scholarly journals A Case Report on Idiopathic Severe Bullous Pemphigoid

2020 ◽  
Vol 10 (4-s) ◽  
pp. 223-225
Author(s):  
Fizza Khan Mohammadi ◽  
Sultana Zoha ◽  
Mohammed Baleeqhuddin ◽  
Salman Mir Ali ◽  
Abdullah Md. Faizan
Keyword(s):  
Bullous Pemphigoid ◽  
Autoimmune Disorder ◽  
The Body ◽  
Topical Steroids ◽  
Adequate Treatment ◽  
Systemic Corticosteroids ◽  
Bullous Lesion ◽  
Clinical Presentations ◽  
Chief Complaints ◽  
Laboratory Investigations

Bullous Pemphigoid (BP) is an autoimmune disorder which exploits the immune system and affecting sub-epidermal region of skin causing mild itching to infection and blistering of sub-epidermal region. Clinical presentations are pruritis, urticarial, papular lesions. These later evolve to bullae in weeks to months and are typically present in the axillae, on the flexor surface of the forearms, medial thighs, trunk, and abdomen. The treatment for bullous pemphigoid is systemic corticosteroids, topical steroids in combination with nicotinamide plus tetracycline, minocycline or doxycycline have shown success in multiple cases. Immunosuppressive therapy is used when steroids do not control the disease or if patients have contraindications for systemic corticosteroid treatments. Patient was brought to emergency department with chief complaints itching, redness, bullous lesion all over the body for 2 months.Oral complaints including solitary erosion seen on right side of buccal mucosa, pharyngeal erythema. Laboratory investigations were carried out. Patient was diagnosed based on physical examination. Patient was provided with adequate treatment and counseling. Keywords: Bullous Pemphigoid, corticosteroid, Autoimmune disorder, sub-epidermal region.

scholarly journals Bullous pemphigoid in 65 years old female: a case report

2019 ◽  
Vol 1 (2) ◽  
Author(s):  
I Dewa Made Rendy Sanjaya ◽  
Putu Artana ◽  
Embun Dini Hari
Keyword(s):  
Case Report ◽  
Bullous Pemphigoid ◽  
Skin Disease ◽  
Autoimmune Disorder ◽  
Good Prognosis ◽  
Topical Steroids ◽  
Current Case ◽  
Chief Complaints ◽  
Intravenous Steroids ◽  
Over Time

Introduction: Bullous pemphigoid is an autoimmune disorder. The incidence of bullous pemphigoid has increased over time, current understanding regarding treatment and complication is an important issue considering the disease often occur in elderly resulting in high rates of morbidity to the patients. Aim of current case report is to describe the clinical relevance regarding symptom and treatment of bullous pemphigoid.Case presentation: A 65 years old female patient, came with chief complaints of bullae in abdominal region with itching and burning sensation in the ruptured bullae. Over time bullae spread in lower and upper extremity. Patient was admitted for four days with therapy intravenous steroids, oral antihistamine, and potent topical steroids. Patient was discharged from hospital in well condition.Conclusion: Bullous pemphigoid is an inflammatory autoimmune skin disease and usually result in good prognosis with adequate management.Keywords: autoimmune, bullous, pemphigoid, skin, disease. 

scholarly journals Advance approaches in alopecia

2017 ◽  
Vol 4 (3) ◽  
pp. 135 ◽  
Author(s):  
Anand Mohan ◽  
Mohd. Adil Khan ◽  
Suresh Chandra
Keyword(s):  
Alopecia Areata ◽  
Targeted Delivery ◽  
Social Impact ◽  
Autoimmune Disorder ◽  
The Body ◽  
Androgenetic Alopecia ◽  
Puva Therapy ◽  
Ultraviolet A ◽  
Combination Treatments ◽  
Systemic Corticosteroids

Alopecia is characterized by hair loss mainly on scalp some time on other resign of the body that has negative psychological and social impact on patients. Androgenetic alopecia and alopecia areata are common disorders. Androgenetic alopecia is the sensitivity of scalp follicles to dihydrotestosterone and alopecia areata is an autoimmune disorder. Current studies have explained the efficacy of corticosteroid therapy or the combination of ultraviolet A therapy and systemic corticosteroids for severe AA. Finasteride opens up new possibilities for the treatment of androgenetic alopecia. Current drug treatment approaches use regrowth stimulators such as minoxidil and finasteride for androgenetic alopecia, as well as corticosteroids, PUVA therapy for alopecia areata. Targeted delivery to the Hair follicle units helps faster targeting to cells that accelerate drug action by faster availability of drug, novel combination treatments combinations like tretinoin with minoxidil shows better results, gene therapy are new approaches that are under developing stage and giving satisfactory results on animal as well as humans.

scholarly journals Renal Clinical - Pathological Manifestations in Bullous Pemphigoid

