scholarly journals UJI EFEKTIVITAS SENYAWA FLAVONOID DARI EKSTRAK ETANOL DAUN SAWILANGIT (Vernonia cinerea (L.) Less) SEBAGAI ANTIPIRETIK PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus) YANG DIINDUKSI VAKSIN DPT

PHARMACON ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 572
Author(s):  
Asriyani Samiun ◽  
Edwin De Queljoe ◽  
Irma Antasionasti
Keyword(s):  
Rattus Norvegicus ◽  
Ethanol Extract ◽  
Male Rats ◽  
Test Material ◽  
Control Group ◽  
White Rats ◽  
Wistar Strain ◽  
One Way Anova ◽  
Vernonia Cinerea ◽  
Dpt Vaccine

ABSTRACTSawilangit leaves (Vernonia Cinerea (L.) Less) is a plant that contains flavonoids as an antipyretic. The purpose of this study was to determine the effectiveness of flavonoid compounds from ethanol extract of sawilangit (Vernonia cinerea (L.) Less) leaves as an antipyretic in male white rats Wistar strain (Rattus norvegicus) induced by DPT vaccine. A total of 15 male rats were divided into 5 treatment groups, namely the negative control group (CMC 1%), the positive control group (paracetamol), and the ethanol extract group of sawilangit leaves with a dose of 200 mg, a dose of 400 mg, a dose of 800 mg. Each mouse was induced intramuscularly with a DPT vaccine at a dose of 0.3 ml. Temperature measurements were carried out before and after induction, then every 30 minutes after giving the test material from the 30th minute to the 180th minute. Data were analyzed statistically with One Way ANOVA and continued with LSD test to see significant differences between treatments. The results showed that the ethanol extract of sawilangit leaves had an antipyretic effect on male white rats Wistar strain..Key words: Antipyretics, Vernonia Cinerea, male white rats ABSTRAKDaun Sawilangit  (Vernonia Cinerea (L.) Less) adalah salah satu tanaman yang mengandung zat Flavonoid sebagai antipiratik. Tujuan penelitian ini untuk mengetahui adanya efektivitas senyawa flavonoid dari ekstrak etanol daun sawilangit (Vernonia cinerea (L.) Less) sebagai antipiretik pada tikus putih jantan galur wistar (Rattus norvegicus) yang diinduksi vaksin DPT. Sebanyak 15 ekor tikus putih jantan dibagi 5 kelompok perlakuan yaitu kelompok kontrol negatif (CMC 1%), kelompok kontrol positif (parasetamol), dan kelompok ekstrak etanol daun sawilangit dosis 3,6 mg, dosis 7,2 mg, dosis 14,4 mg. setiap tikus diinduksi vaksin DPT dosis 0,3 ml secara intramuscular. Pengukuran suhu dilakuan sebelum dan sesudah induksi, kemudian setiap 30 menit  setelah pemberian bahan uji dari menit ke-30 sampai menit ke-180. Data dianalisis secara statistika dengan One Way ANOVA dan dilanjutkan uji LSD untuk melihat beda nyata antar perlakuan. Hasil penelitian menunjukan bahwa Ekstrak etanol daun sawilangit mempunyai efek antipiretik terhadap tikus putih jantan galur wistar. Kata kunci: Antipiretik, Vernonia Cinerea, tikus putih jantan

scholarly journals UJI EFEK ANTIPIRETIK EKSTRAK ETANOL DAUN BELIMBING WULUH (Averrhoa bilimbi L.) PADA TIKUS PUTIH JANTAN (Rattus norvegicus L.)

PHARMACON ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 595
Author(s):  
Anissa Sedu ◽  
Edwin De Queljoe ◽  
Julianri Sari Lebang
Keyword(s):  
Rattus Norvegicus ◽  
Ethanol Extract ◽  
Test Dose ◽  
Positive Control ◽  
Negative Control ◽  
Male Rats ◽  
White Rats ◽  
One Way Anova ◽  
Wistar Male Rats ◽  
Dpt Vaccine

