scholarly journals Cardioprotectant Effect Of Bay Leaf Extract (Syzygiumpolyanthum) On Myocardium Thickness Of Rat Heart

2021 ◽  
Vol 17 (1) ◽  
pp. 19-26
Author(s):  
Dian Yuliartha Lestari ◽  
Rizky Trimaulidia
Keyword(s):  
Blood Pressure ◽  
Left Ventricle ◽  
Rattus Norvegicus ◽  
Rat Heart ◽  
Leaf Extract ◽  
Left Ventricular ◽  
Male Rat ◽  
Wistar Strain ◽  
Post Hoc ◽  
One Way Anova

High salt diet and prednisone administration will increase blood pressure which chronically causes heart muscle remodeling so that it appears macroscopically as left ventricular hypertrophy. Bay leaf extract contains flavonoids which can lower blood pressure and decrease left ventricular thickening. To determine the effect of bay leaf extract (Syzygiumpolyanthum) on the left ventricle thickening of rat heart (Rattus norvegicus wistar strain) in hypertensive model.  True experimental post-test only controls group design with simple random sampling technique. The subjects of this study were 25 male Wistar rats aged 2-3 months weighing 150-200 grams. Rats were induced with prednisone 1.5 mg/ KgBW / day in 2% NaCl for 6 weeks followed by administration of bay leaf extract at a dose of 70 mg/ KgBW, a dose of 140 mg/ KgBW, and a dose of 280 mg/ KgBW. Data analyzed by One Way ANOVA, Post Hoc Bonferroni, followed by Linear: One Way ANOVA test showed significant differences between treatments (p = 0.000). The Bonferroni Post Hoc test concluded that there were significant differences in the treatment of the P2 and P3 groups. Linear regression test obtained R square 0.663 and obtained the equation Y = 1965.838 - 1.275X. The extract of bay leaf (Syzygiumpolyanthum) has an effect on decreasing the left ventricle thickening of the white male rat heart (Rattus norvegicus wistar strain) hypertension model.

scholarly journals AKTIVITAS ANALGESIK EKSTRAK ETANOL DAUN SOYOGIK (Saurauia bracteosa DC) PADA TIKUS PUTIH JANTAN GALUR WISTAR

PHARMACON ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 868
Author(s):  
Dina Imorina Legoh ◽  
Max R.J. Runtuwene ◽  
Paulina V.Y. Yamlean
Keyword(s):  
Analgesic Activity ◽  
Rattus Norvegicus ◽  
Leaf Extract ◽  
Positive Control ◽  
Negative Control ◽  
White Rats ◽  
Wistar Strain ◽  
Before And After ◽  
Thermal Induction ◽  
One Way Anova

ABSTRACT  Soyogik leaves (Saurauia bracteosa DC) are plants that have flavonoid compounds that act as analgesics. This study aims to test the analgesic activity of soyogic leaf extract on male white rats Wistar strain using the thermic pain induction method. This research method is laboratory experimental, using male white rats (Rattus novergicus). The results obtained from the number of responses of mice between before and after giving the test solution. The treatment was initiated by thermal induction of pain in rats. Furthermore, the rat response was calculated, then given negative control (CMC), positive control (paracetamol), and soyogic leaf extract with a dose of 0.375 g / KgBB, 0.75 g / KgBB and 1.5 g / KgBB. The response of the mice after being given the treatment was seen from the 30th, 60th, 90th, and 120th minutes. Data were analyzed using the SPSS program, the real differences between the treatments were tested by one way ANOVA. The results showed that soyogic leaf extract with a dose of 0.375 g / KgBB, a dose of 0.75 g / KgBB and a dose of 1.5 g / KgBB have analgesic activity. Keywords: analgesics, Saurauia bracteosa DC, Rattus norvegicus  ABSTRAK Daun soyogik (Saurauia bracteosa DC) merupakan tanaman yang memiliki senyawa flavonoid yang berperan sebagai analgesik. Penelitian ini bertujuan untuk menguji aktivitas analgesik dari ekstrak daun soyogik pada tikus putih jantan galur wistar dengan metode induksi nyeri cara termik. Metode penelitian ini adalah eksperimental laboratorium, menggunakan tikus putih jantan (Rattus novergicus). Hasil penelitian diperoleh dari jumlah respon tikus antara sebelum dan sesudah pemberian larutan uji. Perlakuan diawali dengan induksi nyeri cara termik pada tikus. Selanjutnya dihitung jumlah respon tikus, kemudian diberikan kontrol negatif (CMC), kontrol positif (paracetamol), dan ekstrak daun soyogik dosis  0,375 g/KgBB, 0,75 g/KgBB dan 1,5 g/KgBB. Respon tikus setelah diberikan perlakuan dilihat mulai dari menit ke 30, 60, 90, dan 120. Data dianalisis menggunakan program SPSS, beda nyata antar perlakuan diuji dengan one way ANOVA. Hasil yang didapat menunukkan ekstrak daun soyogik dosis 0,375 g/KgBB, dosis 0,75 g/KgBB dan dosis 1,5 g/KgBB memiliki aktivitas analgesik.  Kata Kunci: analgesik, Saurauia bracteosa DC, Rattus norvegicus

