scholarly journals Desarrollo de dos fórmulas infantiles como alternativa económica y saludable para seguridad alimentaria y nutricional de la población lactante

2016 ◽  
Vol 18 (2) ◽  
pp. 291
Author(s):  
Beatriz Estella López-Marín ◽  
Julie Maritza Álvarez-Rivera ◽  
Luz Marina Carvajal de Pabón
Keyword(s):  
Folic Acid ◽  
Infant Formula ◽  
Exploratory Study ◽  
Low Cost ◽  
Normal Growth ◽  
Cow Milk ◽  
Infant Formulas ◽  
Growth Requirements ◽  
Microbiological Characteristics ◽  
Two Phases

Introducción: Cuando la lactancia materna no es posible, se recurre a otros alimentos que brinden los nutrientes necesarios a los bebés, como las fórmulas infantiles, con características nutricionales que cumplan con la reglamentación actual y permitan un adecuado crecimiento al lactante. Objetivo: Diseñar dos fórmulas líquidas para lactantes que aporten los requerimientos diarios de macronutrientes y algunos micronutrientes (ácido fólico, zinc, calcio y hierro), con leche de vaca, higienizada por pasteurización, de bajo costo para que sea más asequible para la población lactante vulnerable a la vez que contribuye con su crecimiento. Materiales y métodos: Estudio exploratorio desarrollado en dos fases, formulación y elaboración de los productos y verificación de su eficacia en el crecimiento de lactantes. Resultados: Los productos cumplen con los requisitos de fabricación exigidos, de bajo costo y son capaces de sustentar un crecimiento normal, según clasificación de OMS. Conclusión: Las fórmulas desarrolladas tienen un adecuado aporte de macro y micronutrientes con características sensoriales y microbiológicas bajo los criterios exigidos por la reglamentación internacional y nacional, de bajo costos, permitiendo un adecuado crecimiento al lactante. AbstractIntroduction: When breastfeeding is not feasible, other sources to provide the required nutrients to babies are sought, such as infant formulas that comply with current regulation and with the baby’s growth requirements. Objective: To design two liquid infant formulas that provide daily macronutrients and some micronutrients (folic acid, zinc, calcium, and iron) requirements, based on low-cost pasteurized cow milk in order to be more affordable for vulnerable babies and to contribute with their growth. Materials and Methods: Exploratory study developed in two phases: Formulation and preparation of the infant formula and verification of its efficacy in terms of babies’ growth. Results: The infant formulas comply with all manufacturing requirements, are inexpensive, and appropriate to sustain normal growth, according to WHO. Conclusion: The two infant formulas developed have adequate macronutrient and micronutrient contribution with sensorial and microbiological characteristics that comply with local and foreign regulations, are inexpensive, and appropriate to sustain babies’ normal growth. 

scholarly journals Comparison of the Bifidogenic Effects of Goat and Cow Milk-Based Infant Formulas to Human Breast Milk in an in vitro Gut Model for 3-Month-Old Infants

2020 ◽  
Vol 7 ◽  
Author(s):  
Sophie Gallier ◽  
Pieter Van den Abbeele ◽  
Colin Prosser
Keyword(s):  
Human Milk ◽  
Infant Formula ◽  
Goat Milk ◽  
Cow Milk ◽  
Common Source ◽  
Human Breast Milk ◽  
Infant Formulas ◽  
Infant Gut Microbiome

Human milk contains prebiotic components, such as human milk oligosaccharides (HMOs), which stimulate the growth of specific members of the infant gut microbiota (e.g., Bifidobacteria). Plant-based or synthetic oligosaccharides are often added to infant formulas to simulate the bifidogenic effect of HMOs. Cow milk, the most common source of protein in infant formula, and goat milk, used increasingly in the manufacture of infant formula, contain naturally-occurring prebiotics. This study compared the upper gastrointestinal digestion and subsequent colonic fermentation of human milk vs. goat and cow milk-based infant formulas (goat IF and cow IF, respectively), without additional oligosaccharides using an in vitro model for 3-month-old infants based on the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®). First, a dialysis approach using 3.5 kDa membranes was demonstrated to simulate small intestinal absorption of carbohydrates in conditions similar to those in vivo. During the in vitro digestion experiment, oligosaccharides were detected in human milk and goat IF but barely detected in the cow IF. Further, all three milk matrices decreased colonic pH by boosting acetate, lactate, and propionate production, which related to increased abundances of acetate/lactate-producing Bifidobacteriaceae for human milk (+25.7%) and especially goat IF (33.8%) and cow IF (37.7%). Only cow IF stimulated butyrate production which correlated with an increase in Lachnospiraceae and Clostridiaceae. Finally, Enterobacteriaceae and Acidaminococcaceae also increased with all three milk matrices, while production of proteolytic metabolites (branched-chain fatty acids) was only detected for the cow IF. Overall, goat and cow milk-based formulas without added oligosaccharides impacted gut microbial activity and composition similarly to human milk. This suggests that even without supplementation of formula with oligosaccharides, whole goat milk, whole cow milk and cow milk ingredients already supply compounds in formulas that exert beneficial bifidogenic effects. Further clinical research is warranted to elucidate the effect of whole goat milk-based formulas on the infant gut microbiome.