ABSTRACTStarfruit leaves (Averrhoa Bilimbi L) is a plant that contains tannins and flavonoids. In accordance with previous research it was stated that tannins and flavonoids have antiperetic activity. This study aims to determine whether the ethanol extract of starfruit leaves has an antiperetic effect in wistar male rats (Rattus Norvegicus L) induced by the DPT vaccine. This study used 15 test animals and devided into 5 grops consisting of negative control (cmc 1%), positive control (paracetamol) and the test dose group namely the administration of starfruit leaves extract 3,6 mg/200 grams BW, 7,2 mg/200 grams BW and 14,4 mg/200 grams BW. Each mouse was induced with DPT vaccine doses of 0,2 ml intramuscularly. Temperature measurements were made taken before induction, 2 hours after induction and every 30 minutes for 3 hours. The results showed a decrease in temperature in the 60th minute of starfruit leaves 3,6 mg/200 grams BW, 7,2 mg/200 grams BW and 14,4 mg/200 grams BW. The data obtained were analyzed using one-way ANOVA test and LSD test. Based on the results of the study it can be concluded that the ethanol extract of starfruit leaves 3,6 m, 7,2 mg and 14,4 mg has antiperetic activity in male white rats. Keywords : Averrhoa bilimbi L,Antiperetic,Rattus novergicus L,Vaksin DPTABSTRAK Daun belimbing wuluh (Averrhoa bilimbi L.)  adalah salah satu tanaman yang mengandung zat tanin dan flavonoid. Berdasarkan penelitian-penelitian sebelumnya menyatakan bahwa tanin dan flavonoid mempunyai aktivitas antipiretik. Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol daun belimbing wuluh memiliki efek sebagai antipiretik pada tikus putih jantan (Rattus norvegicus L.) yang di induksikan vaksin DPT. Penelitian ini menggunakan hewan uji sebanyak 15 ekor dan dibagi menjadi 5 kelompok yang terdiri dari kontrol negatif (CMC 1%),  kontrol positif (parasetamol) dan kelompok dosis uji yaitu pemberian ekstrak daun Belimbing wuluh 3,6 mg/200 gram BB, 7,2 mg/200 gram BB, dan 14,4 mg/200 gram  BB. Tiap  tikus diinduksi dengan vaksin DPT sebanyak 0,2 ml secara intramuskular. Pengukuran suhu dilakukan sebelum induksi, 2 jam setelah pemberian induksi dan setiap 30 menit selama 3 jam. Hasil penelitian menunjukkan terjadi penuruan suhu pada menit yang ke 60 ekstrak etanol daun belimbing wuluh 3,6 mg/200 gram BB, 7,2 mg/200 gram BB, dan 14,4 mg/200 gram BB.  Data yang diperoleh dianalisis dengan menggunakan uji ANOVA satu arah dan uji LSD dapat menurunkan suhu rektal tikus. Data yang diperoleh dianalisa menggunakan ANOVA. Berdasarkan hasil penelitian dapat disimpulkan bahwa ekstrak etanol daun belimbing wuluh 3,6 mg, 7,2 mg, dan 14,4 mg mempunyai aktivitas antipiretik pada tikus putih jantan.  Kata Kunci :  Averrhoa bilimbi L., Antipiretik, Rattus norvegicus L,  Vaksin DPT

scholarly journals UJI EFEK ANALGESIK EKSTRAK ETANOL DAUN KELOR (Moringa oleifera Lam.) PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus)

PHARMACON ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 325
Author(s):  
Alyah A.P Tamimi ◽  
Edwin De Queljoe ◽  
Jainer P. Siampa
Keyword(s):  
Rattus Norvegicus ◽  
Analgesic Effect ◽  
Moringa Oleifera ◽  
Ethanol Extract ◽  
Negative Control ◽  
Test Material ◽  
Control Group ◽  
White Rats ◽  
Wistar Strain ◽  
Moringa Oleifera Lam

