scholarly journals Effect of Consuming Different Varieties of Bambara Groundnut (Vigna subterranea) Seeds on Glycaemia and Lipid Profile of Diabetic and Non-Diabetic Rats

2021 ◽  
Vol 11 (5-S) ◽  
pp. 6-12
Author(s):  
Daniel Hassan Mhya ◽  
Abdulrashid Mohammed
Keyword(s):  
Lipid Profile ◽  
Diabetic Rats ◽  
Bambara Groundnut ◽  
Dietary Therapy ◽  
Diabetic Patients ◽  
Dependent Manner ◽  
Plant Seed ◽  
Continuous Increase ◽  
Group A ◽  
Group B

Background: Bambara groundnut seed is reported to possess high fibre and good nutritional content, and is locally used as a daily dietary therapy by diabetic patients in northern Nigeria. The plant seeds are of different varieties and whether the antidiabetic effect may vary with the varieties is largely unknown. This has prompted the current study to investigate effect of consuming different varieties of Bambara groundnut seeds on glycaemia and lipid profile of diabetic and non-diabetic rats. Materials and Methods: Bambara groundnut seed’s varieties were processed into flour and use in formulating feeds which were given to diabetic and non-diabetic rats as follows; group A (ALK01 feed), group B (ALK02 feed), group C (ALK03 feed), group D (ALK04 feed), group E (Basal feed), and group F (Normal animal’s feed) for 28 days during which blood glucose and weights were measured weekly while lipid profile was assayed at the end of the study. Results: The result of the study showed continuous increase in glycemic levels for diabetic rats fed basal and normal feeds compared to those fed plant seed formulated feeds. While, glycemic levels for non-diabetic rats fed plant seed formulated feeds, normal or basal feeds remain within normal range. The lipid components of diabetic rats fed basal and normal feeds were elevated and are significantly different (P<.05) from those fed plant seed formulated feeds. Conclusion: The study concluded that consumption of different varieties of Bambara groundnut seed could ameliorate hyperglycemia and hyperlipidemia by a variety dependent manner.  Keywords:  Bambara groundnut, seed varieties, effect, glycaemia, lipid profile, rats

scholarly journals Effects of Consuming Different Varieties of Bambara Nut (Vigna subterranea) Seeds on Liver and Kidney of Diabetic and Non-diabetic Subject

2021 ◽  
pp. 25-35
Author(s):  
Abdulrashid Mohammed ◽  
Daniel Hassan Mhya
Keyword(s):  
Biological Effects ◽  
Diabetic Rats ◽  
Diabetic Subject ◽  
Dietary Therapy ◽  
Dependent Manner ◽  
High Fiber ◽  
Plant Seeds ◽  
Liver And Kidney ◽  
Group A ◽  
Group B

Aims: Bambara nut seeds have been reported as a good source of food with high fiber and nutritional contents, and is consumed by persons with diabetes as one of the dietary therapy. However, the plant seeds are of different varieties and whether they might have vary biological effects on renal and liver functions is not fully known. This has prompted the study to evaluate effects of consuming different varieties of Bambara Nut seeds on liver and kidney of both diabetic and non-diabetic rats. Methodology: Four Bambara nut seeds varieties were dehulled and each heated at 60oC, cooled then grounded into flour using a mechanical grinder. The flours were used to formulate feeds which were given to different diabetic and non-diabetic rats’ groups as follows; group A (ALK01 feed), group B (ALK02 feed), group C (ALK03 feed), group D (ALK04 feed), group E (Basal feed), and group F (Normal animal’s feed). The animals were fed for 28 days then sacrifice, blood collected and serum separated and used for hepatic and renal parameters analysis. Results: The results of the study showed decrease levels of serum total protein and albumin, and elevation of AST and ALT activities as well as urea and creatinine concentrations in diabetic rats fed basal and normal diets, whereas, reverse in these parameters were recorded from diabetic rats fed varieties of Bambara nut seeds’ formulated feeds.  Conclusion: Findings from the study suggest consumption of Bambara nut seeds of different varieties is safe and has ability to ameliorate diabetic hepatic and renal failure in a variety dependent manner where; ALK 04 is more likely the most effective.