scholarly journals Excessive Leucine-mTORC1-Signalling of Cow Milk-Based Infant Formula: The Missing Link to Understand Early Childhood Obesity

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Bodo C. Melnik
Keyword(s):  
Childhood Obesity ◽  
Human Milk ◽  
Infant Formula ◽  
Metabolic Diseases ◽  
Mammalian Target Of Rapamycin ◽  
Milk Proteins ◽  
Cow Milk ◽  
Infant Formulas ◽  
Great Chance ◽  
Induce Insulin Resistance

Increased protein supply by feeding cow-milk-based infant formula in comparison to lower protein content of human milk is a well-recognized major risk factor of childhood obesity. However, there is yet no conclusive biochemical concept explaining the mechanisms of formula-induced childhood obesity. It is the intention of this article to provide the biochemical link between leucine-mediated signalling of mammalian milk proteins and adipogenesis as well as early adipogenic programming. Leucine has been identified as the predominant signal transducer of mammalian milk, which stimulates the nutrient-sensitive kinase mammalian target of rapamycin complex 1 (mTORC1). Leucine thus functions as a maternal-neonatal relay for mTORC1-dependent neonatalβ-cell proliferation and insulin secretion. The mTORC1 target S6K1 plays a pivotal role in stimulation of mesenchymal stem cells to differentiate into adipocytes and to induce insulin resistance. It is of most critical concern that infant formulas provide higher amounts of leucine in comparison to human milk. Exaggerated leucine-mediated mTORC1-S6K1 signalling induced by infant formulas may thus explain increased adipogenesis and generation of lifelong elevated adipocyte numbers. Attenuation of mTORC1 signalling of infant formula by leucine restriction to physiologic lower levels of human milk offers a great chance for the prevention of childhood obesity and obesity-related metabolic diseases.

Letters to the Editor

PEDIATRICS ◽  
1963 ◽  
Vol 32 (3) ◽  
pp. 463-463
Author(s):  
Keyword(s):  
Folic Acid ◽  
Cow Milk ◽  
Committee Report ◽  
Infant Formulas ◽  
Letters To The Editor ◽  
Nutritional Adequacy ◽  
Milk Substitutes

The Committee on Nutrition has reviewed the interesting letter from Drs. Naiman and Oski regarding the Committee Report, "Appraisal of Nutritional Adequacy of Infant Formulas Used as Cow Milk Substitutes." In this letter they call attention to a discrepancy between their own values for folic acid (60 µg/qt) and those mentioned in the Committee report (2 µg/qt). The Committee is aware that the S. fecalis assay is quite low in comparison to the L. casei assay, whereas bioassay values are intermediate. The complexity of the problem is obvious from the following letter by Drs. Luhby and Cooperman.

Impact of an Infant Formula Containing a Novel Fat Blend (Cow’s Milk Fat, Fish and Vegetable Oil) and Prebiotics on Stool Fatty Acid Soaps and Erythrocyte Fatty Acid Profiles in Full-Term Healthy Newborns

2021 ◽  
pp. 1-8
Author(s):  
Maroula Lambidou ◽  
Birgit Alteheld ◽  
Rolf Fimmers ◽  
Frank Jochum ◽  
Antonia Nomayo ◽  
...  
Keyword(s):  
Body Weight ◽  
Fatty Acid ◽  
Infant Formula ◽  
Milk Fat ◽  
Control Group ◽  
Human Breast Milk ◽  
Infant Formulas ◽  
Fa Composition ◽  
And Control ◽  
Breast Fed