ABSTRACTAnalgesic medicinals are medicinals that can inhibit pain. Moringa leaves (Moringa oleifera Lam.) are known to contains alkaloid and flavonoid which have analgesic effects.The purpose of this study was to determine the analgesic effects of the ethanol extract of Moringa leaves on male white rats wistar strain (Rattus norvegicus). A total of 15 rats were divided into 5 treatment groups, namely the negative control group (CMC), positive control group (paracetamol), and the group of ethanol extract of Moringa leaves with different doses of 0.1 g, 0.2 g, and 0.4 g. Rat response was observed before giving test material and after giving test material from the 30th, 60th, 90th, and 120th minutes. Data were analyzed using ANOVA then continued with LSD test. The results showed that the ethanol extract of Moringa leaves with dosages of 0.1 g, 0.2 g, and 0.4 g had an analgesic effect on male white rats wistar strain. And among these three doses the best in providing analgesic effect is a dose of 0.4 g. Keywords: Analgesic, Moringa leaf (Moringa oleifera Lam.), Rattus norvegicus. ABSTRAKObat analgesik merupakan obat yang dapat menghambat rasa nyeri. Daun kelor (Moringa oleifera Lam.) diketahui mengandung alkaloid dan flavonoid yang memiliki efek analgesik. Tujuan penelitian ini untuk mengetahui adanya efek analgesik dari ekstrak etanol daun kelor (Moringa oleifera Lam.) pada tikus putih jantan galur wistar (Rattus norvegicus). Sebanyak 15 ekor tikus dibagi 5 kelompok perlakuan, yaitu kelompok kontrol negatif, kelompok kontrol positif, dan kelompok ekstrak etanol daun kelor dengan dosis berbeda 0,1 g, 0,2 g, dan 0,4 g. Respon tikus diamati sebelum pemberian bahan uji dan setelah pemberian bahan uji dari menit ke 30, 60, 90, dan 120. Data dianalisis menggunakan ANOVA kemudian dilanjutkan uji LSD. Hasil penelitian menunjukkan bahwa ekstrak etanol daun kelor  dengan dosis 0,1 g 0,2 g, dan 0,4 g memiliki efek analgesik terhadap tikus putih jantan galur wistar. Dan diantara ketiga pemberian dosis tersebut yang paling baik dalam memberikan efek analgesik yaitu dosis 0,4 g. Kata kunci: Analgesik, Daun Kelor (Moringa oleifera Lam.), Rattus norvegicus.

scholarly journals THE EFFECTIVENESS OF CORIANDER (Coriandrum sativum L.) EXTRACTS ON REDUCING THE BLOOD SUGAR LEVELS OF ALLOXAN INDUCED WISTAR MALE RATS (Rattus norvegicus L.)

2020 ◽  
Vol 6 (1) ◽  
pp. 36-44
Author(s):  
Kalvin Dersing
Keyword(s):  
Blood Sugar ◽  
Rattus Norvegicus ◽  
Water Extract ◽  
Coriandrum Sativum ◽  
Male Rats ◽  
Control Group ◽  
Control Group Design ◽  
White Rats ◽  
Wistar Strain ◽  
Sugar Levels

AbstractBackground : Diabetes mellitus is the most common metabolic syndrome in the whole world with an incidence of 1-8%. This disease arises when insufficient insulin is produced or insulin cannot function properly.The ability of coriander juice water extract is expected to reduce blood glucose levels because the action is similar to insulin and can stimulate insulin release. Purpose : Knowing effectiveness coriander extract (Coriandrum sativum L.)to decline blood sugar levels in male white rats (Rattus norvegicus L.) wistar strain induced by alloxan. Method : This is a pure experimental study (true-experiment) using a pre and post test design with control group design using subjects namely white rats (Rattus norvegicus L.) male Wistar strain aged 10-12 weeks with a weight of 150-200 grams. By looking at changes in blood sugar levels during administration of alloxan and administration of coriander extract. Results : There were significant changes in some groups induced alloxan (p <0.05), but the effect of coriander extract was not very significant (p> 0.05). Conclusion : Coriander extract can control blood sugar levels to be stable or normal, but it takes longer and more research.  Keywords : coriander extract, blood sugar levels, alloxan

scholarly journals UJI EFEK ANALGESIK EKSTRAK ETANOL DAUN KEJI BELING (Strobilanthes crispus L) PADA TIKUS PUTIH GALUR WISTAR (Rattus norvegicus)

PHARMACON ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 170
Author(s):  
Ariesthya D. C. Olii ◽  
Widdhi Bodhi ◽  
Hosea J. Edi
Keyword(s):  
Analgesic Effect ◽  
Emotional Experience ◽  
White Male ◽  
Ethanol Extract ◽  
Male Rats ◽  
Test Material ◽  
Analgesic Effects ◽  
Wistar Strain ◽  
Strobilanthes Crispus ◽  
One Way Anova

