scholarly journals TOXIC AND IMMUNE ALLERGIC RESPONSES OF ANT VENOM TOXINS: A REVIEW

2021 ◽  
pp. 1-7
Author(s):  
SIMRAN SHARMA ◽  
RAVI KANT UPADHYAY!
Keyword(s):  
Immune Responses ◽  
Biological Effects ◽  
Therapeutic Agents ◽  
Microbial Pathogens ◽  
Intense Pain ◽  
Venom Toxins ◽  
Potential Source ◽  
Ant Venom ◽  
Peptide Toxins ◽  
Promising Source

Present review article explains ant venom components and its allergic and biological effects in man and animals. Red ants or small fire ants secrete and inject venom very swiftly to defend their nest against predators, microbial pathogens, and competitors and to hunt the prey. Ant venom is a mixture of various organic compounds, including peptides, enzymes, and polypeptide toxins. It is highly toxic, allergic, invasive and venomous. It imposes sever paralytic, cytolytic, haemolytic, allergenic, pro-inflammatory, insecticidal, antimicrobial, and pain-producing pharmacologic activities after infliction. Victims show red ring-shaped allergic sign with regional swelling marked with intense pain. Ant venom also contains several hydrolases, oxidoreductases, proteases, Kunitz-like polypeptides, and inhibitor cysteine knot (ICK)-like (knottin) neurotoxins and insect defensins. Ant venom toxins/proteins generate allergic immune responses and employ eosinophils and produce Th2 cytokines, response. These compounds from ant venom could be used as a potential source of new anticonvulsants molecules. Ant venoms contain many small, linear peptides, an untapped source of bioactive peptide toxins. The remarkable insecticidal activity of ant venom could be used as a promising source of additional bio-insecticides and therapeutic agents.

scholarly journals Potential Application of Some Lamiaceae Species in the Management of Diabetes

Plants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 279
Author(s):  
Ninon G.E.R. Etsassala ◽  
Ahmed A. Hussein ◽  
Felix Nchu
Keyword(s):  
Metabolic Disorders ◽  
Review Paper ◽  
Chemical Constituents ◽  
Folk Medicine ◽  
Therapeutic Agents ◽  
Antidiabetic Activity ◽  
Adverse Side Effects ◽  
Potential Source ◽  
Ancient Times ◽  
Phytochemical Constituents

Diabetes is one of the most dangerous metabolic disorders, with high rates of mortality worldwide. Since ancient times, medicinal plants have been used in traditional medicine to treat many diseases, including diabetes and its related complications. Plants are widely accepted, affordable, and perceived to have minimal adverse side effects. The Lamiaceae family is a potential source of therapeutic agents for the management of metabolic disorders, including diabetes. Hence, this review paper summarizes the antidiabetic use of Lamiaceae species in folk medicine globally. Furthermore, we present the antidiabetic activities and phytochemical constituents of twenty-three (23) Lamiaceae species and the antidiabetic activity of some notable chemical constituents isolated from some of these Lamiaceae species.

scholarly journals Assessment of Cow Dung Pellets as a Renewable Solid Fuel in Direct Combustion Technologies

Energies ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 1192
Author(s):  
Aneta Szymajda ◽  
Grażyna Łaska ◽  
Magdalena Joka
Keyword(s):  
Renewable Energy ◽  
Calorific Value ◽  
Cow Dung ◽  
Fixed Carbon ◽  
Direct Combustion ◽  
Potential Source ◽  
Novel Approach ◽  
Combustion Tests ◽  
Promising Source ◽  
Compaction Properties

Recently, biomass application as a renewable energy source is increasing worldwide. However, its availability differs in dependence on the location and climate, therefore, agricultural residues as cow dung (CD) are being considered to supply heat and/or power installation. This paper aims at a wide evaluation of CD fuel properties and its prospect to apply in the form of pellets to direct combustion installations. Therefore, the proximate, ultimate composition and calorific value were analyzed, then pelletization and combustion tests were performed, and the ash characteristics were tested. It was found that CD is a promising source of bioenergy in terms of LHV (16.34 MJ·kg−1), carbon (44.24%), and fixed carbon (18.33%) content. During pelletization, CD showed high compaction properties and at a moisture content of 18%,and the received pellets’ bulk density reached ca. 470 kg·m−3 with kinetic durability of 98.7%. While combustion, in a fixed grate 25 kW boiler, high emissions of CO, SO2, NO, and HCl were observed. The future energy sector might be based on biomass and this work shows a novel approach of CD pellets as a potential source of renewable energy available wherever cattle production is located.