scholarly journals The Protective Effect of Radix Polygoni Multiflori on Diabetic Encephalopathy via Regulating Myosin Light Chain Kinase Expression

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Yu He ◽  
Feng Wang ◽  
Shiqiang Chen ◽  
Mi Liu ◽  
Wei Pan ◽  
...  
Keyword(s):  
Hippocampal Neurons ◽  
Neuroprotective Effect ◽  
Diabetic Rats ◽  
Control Group ◽  
Dependent Manner ◽  
Diabetic Encephalopathy ◽  
Diabetes Group ◽  
Group A ◽  
Group B ◽  
Kinase Expression

Currently there has been no effective treatment of diabetic encephalopathy. Radix Polygoni Multiflori, a famous traditional Chinese medicine, is widely used in antiaging treatment, especially in prevention and treatment of Alzheimer’s diseases. In this study we tried to explore the effect of Radix Polygoni Multiflori on cognitive function among diabetic rats with demonstrated cognitive impairment. SD rats were divided into group A (control group), group B (diabetes), group C (treated with Radix Polygoni Multiflori at the dose of 2 g/kg/d), and group D (treated with same drug at the dose of 1 g/kg/d). The results showed that 8 weeks of Radix Polygoni Multiflori treatment could improve the cognitive dysfunction of diabetic rats (P<0.01), recover the ultrastructure of hippocampal neurons, and increase the number of synapses in a dose-dependent manner. Further experiment also suggested that the neuroprotective effect of Radix Polygoni Multiflori was partly achieved by downregulating MLCK expression in hippocampus via ERK signaling.

scholarly journals Role of Helicobacter Pylori Infection on Diabetic and Lipid Profile in Pre-diabetic Patients

2021 ◽  
Author(s):  
Akash Chaudhary ◽  
Abdullah Ansari
Keyword(s):  
Lipid Profile ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
P Value ◽  
Diabetic Patients ◽  
Peptic Ulcers ◽  
Cholesterol Levels ◽  
Group A ◽  
Group B

Introduction:Helicobacter Pylori (H.pylori) infection is related to gastritis, peptic ulcers, gastric cancers and Mucosa Associated Lymphoid Tissue lymphomas (MALT). It is also associated with several extra-gastrointestinal pathologies owing to its association with increased production of proinflammatory cytokines, bacterial virulence factors and environmental factors. It may have an effect on onset of diabetes mellitus and alter lipid profile. Aim: To find the effect of H.pylori infection on diabetic and lipid profile in pre-diabetic patients. Materials and Methods: A single centre, cross-sectional study was conducted over a period from January 2019 to June 2020, on pre-diabetic patients (HbA1c 5.7-6.4%.). A total of 118 patients were recruited in the study and divided into two groups based on the H.pylori positive (group A) and negative (group B) results. HbA1c, Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL) were investigated at baseline, six months and 12 months and the results of the two groups were compared using student’s t-test. Supply Support Planning and Execution (SSPE) Software version 20.0 were used for analysis of the collected data. A p-value<0.05 to be considered significant. Results: Of the 118 patients, 96 (mean age 48.3 years) completed the study. There 59 (61.5%) were males and 37 (38.5%) were females. A total of 54 (56%) of the study population tested positive for the H.pylori colonisation. The study showed that patients infected with H.pylori (group A) had comparative rapid increase in the HbA1c levels (p-value=0.048) when compared with the non-infective group (group B). The group A also had statistically significant increase in the LDL cholesterol levels (p-value=0.032) and decrease in HDL cholesterol levels (p-value=0.02) than group B. Conclusion: Infection with H.pylori is associated with increase in the level of HbA1c in pre-diabetics. It is also associated with increase in the LDL cholesterol levels and decrease in the HDL cholesterol levels. Eradication of the pathogen may help in preventing or delaying the progression of pre-diabetes and dyslipidemia. However, larger studies without any confounding factors are needed to establish the association between H.pyloriinfection and its effect on diabetic and lipid profile.

