scholarly journals CORONAVIRUS DISCOURSE OF UNCERTAINTY IN THE GUISE OF REASSURANCE: WE STAND TOGETHER ONLY WHEN WE DO NOT STAND APART

2021 ◽  
pp. 409
Author(s):  
Željka Babić ◽  
Emir Muhić ◽  
Dijana Tica
Keyword(s):  
Normal State ◽  
Corpus Analysis ◽  
The Novel ◽  
New Normal ◽  
Critical Theories ◽  
Geographical Regions ◽  
State Of Mind ◽  
Novel Coronavirus ◽  
Theoretical Insight ◽  
Insight Into

The novel coronavirus communicative modalities are ever-emergent and infinitely adaptable systems of the new normal state of mind and play. By focusing on specificities found in the corpus extracted from three leading Bosnian and Herzegovinian (B&H) newspapers, the paper attempts to merge the predominant theoretical insight into a mixture of conceptual and critical theories of language. The focus of the paper is two-fold. The first one is targeted at testing the extracted theoretical posits on the linguistic corpora. The second aims at challenging the notions of togetherness and separateness in the B&H society by mirroring them through the prism of Covid-19 newspaper reports. The results of the corpus analysis suggest that it is still possible to draw a line between the notions in accordance with the specific geographical regions from which the data are drawn.

scholarly journals Tipping in Crises: Evidence from Chicago Taxi Passengers during COVID-19

2021 ◽  
Author(s):  
Sarah Conlisk
Keyword(s):  
The United States ◽  
The Novel ◽  
Taxi Drivers ◽  
Percentage Points ◽  
Level Data ◽  
Increased Risk ◽  
Novel Coronavirus ◽  
Tipping Behavior ◽  
Theoretical Insight ◽  
Insight Into

In early 2020, the novel coronavirus (COVID-19) spread to the United States and upended normal life. Using trip-level data on over 17 million taxi rides taken in Chicago from 2018-2021, I document how tipping behavior changed during the COVID-19 pandemic. I find that the average non-zero tip increased by almost 2 percentage points, from roughly 26% to 28% of the taxi fare. Meanwhile, the likelihood that a passenger left a tip at all declined by roughly 5 percentage points, down from a pre-pandemic likelihood of 95%. My preferred specification suggests that the effect on the intensive margin dominates that in the extensive margin, leading to an aggregate increase in tipping generosity during the pandemic. I leverage granularity in the data to explore the mechanisms behind these trends and offer two explanations consistent with thedata. First, passengers responded to the two economic shocks of the pandemic – unemployment and savingsoverhangs – by varying their tipping rates accordingly. Second, passengers internalized the increased risk of COVID-19 infection as an additional cost for taxi drivers and increased their tips as compensation. My analysis testifies to the sustainability of tipping in times of crises and offers theoretical insight into what drives tipping behavior.

scholarly journals Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2)

2020 ◽  
Author(s):  
Xingyi Guo ◽  
Zhishan Chen ◽  
Yumin Xia ◽  
Weiqiang Lin ◽  
Hongzhi Li
Keyword(s):  
Genetic Variation ◽  
The Novel ◽  
S Protein ◽  
Angiotensin Converting Enzyme 2 ◽  
Missense Variants ◽  
Catalytic Metal ◽  
Using Data ◽  
Novel Coronavirus ◽  
Insight Into

Abstract Background: The outbreak of coronavirus disease (COVID-19) was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), through its surface spike glycoprotein (S-protein) recognition on the receptor Angiotensin-converting enzyme 2 (ACE2) in humans. However, it remains unclear how genetic variations in ACE2 may affect its function and structure, and consequently alter the recognition by SARS-CoV-2. Methods: We have systemically characterized missense variants in the gene ACE2 using data from the Genome Aggregation Database (gnomAD; N = 141,456). To investigate the putative deleterious role of missense variants, six existing functional prediction tools were applied to evaluate their impact. We further analyzed the structural flexibility of ACE2 and its protein-protein interface with the S-protein of SARS-CoV-2 using our developed Legion Interfaces Analysis (LiAn) program.Results: Here, we characterized a total of 12 ACE2 putative deleterious missense variants. Of those 12 variants, we further showed that p.His378Arg could directly weaken the binding of catalytic metal atom to decrease ACE2 activity and p.Ser19Pro could distort the most important helix to the S-protein. Another seven missense variants may affect secondary structures (i.e. p.Gly211Arg; p.Asp206Gly; p.Arg219Cys; p.Arg219His, p.Lys341Arg, p.Ile468Val, and p.Ser547Cys), whereas p.Ile468Val with AF = 0.01 is only present in Asian.Conclusions: We provide strong evidence of putative deleterious missense variants in ACE2 that are present in specific populations, which could disrupt the function and structure of ACE2. These findings provide novel insight into the genetic variation in ACE2 which may affect the SARS-CoV-2 recognition and infection, and COVID-19 susceptibility and treatment.

