Formulation and Development of Transdermal Patches of Piroxicam

The aim of the given study was to formation as well as development of patches of piroxicam. Piroxicam basically a steroidal anti-inflammatory drug. Less dosage result in the longer duration of action which make these patches a remarkable in curing the infection for the increase of transdermal properties of the patches various batches were prepared using hydroxyl propyl methyl cellulose, ethyl cellulose and poly vinyl pyrrolidone for best result various parameters are considered like thickness,weight are considered during various test in different batches and the last are i.e. the 6th batch comes good result batch 6th show best evaluation parameter whereas batch 7th show a 95 % release of drug there parameters including moisture content and above mention were tested and were evaluated for best possible result.

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Preparation and Characterization of Polymer Blends of Ethyl Cellulose and its Composites

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.665.336 ◽

2013 ◽

Vol 665 ◽

pp. 336-340 ◽

Cited By ~ 1

Author(s):

Eknath Nivrtirao ◽

Basavaraja Sannakki

Keyword(s):

Activation Energy ◽

Dielectric Permittivity ◽

Polymer Blend ◽

Ethyl Cellulose ◽

Weight Percent ◽

Vinyl Pyrrolidone ◽

X Ray ◽

Poly Vinyl Pyrrolidone ◽

Different Thickness

The polymer blend of Ethyl Cellulose (EC) with Poly (vinyl) pyrrolidone (PVP) of various weight percentages at different thickness are used for measurement of dielectric permittivity, electrical conductivity and optical properties. The activation energies of the EC and its blend with PVP are obtained through measurement of dc conductivity. The samples are characterized by using X-ray diffractometer (XRD). The blends of EC with PVP in the ratio of 50:50 weight percent using FTIR over the range of wavenumber 4000-500 cm-1. Key words: Polymer Blend, XRD, SEM, FTIR, dielectric permittivity, activation energy.

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Microstructures and Electrical Properties of HPMC/PVP Polymer Blend Films Complex with Ferric Chloride (FeCl3)

Material Science Research India ◽

10.13005/msri/110208 ◽

2014 ◽

Vol 11 (2) ◽

pp. 153-158

Author(s):

H Ananda ◽

T Urs ◽

Y Prakash ◽

K Hemalatha ◽

H Somashekarappa ◽

...

Keyword(s):

Electrical Conductivity ◽

Structural Modification ◽

Dopant Concentration ◽

Methyl Cellulose ◽

Vinyl Pyrrolidone ◽

X Ray Diffraction ◽

X Ray ◽

Blend Films ◽

Poly Vinyl Pyrrolidone ◽

Microstructural Studies

Microstructural studies on FeCl3 doped Hydroxypropyl methyl cellulose (HPMC)/Poly vinyl pyrrolidone (PVP) blend films were carried out using X-Ray diffraction studies. The XRD data revealed that the crystalline regions of the HPMC/PVP blend film decreases up to a certain percentage of FeCl3 and then increases. Electrical conductivity studies on these doped films suggest complex formation due to doping which affects microstructure and also ac conductivity of polymer films. All these results were analyzed and explained on the basis of micro structural modification of HPMC/PVP blends as function of dopant concentration.

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Microsegregating blends of ethyl cellulose and poly(vinyl pyrrolidone): a combined thermo-mechanical and positron annihilation spectroscopy study

Cellulose ◽

10.1007/s10570-018-2220-6 ◽

2019 ◽

Vol 26 (3) ◽

pp. 1619-1630 ◽

Cited By ~ 1

Author(s):

Guido Panzarasa ◽

Alina Osypova ◽

Giovanni Consolati ◽

Stefano Pandini

Keyword(s):

Positron Annihilation ◽

Ethyl Cellulose ◽

Positron Annihilation Spectroscopy ◽

Vinyl Pyrrolidone ◽

Spectroscopy Study ◽

Poly Vinyl Pyrrolidone

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Formulation and Evaluation of Chlorpheniramine Maleate Mouth Dissolving Films