scholarly journals Comparison the Effect of Niacin Treatment with and without Atorvastatin on Lipid Profile in Type 2 Diabetic Patients

2020 ◽  
Author(s):  
Mohammad Afkhami-Ardekani ◽  
Mahmoo Emami-Meibodi ◽  
Naimeh Mostafae ◽  
Arezoo Afkhami-Ardekani ◽  
Boshra Najafi
Keyword(s):  
Blood Pressure ◽  
Diabetic Patient ◽  
Lipid Profile ◽  
High Density Lipoproteins ◽  
P Value ◽  
Diabetic Patients ◽  
Diabetes Research ◽  
Type 2 Diabetic Patients ◽  
Group A ◽  
Group B

Objective: The risk of cardiovascular disease increased in diabetic patients due to lipoprotein metabolism disorder and insulin resistance. There is different type of dyslipidemia in diabetic patient. The nicotinic acid (niacin) is categorized as vitamin B family and decreases low-density lipoproteins (LDL) and triglyceride (TG) level and increases high-density lipoproteins (HDL). The aim of this study was to compare the effect of niacin treatment with and without atorvastatin on lipid profile on diabetic patient. Materials and Methods: This study is cross over clinical trial on 30 diabetic patients (9 men, 21women) referred to diabetes research center of Yazd (IRAN). At initiation of study administered atorvastatin alone (20 mg/day) for 6 weeks (protocol A), and after 3 weeks washout period, started atorvastatin (20 mg/day) with niacin (50 mg/day) for 6 weeks (protocol B). Statistical analysis was accomplished by using SPSS for windows, version 11.50 and kappa and paired T-test. Results: Patients on protocol B had statistically significant more increase of HDL-C (P-value= 0.08) and decrease of TG than profile A (P-value= 0.024). Also, 2 hours post prandial blood sugar and HbA1c changes in two groups were not significant A (P-value= 0.226), B (P-value= 0.918). Patient in group B had statistically significant decrease in systolic blood pressure and diastolic blood pressure than group A (P-value= 0.010, P-value= 0.015). Conclusion: This study showed decrease of TG, LDL-C and total cholesterol and increase of HDL in both groups. There are significant changes in HDL-C and TG in group B that used niacin with atorvastatin than group A.

Blind Comparative study between Silver nanoparticles dressings and Standard Moist Wound Dressings (SMWD) in management of diabetic foot ulcers

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Amr Abdelaal ◽  
Mostafa Soliman ◽  
Hany Rafik ◽  
Mohamed Emam ◽  
Mohamed Mahmoud Mohamed Elsadek
Keyword(s):  
Silver Nanoparticles ◽  
Diabetic Foot ◽  
Wound Dressing ◽  
Treatment Modalities ◽  
Controlled Study ◽  
Foot Ulcers ◽  
Diabetic Patients ◽  
Diabetic Foot Ulcers ◽  
Group A ◽  
Group B

Abstract Background Diabetic foot ulcers (DFUs) are the main cause of hospitalization in diabetic patients and they are considered a major worldwide health problem. Thus, there is a need to evaluate various treatment modalities. In this study we will assess the clinical efficacy of Silver nanoparticles dressing vs Standard Moist Wound Dressing (SMWD) in management of diabetic foot ulcers. Objective To compare wound outcome, limb salvage, healing time of diabetes related foot ulcers and cost effectiveness in terms of duration of hospital stay between Silver nanotechnology dressings and Standard moist wound therapy (SMWT) in management of diabetic foot ulcers. Patients and Methods This is a prospective randomized controlled study involving 34 patients with active diabetic foot ulcers, in a high volume tertiary referral vascular center. They were divided into 2 groups: 17 patients (group A) were prescribed SMWD and the other 17 patients (group B) received Silver nanoparticles wound dressing. Results Our study correlates with the study conducted by K.Suhas et al. which had observed that Silver nanoparticles wound dressing was safe and effective treatment for complex diabetic foot wounds and could lead to higher proportion of healed wounds and faster healing rates. At the end of the study, group B promised a better outcome as compared to group A. Conclusion The role of Silver nanoparticles wound dressing in healing of diabetic foot ulcers has been proposed as a novel method of manipulating the chronic wound environment in a way that it reduces bacterial burden and chronic interstitial wound fluid, increases vascularity and cytokine expression and to an extent mechanically exploiting the viscoelasticity of peri wound tissues.