scholarly journals Evolutionary Frequency of the Available Human Coronavirus Genomes

2020 ◽  
Author(s):  
Ashfaq Ahmad ◽  
Sidra Majaz ◽  
Faisal Nouroz
Keyword(s):  
Evolutionary Process ◽  
The United States ◽  
Spatial Diversity ◽  
Global Scale ◽  
The Novel ◽  
Human Coronavirus ◽  
The Usa ◽  
Severity Of The Disease ◽  
Novel Coronavirus ◽  
Insight Into

Abstract Background. A novel, human-infecting coronavirus causing CoVID-19 was first identified in Wuhan, China in late December, 2019. Within a short span of time more the virus has recorded more than 1 million deaths world-wide. This study is designed to address the overall evolutionary process of the novel Coronavirus complete genomes. Addressing the complexity and huge population size, network-based approaches are used in mapping samples to their reported locations. Results. Total of 473 complete human-coronavirus genomes representing 20 different countries are studied including 17 states from the United States and samples collected from the Cruise-diamond princess. The phylodynamic network of global-scale is classified into five clusters contained two clusters U1 and U2 of the USA samples. Cluster B is a shared cluster of China and the USA while A and C are of diverse nature. We found that Chinese samples aggregated in cluster A and B which aided in retaining the homogeneous viral genomic pool. In contrast, samples from the USA and Spain were split into distinct clusters indicating multiple port entries and a possibility in implying a delay in quarantine measures. Among the samples from the USA, we found that sequences reported from Washington and Virginia are scattered indicating evolutionary diversity.Conclusion. This report provides insight into the transmission pattern of CoV2 which is complicated to evaluate exclusively through conventional surveillance means. Our data not only identify the transmission network but also suggest that the severity of the disease is linked to the spatial diversity of infection.

Energy Arbitration and Emerging Claims: A Post-COVID-19 New Normal?

2020 ◽  
Vol 1 (2) ◽  
pp. 205-210
Author(s):  
David Yibakuo Amakiri ◽  
Solomon Ugochukwu Ezike
Keyword(s):  
Paradigm Shift ◽  
Energy Sector ◽  
The Novel ◽  
Low Carbon ◽  
New Normal ◽  
Low Carbon Economy ◽  
Legal Risks ◽  
Novel Coronavirus ◽  
The Impact ◽  
Carbon Economy

The responses of government to the novel coronavirus has snowballed into circumstances that can aptly be termed a new normal likewise are the ongoing efforts to transition to a low carbon economy. The effect of these combinations is a paradigm shift in the energy sector and the investments that underpin the linkages. Many aspects of these investments in the energy sector have also been thrown into murky waters arising from the hardship operators face now and the consequent inability to perform agreed obligations adequately. In a post-COVID-19 world, these scenarios pose legal risks and will be subject of energy arbitration proceedings. This article highlights the impact of COVID-19 on the energy industry, the claims emerging from it, and the repercussions for arbitration of energy disputes. It also highlights how these changes affect the quest for a just transition to a low-carbon economy.

scholarly journals COVID-19: A natural phenomena or laboratory-based origin?