scholarly journals Acute effects of nandrolone decanoate on cardiodynamic parameters in isolated rat heart

2016 ◽  
Vol 94 (10) ◽  
pp. 1048-1057 ◽  
Author(s):  
Tamara R. Nikolic ◽  
Vladimir I. Zivkovic ◽  
Ivan M. Srejovic ◽  
Dragan S. Radovanovic ◽  
Nevena S. Jeremic ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Rat Heart ◽  
Coronary Flow ◽  
Left Ventricular ◽  
Isolated Rat Heart ◽  
Albino Rats ◽  
Coronary Perfusion ◽  
Nandrolone Decanoate ◽  
Acute Effects ◽  
Isolated Rat

Despite worldwide use of anabolic steroids in last decades, there is still contradictory information about their acute influence on myocardium. The aim of this study was to examine the acute effects of nandrolone decanoate (ND) on cardiodynamics and coronary flow in isolated rat heart. The hearts of male Wistar albino rats (n = 48, 12 per group, age 8 weeks, body mass 180–200 g) were excised and perfused according to the Langendorff technique at gradually increased coronary perfusion pressures (40–120 cmH2O). After the control sets of experiments, the hearts in different groups were perfused with different doses of ND (1, 10, or 100 μmol/L separately). Using a sensor placed in the left ventricle, we registered maximum and minimum rate of pressure development in the left ventricle (dP/dtmax and dP/dtmin), systolic and diastolic left ventricular pressure (SLVP and DLVP), and heart rate (HR). Coronary flow (CF) was measured flowmetrically. The results clearly show the depression in cardiac function caused by higher doses of ND. The highest concentration of ND (100 μmol/L) induced the most deleterious impact on the myocardial function and perfusion of the heart (coronary circulation), which could be of clinical significance.

scholarly journals ANTIBACTERIAL EFFECTIVITY OF KASTURI LEAF EXTRACT (Mangifera casturi) AGAINST THE GROWTH OF Streptococcus sanguinis BACTERIA

2020 ◽  
Vol 5 (1) ◽  
pp. 33
Author(s):  
Dita Puspita Sari ◽  
Didit Aspriyanto ◽  
Irham Taufiqurrahman
Keyword(s):  
Leaf Extract ◽  
Periodontal Diseases ◽  
Tooth Surface ◽  
Control Group ◽  
Dilution Method ◽  
Control Group Design ◽  
Streptococcus Sanguinis ◽  
Significant Difference ◽  
Post Hoc ◽  
One Way Anova

Background: Caries is a disease that occurs because of the fermentation carbohydrates process by microorganisms in the oral cavity. One of the bacteria that causes caries is Streptococcus sanguinis. These bacteria will colonize on the tooth surface, then form dental plaques and contribute to the causes of caries and other periodontal diseases. Kasturi leaf extract (Mangifera casturi) has various compounds such as tannins, terpenoids, alkaloids, and flavonoids that have antimicrobial substances. Purpose: The aim of this study was to determine antibacterial effectivity of kasturi leaf extract (Mangifera casturi) against the growth of Streptococcus sanguinis bacteria. Method: This research was an experimental method laboratory (true experimental), with a randomized pre test and post test with control group design using 5 treatments: kasturi leaf extract (concentration: 20 mg/ml, 25 mg/ml, and 30 mg/ml); and two groups of control: positive control and negative control. Each treatment was repeated 5 times. Antibacterial activity testing used a liquid dilution method. Measurement of minimum inhibitory concentration (MIC) used a Uv-Vis Spectrophotometer and measurement of the minimum bactericidal concentration (MBC) used a colony counter. The MIC data were analyzed using One Way Anova and continued with the Dunnet Post Hoc test. MBC data were analyzed using the Kruskal-Wallis test and continued with the Mann-Whitney Post Hoc test. Result: One-Way Anova test showed that MIC had a significant difference, and the Kruskal-Wallis test showed that MBC also had significant differences. MIC was obtained at the concentration of 20 mg/ml and MBC was obtained at the concentration of 30 mg / ml. Conclusion: There is antibacterial effectiveness in kasturi leaf extract (Mangifera casturi) against the growth of Streptococcus sanguinis.