2014 ◽  
Vol 7 (1) ◽  
pp. 98-101
Author(s):  
Ke-Zhong Zhao ◽  
Zhang Lian ◽  
Jian-Feng Liu ◽  
Yong-Hong Cai ◽  
Rui-Hong Han ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Bullous Pemphigoid ◽  
Kidney Biopsy ◽  
Autoimmune Disorder ◽  
Basement Membrane Zone ◽  
The Body ◽  
Intravenous Cyclophosphamide ◽  
Mesangial Proliferation ◽  
History Of ◽  
Epidermal Basement Membrane

A 61-year old man was admitted with a 2-month history of skin rash, and proteinuria and intermittent hemoptysis for 2 weeks. The patient had developed circular erythema and blisters all over the body with scab formation. Edema of the legs and eyelids appeared 2 weeks prior to admission. Kidney biopsy showed membranous nephropathy (phase II) with focal segmental mesangial proliferation and deposits of IgG along the GBM. Skin biopsy demonstrated IgG deposits in the epidermal basement membrane zone. The simultaneous development of a rare renal and skin autoimmune disorder, resulting from non-cross-reactive autoantibodies, suggests that a common triggering event could be responsible for the autoimmune injury. This patient with bullous pemphigoid was treated with corticosteroids, which were tapered to an acceptable and effective maintenance dose following treatment with intravenous cyclophosphamide.

Fournier’s gangrene due to Salmonella Typhimurium in a healthy male: a rare aberrant infection

2020 ◽  
Vol 20 ◽  
Author(s):  
Varsha Gupta ◽  
Lipika Singhal ◽  
Kritika Pal ◽  
Mani Bhushan ◽  
Rajeev Sharma ◽  
...  
Keyword(s):  
Salmonella Typhimurium ◽  
Systemic Disease ◽  
External Genitalia ◽  
Fournier’S Gangrene ◽  
The Body ◽  
Healthy Male ◽  
Fournier's Gangrene ◽  
Salmonella Infections ◽  
Chief Complaints ◽  
Human Infections

Introduction: Human Salmonella infections have been classically distinguised into diseases caused by typhoidal and non-typhoidal salmonella (NTS). Typhiodal salmonella includes S. enterica serovars Typhi and Paratyphi that cause the systemic disease but are restricted to human infections, while NTS consists mainly of other serovars that predominantly cause self-limiting gastroenteritis in humans. Localisation of foci with persisting infection occurs due to dissemination of the bacteria throughout the body and can cause a variety of rare clinical syndromes at aberrant sites. Fournier’s gangrene, a rapidly progressive, often fatal, necrotizing fasciitis of the external genitalia and perineum due to Salmonella Typhimurium, is a rare manifestation and has never been reported. Case: A 22-year-old male, apparently healthy patient with no relevant past medical history presented to surgical emergency with chief complaints of swelling of bilateral scrotal area. Infective etiology was considered and a diagnosis of fournier’s gangrene was made. Pure growth of Salmonella Typhimurium was obtained after repeated subculture and was identified biochemically and on serotyping, as Salmonella enterica serotype Typhimurium using specific antisera. Conclusion: In our case report, we describe a case of fournier’s gangrene due to Salmonella Typhimurium in an otherwise healthy male to highlight the unusual presentation of Non typhoidal salmonellae at an aberrant site. We also emphasize the importance of using selective media like Selenite F broth for isolation of Salmonella Typhimurium from a pus sample.

scholarly journals A randomised, open label comparative study of hydroxychloroquine with betamethasone oral mini pulse in the management of patients with alopecia areata

2021 ◽  
Vol 10 (2) ◽  
pp. 187
Author(s):  
Jeyasudha Jambusayee ◽  
Kulur Mukhyaprana Sudha
Keyword(s):  
Alopecia Areata ◽  
Life Quality ◽  
Autoimmune Disorder ◽  
Study Groups ◽  
Pulse Therapy ◽  
The Body ◽  
Control Group ◽  
Study Group ◽  
Open Label ◽  
Significant Difference

Background: Alopecia areata is an autoimmune disorder causing patchy hair loss on scalp and other parts of the body and leading to poor self-esteem and anxiety in patients. Treatment with topical or systemic drugs like steroids or other immunosuppressants is associated with adverse effects. Hydroxychloroquine is an antimalarial drug, with T cell modulating function. This study was undertaken to assess the safety, efficacy and tolerability of Hydroxychloroquine in Alopecia areata compared to betamethasone oral mini pulse (OMP) therapy. Methods: 60 patients with alopecia areata were randomized into two groups of 30 each. Control group received tab. betamethasone 5 mg/day on two consecutive days of week for 12 weeks and Study group received tab. hydroxychloroquine 200 mg/day for 12 weeks. They were followed-up for further 12 weeks. Scale of alopecia tool, dermatology life quality index and global assessment at baseline, 12 weeks and 24 weeks were used to assess the outcome.Results: 94 patients were screened and 60 patients were included. All patients completed the study. At the end of 12 weeks, there was a statistically significant reduction in SALT and DLQI scores in both control and study groups. But at the end of 24 weeks, the study group showed an increase in the scores. Relapses were more in the study group. No significant difference in the incidence of adverse events was noted between the two groups.Conclusions: Hydroxychloroquine 200 mg/day is less efficacious in the management of alopecia areata in comparison to betamethasone oral mini pulse therapy.

