Background:
“Health is wealth” and to maintain it 7 essential nutrients are required.
Among these, Vitamin is one that has great importance in very low concentration. As per the solubility,
it divides into water-soluble and water-insoluble vitamins. This study concentrates on Vitamin C, a
water-soluble vitamin which is essential for human growth due to its activity in the synthesis of carnitine,
collagen, and neurotransmitter. It possesses antioxidant, antiatherogenic, and immunomodulatory
functions, which may lead to the activity of Vitamin C in many diseases. But humans and some
other non-human primates are unable to produce Vitamin C from glucose due to the absence of enzyme
gulonolactone oxidase. As a result, humans are dependent on various dietary sources of Vc especially
citrus fruit. But these dietary supplies also fail to achieve the required level in the body due to
its poor bioavailability and storage.
Method:
Vitamin C has already proven its activity in cancer therapy. It is also used as a prodrug of
H2O2. But due to the poor bioavailability and storage of Vitamin C in the human body, mankind is unable
to avail the benefits of Vitamin C. These problems lead to generating different and suitable
nanoformulations to incorporate Vitamin C and its derivatives into it. Different research work shows
several ways to develop nanoformulations. Amongst all liposomes, microsphere, nanocarriers are of
great importance. For Vitamin C incorporation into the nanoformulation, nanocarriers become the
most popular choice for researchers. There were several nanocarrier systems developed using Chitosan-
Alginate, Silica-Coated-Au Nanoparticles, Chitosan, Mesoporous-silica NCs for suitable incorporation
of Vitamin C into these. The performances were assured by performing different in vitro and
in vivo tests which will be discussed here.
Result:
As a result, Vitamin C is now in use for many purposes. It includes not only the above mentioned
functions but also other functions too. Due to an antioxidant property, Vitamin C is able to
quench reactive oxygen species (ROS) by inhibiting ROS-mediated Nitric Oxide (NO) inactivation.
Vitamin C helps to elevate the level of absorption of iron within the cell from dietary iron sources. It
also prevents the oxidation of drugs. To achieve all these functions, NCs or nanoformulation plays a
great role.
Conclusion:
It can be concluded that depending on the biocompatibility, loading capacity, protection
of the loading molecule, efficiency of cellular uptake, controllable rate of release to achieve the desired
effect, and many more factors, the choice of different Nanocarriers (NCs) will be done which ultimately
help the human to use it for different purposes. This paper tries to gather some information in
one place with respect to different experimental studies.