2020 ◽  
Author(s):  
Fanila Shahzad ◽  
Md Talat Nasim
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Medical Science ◽  
Health Concern ◽  
The Novel ◽  
Natural Phenomena ◽  
Viral Reservoirs ◽  
Major Health ◽  
Novel Virus ◽  
Novel Coronavirus ◽  
Insight Into

The novel coronavirus, otherwise known as COVID-19 has fast become a major health concern. The current pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV‐ 2) is the third coronavirus outbreak, following severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses. Since the initial cases of a pneumonia of unknown aetiology, which was later identified as COVID-19 in Wuhan, Hubei province, China, there has been much debate and speculation regarding the origins of this novel virus. This review aims to provide an insight into the origin of SARS-CoV-2 by reflecting on genomic data gathered thus far. Identifying the origins of SARS-CoV-2 can lead to better understanding of hidden viral reservoirs that may exist and pose a threat to society as well as allow greater understanding of the mechanisms by which these viruses have successfully achieved cross species transmission. Greater knowledge in regard to this can lead to the development of strategies which can aid in preventing future outbreaks of this scale. Bangladesh Journal of Medical Science Vol.19(0) 2020 p. p. S 85-S 87

scholarly journals The temporal correlation between positive testing and death in Italy: from the first phase to the later evolution of the COVID-19 pandemic

2021 ◽  
Author(s):  
Vincenzo d'Alessandro ◽  
Nicole Balasco ◽  
Pietro Ferrara ◽  
Luigi Vitagliano
Keyword(s):  
Phase 1 ◽  
Temporal Correlation ◽  
Mean Value ◽  
The Novel ◽  
Temporal Shift ◽  
Interesting Insight ◽  
Global Spread ◽  
Novel Coronavirus ◽  
The Impact ◽  
Insight Into

After the global spread of the novel coronavirus disease 2019 (COVID-19), research has concentrated its efforts on several aspects of the epidemiological burden of pandemic. In this frame, the presented study follows a previous analysis of the temporal link between cases and deaths during the first epidemic wave (Phase 1) in Italy (March-June 2020). We here analyze the COVID-19 epidemic in the time span from March 2020 to June 2021. The elaboration of the curves of cases and deaths allows identifying the temporal shift between the positive testing and the fatal event, which corresponds to one week from W2 to W33, two weeks from W34 to W41, and three weeks from W42 to W67. Based on this finding, we calculate the Weekly Lethality Rate (WLR). The WLR was grossly overestimated (~13.5%) in Phase 1, while a mean value of 2.6% was observed in most of Phase 2 (starting from October 2020), with a drop to 1.4% in the last investigated weeks. Overall, these findings offer an interesting insight into the magnitude and time evolution of the lethality burden attributable to COVID-19 during the entire pandemic period in Italy. In particular, the analysis highlighted the impact of the effectiveness of public health and social measures, of changes in disease management, and of preventive strategies over time.

scholarly journals “A Labour of Love”: Active Lifestyle Entrepreneurship (Occupational Devotion) During a Time of COVID-19

2021 ◽  
Vol 3 ◽  
Author(s):  
Richard Keith Wright ◽  
Cindy Wiersma ◽  
Richard Opara Ajiee
Keyword(s):  
Qualitative Methodology ◽  
Management Strategies ◽  
The Novel ◽  
Active Lifestyle ◽  
Personal Cost ◽  
Serious Leisure Perspective ◽  
Sport Events ◽  
Novel Coronavirus ◽  
Analytical Practice ◽  
Insight Into

The Novel Coronavirus (COVID-19) crisis management strategies adopted by world leaders across the globe in 2020 impacted the work-life balance of billions of people. Entire populations were forced to stay at home and maintain a safe distance from family members, friends, colleagues, and customers. Occupational devotion is defined as a feeling of strong, positive attachment to a form of self-enhancing employment, where achievement and fulfillment are high, and the core activity has such intense appeal that the line between this work and leisure is virtually erased. Although it is not a new concept, this area of the serious leisure perspective has been largely overlooked by scholars observing the world of sport events and entrepreneurship. Using Creative Analytical Practice (CAP), a post-qualitative methodology, we present the personal narrative of a New Zealand-based active lifestyle entrepreneur who, as a result of a nationwide COVID19 lockdown, was forced to re-assess his long-established occupational devotion. Our co-constructed story offers an emotive insight into the personal cost and consequences of finding yourself living in a lockdown.

scholarly journals Molecular Docking Studies of some Antiviral and Antimalarial Drugs Via Bindings to 3CL-Protease and Polymerase Enzymes of the Novel Coronavirus (SARS-CoV-2)