scholarly journals UJI EFEKTIVITAS SENYAWA FLAVONOID DARI EKSTRAK ETANOL DAUN SAWILANGIT (Vernonia cinerea (L.) Less) SEBAGAI ANTIPIRETIK PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus) YANG DIINDUKSI VAKSIN DPT

PHARMACON ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 572
Author(s):  
Asriyani Samiun ◽  
Edwin De Queljoe ◽  
Irma Antasionasti
Keyword(s):  
Rattus Norvegicus ◽  
Ethanol Extract ◽  
Male Rats ◽  
Test Material ◽  
Control Group ◽  
White Rats ◽  
Wistar Strain ◽  
One Way Anova ◽  
Vernonia Cinerea ◽  
Dpt Vaccine

ABSTRACTSawilangit leaves (Vernonia Cinerea (L.) Less) is a plant that contains flavonoids as an antipyretic. The purpose of this study was to determine the effectiveness of flavonoid compounds from ethanol extract of sawilangit (Vernonia cinerea (L.) Less) leaves as an antipyretic in male white rats Wistar strain (Rattus norvegicus) induced by DPT vaccine. A total of 15 male rats were divided into 5 treatment groups, namely the negative control group (CMC 1%), the positive control group (paracetamol), and the ethanol extract group of sawilangit leaves with a dose of 200 mg, a dose of 400 mg, a dose of 800 mg. Each mouse was induced intramuscularly with a DPT vaccine at a dose of 0.3 ml. Temperature measurements were carried out before and after induction, then every 30 minutes after giving the test material from the 30th minute to the 180th minute. Data were analyzed statistically with One Way ANOVA and continued with LSD test to see significant differences between treatments. The results showed that the ethanol extract of sawilangit leaves had an antipyretic effect on male white rats Wistar strain..Key words: Antipyretics, Vernonia Cinerea, male white rats ABSTRAKDaun Sawilangit  (Vernonia Cinerea (L.) Less) adalah salah satu tanaman yang mengandung zat Flavonoid sebagai antipiratik. Tujuan penelitian ini untuk mengetahui adanya efektivitas senyawa flavonoid dari ekstrak etanol daun sawilangit (Vernonia cinerea (L.) Less) sebagai antipiretik pada tikus putih jantan galur wistar (Rattus norvegicus) yang diinduksi vaksin DPT. Sebanyak 15 ekor tikus putih jantan dibagi 5 kelompok perlakuan yaitu kelompok kontrol negatif (CMC 1%), kelompok kontrol positif (parasetamol), dan kelompok ekstrak etanol daun sawilangit dosis 3,6 mg, dosis 7,2 mg, dosis 14,4 mg. setiap tikus diinduksi vaksin DPT dosis 0,3 ml secara intramuscular. Pengukuran suhu dilakuan sebelum dan sesudah induksi, kemudian setiap 30 menit  setelah pemberian bahan uji dari menit ke-30 sampai menit ke-180. Data dianalisis secara statistika dengan One Way ANOVA dan dilanjutkan uji LSD untuk melihat beda nyata antar perlakuan. Hasil penelitian menunjukan bahwa Ekstrak etanol daun sawilangit mempunyai efek antipiretik terhadap tikus putih jantan galur wistar. Kata kunci: Antipiretik, Vernonia Cinerea, tikus putih jantan

scholarly journals The Influence of Giving Tempe Flour Toward the Amount and Morphology of White Male Rat (Rattus norvegicus) Erythrocytes Wistar Strain was Affected by Cigarette Smoke

2019 ◽  
Vol 15 (2) ◽  
pp. 71
Author(s):  
I Made Subhawa Harsa
Keyword(s):  
Free Radicals ◽  
Treatment Group ◽  
Cigarette Smoke ◽  
Rattus Norvegicus ◽  
White Male ◽  
Male Rat ◽  
Special Treatment ◽  
Control Group ◽  
Wistar Strain ◽  
Group 2