ABSTRACT Pain is an unpleasant sensory and emotional experience due to tissue damage both actual and potential. Analgesics are a drug used to relieve pain without losing consciousness. Keji beling leaves (Strobilanthes crispus L) contain glycosidic ester compounds from caffeic acid, which have analgesic effects. This study aims to determine whether there is an analgesic effect on the ethanol extract of keji beling leaves with different doses, namely dose 0.0023g / 200gBW, 0.0047g / 200gBW, and 0.0094g / 200gBW in test animals of wistar strain male rats. This study uses a laboratory experimental research design using wistar strain male white rat as a test animal. The analgesic effect test was carried out by the heat stimulation method using a 53 °C water bath. The rat response was observed in the form of movements of licking the hind legs or jumping from before giving test material and after giving test material at 30, 60, 90 and 120 minutes, respectively. From the results of statistical data analysis with One Way Anova and LSD showed that the extracts keji beling leaves has an analgesic effect. Where among those three doses the best dose was 0.0023g / 200gBW. Keywords: Analgesic, anova, keji beling leaves, white male wistar rats. ABSTRAK Rasa nyeri merupakan pengalaman sensorik dan emosional yang tidak menyenangkan akibat kerusakan jaringan baik aktual maupun potensial. Analgesik ialah suatu obat yang digunakan untuk menghilangkan rasa sakit tanpa menghilangkan kesadaran. Daun keji beling (Strobilanthes crispus  L) mengandung senyawa glikosidik ester dari asam caffeic yang memiliki efek analgesik. Penelitian ini bertujuan untuk mengetahui ada tidaknya efek analgesik pada ekstrak etanol daun keji beling dengan dosis berbeda-beda yaitu dosis 0,0023g/200gBB, 0,0047g/200gBB, dan 0,0094g/200gBB pada hewan uji tikus putih jantan galur wistar. Penelitian ini menggunakan Rancangan penelitian eksperimental laboratorium dengan menggunakan hewan uji tikus putih jantan galur wistar. Pengujian efek analgesik dilakukan dengan metode rangsangan panas menggunakan waterbath suhu 53°C. Respon tikus diamati berupa gerakan menjilat kaki belakang atau melompat dari sebelum pemberian bahan uji dan sesudah pemberian bahan uji  berturut-turut pada menit ke 30, 60, 90 dan 120. Dari hasil analisis data secara statistika dengan One Way Anova dan LSD menunjukkan bahwa ekstrak daun keji beling memiliki efek analgesik. Dimana antara ketiga dosis tersebut yang paling terbaik ialah dosis 0,0023 g/200gBB. Kata kunci : Analgesik, Anova, Daun Keji Beling, tikus putih jantan galur wistar

scholarly journals EFFECT OF NIFEDIPINE ON APOPTOSIS, NECROSIS AND VIABILITY OF GERMINAL EPITHELIAL CELLS IN THE CONTRALATERAL TESTICLE AND PLASMA TESTOSTERONE LEVELS IN MALE WHITE RATS (RATTUS NORVEGICUS, WISTAR STRAIN) AFTER UNILATERAL TESTICULAR TORSION

2019 ◽  
Vol 26 (2) ◽  
Author(s):  
Hajid Rahmadianto Mardihusodo ◽  
Fikri Rizaldi ◽  
Lukman Hakim
Keyword(s):  
Epithelial Cells ◽  
Rattus Norvegicus ◽  
Testicular Torsion ◽  
White Male ◽  
Male Rats ◽  
Plasma Testosterone ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
White Rats ◽  
Wistar Strain

Objective: To compare the number of apoptosis, necrosis and viability of germinal epithelial cells in the contralateral testicle (CT) and plasma testosterone (PT) levels in white male rats which administered Nifedipine after unilateral testicular torsion (TT) compared with control group. Material & Methods: This research was an experimental study using male white rats (Rattus Norvegicus, Wistar strain) aged 10-12 weeks and body weight 150-200 gram. A total of 30 rats were then randomly divided into 5 groups (n=6) which were negative control group (KN), positive control group (KP1 and KP2) and Nifedipine-administered group (N1 and N2). Each group performed unilateral left side torsion of testicular of 1080o anticlockwise except the KN group. There was 4-hour ischemic duration in the KP1 and N1 groups while 10 hours in the KP2 and N2 groups. Administration of Nifedipine 30 minutes before detorsion by intraperitoneal injection dosed 100 μg/kgBW. All groups performed right orchidectomy and plasma blood sampling. Measurement of apoptosis, necrosis and viability of germinal epithelial cells in the CT using flowcytometry. Measurement of PT levels using Enzyme-Linked Immunosorbent Assay (ELISA). Results: The number of apoptosis, necrosis and viability of contralateral testicular germinal epithelial cells and PT levels in the KN group compared with KP1 and KP2 groups were significantly different (p<0.05). There was no significant discrepancy in apoptosis (p>0.05) in KP1 group compared with N1 group, as well as in KP2 group compared with N2 groups. The number of necrosis, viability of germinal epithelial cells in the CT and PT level in KP1 group in compared with N1 group, as well as in KP2 group in compared with N2 group were significantly different (p<0.05). Conclusion: Nifedipine administration prior to testicular detorsion can maintain cell viability and decrease the amount of necrotic germinal epithelial cells in the CT and prevent the decrease in PT levels after unilateral TT.