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v9i1-s.2417 ◽

2019 ◽

Vol 9 (1-s) ◽

pp. 244-251 ◽

Cited By ~ 1

Author(s):

D Teja ◽

E Jasvanth ◽

B Mounika ◽

Buchi N Nalluri

Keyword(s):

Drug Release ◽

Release Kinetics ◽

Methyl Cellulose ◽

The Elderly ◽

Physicomechanical Properties ◽

Vinyl Pyrrolidone ◽

Release Mechanism ◽

Chlorpheniramine Maleate ◽

Poly Ethylene ◽

Poly Vinyl Pyrrolidone

The present investigation was aimed at preparation and evaluation of mouth dissolving films (MDFs) of an anti-histamine drug, Chlorpheniramine Maleate (CPM) to enhance convenience and compliance to the elderly and paediatric patients. The MDFs were prepared using wet film applicator and evaluated for physicochemical and physicomechanical properties. MDFs were prepared with 0.6% and 0.8% w/w CPM. The MDFs with 0.8% w/w drug load showed re-crystallisation within 10 days, while the MDFs with 0.6% w/w CPM load were transparent with no re-crystallization. The effect of film formers, film thickness, film modifiers, saliva stimulating and soothing agents on the physicomechanical properties and CPM release from MDFs were evaluated. MDFs casted at 30mil thickness containing poly ethylene glycol (PEG-400) as plasticizer showed superior CPM release rates along with good physicomechanical properties. MDFs with hydroxy propyl methyl cellulose (HPMC) E3 as film former gave superior CPM release rate when compared to E5 and E15 formulations. MDFs with poly vinyl pyrrolidone K30 (PVPK30) gave superior drug release properties when compared to MDFs without PVP K30. The MDFs with citric acid (CA) and xylitol gave superior CPM release than the other MDFs. Release kinetics data reveals diffusion as drug release mechanism.

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Preparation and In vitro Characterization of Aceclofenac Nanosuspension (ACNS) for Enhancement of Percutaneous Absorption using Hydrogel Dosage Form

Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) ◽

10.31351/vol30iss2pp86-98 ◽

2021 ◽

Vol 30 (2) ◽

pp. 86-98

Author(s):

Aseel Kadhem Thamer ◽

Ahmed Najem Abood

Keyword(s):

Particle Size ◽

Dissolution Rate ◽

Physical Stability ◽

Methyl Cellulose ◽

Aqueous Solubility ◽

Vinyl Pyrrolidone ◽

Precipitation Method ◽

Characterization Methods ◽

Anti Inflammatory

Aceclofenac (AC) is an orally active phenyl acetic acid derivative, non-steroidal anti-inflammatory drug with exceptional anti-inflammatory, analgesic and antipyretic properties. It has low aqueous solubility, leading to slow dissolution, low permeability and inadequate bioavailability. The aim of the current study was to prepare and characterize AC-NS-based gel to enhance the dissolution rate and then percutaneous permeability. NS.s were prepared using solvent/antisovent precipitation method at different drug to polymer ratios (1:1, 1:2, and 1:3) using different polymers such as poly vinyl pyrrolidone (PVP-K25), hydroxy propyl methyl cellulose (HPMC-E5) and poloxamer® (388) as stabilizers alone and in combinations of two polymers (1:2 and 1:4 Drug: polymer ratio). Fifteen formulas of AC-NS.s were prepared and characterized for production yield, loading efficiency, particle size, polydispersity index and physical stability. The best formulas of NS were then lyophilized to be characterized by FTIR, DSC, P-XRD and SEM. After that, the best prepared formula of AC-NS regarding the involved characterization methods was incorporated in gel dosage forms using carbopol®940. From this study, we conclude that the dissolution rate and permeability of AC were improved when the particle size was reduced to Nano-scale as compared with pure drug.