Pharmacist Impact on Physician Practices Related to Diabetes Management

2021 ◽  
Vol 8 (4) ◽  
pp. 560-575
Author(s):  
Amina Ammar ◽  
Lindsay M. Darghali ◽  
Wassim Tarraf ◽  
Helen D. Berlie ◽  
Linda A. Jaber
Keyword(s):  
Blood Pressure ◽  
Diabetes Management ◽  
Individual Treatment ◽  
Diabetic Patients ◽  
Composite Target ◽  
Physician Practices ◽  
Physical Presence ◽  
Group A ◽  
Group B ◽  
The Impact

To examine the impact of a pharmacist’s physical presence on (1) the achievement of individual and combined targets for hemoglobin A1c (A1C), blood pressure (BP), and low-density lipoprotein cholesterol (LDL-C) (composite target), and (2) physician practices in relation to the American Diabetes Association (ADA) standards of medical care.   Methods A retrospective, comparative study of randomly selected diabetic patients seen within an underserved primary care setting at least twice annually between June 1, 2018- December 31, 2019. Patients were allocated by whether they had received care in one of the physician-pharmacist clinics (Group A) or the physician-only clinic (Group B). Study outcomes included the proportion of patients achieving the composite and individual treatment targets for A1C, BP, and LDL-C.   Results A total of 394 patients were included; Majority were underserved African Americans. The composite target was attained by 20% of participants in Group A and 13% in Group B (p=0.09). There were no statistically significant differences in achievement of individual targets between groups. A significantly higher proportion of participants in Group A achieved better control of diastolic blood pressure control (85% vs. 74%), had microalbuminuria tested (50% vs. 12%), were prescribed aspirin (43% vs. 32%), and had lower utilization of non-insulin glucose-lowering agents relative to those in Group B.   Conclusion The impact of a pharmacist’s physical presence on physician practice demonstrated a general trend towards improvement in clinical outcomes related to diabetes management. Future studies are needed to further characterize the impact provided by the physician-pharmacist relationship.

scholarly journals Maintenance treatment of diabetic patients, associating arterial obstructive tibio-peroneal disease

1995 ◽  
Vol 113 (1) ◽  
pp. 701-705
Author(s):  
Nelson Wolosker ◽  
Ruben Miguel Ayzin Rosoky ◽  
Baptista Muraco Neto ◽  
Berilo Langer
Keyword(s):  
Maintenance Treatment ◽  
Diabetic Patients ◽  
Type I ◽  
Group I ◽  
Significant Difference ◽  
Therapeutic Procedures ◽  
Arterial Pulsation ◽  
Group A ◽  
Group B ◽  
Better Than

When a melito-diabetic patient presents trophic infected injury on the limb, it is essential an evaluation of the circulatory conditions for therapeutic procedures orientation. In some circumstances, although arterial pulsation is absent, there is no ischemia of tissues. In these cases, the maintenance treatment, with eventual resection of the necrosed and infected tissues may be adopted. Evolution of 70 diabetic patients with trophic injuries on extremities were submitted to a maintenance treatment. Age of patients varied from 28 to 88 years, with an average of 56.8. The most occurrence was verified in women, with 42 cases. Diabetes non-dependant on insuline (type II) was observed in 64 patients (91.5%), being the remaining 6 patients of type I. Diabetic retinopathy was observed in 14 (20%) of the patients, neuropathy in 22 (31%) and nephropathy in 8 patients (11.4%). All the patients presented arterial pulsation until the popliteal region. They were divided in 2 groups, considering trunk arteries of legs: Group I, pervial legs arteries, composed by 48 patients; Group II, occluded legs arteries, with 22 patients. In what refers to the anatomic local of the injuries, patients were classified in three groups: Group A, formed by 32 patients (45.7%), presenting injuries in one or two toes only, without affecting the metatarsic region; Group B, formed by 16 patients (22.9%), trophic injuries affecting the metatarsic region and Group C, formed by 22 patients (31.4%), injuries affecting the calcaneous region. Injuries in both of the groups were caused by mechanical traumatism. Duration of the injury in the inferior member varied from 7 to 48 days, resulting in a 12 days average. Analyzing pervicacity in trunk arterias and evolution of patients, it may be observed that there has been a significantly better result in those with all the pulses present (81.3% x 45.5%)(p<0,01). Studying the injury locals associated to the evaluation of the cases, we may observe that for injuries in the extreme digital, result is significantly better than in locals more nearly. When distal pulses are absent, there is no significant difference in the result of the treatment, being performed in distal injuries or in the more near ones (p>0,05)(Table IV).