scholarly journals PENGARUH PEMBERIAN INFUSA DAUN LABU SIAM (Sechium edule) TERHADAP PENURUNAN KADAR KOLETEROL DARAH TOTAL TIKUS PUTIH JANTAN (Rattus norvegicus)

PHARMACON ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 151
Author(s):  
Ausich Singal ◽  
Edwin De Queljoe ◽  
Paulina Yamlean
Keyword(s):  
Rattus Norvegicus ◽  
Dose Group ◽  
T Test ◽  
Blood Cholesterol ◽  
Control Group ◽  
Cholesterol Levels ◽  
White Rats ◽  
Sechium Edule ◽  
One Way Anova ◽  
Paired T Test

ABSTRACT This study aims to determine the effect of infusion of conjoined pumpkin leaves (Sechium edule) on reducing total blood cholesterol of male white rats (Rattus norvegicus). The subjects of this study were 15 male white rats with an average body weight of 200 grams which were divided into 5 groups, each group consisted of 3 mice. The method used is a laboratory experiment with a completely randomized design. The results were obtained from 2 measurements of blood cholesterol levels, namely measurements before and after treatment. The treatment begins with the provision of high-fat foods for 48 days. On the 49th day a blood cholesterol level was measured before treatment. Furthermore, treatment was given to each group, namely aquades in the negative control group, simvastatin in the positive control group, and squash leaves infusion with their respective doses in the dose group I (40%), the dose group II (20%), and the dose group III (10%). Measurement of cholesterol levels after treatment was carried out on day 54. Data were analyzed by Paired t-test and One Way ANOVA. The analysis showed that there were no significant differences between treatment groups. Judging from the change in average and percentage, 40% infusion dose of siamese pumpkin leaves gives the best reduction in cholesterol levels. Keywords: Cholesterol, pumpkin leaves, male white mouse infusion. ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh pemberian infusa daun labu siam (Sechium edule ) terhadap penuruan kolesterol darah total tikus putih jantan (Rattus norvegicus). Subjek penelitian ini berupa tikus putih jantan berjumlah 15 ekor dengan berat badan rata-rata 200 gram yang dibagi dalam 5 kelompok, masing-masing kelompok sebanyak 3 ekor. Metode yang digunakan yaitu eksperimen laboratorium dengan rancangan acak lengkap. Hasil penelitian diperoleh dari 2 kali pengukuran kadar koleterol darah yaitu pengukuran sebelum dan sesudah perlakuan. Perlakuan dimulai dengan pemberian makanan tinggi lemak selama 48 hari. Pada hari ke49 dilakukan pengukuran kadar kolesterol darah sebelum perlakuan. Selanjutnya diberikan perlakuan pada tiap kelompok yaitu aquades pada kelompok kontrol negatif, simvastatin pada kelompok kontrol positif, dan infusa daun labu siam dengan dosis masing-masing pada kelompok dosis I (40 %), kelompok dosis II (20 %), dan kelompok dosis III (10%). Pengukuran kadar kolesterol sesudah perlakuan dilakukan pada hari 54. Data diananlisis dengan Paired t-test dan One Way ANOVA. Hasil analisa menunjukan tidak terdapat perbedaan yang bermakna antar kelompok perlakuan. Dilihat dari perubahan rerataan dan presentase, dosis infusa  40% daun labu siam memberikan penurunan kadar koleterol terbaik. Kata kunci : Infusa daun Labu siam, kolesterol, tikus putih jantan.

scholarly journals UJI ANTIDIABETIK EKSTRAK ETANOL BUNGA PEPAYA (Carica papaya L.) TERHADAP TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI ALOKSAN