Abstract: Cigarette smoke was one of free radicals source for the body. Free radical contain in cigarette smoke were hydroxide radicals (•OH). Hydroxide radicals would cause erythrocytes damage. Antioxidants were substances that can prevent free radicals. Now, natural antioxidants source has developed, one of that is tempe, because of it contained antioxidants substances such as carotene, Vitamin E, isoflavon, and factor II antioxidants. This resource was for knowing the influence of giving tempe flour toward the amount and morphology of white male rat (Rattus norvegicus) erythrocytes wistar strain was affected by cigarette smoke. A pure experiment which was used the post test only-control group design method. Sample of the resource was white male rat wistar strain aged of 3-4 month as much 30 rats by the weight around 180-220 gram. The samples divided into 3 groups that were control group (K1), treatment group 1 (K2), and treatment group 2 (K3), each group consists of 10 rats. Control group was not given a special treatment, it only got a standard feed, treatment group 1 got special treatment and it was affected by cigarette smoke, furthermore, treatment group 2 got standard feed, it was affected by cigarette smoke and tempe. Analysis of data used one way anova experiment. The test showed the significance P-value = 0,036 that was <α (0,05). The result showed that there was the influence of giving tempe flour toward the amount and morphology of white male rat (Rattus norvegicus) erythrocytes wistar strain was affected by cigarette smoke. Keywords: cigarette smoke, free radicals, erythrocytes, antioxidants, tempe

scholarly journals The Effectiveness Of The Papaya Leaf Extract (Carica Papaya L) On The Growth Of Epidermidic Staphylococcus Bacteria

2020 ◽  
Vol 11 (1) ◽  
pp. 65
Author(s):  
Charles Manurung ◽  
Melysa Loeslim ◽  
Setia Budi Tarigan
Keyword(s):  
Staphylococcus Epidermidis ◽  
Leaf Extract ◽  
Sampling Method ◽  
Inhibition Zone ◽  
Inhibitory Zone ◽  
Positive Bacterium ◽  
Post Test ◽  
The One ◽  
Post Hoc ◽  
One Way Anova

This research was conducted to determine the effectiveness test of papaya leaf extract with a concentration of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80% and 90% and 100% against staphylococcus epidermidis bacteria. Staphylococcus epidermidis is a gram-positive bacterium in the form of cocci and is harmful to humans. This research was conducted with an experimental method with a post-test only design and sampling with a purposive sampling method. The investigation of the effectiveness of papaya leaf extract against staphylococcus epidermidis was done by diffusion using paper discs, namely by calculating the diameter of the bacterial inhibition zone of paper discs that have been moistened with papaya leaf extract. The results of this study were analyzed out with the One-Way ANOVA test followed by the Post Hoc Test. The test showed that there were significant differences from each treatment given with a 95% confidence index. The bacteria treated with papaya leaf extract 100% against staphylococcus epidermidis had the highest average inhibitory zone power compared to other concentrations of 14.97 mm. The papaya leaf extract 100% has the best antibacterial effect compared to other concentrations because the best inhibitory zone power is found on those extract concentrations.

Effect of aldosterone and of plasma extracts on a rat heart-lung preparation

1960 ◽  
Vol 199 (2) ◽  
pp. 221-225 ◽  
Author(s):  
Kathryn Ballard ◽  
Allan Lefer ◽  
George Sayers
Keyword(s):  
Blood Pressure ◽  
Cardiac Output ◽  
Mean Arterial Blood Pressure ◽  
Rat Heart ◽  
Left Ventricular ◽  
Arterial Blood ◽  
Work Index ◽  
Lung Preparation ◽  
Adrenalectomized Rats ◽  
Intact Rats

Heart-lungs from intact rats were perfused with blood from intact rats (intact-intact preparations) or with blood from adrenalectomized rats (intact-adrenalectomized preparations). Left ventricular work index (LVWI) was employed to evaluate performance of the heart-lung and calculated as the product of cardiac output and mean arterial blood pressure. In confirmation of a previous report from this laboratory, LVWI was less for intact-adrenalectomized preparations than for intact-intact preparations. Aldosterone, added to perfusion blood from adrenalectomized rats to make a concentration of 2 x 10–3, 8 x 10–3 or 3.2 x 10–2 µg/100 ml, increased LVWI of the intact-adrenalectomized preparation to that of the intact-intact preparation. Extracts of plasma from intact rats, which may be expected to contain corticosteroids, were also capable of increasing LVWI of the intact-adrenalectomized preparation. Extracts of plasma from adrenalectomized rats were inactive.