scholarly journals Cervical intradural extramedullay vascular schwannoma in a thirty eight year old male

2019 ◽  
Vol 6 (7) ◽  
pp. 2634
Author(s):  
Shipra Singhal ◽  
Sufian Zaheer ◽  
Rashmi Arora
Keyword(s):  
Peripheral Nerve ◽  
Peripheral Nerves ◽  
Neck Region ◽  
The Body ◽  
Vascular Changes ◽  
Vascular Tissues ◽  
Clinical Presentations ◽  
Cervical Swelling ◽  
Head Neck

Schwannomas are benign peripheral nerve sheet tumours that may arise almost anywhere in the body but are commonly seen in the head, neck region and in the extremities. They may be associated with variable clinical presentations depending on their location. The peripheral nerves are closely related to vascular tissues morphologically and physiologically and therefore schwannomas may be associated with vascular changes like vascular hyperplasia and vascular dilation. Here authors represent one such case where a 38-year-old patient presented with a cervical swelling which on histopathology was diagnosed as vascular schwannoma.

scholarly journals Huntington`s Chorea - a Case Report and review of literature

2016 ◽  
Vol 9 (4) ◽  
Author(s):  
Muhammad Afzal ◽  
Anjum Iqbal ◽  
Nadeem Azam ◽  
Koukab Javed ◽  
Ghana Shahid
Keyword(s):  
Serum Alkaline Phosphatase ◽  
Cerebral Atrophy ◽  
Serum Copper ◽  
The Body ◽  
Early Dementia ◽  
Similar Disease ◽  
History Of ◽  
Eye Examination ◽  
Laboratory Investigations ◽  
Naval Hospital

A 45 years old gentleman presented to Medical Clinic of Naval Hospital (PNS Hafeez) Islamabad in January 2001 with choreform movements of the body and early dementia of six months duration. He had a strong family history of similar disease, which included his father and two brothers. On neurological examination he had choreoathetoid movements and features of early dementia. His chest was clinically clear and examination of heart and abdomen was normal. Eye examination did not reveal any evidence of Kayser-Fleischer rings (seen in Wilson`s disease). Laboratory investigations showed haemoglobin 13.8 Gm/dl, WBC 7.7 x10e9/L, serum urea 32 mg/dl, serum sodium 139 mmol/L serum potassium 3.8 mmol/L, ASO titre less than 200 IU/ml, serum bilirubin 6 umol/L, ALT 102 U/L, serum alkaline phosphatase 155 U/L, serum caeruloplasmin 42 mg/dl and serum copper 164 mmol/L (WNL). X-ray chest was normal and CT scan brain showed early generalized cerebral atrophy. He was managed with haloperidol (0.5mg) 12 hourly, Procyclidine (kemadrin, 5mg) 8 hourly and Propranolol (Inderal 10mg) 8 hourly. He was discharged from hospital with relative improvement after 2 weeks.

scholarly journals Clinical, Aetiologic, And Evolution-Related Aspects Of Pleurisy In Children

2015 ◽  
Vol 21 (4) ◽  
pp. 212-216
Author(s):  
Frecus Corina ◽  
Balasa Adriana ◽  
Ungureanu Adina ◽  
Mihai Larisia ◽  
Cuzic Viviana ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Clinical Manifestations ◽  
Clinical Aspects ◽  
Age Group ◽  
Adequate Treatment ◽  
Radiologic Imaging ◽  
Specific Pathogen ◽  
Laboratory Investigations ◽  
Group Distribution ◽  
Clinical Emergency

Abstract Objectives: Establishing the frequency of pleurisy from the total number of admissions in the Paediatrics Department, as well as the frequency of pleurisy from the total number of respiratory ailments that required hospitalization; evaluating age group distribution and determining the influence of environmental factors; describing clinical manifestations, laboratory, radiologic, and bacteriological investigations in patients with pleurisy; quantifying clinical manifestations and investigations so as to establish an appropriate therapeutic approach; identifying clinical aspects that indicate a favourable/unfavourable evolution; analyzing the evolution of cases after treatment as revealed by radiologic imaging. Method: Retrospective study on 47 patients diagnosed with pleurisy and admitted in the Paediatrics Department of Constanta Clinical Emergency Hospital, over a span of 3 years (2011-2013), based on data collected from observation sheets. Results: A downward trend in what regards the frequency of pleurisy can be observed from 2011 to 2013. Rural provenience and other environmental factors continue to play an important role. Clinical manifestations tend to be more significant for younger patients and they are directly related to the specific pathogen identified during laboratory investigations. Conclusion: Following an early diagnosis and a subsequent adequate treatment, evolution tends to be favourable in most cases, although certain post-hospitalization measures still need to be implemented in order to ensure full recovery and restitution ad integrum.