<b><i>Introduction:</i></b> Recently, new commercial infant formulas have been composed considering novel fat blends and oligosaccharides to better resemble the fatty acid (FA) composition and stereospecific distribution (e.g., increased amount of ß-palmitate) as well as probiotics content of human breast milk. We hypothesized that these newly composed infant formulas may decrease fecal FA soap excretion and may positively affect erythrocyte FA profiles compared with regular formulas. <b><i>Methods:</i></b> Healthy infants were randomly assigned to receive a high-sn-2-palmitate formula (&#x3e;25% of the PA is esterified to the sn-2 position of the glycerol backbone, verum: <i>n</i> = 30) or a “standard” formula containing &#x3c;10% of PA in sn-2 position and no oligosaccharides (control: <i>n</i> = 27); a non-randomized group of breast-fed infants served as control. Anthropometric data of the infants (body weight, recumbent length, and head circumference) were recorded at inclusion (visit 1) and 6 and 12 weeks after onset of intervention (visits 2 and 3). Blood samples for erythrocyte FA analysis (gas chromatography) were taken at visits 1 and 2; stool samples were collected at visit 2. <b><i>Results:</i></b> Quantitative formula intake (mL/kg body weight × day) at visit 2 (verum: 155 ± 30, control: 164 ± 30) and visit 3 (verum: 134 ± 26, control: 134 ± 21) was comparable. Six weeks after onset of intervention, stool total FA soaps, palmitate soaps, and total FAs were similar in both formula-fed groups but significantly higher than in breast-fed infants. During the 6-week intervention, erythrocyte palmitate decreased significantly from baseline in all 3 groups with no group differences (verum: 29.20 ± 1.17 to 27.12 ± 0.66, control: 29.88 ± 2.00 to 27.01 ± 0.94, breast-fed: 30.20 ± 0.86 to 26.84 ± 0.98). For selected FAs, significant changes over time in verum and control group were obvious but without formula effects. Some variations in the FA profile of breast-fed infants compared to both verum and control groups were observed. <b><i>Conclusions:</i></b> In contrast to our hypothesis, feeding a newly composed infant formula based on a fat blend with 25% of PA in the sn-2 position of triacylglycerols and supplemented with a prebiotic could not decrease insoluble FA soap excretion compared with a standard product; in this respect, breastfeeding is obviously the best choice. Surprisingly, erythrocyte FA profiles were comparable in formula-fed and breast-fed infants; obvious alterations in FA composition of the respective fat sources and structure did not affect FA incorporation into membranes. Caution should be, however, exercised in drawing robust conclusions in the absence of larger, adequately powered intervention studies.

A simple device to apply equibiaxial strain to cells cultured on flexible membranes

2008 ◽  
Vol 294 (1) ◽  
pp. H532-H540 ◽  
Author(s):  
Obaida R. Rana ◽  
Carsten Zobel ◽  
Esra Saygili ◽  
Klara Brixius ◽  
Felix Gramley ◽  
...  
Keyword(s):  
Cell Biology ◽  
Low Cost ◽  
Normal Growth ◽  
Neonatal Rat ◽  
Simple Device ◽  
Static Stretch ◽  
Voltage Gated ◽  
Wide Range ◽  
Dose Dependent ◽  
Cells Cultured

The biomechanical environment to which cells are exposed is important to their normal growth, development, interaction, and function. Accordingly, there has been much interest in studying the role of biomechanical forces in cell biology and pathophysiology. This has led to the introduction and even commercialization of many experimental devices. Many of the early devices were limited by the heterogeneity of deformation of cells cultivated in different locations of the culture plate membranes and were also attached with complicated technical/electronic efforts resulting in a restriction of the reproducibility of these devices. The objective of this study was to design and build a simple device to allow the application of dose-dependent homogeneous equibiaxial static stretch to cells cultured on flexible silicone membranes to investigate biological and biomedical questions. In addition, cultured neonatal rat atrial cardiomyocytes were stretched with the proposed device with different strain gradients. For the first time with this study we could demonstrate that stretch up to 21% caused dose-dependent changes in biological markers such as the calcineurin activity, modulatory calcineurin-interacting protein-1, voltage-gated potassium channel isoform 4.2, and voltage-gated K+ channel-interacting proteins-2 gene expression and transient outward potassium current densities but not the protein-to-DNA ratio and atrial natriuretic peptide mRNA. With both markers mentioned last, dose-dependent stretch alterations could only be achieved with stretch up to 13%. The simple and low-cost device presented here might be applied to a wide range of experimental settings in different fields of research.

EFFICACY AND SAFETY OF HYDROLYZED COW MILK AND AMINO ACID-DERIVED FORMULAS IN INFANTS WITH COW MILK ALLERGY

PEDIATRICS ◽  
1996 ◽  
Vol 98 (2) ◽  
pp. 322-322
Author(s):  
Timothy Pham ◽  
Michael Kaplan
Keyword(s):  
Amino Acid ◽  
Normal Growth ◽  
Cow Milk ◽  
Food Allergies ◽  
Milk Allergy ◽  
Efficacy And Safety ◽  
Cow Milk Allergy

Extensively hydrolyzed formulas are safe and effective for most infants; amino acid-derived formulas may be preferable for infants with multiple food allergies, especially for the maintenance of normal growth.