Pengaruh Pemberian Air Rendaman Rumput Fatimah (Anastatica Hierochuntica) Terhadap Kadar Hormon Oksitosin dan Hormon Prolaktin Pada Tikus Putih (Rattus Norvegicus) Menyusui Perbandingan

2019 ◽  
Vol 8 (1S) ◽  
pp. 31
Author(s):  
Yunni Safitri ◽  
Afriwardi Afriwardi ◽  
Eny Yantri
Keyword(s):  
Rattus Norvegicus ◽  
Multiple Comparisons ◽  
Control Group ◽  
Post Hoc ◽  
One Way Anova

Rumput fatimah (Anastatica Hierochuntica) mengandung senyawa fitokimia seperti alkaloid, tanin, dan flavonoid yang merupakan bagian fitoestrogen. Tujuan Penelitian ini untuk menganalisis pengaruh pemberian air rendaman rumput fatimah (Anastatica Hierochuntica) terhadap hormon oksitosin dan hormon prolaktin pada tikus putih (Rattus Norvegicus) menyusui. Jenis penelitian ini adalah eksperimental dengan desain Post-Tes Only Control Group. Jumlah sampel 32 tikus menyusui yang dibagi menjadi 4 kelompok, yaitu kelompok kontrol dan 3 kelompok perlakukan P1, P2 dan P3 yang masing–masing diberi 10gr, 20gr dan 40gr rendaman Anastatica Hierochuntica. Penelitian dilakukan di Labor Farmasi dan Biomedik Universitas Andalas. Hormon oksitosin dan hormon prolaktin diukur dengan mengunakan metode ELISA. Uji statistik menggunakan uji Shapiro Wilk untuk mengetahui normalitas data, dilanjutkan One Way ANOVA dan untuk mengetahui perbedaan pada kelompok digunakan uji Multiple Comparisons (post hoc test) jenis Bonferroni. Hasil penelitian ini menunjukkan terdapat perbedaan signifikan (p<0,05) kadar hormon oksitosin antara kelompok kontrol (56,604±10,907) dengan kelompok P2 (44,095±6,117). Pada hormon prolaktin juga berbeda secara bermakna (p<0,05) antara kelompok kontrol (11,794±1,633) dengan kelompok P3 (16,991±3,735). Terdapat perbedaan yang bermakna terhadap pemberian air rendaman rumput fatimah (Anastatica Hierochuntica) terhadap hormon oksitosin dan hormon prolaktin pada tikus putih (Rattus Norvegicus) menyusui.

Pulsatile Load and Wasted Pressure Effort are Reduced Following an Acute Bout of Aerobic Exercise

2021 ◽  
Author(s):  
Jordan C. Patik ◽  
Joseph M. Stock ◽  
Ninette Shenouda ◽  
Nicholas V. Chouramanis ◽  
Justin D. Mehrer ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Left Ventricle ◽  
Aerobic Exercise ◽  
Wave Amplitude ◽  
Characteristic Impedance ◽  
Left Ventricular ◽  
Moderate Intensity ◽  
Post Exercise ◽  
Reflected Wave ◽  
Pulsatile Load

Following aerobic exercise, sustained vasodilation and concomitant reductions in total peripheral resistance (TPR) result in a reduction in blood pressure that is maintained for two or more hours. However, the time course for postexercise changes in reflected wave amplitude and other indices of pulsatile load on the left ventricle have not been thoroughly described. Therefore, we tested the hypothesis that reflected wave amplitude is reduced beyond an hour after cycling at 60% V̇O2peak for 60 min. Aortic pressure waveforms were derived in 14 healthy adults (7 men, 7 women; 26 ± 3 yr) from radial pulse waves acquired via high-fidelity applanation tonometry at baseline and every 20 min for 120 min postexercise. Concurrently, left ventricle outflow velocities were acquired via Doppler echocardiography and pressure-flow analyses were performed. Aortic characteristic impedance (Zc), forward (Pf) and backward (Pb) pulse wave amplitude, reflected wave travel time (RWTT), and wasted pressure effort were derived. Reductions in aortic blood pressure, Zc, Pf, and Pb were all sustained postexercise while increases in RWTT emerged from 60-100 min post exercise (all P<0.05). WPE was reduced by ~40% from 40-100 min post exercise (all P<0.02). Stepwise multiple regression analysis revealed that the peak ∆WPE was associated with ∆RWTT (β=-0.57, P=0.003) and ∆Pb (β=0.52, P=0.006), but not ∆cardiac output, ∆TPR, ∆Zc, or ∆Pf. These results suggest that changes in pulsatile hemodynamics are sustained for ≥100 min following moderate intensity aerobic exercise. Moreover, decreased and delayed reflected pressure waves are associated with decreased left ventricular wasted effort after exercise.

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