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Ethyl Cellulose and Hydroxypropyl Methyl Cellulose Blended Methotrexate-Loaded Transdermal Patches: In Vitro and Ex Vivo

Polymers ◽

10.3390/polym13203455 ◽

2021 ◽

Vol 13 (20) ◽

pp. 3455

Author(s):

Muhammad Shahid Latif ◽

Abul Kalam Azad ◽

Asif Nawaz ◽

Sheikh Abdur Rashid ◽

Md. Habibur Rahman ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Ethyl Cellulose ◽

Ex Vivo ◽

In Vitro Release ◽

Methyl Cellulose ◽

Transdermal Patches ◽

Percent Moisture ◽

Vitro Release

Transdermal drug delivery systems (TDDSs) have become innovative, fascinating drug delivery methods intended for skin application to achieve systemic effects. TDDSs overcome the drawbacks associated with oral and parenteral routes of drug administration. The current investigation aimed to design, evaluate and optimize methotrexate (MTX)-loaded transdermal-type patches having ethyl cellulose (EC) and hydroxypropyl methyl cellulose (HPMC) at different concentrations for the local management of psoriasis. In vitro release and ex vivo permeation studies were carried out for the formulated patches. Various formulations (F1–F9) were developed using different concentrations of HPMC and EC. The F1 formulation having a 1:1 polymer concentration ratio served as the control formulation. ATR–FTIR analysis was performed to study drug–polymer interactions, and it was found that the drug and polymers were compatible with each other. The formulated patches were further investigated for their physicochemical parameters, in vitro release and ex vivo diffusion characteristics. Different parameters, such as surface pH, physical appearance, thickness, weight uniformity, percent moisture absorption, percent moisture loss, folding endurance, skin irritation, stability and drug content uniformity, were studied. From the hydrophilic mixture, it was observed that viscosity has a direct influence on drug release. Among all formulated patches, the F5 formulation exhibited 82.71% drug release in a sustained-release fashion and followed an anomalous non-Fickian diffusion. The permeation data of the F5 formulation exhibited about a 36.55% cumulative amount of percent drug permeated. The skin showed high retention for the F5 formulation (15.1%). The stability study indicated that all prepared formulations had very good stability for a period of 180 days. Therefore, it was concluded from the present study that methotrexate-loaded transdermal patches with EC and HPMC as polymers at different concentrations suit TDDSs ideally and improve patient compliance for the local management of psoriasis.

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FABRICATION AND ASSESSMENT OF LERCANIDIPINE HYDROCHLORIDE SOLID DISPERSIONS FOR SOLUBILITY PREFERMENT USING POLYMER COMBINATION

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2021.v14i7.41972 ◽

2021 ◽

pp. 77-81

Author(s):

NAZEMOON REDDY ◽

SWARNALATHA DUGASANI ◽

DEVANNA NAYAKANTI

Keyword(s):

Solid Dispersions ◽

Methyl Cellulose ◽

Solvent Evaporation ◽

Vinyl Pyrrolidone ◽

Melting Method ◽

Poloxamer 188 ◽

Model Drug ◽

Poly Vinyl Pyrrolidone ◽

Lercanidipine Hydrochloride ◽

Made In

Objective: An attempt has made in fabricating solid dispersions (SDs) by taking lercanidipine hydrochloride (LCD) as a model drug. Methods: The SDs were made using a poly mix of poly vinyl pyrrolidone (PVP) K-30, Poloxamer-188, and hydroxy propyl methyl cellulose (HPMC) K4M. Different proportions of LCD: polymer mix in 1:1, 1:3, 1:5, and 1:7 ratios were fabricated as SDs by solvent evaporation and melting method, further compressed into tablets. The LCD SDs were assessed for physicochemical, and LCD release possessions. Results: The results were observed to be attractive with the increase in solubility LCD SD (F-3 and F-7) with 1:5 ratios of LCD. Conclusion: The study concludes that the poly mix of PVP K-30, Poloxamer-188, and HPMC K4M and was found to be a better combination for elevating the solubility and release of LCD from the SDs.

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