Survey of Vulnerabilities and Mitigation Techniques for Mooc-Based Applications

2016 ◽  
Vol 7 (4) ◽  
pp. 1-18 ◽  
Author(s):  
Hossain Shahriar ◽  
Hisham M. Haddad ◽  
David Lebron ◽  
Rubana Lupu
Keyword(s):  
Open Source Software ◽  
Exploratory Study ◽  
Online Courses ◽  
Software Security ◽  
Low Cost ◽  
Massive Open Online Courses ◽  
Massive Open Online ◽  
Security Vulnerabilities ◽  
Cloud Environments ◽  
Mitigation Techniques

Massive Open Online Courses (MOOCs) are commonly hosted as web servers for learners worldwide to access education and learning materials at low cost. Many of the well-known MOOCs have adopted open source software and database technologies and frequently operate within cloud environments. It is likely that the well-known software security vulnerabilities may manifest to MOOC-based applications. Unfortunately, few studies have identified a set of common vulnerabilities applicable to MOOC-based applications. This paper1 presents an exploratory study of potential security vulnerabilities and challenges for MOOC platforms, and it provide some guidelines and suggestions to mitigate these concerns. This study helps practitioners (educators and developers) to adopt MOOC applications while considering potential vulnerabilities and be prepared to deal with these risks.

scholarly journals Interprofessional Practice in the Emergency Service: specific and shared assignments of nurses

2019 ◽  
Vol 72 (suppl 1) ◽  
pp. 213-220
Author(s):  
Ruth Ester Assayag Batista ◽  
Marina Peduzzi
Keyword(s):  
Exploratory Study ◽  
Delphi Technique ◽  
Emergency Service ◽  
Nursing Interventions ◽  
Interprofessional Practice ◽  
Potential Factor ◽  
Two Phases ◽  
Definition Of

ABSTRACT Objective: To map and categorize, according to the Nursing Interventions Classification (NIC), the specific assignments of the nurses and to identify the assignments shared with doctors and physiotherapists in the Emergency Service. Method: Descriptive exploratory study, carried out in two phases: first, the analysis of dissertations /theses from the database of the Center for Studies and Research of the Brazilian Nursing Association; Second, the use of the Delphi Technique to reach the consensus about which assignments were specific to the nurse and which were shared with physiotherapists and doctors. Results: The results were 45.7% for specific to the nurses, 14.2% for shared with physiotherapists and/or doctors, and in 40% (n=42) there was no consensus about the sharing of assignments. Conclusion: The sharing of actions among professionals shows an increase in the scope of the practice of professions and the constitution of a common sphere of work, but the high number of assignments with no consensus among specialists can be a potential factor in conflicts due to the lack of definition of these assignments.

scholarly journals Are Faba Bean and Pea Proteins Potential Whey Protein Substitutes in Infant Formulas? An In Vitro Dynamic Digestion Approach

Foods ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 362
Author(s):  
Linda Le Roux ◽  
Olivia Ménard ◽  
Raphaël Chacon ◽  
Didier Dupont ◽  
Romain Jeantet ◽  
...  
Keyword(s):  
Faba Bean ◽  
Whey Proteins ◽  
Milk Proteins ◽  
Protein Digestibility ◽  
Cow Milk ◽  
Partial Substitution ◽  
Infant Formulas ◽  
Pea Proteins

Infant formulas (IFs) are used as substitutes for human milk and are mostly based on cow milk proteins. For sustainability reasons, animal protein alternatives in food are increasingly being considered, as plant proteins offer interesting nutritional and functional benefits for the development of innovative IFs. This study aimed to assess how a partial substitution (50%) of dairy proteins with faba bean and pea proteins influenced the digestibility of IFs under simulated dynamic in vitro digestion, which were set up to mimic infant digestion. Pea- and faba bean-based IFs (PIF and FIF, respectively) have led to a faster aggregation than the reference milk-based IF (RIF) in the gastric compartment; that did not affect the digesta microstructure at the end of digestion. The extent of proteolysis was estimated via the hydrolysis degree, which was the highest for FIF (73%) and the lowest for RIF (50%). Finally, it was apparent that in vitro protein digestibility and protein digestibility-corrected amino acid score (PDCAAS)-like scores were similar for RIF and FIF (90% digestibility; 75% PDCAAS), but lower for PIF (75%; 67%). Therefore, this study confirms that faba bean proteins could be a good candidate for partial substitution of whey proteins in IFs from a nutritional point of view, provided that these in vitro results are confirmed in vivo.

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