  
World Health ◽  
World Health Assembly ◽  
The World ◽  
Set Up ◽  
Health Organization ◽  
First World

The International Health Conference, convened by the United Nations in New York in the summer of 1946, adopted a Constitution for a World Health Organization. It set up an Interim Commission of persons designated by eighteen named states to prepare for the First World Health Assembly and to carry on tasks inherited from previous international organizations. Unexpected delays in ratifications of the Constitution obliged the Interim Commission to operate for two years. WHO has thus been free to shape its destiny only from the time of the First World Health Assembly in the summer of 1948; it began its work formally as of September 1, 1948. The activities from 1946 to 1948 were largely determined by heritages from earner organizations; these, indeed, dominated the first program of WHO. The intervening three years have witnessed new trends, which some observers applaud and others view with doubt, if not alarm. It may be fruitful at this time to record some of these trends, to note the pressures which caused them and their implications for WHO's program and work-plan.

scholarly journals “The New Pandemic Challenge in Dentistry” Ozone in Aerosol Free Dental Procedures Post COVID 19 - A Review Article

2021 ◽  
Vol 10 (30) ◽  
pp. 2325-2330
Author(s):  
Sahana Sadasivam ◽  
Geeta IB
Keyword(s):  
Treatment Options ◽  
Oxidation Potential ◽  
World Health ◽  
Treatment Modalities ◽  
Ozone Therapy ◽  
Aerosol Exposure ◽  
Dental Procedures ◽  
Dental Practitioners ◽  
Set Up ◽  
Health Organization

The world health organization declared the outbreak of Corona virus as a public health emergency of international concern on 30th January 2020. The disease is transmitted by inhalation or contact with infected droplets and the incubation period ranges from 2 to 14 days. This mode of transmission has led to a concern for dentists worldwide. Due to the characteristics of dental settings, the risk of cross infection can be high between patients and dental practitioners. Various modifications in treatment options have been investigated to reduce the release of aerosols and minimize patient and dentist exposure. These modifications in the dental set up are incorporated to protect the practitioner and the patient from cross contamination. One such treatment modality in reducing aerosol production is the use of Ozone. Ozone is an allotropic form of oxygen and has been used successfully in the treatment of various diseases for over a hundred years. It has a high oxidation potential and is 1.5 times greater than chlorine when it is used as an antimicrobial agent. It has also shown to stimulate remineralization and has hence led to its increasing popularity and demand in the dental field. Its unique properties include analgesic, antimicrobial and antihypnotic actions. Its atraumatic, painless, non-invasive, and relative absence of discomfort and side effects has led to its use in dentistry with increased patient’s acceptability and compliance thus making it an ideal choice for various treatment options in dentistry which would eventually lead to reduced aerosol exposure. This review is an attempt to highlight various treatment modalities of Ozone therapy during post Covid-19 scenario in dental practices and its possible clinical applications in future. KEY WORDS Covid-19, Ozone Therapy, Dental Practice

scholarly journals Analysis of the Recomposition of Norms and Representations in the Field of Psychiatry and Mental Health in the Age of Electronic Mental Health: Qualitative Study (Preprint)

2018 ◽  
Author(s):  
Margot Morgiève ◽  
Déborah Sebbane ◽  
Bianca De Rosario ◽  
Vincent Demassiet ◽  
Soraya Kabbaj ◽  
...  
Keyword(s):  
Mental Health ◽  
Qualitative Study ◽  
New Technologies ◽  
Comparative Method ◽  
World Health ◽  
Group Discussions ◽  
Set Up ◽  
Health Organization ◽  
Social Autonomy ◽  
Therapeutic Activities

BACKGROUND For the World Health Organization, electronic health (eHealth) is seen as an effective way to improve therapeutic practices and disease prevention in health. Digital tools lead to major changes in the field of mental medicine, but specific analyses are required to understand and accompany these changes. OBJECTIVE Our objective was to highlight the positions of the different stakeholders of the mental health care system on eHealth services and tools, as well as to establish professional and user group profiles of these positions and the uses of these services. METHODS In order to acquire the opinions and expectations of different categories of people, we carried out a qualitative study based on 10 focus groups (n=70, from 3-12 people per group) composed of: general practitioners, psychiatrists, psychologists, social workers, occupational therapists, nurses, caregivers, mental health services users, user representatives, and the general public. The analyses of focus group discussions were performed independently by four investigators through a common analysis grid. The constant comparative method was adopted within this framework. RESULTS The interviewees expressed different problems that new technologies engender in the field of mental health. What was previously strictly under the jurisdiction of physicians now tends to be fragmented and distributed over different groups and locations. New technologies reposition care in the field of domestic, rather than therapeutic, activities, and thus the conception of care as an autonomous activity in the subject’s life is questioned. The ideal of social autonomy through technology is part of the new logic of health democracy and empowerment, which is linked to a strong, contemporary aspiration to perform. Participants emphasized that there was the potential risk of a decrease in autonomy for the digitally engaged patient, while personal empowerment could become a set of obligations. CONCLUSIONS This qualitative research highlights the heterogeneity of opinions among the groups and within each group. It suggests that opinions on electronic mental health devices are still far from being stabilized, and that a change management process should be set up to both regulate the development and facilitate the use of these tools.

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