2020 ◽  
Vol 10 (5) ◽  
pp. 6444-6459 ◽  
Keyword(s):  
Molecular Docking ◽  
Docking Studies ◽  
Antimalarial Drugs ◽  
The Novel ◽  
Rapid Spread ◽  
Novel Virus ◽  
Novel Coronavirus ◽  
3Cl Protease ◽  
Insight Into

The rapid spread of the novel coronavirus (SARS-CoV-2) as a serious threat to the world public health is in dire need of finding potential therapeutic agents. Chinese have tested several antiviral and antimalarial drugs as potent inhibitors for the novel virus, such as remdesivir, chloroquine, hydroxychloroquine, umifenovir and favipiravir. In this study, we used the molecular docking models to study the binding interactions between these pharmaceuticals, as well as our proposed remdesivir analogue (AZCV-20) with the 3CLpro and RNA-dependent RNA polymerase (RdRp) of the SARS-CoV-2, using MEO and Autodock4 methods. Our study provides insight into the possible role of structural flexibility and efficacy during interactions between 3CLpro, RdRp and the drugs.

scholarly journals Disinfeksi Novel Coronavirus di Dalam Air Minum PDAM dan Air Limbah Untuk Fase Normal Baru

2020 ◽  
Author(s):  
Gede H Cahyana
Keyword(s):  
Drinking Water ◽  
Scientific Information ◽  
Genetic Material ◽  
Mechanical Action ◽  
Treated Wastewater ◽  
The Novel ◽  
Oxidation Pond ◽  
New Normal ◽  
Normal Water ◽  
Novel Coronavirus

The first COVID-19 outbreak was occurred in Wuhan, December 2019. WHO has assigned the outbreak as pandemic on March 11, 2020. This article aims to review the effectiveness of chlorination in eradicating viruses (and bacteria) in drinking water and wastewater so that people have scientific information in eradication practice. Articles were obtained from scholar.google.com, National Library, textbooks. During pandemic doctors, paramedics have carried out curative efforts. People have carried out preventive efforts. A third attempt is needed, mechanical action using chlorine. Chlorine was able to inactivate viruses in objects affected by droplets. At a dose 0.2–40 mg/l and free chlorine residual 0.2–0.5 mg/l, chlorination was effective in eradicating viruses (and bacteria) in drinking water. Bacteria can be used as a host by viruses. If the bacteria die, viruses are inactive. The novel Coronavirus envelope can be destroyed by chlorine. Researchers have found genetic material of novel Coronavirus in wastewater. The SARS virus has also been found in raw wastewater and treated wastewater with disinfectant. This states, chlorination is not effective in eradicating viruses (and bacteria) in wastewater because of its abundant of faeces. Chlorination is also not effective for killing viruses (and bacteria) in the oxidation pond. Effluents always contain significant amounts of viruses (and bacteria). The genetic material of novel Coronavirus found in wastewater will be a latent danger after pandemic (new normal). Water treated by PDAM will become more important in new normal and must be provided in public and social facilities.

scholarly journals COVID-19: An insight into the developments in diagnostics and therapeutics in India

2020 ◽  
Vol 72 ◽  
pp. 77-82 ◽  
Author(s):  
Vishal Rao ◽  
Swetha Kannan ◽  
Jitendra Kumar ◽  
Gururaj Arakeri ◽  
Anand Subash ◽  
...  
Keyword(s):  
Infection Prevention ◽  
Therapeutic Strategies ◽  
Therapeutic Interventions ◽  
Infection Prevention And Control ◽  
The Novel ◽  
Indian Government ◽  
Recent Developments ◽  
Novel Coronavirus ◽  
And Control ◽  
Insight Into

The unexpected pandemic set off by the novel coronavirus (SARS-CoV2) has spread to more than 210 countries across the globe, including India. In the current pandemic situation, various steps have been taken by the Indian government to prevent and control the spread of the SARS-CoV2 infection. To date, there are no proven vaccines or effective therapeutic interventions against the virus. Current clinical management includes infection prevention and control, symptom-specific relief and supportive care. Physicians and scientists across the country have been tirelessly working on developing effective diagnostic and therapeutic strategies and to combat and control this infection. As the demand for diagnostics and therapeutics continues to rise in India and around the globe, it is essential to rapidly develop various algorithms to successfully identify and contain the virus. This review discusses the updates on the recent developments in COVID-19 diagnostics and therapeutics in India.

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