scholarly journals Immediate Effect of Muscle Energy Technique and Kalternborn Mobilisation Technique on Pain in Diabetic Patients with Periarthritis of Shoulder

2021 ◽  
pp. 220-228
Author(s):  
Kamya Somaiya ◽  
G. D. Vishnu Vardhan ◽  
Ashish Bele
Keyword(s):  
Quality Of Life ◽  
Adhesive Capsulitis ◽  
Frozen Shoulder ◽  
Diabetic Patients ◽  
Tissue Degeneration ◽  
Muscle Energy Technique ◽  
Group A ◽  
Muscle Energy ◽  
Group B

Background: Periarthritis Shoulder, also known as adhesive capsulitis, is a condition that results in tissue degeneration, thickening of the joint capsule, and a narrowing of the glenoid cavity. Diabetes mellitus is linked to many debilitating musculoskeletal disorders of the hand and shoulder. Prevalence of adhesive capsulitis or frozen shoulder is estimated to be 11-30 percent in people with diabetes. Various interventions have already been used to prevent pain and improve quality of life. Both Muscle Energy Technique and Kalternborn Mobilization Technique are thought to have a pain-relieving effect. Aim & Objective: The study's aim is to compare the effects of both techniques on pain in diabetic patients. Methods/Design: In this study experimental study, the participants will be divided into two groups: Kalternborn Mobilization Technique Group (A) and Muscle Energy Technique Group (B) based on inclusion and exclusion criteria. Both interventions include 30-45 min session which will be carried out for duration of four days. Outcome will be Pain and Quality of Life and outcome measures will be evaluated at beginning and at the end of intervention period. Result: Successful Completion of trial of Muscle Energy Technique and Kalternborn Mobilisation Technique will provide evidence for best strategy targeting Pain and quality of life in diabetic patients with Periarthritis of Shoulder. Conclusion: The study will be concluded with the significant effect of Muscle Energy Technique and Kalternborn Mobilisation Technique on Periarthritis shoulder of diabetic patients.

scholarly journals Treatment of Diabetic Condition in Streptozotocin Induced Diabetic Wister Rats Using Food Blends Such as Unripe Plantain, Soybean and Ginger

2019 ◽  
pp. 1-12
Author(s):  
I. Iwanegbe ◽  
M. Suleiman ◽  
A. Jimah
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Lipid Profile ◽  
Cell Volume ◽  
Glucose Level ◽  
Normal Control ◽  
Packed Cell Volume ◽  
Diabetic Rats ◽  
Diabetic Patients

