scholarly journals ADVERSE DRUG REACTION PROFILE OF DRUGS PRESCRIBED IN CORONAVIRUS DISEASE - 19 PATIENTS – A CROSS-SECTIONAL STUDY

Author(s):  
RIDHDHI K HIRAPARA ◽  
BHARTI N KARELIA ◽  
ANIL P SINGH ◽  
ARTI TRIVEDI

Objective: The objective of this study is to assess adverse drug reaction (ADR) profile of the drugs prescribed to treat Coronavirus Disease (COVID-19) positive patients and to determine whether ADRs are associated with any comorbidities. Methods: A cross-sectional study was done with Laboratory confirmed COVID-19 positive patients who experienced ADRs during their admission period at tertiary care center, Rajkot from April 2020 to March 2021. All the necessary information including ADRs information was obtained from patient’s case record file and filled in suspected ADR reporting form. Suspected ADRs were assessed for demographic parameters and causality, preventability, and severity using World Health Organization (WHO) scale and Naranjo algorithm, modified Schumock and Thornton’s criteria, and modified Hartwig’s criteria, respectively. Results: Out of the 100 patients there were 60 males. The mean age of the patients was 52.65±13.95 year. Fourty-six patients had comorbidities. The most common type of ADR was GI disorders. Among the single suspected medication, most common drug was methylprednisolone and among the two drugs, azithromycin was common. According to the WHO and Naranjo scale, Probable ADRs were 70% and 36%, respectively. The percentage for mild, moderate and severe ADRs were 44%, 39%, 17%, respectively. Eighty-six percent ADRs were definitely preventable. Fifty-one patients were recovered from adverse reactions. Conclusions: Seriousness of reactions is mainly associated with co-morbid conditions. This indicates that patients with comorbidity should be closely monitored to avoid harmful consequences. These ADRs monitoring and reporting program will help physicians to choose their therapy sensibly and decrease chances of mortality in this pandemic era.

Author(s):  
Nidhi Jauhari ◽  
Deepak Chopra ◽  
Siraj Ahmad

<p class="abstract"><strong>Background:</strong> World Health Organization (WHO) in 2019, released the estimates which show that approximately 80% of the causes of blindness and severely reduced visual acuity are preventable and avoidable. The aim of the study was to assess the prevalence of preventable causes of blindness in an OPD setup in the city of Lucknow.</p><p class="abstract"><strong>Methods:</strong> Descriptive cross-sectional study was done from January, 2019 to March, 2019 at the ophthalmology department OPD, Dr Ram Manohar lohia hospital, Lucknow. Patient presenting with complains of Blurring of vision or blindness during the defined OPD days at the study place, sample size- 550. Convenience sampling, all the eligible patients who were attending the OPD on defined days during the study period.  </p><p class="abstract"><strong>Results:</strong> The current study found the prevalence of blindness in the OPD based patients to be 13.5% and 25% (WHO and NPCB standards) respectively which is higher than the other reported statistics and found cataract to be the single most contributor of cause of blindness in accordance with other literature.</p><p class="abstract"><strong>Conclusions:</strong> The study demonstrates that even after the implementation of a national program (NPCB), the prevalence of blindness continues to be on the higher side and cataract remains to the most common cause of preventable blindness.</p>


Author(s):  
Vimarshitha Prakash ◽  
Sheela S. R. ◽  
Krithika Raj ◽  
Pradeep Tarikere Satyanarayana

Background: World Health organization (WHO) states that to ensure child health and survival, Breast feeding can be best tool. It also mentions that nearly 2 out of 3 are not exclusively breast fed and a special note that only 41 % are exclusively breast fed for 6 months. Breastfeeding satisfaction is defined as, “the satisfying feeling obtained during breastfeeding resulting from cooperation between the mother and the infant to fulfill desires or needs”.Methods: This was a hospital based cross sectional study carried at Department of Obstetrics and Gynecology, Sri Devaraj Urs Medical College, SDUAHER, Kolar from December 2019 to August 2020 for a period of 10 months. Sample size was calculated based on previous study.Results: The present study was a cross sectional study carried out for a period of 9 months at SDUMC tertiary care center. 270 mothers were part of study among which 82 (30.3%) had completed high school, 110 (40.7%) belonged to 21-25 years, 184 (68.07%) were Hindus, 125 (46.2%) belonged to Upper middle class of Modified BG Prasad’s classification 2019, 199 (73.6%) had delivered through normal delivery and 142 (52.7%) had more than one child. Out of 270 breast feeding mothers, 214 (79.3%) has satisfactory knowledge, 148 (54.8%) had satisfactory attitude and only 47 (17.4%) had satisfactory practice. Mothers having  higher education status, having more than one child, home makers and those delivered by Normal delivery had higher scores were statistically significant.Conclusions: Perceptions regarding breast feedings were not satisfactory at various segments and breast feeding satisfaction were influenced by education, working status, number of children and family members were significant factors influencing breast feeding satisfaction.