scholarly journals Case Report on Rheumatoid Arthritis

2021 ◽  
pp. 212-216
Author(s):  
Roshani Dhanvijay ◽  
Savita Pohekar
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Report ◽  
Autoimmune Disorder ◽  
The Body ◽  
Health Care Practitioner ◽  
Recurrent Pain ◽  
Reactive Protein ◽  
Rheumatoid Arthritis Joint ◽  
Long Time ◽  
Tunnel Syndrome

Rheumatoid arthritis (RA) is an autoimmune disorder that inhibits the body's immune system that induces inflammation in the injured areas of the body. It is commonly caused the joints of the palms, wrists, and knees. An inflaming rheumatoid arthritis joint contributes to joint tissue damage. This condition may cause chronic or long term discomfort, instability, and deformation. Symptoms include exhaustion, pain, and depression. If the patient does not undergo early diagnosis and care for symptoms, a series of symptoms can arise including Osteoporosis, rheumatoid nodules, dry eye and mouth, carpal tunnel syndrome Case Report: The female patient name is Yogita Shinde 65-year-old religion Hindu lived in the kandhali. She was admitted to AVBR Hospital with the chief complaint of pain in her shoulder and hands, joints pain, swelling on both the hands. She started taking ibuprofen 800 mg 3 times per day to relieve discomfort and rigidity.  Three months earlier, as she was doing her job, she had pain on her right and left shoulders. She still started to feel very sleepy and short-tempered. Tab ibuprofen was not an effective very long time for pain.  One morning, Yogita couldn't lift her arms without the intense pain of her back. She was conscious that it was time for help. She had spoken to her parents, and they advised her to see a physician. The primary healthcare practitioner (PHP), who tested and carried out a variety of blood test. Positive-rheumatoid factors, CCP antibiotics, higher ESR, and C-reactive protein were seen via the blood samples. These findings were communicated to Yogita and the Rheumatologist was directed at her PCP to see her as soon as possible. The primary health care practitioner inquired about the medical records of Yogita parents and grandparents, family conditions, medical and operative records of yogita, and details on their family and working lives. And after that, the physician started the treatment, after which Yogita feels better for some days. After a few weeks she having recurrent pain in her hand and foot, this is intolerable to her. And then she is admitted to AVBR Hospital on date 20th Sept 2020

scholarly journals A COMPARATIVE CLINICAL STUDY ON JARA WITH RESPECT TO AGEING PROCESS WITH ASHWAGANDHA RASAYANA AND MATRA BASTI

2016 ◽  
Author(s):  
Singh Binod Kumar ◽  
Bharkher D.L
Keyword(s):  
Life Expectancy ◽  
Small Sample Size ◽  
Small Sample ◽  
The Body ◽  
World Health ◽  
Ageing Process ◽  
Health Security ◽  
Chief Complaints ◽  
Comparative Clinical Study ◽  
Later Phase

The problem of ageing is experienced by all the countries. According to World Health statistics the life expectancy of Nepalese people has risen from 58.91 years to 67.86 years (1996 to 2015). Ageing is emerging issue in Nepal as well as global. Its tempo is expected to be unexpectedly fast as mortality continues to decline and life expectancy continues to increase. Ayurveda the science of life has observed ageing as a Jara avastha, which is a later phase of life, it is natural, inevitable phenomenon, in which maximum decline of bodily elements that may become as major cause of disability and functional dependency requiring services that affect many sectors of economy, health, security, income, housing, transportation etc. Jara chikitsa has been mentioned as one independent Anga in Ashtanga Ayurveda where Rasayana therapy is capable to impede the ageing process and to delay the degenerative process in the body. In this study we measured the effectiveness of Ashwagandha rasayana and Matra basti and compared with the Ashwagandha Rasayan only in Jara avastha. A total of thirty elderly patients were selected and divided in two groups A and B, given them either Ashwagandha Rasayana with Matra basti or Ashwagandha rasayana in prescribed doses for 45 days. Changes in the subjective complaints, objective parameters of the patients and appearance of adverse events were also evaluated. Both the groups provided better results on the chief complaints But, comparison in between both the groups is insignificant, that may be due to small sample size.

Sign in / Sign up

Export Citation Format

Share Document