Aims: To investigate the effect of food blends (plantain, soybean and ginger) on the blood glucose, lipid profile and haematological indices on streptozotocin induced diabetic rats. Methodology: A total of 35 rats of mean body weight 219.07 g separated into7 groups (5 per group) where induced by a single intraperitoneal (I.P) injection of streptozotocin (0.1 g dissolved in 5 ml of freshly prepared sodium citrate buffer 0.1 M, pH 4.5) at a dose of 40 mg/kg body weight after fasting for 12 hours and fed with flours/blends. The flours were produced from plant materials for different treatments/blends (blend A=100% unripe plantain, B=80% unripe plantain, 14% soybean, 6% ginger, C=70% unripe plantain, 26% soybean, 4% ginger, D= 60% unripe plantain, 38% soybean, 2% ginger, E= 50% unripe plantain, 50% soybean) and the phytochemicals and minerals content were determined. Blood glucose was determined at 5 days interval for 25 days. Diabetes was confirmed in rats with blood glucose concentrations >200 mg/dl. After 25 days rats were anaesthetized with chloroform vapour and blood samples collected by cardiac puncture for haematology and lipid profile determination. Results: The results showed that unripe plantain, soya beans and ginger in adequate proportion(C=70% unripe plantain, 26% soybean, 4% ginger or D= 60% unripe plantain, 38% soybean, 2% ginger) could help to reduce blood glucose, improve haematological parameters and lipid profile. Significant reduction was observed in the blood glucose level of rats fed blends C and D from 286 to 85 mg/dl and 307 to 90 mg/dl respectively at the end of experiment. These results also demonstrated that the inclusion of ginger at 6% causes rise in blood glucose level. Total cholesterol (TC) increased in all the blends. However, the lowest concentration of TC was observed in blends C and D. The highest packed cell volume (60%) and Haemoglobin (20 g/dl) level observed in rats fed blend C was significantly higher than the normal control fed conventional feeds. The increase in packed cell volume (PCV) (50%) and Hb (17 g/dl) in diabetic rats demonstrated that the formulated blend C was able to raise PCV and Hb above 50% and 17 g/dl (Normal control NC) respectively. Significant increase (P<0.05) in low density lipoprotein cholesterol (LDLc) was also observed in all the blends with blend C having the least (4.0 mg/dl) close to NC (2.0 mg/dl). Conclusion: From the results it is evident that blend C will manage and improve the health status of diabetic patients.

scholarly journals Protective effect of LIF-huMSCs on the retina of diabetic model rats

2021 ◽  
Vol 14 (10) ◽  
pp. 1508-1517
Author(s):  
Shan-Na Chen ◽  
◽  
Ying-Xue Ma ◽  
Song Chen ◽  
Guang-Hui He ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Control Group ◽  
Diabetic Model ◽  
Group A ◽  
Retinal Structure ◽  
Hs Crp ◽  
Group B ◽  
And Function ◽  
Group D ◽  
Control Group Group

AIM: To investigate the protective effect of human umbilical cord mesenchymal stem cells (hUCMSCs) modified by the LIF gene on the retinal function of diabetic model rats and preliminarily explore the possible mechanism. METHODS: A stably transfected cell line of hUCMSCs overexpressing leukemia inhibitory factor (LIF) was constructed. Overexpression was verified by fluorescent quantitative polymerase chain reaction (qPCR). Forty-eight adult Sprague-Dawley rats were randomly divided into a normal control group (group A), streptozotocin-induced diabetic control group (group B), diabetic rats at 3mo injected with empty vector-transfected hUCMSCs (group C) or injected with LIF-hUCMSCs (group D). Four weeks after the intravitreal injection, analyses in all groups included retinal function using flash electroretinogram (F-ERG), retinal blood vessel examination of retinal flat mounts perfused with fluorescein isothiocyanate-dextran (FITC-dextran), and retinal structure examination of sections using hematoxylin and eosin staining. Expression levels of adiponectin (APN), high-sensitivity C-reactive protein (hs-CRP), and neurotrophin-4 (NT-4) in each group was detected using immunohistochemistry, PCR, Western blotting, and ELISA, respectively. RESULTS: A stable transgenic cell line of LIF-hUCMSCs was constructed. F-ERG and FITC-dextran examinations revealed no abnormalities of retinal structure and function in group A, severe damage of the retinal blood vessels and function in group B, and improved retinal structure and function in group C and especially group D. qPCR, ELISA, and Western blot analyses revealed progressively higher APN and NT-4 expression levels in groups B, C, and D than in group A. hs-CRP expression was significantly higher in group B than in groups A, C, and D, and was significantly higher in group C than in group D (P<0.05). CONCLUSION: LIF-hUCMSCs protect the retina of diabetic rats by upregulating APN and NT-4 expression and downregulating hs-CRP expression in the retina.

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