PHARMACON ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 160
Author(s):  
Adinda Fransisca Pongoh ◽  
Edwin De Queljoe ◽  
Henki Rotinsulu
Keyword(s):  
Blood Glucose ◽  
Rattus Norvegicus ◽  
Carica Papaya ◽  
Fasting Blood Glucose ◽  
Ethanol Extract ◽  
Control Group ◽  
Homogeneity Test ◽  
Glucose Levels ◽  
White Rats ◽  
Blood Glucose Levels

ABSTRACT This study aims to determine the antidiabetic activity of papaya flower ethanol extract (Carica papaya L.) against male white rats (Rattus norvegicus) induced by alloxan. This research is experimental. Fifteen rats were divided into 5 treatment groups, each group consisted of 3 rats. The first group was the negative control group given Aquades, the second group was positive control given Glibenklamid, the three groups were 200 mg dose variation groups, four groups were 400 mg dose variations, and the five groups were 800 mg dose variations. Previously, rats were examined fasting blood glucose levels, then mice were induced by an alloxan dose of 120 mg / kgBW intraperitoneally. On the 3rd day blood glucose levels were examined and then treated according to groups for 7 days, measurement of blood glucose levels after the treatment was carried out once every 3 days namely day 3, day 7, and day 10. Data obtained were then analyzed statistically using SPSS , including normality test (Shapiro-Wilk), homogeneity test (Levene), ANOVA test (One way). The results of this study indicate that Papaya Flower (Carica papaya L.) Ethanol Extract can provide the best blood glucose level reduction effect at a dose of 800 mg. Keywords : Antidiabetic, Papaya Flower Extract (Carica papaya L.), Diabettes Mellitus, Male White Rat (Rattus norvegicus), Aloxan.  ABSTRAK Penelitian ini bertujuan untuk mengetahui efektivitas Antidiabetik Ekstrak Etanol Bunga Pepaya (Carica papaya L.) Terhadap Tikus Putih Jantan (Rattus norvegicus) Yang Diinduksi Aloksan. Penelitian ini bersifat eksperimental. Sebanyak 15 ekor tikus dibagi ke dalam 5 kelompok perlakuan masing- masing kelompok terdiri dari 3 ekor tikus. Kelompok pertama kelompok Kontrol negatif yang diberikan Aquades, Kelompok kedua Kontrol Positif yang diberikan Glibenklamid, kelompok tiga kelompok variasi dosis 200 mg, kelompok empat kelompok variasi dosis 400 mg, dan kelompok lima kelompok variasi dosis 800 mg. Sebelumnya tikus dilakukan pemeriksaan kadar glukosa darah puasa, selanjutnya tikus diinduksi Aloksan dosis 120 mg/kgBB secara intraperitoneal. Pada hari ke 3 diperiksa kadar Glukosa darah kemudian diberikan perlakuan sesuai kelompok selama 7 hari, pengukuran kadar glukosa darah setelah perlakuan dilakukan 3 hari sekali yaitu hari ke 3, hari ke 7, dan hari ke 10. Data yang diperoleh kemudian dianalisis secara statistik menggunakan SPSS, meliputi uji normalitas (Shapiro-Wilk), uji homogenitas (Levene), uji ANOVA (One way). Hasil penelitian ini menunjukkan bahwa Ekstrak Etanol Bunga Pepaya (Carica papaya L.)  dapat memberikan efek penurunan kadar glukosa darah yang paling baik yaitu pada dosis 800 mg. Kata kunci : Antidiabetik, Ekstrak Bunga pepaya (Carica papaya L.), Diabettes Mellitus, TikusPutih Jantan (Rattus norvegicus), Aloksan.

scholarly journals The Effect of Balimo (Zanthoxylum nitidum) Immersion Water On The Hematological Profile of White Rats (Rattus norvegicus) That Given Liquor (Ciu)

2021 ◽  
Vol 10 (1) ◽  
pp. 47-57
Author(s):  
Panca Buana Wijaya ◽  
Tyas Rini Saraswati ◽  
Silvana Tana ◽  
Sunarno Sunarno ◽  
Erma Prihastanti
Keyword(s):  
Rattus Norvegicus ◽  
Male Rats ◽  
Excessive Alcohol Consumption ◽  
White Rats ◽  
Excessive Alcohol ◽  
The Mean ◽  
Zanthoxylum Nitidum ◽  
The Difference ◽  
Antioxidant Effects ◽  
One Way Anova