Host Innate Immune Responses to Microbial Pathogens

2013 ◽  
Vol 11 (2) ◽  
pp. 123-132
Author(s):  
Julie Delaloye ◽  
Thierry Calandra
Keyword(s):  
Immune Responses ◽  
Innate Immune ◽  
Microbial Pathogens ◽  
Innate Immune Responses

scholarly journals Emerging Roles of Protein Deamidation in Innate Immune Signaling

2016 ◽  
Vol 90 (9) ◽  
pp. 4262-4268 ◽  
Author(s):  
Jun Zhao ◽  
Junhua Li ◽  
Simin Xu ◽  
Pinghui Feng
Keyword(s):  
Immune Responses ◽  
Innate Immune ◽  
Microbial Pathogens ◽  
Biological Processes ◽  
Innate Immune Responses ◽  
Immune Signaling ◽  
Host Immune Responses ◽  
Innate Immune Signaling ◽  
Enzyme Deficient ◽  
Signaling Components

Protein deamidation has been considered a nonenzymatic process associated with protein functional decay or “aging.” Recent studies implicate protein deamidation in regulating signal transduction in fundamental biological processes, such as innate immune responses. Work investigating gammaherpesviruses and bacterial pathogens indicates that microbial pathogens deploy deamidases or enzyme-deficient homologues (pseudoenzymes) to induce deamidation of key signaling components and evade host immune responses. Here, we review studies on protein deamidation in innate immune signaling and present several imminent questions concerning the roles of protein deamidation in infection and immunity.

Pathogen recognition in the innate immune response

2009 ◽  
Vol 420 (1) ◽  
pp. 1-16 ◽  
Author(s):  
Himanshu Kumar ◽  
Taro Kawai ◽  
Shizuo Akira
Keyword(s):  
Immune Responses ◽  
Germ Line ◽  
Innate Immune ◽  
Microbial Pathogens ◽  
Signalling Pathways ◽  
Pathogen Recognition ◽  
Adaptive Immune ◽  
Evolutionarily Conserved ◽  
Cellular Compartments ◽  
Inducible Gene

Immunity against microbial pathogens primarily depends on the recognition of pathogen components by innate receptors expressed on immune and non-immune cells. Innate receptors are evolutionarily conserved germ-line-encoded proteins and include TLRs (Toll-like receptors), RLRs [RIG-I (retinoic acid-inducible gene-I)-like receptors] and NLRs (Nod-like receptors). These receptors recognize pathogens or pathogen-derived products in different cellular compartments, such as the plasma membrane, the endosomes or the cytoplasm, and induce the expression of cytokines, chemokines and co-stimulatory molecules to eliminate pathogens and instruct pathogen-specific adaptive immune responses. In the present review, we will discuss the recent progress in the study of pathogen recognition by TLRs, RLRs and NLRs and their signalling pathways.

scholarly journals Edible insects unlikely to contribute to transmission of coronavirus SARS-CoV-2

2020 ◽  
Vol 6 (4) ◽  
pp. 333-339 ◽  
Author(s):  
M. Dicke ◽  
J. Eilenberg ◽  
J. Falcao Salles ◽  
A.B. Jensen ◽  
A. Lecocq ◽  
...  
Keyword(s):  
Food Safety ◽  
Companion Animals ◽  
Microbial Pathogens ◽  
Human Consumption ◽  
The Novel ◽  
Edible Insects ◽  
Animal Products ◽  
Livestock Species ◽  
Potential Source ◽  
Pathogenic Viruses

In the context of food safety, edible insects are evaluated for biological hazards such as microbial pathogens according to regulations currently in place. When the European Food Safety Authority evaluated the hazards of edible insects as a potential source of pathogenic viruses for humans and livestock, the novel zoonotic coronavirus SARS-CoV-2 had not yet emerged but other pathogenic coronaviruses such as SARS (SARS-CoV) and MERS (MERS-CoV) were known. As a result of the COVID-19 pandemic, animal sources of protein for human consumption are being evaluated for the risks of being a transmission vector of coronaviruses, like SARS-CoV-2. Insects lack a receptor that can bind SARS-CoV-2, thus preventing the virus from replicating in insects, unlike some vertebrate livestock species and companion animals. Despite extensive monitoring, coronaviruses have never been recorded in insect microbiomes. Contamination of insects produced for food or feed may occur during the production process, resulting from rearing substrate or from insect farmers. However, the currently permitted rearing substrates do not include animal products and the farming process is highly automated, thus limiting interactions between farmers and insects. If contamination would still occur, the fact that the insects in production are not hosts to SARS-CoV-2 precludes virus replication and the further processing of the insects will destroy the contamination. We conclude that the hazard of edible insects being a transmission vector of SARS-CoV-2 is extremely low.