2021 ◽  
Vol 59 (236) ◽  
Author(s):  
Dhan Bahadur Shrestha ◽  
Ratna Khatri ◽  
Prakash Raj Oli ◽  
Rosy Malla ◽  
Cimona Shrestha ◽  
...  

Introduction: Cesarean section is a common obstetric procedure which is done to reduce complications in high risk pregnancies. The aim of study was to find out the prevalence of cesarean section in a maternity unit of a tertiary care center. Methods: A descriptive cross-sectional study was conducted among 497 pregnant women presenting in a maternity unit of a tertiary center of Kathmandu, Nepal over a period of six months from March to August 2017 after taking ethical approval from Institutional Review Committee (Ref. 24). In this study, the prevalence of cesarean section, perinatal outcome, maternal and neonatal complications if any were observed. Data and descriptive analysis were done using Statistical Package for the Social Sciences version 22. Point estimate at 95% Confidence Interval was calculated along with frequency and percentage for binary data. Results: The prevalence of cesarean section was 171 (34.4%) at 95% Confidence interval (30.2-38.7). Most common indication for cesarean section was fetal distress 53 (31%). The maternal complications developed in 11 (6.4%) among those who delivered via cesarean delivery; Surgical Site Infection being the most common maternal complication. The neonatal intensive care unit admission rate among the newborns via cesarean section delivery was 48 (27.43%) and neonatal sepsis 14 (8%) was most common adverse neonatal outcome. Conclusions: The cesarean rate at the study center is higher than standard target rate of World Health Organization. Neonatal and maternal adverse outcome in current study were comparable with existing literatures.


Author(s):  
Meera Shankar ◽  
Ramasubramanian V. ◽  
Balasubramaniam Ramakrishnan

Background: Tuberculosis is highly prevalent in developing countries like India and several strategies have been implemented by the World Health Organization and Government of India in order to minimize its burden. However, effectiveness of these strategies is best achieved when there is adequate awareness among the general population regarding the cause and spread of the disease. This study was carried out to evaluate the knowledge, attitude and practices regarding tuberculosis among general population.Methods: This cross sectional study was carried out among 500 adults visiting our tertiary care center as patients or attenders for a period of one year between April 2018 and March 2019. A structured interview schedule was used to collect information regarding the knowledge, attitude and practices regarding the cause, spread and management of tuberculosis infection.Results: About 73.6% of the study participants felt that tuberculosis was a genetic disorder, while only 12.4% of them were aware that the infection was transmitted through coughing, etc. Moreover, 18% of the participants believed that the medications for treating tuberculosis could be stopped without the supervision of the health care provider.Conclusions: This study has elicited the prevailing misconception regarding the cause, transmission, treatment and prevention of tuberculosis. It is important for policy makers and public health program implementation experts to develop health literacy campaigns to specifically create awareness among the population, so as to facilitate successful mitigation of the disease.


2020 ◽  
Vol 15 ◽  
Author(s):  
Solomon Hambisa ◽  
Rediet Feleke ◽  
Ameha Zewudie ◽  
Mohammed Yimam

Background:: Rational drug use comprises aspects of prescribing, dispensing and patient use of medicines for different health problems. This study is aimed to assess drug prescribing practice based on the world health organization prescribing indicators in Mizan-Tepi University teaching hospital. Methods:: An institutional based retrospective cross sectional study was conducted to evaluate prescribing practices in Mizan-Tepi University teaching hospital. Data were collected based on World health organization drug use indicators using prescription papers. 600 prescriptions dispensed through the general outpatient pharmacy of the hospital were collected by systematic random sampling method from prescriptions written for a 1-year time in Mizan-Tepi University teaching hospital. Results:: The present study found that the average number of drugs per prescription was 2.04 ± 0.87 in Mizan-Tepi University teaching hospital with a range between 1 and 5. Prescribing by generic name was 97.6 % and 47.8% of prescriptions contained antibiotics in the hospital. 27.7% of prescriptions contained at least one injectable medication in Mizan-Tepi University teaching hospital. From prescribed drugs, 96.7% of them were prescribed from Ethiopian essential drug list. Conclusion:: Present study indicated that the average number of drugs prescribed per encounter, the percentage of generic prescribing and prescribing from the EDL were close to optimal value. However, the percentage of encounters with antibiotics and injections prescribed were found be very high. Thus, the study highlights some improvements in prescribing habits, particularly by focusing on the inappropriate consumption of antibiotics and injections.


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