Consumption of liquor such as Ciu in excessive doses can cause a decrease in hematological status. Balimo stem is an alternative treatment to improve hematological status due to excessive alcohol consumption because it contains alkaloids, flavonoids, and other secondary metabolic compounds, that have functions as antioxidant effects. This study aims to examine and analyze the effect of Balimo immersion water on the hematological status of mice with the observed variables, namely the erythrocytes count, hemoglobin levels, hematocrit value, and total count of leukocytes in rats that had been given Ciu. The study used 20 Rattus norvegicus male rats which were divided into 4 groups. The data were analyzed using one-way ANOVA. The results showed no significant differences (p <0.05) on the Balimo immersion water treatment, but if it was seen from the difference in the mean data of each variable, it could still be seen the difference from each treatment. In this study, it can be concluded that Balimo immersion water was able to improve the hematological status of rats that had been given Ciu liquor with a 0,2 mL dose.

TOTAL FLAVONOID DAN EFEKTIVITAS EKSTRAK ETANOL BIJI KELOR (Moringa oleifera L) ASAL KOTA PALU SULAWESI TENGAH TERHADAP HISTOPATOLOGI PANKREAS TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI STREPTOZOTOCIN

2020 ◽  
Vol 6 (1) ◽  
pp. 24
Author(s):  
Viani Anggi ◽  
Joni Tandi ◽  
Veronika Veronika
Keyword(s):  
Ethanol Extract ◽  
Negative Control ◽  
Total Flavonoid ◽  
Male Rats ◽  
Control Group ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
White Rats ◽  
Group I ◽  
Streptozotocin Induced Diabetes

This study aims to determine the content of flavonoid and the effect of ethanol extract of moringa seeds on the regeneration of pancreatic β cells in male white rats streptozotocin induced diabetes. This study method used has total flavonoid equivalent quercetin by spectrophotometry uv-vis and to regeneration of pancreatic β cells in male white rats used 30 test animals,namely male white rats divided into 6 groups, each group consisted of 5 male white rats with details of group I as normal control, Group II as negative control given 0.5% Na-CMC suspension, Group III as positive control given glibenclamide suspension and in Groups IV, V, and VI were given with each dose of 100 mg/kg BW, 200 mg/kg BW and 400 mg/kg BB. Histopathological damage picture of the pancreas was observed by staining HE using a 400x magnification olympus Cx21 microscope. The results showed that the ethanol extract of moringa seeds contained secondary metabolites, namely flavonoids, alkaloids, saponins and tannins. The results showed has total flavonoid equivalent quercetin of moringa seeds is 1,26% and regeneration of pancreatic β cells in male white rats streptozotocin induced diabetes of Moringa seed ethanol extract at a dose of 400 mg/kg BB can have an effect on the regeneration of β cells in the pancreas of white diabetic male rats.  

scholarly journals Effect of Giving Mahkota Dewa Fruits (Phaleria Macrocarpa) Extract to Epithelialization In Incision Wound of White Rats (Rattus Norvegicus)

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Idola Perdana Sulistyoning Suharto
Keyword(s):  
Treatment Group ◽  
Rattus Norvegicus ◽  
Male Rats ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
White Rats ◽  
Significant Difference ◽  
Phaleria Macrocarpa ◽  
Incision Wound

The research purpose was to analysis effect of giving mahkota dewa fruits (Phaleria macrocarpa) extract to epithelialization in incision wound of white rats (Rattus norvegicus). The method was randomized posted-only control group design. There were 30 male rats (Rattus norvegicus) grouped on control and treatment group. Control group divided into three groups (KK1, KK2, KK3) and also treatment group divided into three groups (KP1, KP2, KP3). Control group just given CMC 1% peroral without mahkota dewa fruits extract, the treatment group given mahkota dewa fruits extract 22.5 mg/kg body weight. The data was analyzed by Kruskall Wallis. Based on Kruskall Wallis test, obtained result that there was a significant difference (p<0.05) epithelialization variable with p value p = 0.000 between control and treatment group. And based on One-way Anova test, obtained result that there was a significant difference (p<0.05) with p value p =0.000 between control and treatment group. The conclusion of this research was giving mahkota dewa fruits (Phaleria macrocarpa) extract can increase epithelialization in incision wound of white rats (Rattus norvegicus). Keywords : Mahkota Dewa Fruits (Phaleria Macrocarpa) Extract, Epithelialization, Incision Wound 

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