scholarly journals Differential Release of Mast Cell Interleukin-6 Via c-kit

Blood ◽  
1997 ◽  
Vol 89 (8) ◽  
pp. 2654-2663 ◽  
Author(s):  
Eleni Gagari ◽  
Mindy Tsai ◽  
Chris S. Lantz ◽  
Lisa G. Fox ◽  
Stephen J. Galli
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Immune Responses ◽  
Interleukin 6 ◽  
Specific Antigen ◽  
Leukotriene C4 ◽  
Potential Source ◽  
Acquired Immune Responses ◽  
Factor Α ◽  
Necrosis Factor

Abstract Mast cells represent a potential source of interleukin-6 (IL-6) and other cytokines that have been implicated in host defense, tissue maintenance/remodeling, immunoregulation, and many other biologic responses. In acquired immune responses to parasites or allergens, the extensive IgE-dependent activation of mast cells via FcεRI can result in the release of large quantities of biogenic amines that are stored in the cells' cytoplasmic granules as well as the production of lipid mediators and many cytokines; these products together can orchestrate an intense inflammatory response. We now report that activation of mouse mast cells via c-kit, the receptor for the pleiotropic survival/growth factor, stem cell factor (SCF ), can induce the release of IL-6. Upon challenge with SCF, bone marrow-derived cultured mouse mast cells (BMCMCs) released amounts of IL-6 that were greater than 100-fold more than those produced by unstimulated cells, but that were substantially less than those produced in response to IgE and specific antigen. Moreover, BMCMCs released IL-6 upon challenge with concentrations of SCF that resulted in little or no detectable release of tumor necrosis factor-α, leukotriene C4 , histamine, or serotonin. These findings indicate that SCF, a widely expressed protein that is critical for mast cell development and survival, can also regulate the differential release of mast cell mediators.

scholarly journals Cerebral sterile inflammation in neurodegenerative diseases

2020 ◽  
Vol 40 (1) ◽  
Author(s):  
Kento Otani ◽  
Takashi Shichita
Keyword(s):  
Immune Responses ◽  
Neurodegenerative Diseases ◽  
Molecular Mechanisms ◽  
Therapeutic Agents ◽  
Sterile Inflammation ◽  
Cellular Damage ◽  
Cellular Mechanisms ◽  
Abnormal Accumulation ◽  
The Brain ◽  
Lateral Sclerosis

AbstractTherapeutic strategies for regulating neuroinflammation are expected in the development of novel therapeutic agents to prevent the progression of central nervous system (CNS) pathologies. An understanding of the detailed molecular and cellular mechanisms of neuroinflammation in each CNS disease is necessary for the development of therapeutics. Since the brain is a sterile organ, neuroinflammation in Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) is triggered by cerebral cellular damage or the abnormal accumulation of inflammatogenic molecules in CNS tissue through the activation of innate and acquired immunity. Inflammation and CNS pathologies worsen each other through various cellular and molecular mechanisms, such as oxidative stress or the accumulation of inflammatogenic molecules induced in the damaged CNS tissue. In this review, we summarize the recent evidence regarding sterile immune responses in neurodegenerative diseases.

Characterisation of novel Australian snake venom toxins as potential therapeutic agents

2013 ◽  
Vol 221 ◽  
pp. S194-S195
Author(s):  
Liam St Pierre ◽  
Paul Masci ◽  
Kong-Nan Zhao ◽  
John De Jersey ◽  
Martin Lavin
Keyword(s):  
Snake Venom ◽  
Therapeutic Agents ◽  
Venom Toxins

scholarly journals Isoniazid Induces Apoptosis Of Activated CD4+ T Cells

2014 ◽  
Vol 289 (44) ◽  
pp. 30190-30195 ◽  
Author(s):  
Sultan Tousif ◽  
Dhiraj Kumar Singh ◽  
Shaheer Ahmad ◽  
Prashini Moodley ◽  
Maitree Bhattacharyya ◽  
...  
Keyword(s):  
Infectious Disease ◽  
T Cells ◽  
Immune Responses ◽  
Therapeutic Agents ◽  
Current Therapy ◽  
Drug Resistant ◽  
Tb Treatment ◽  
Short Course ◽  
Directly Observed Treatment ◽  
Immune Impairment

Tuberculosis (TB) remains the second highest killer from a single infectious disease worldwide. Current therapy of TB is lengthy and consists of multiple expensive antibiotics, in a strategy referred to as Directly Observed Treatment, Short Course (DOTS). Although this therapy is effective, it has serious disadvantages. These therapeutic agents are toxic and are associated with the development of a variety of drug-resistant TB strains. Furthermore, patients treated with DOTS exhibit enhanced post-treatment susceptibility to TB reactivation and reinfection, suggesting therapy-related immune impairment. Here we show that Isoniazid (INH) treatment dramatically reduces Mycobacterium tuberculosis antigen-specific immune responses, induces apoptosis in activated CD4+ T cells, and renders treated animals vulnerable to TB reactivation and reinfection. Consequently, our findings suggest that TB treatment is associated with immune impairment.

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