scholarly journals ANTICONVULSANT EFFECT OF AQUEOUS EXTRACT OF AERIAL ROOT OF FICUS RELIGIOSA IN ANIMAL MODELS

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Smita Singh ◽  
Md. Parwez Ahmad ◽  
Deependra Prasad Sarraf ◽  
Chandan Mishra ◽  
Prabin Kumar Singh
Keyword(s):  
Animal Models ◽  
Aqueous Extract ◽  
Anticonvulsant Effect ◽  
Ficus Religiosa

scholarly journals Anticonvulsant Effect of Antiaris toxicaria (Pers.) Lesch. (Moraceae) Aqueous Extract in Rodents

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Priscilla Kolibea Mante ◽  
Donatus Wewura Adongo ◽  
Eric Woode ◽  
Kennedy Kwami Edem Kukuia ◽  
Elvis Ofori Ameyaw
Keyword(s):  
Animal Models ◽  
Sodium Valproate ◽  
Aqueous Extract ◽  
Anticonvulsant Activity ◽  
Gabaergic System ◽  
Anticonvulsant Drugs ◽  
Anticonvulsant Effect ◽  
Maximal Electroshock ◽  
Maximal Electroshock Test ◽  
Ptz Test

Antiaris toxicaria (Moraceae) was evaluated for anticonvulsant activity in rodents. Animal models used include maximal electroshock test (MEST); pentylenetetrazole-induced (PTZ) convulsions; picrotoxin-induced (PCT) convulsions; strychnine- (STR-) and 4-aminopyridine-induced convulsions. Increase in latency to seizures as well as reduction in duration and frequency of seizures indicated anticonvulsant activity. The extract was more effective in all models used except the maximal electroshock test and strychnine-induced convulsions. Antiaris toxicaria aqueous extract (200, 400, and 800 mg kg−1) significantly () shortened the duration of convulsions in PTZ- and PCT-induced seizures. Delay in the onset of convulsions in the two tests was significant (). Reduction in the frequency of seizures was also significant () in both tests. Antiaris further delayed the onset of seizures in 4-aminopyridine model while producing 75% protection against death in mice. Diazepam (0.1, 0.3, and 1 mg kg−1), carbamazepine (3, 10, and 30 mg kg−1), and sodium valproate (100–400 mg kg−1) were used as reference anticonvulsant drugs for various models. Flumazenil blocked the effect of the extract in the PTZ test significantly suggesting that Antiaris toxicaria may be acting by enhancing the effects of the GABAergic system. Antiaris toxicaria aqueous extract therefore possesses anticonvulsant activity.

In-vitro and in-vivo Evaluation of Anti-asthmatic Activity of Eugenia jambolana bark

2021 ◽  
pp. 3337-3342
Author(s):  
Bhong Prabha N. ◽  
Naikawade Nilofar. S. ◽  
Mali Pratibha. R. ◽  
Bindu Madhavi. S.
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Animal Models ◽  
Aqueous Extract ◽  
Guinea Pigs ◽  
Bark Extract ◽  
Eugenia Jambolana ◽  
In Vivo Animal Models

Objectives: The present study designed to evaluate the Antiasthmatic activity of aqueous extract of bark of Eugenia Jambolana (AEEJ) on in vitro and in vivo animal models. Materials and methods: Different in vitro and in vivo animal models was used to study the anti asthmatic activity as isolated goat tracheal chain preparation, Acetylcholine and Histamine induced bronconstriction in guinea pigs, effect of drug extract on histamine release from mast cell was checked by clonidine-induced mast cell degranulation, and milk-induced eosinophilia and leukocytosis. Results: In-vitro study on goat tracheal chain preparation revealed that aqueous extract of Eugenia jambolana (AEEJ)bark exerted antagonistic effect on the histamine induced contraction. (P<0.05) The guinea pigs when exposed to 0.2% histamine aerosol showed signs of progressive dyspnoea leading to convulsions. AEEJ significantly prolonged the latent period of convulsions (PCT) as compared to control following the exposure of histamine (0.2%) aerosol (P<0.01). The observation of present study indicates aqueous extract of Eugenia jambolana shows significant inhibition of milk induced eosinophilia and leukocytosis. Group of animals pretreated with aqueous Eugenia jambolana bark extract showed significant reduction in degranulation of mast cells when challenged with clonidine. The prevention of degranulation process by the aqueous Eugenia jambolana bark extract (P<0.01) indicates a possible stabilizing effect on the mast cells, indicating mast cell stabilizing activity. Conclusions: Thus, AEEJ showed antihistaminic, mast cell stabilizing and protective in guinea pigs against histamine induced PCD, reduced eosinophilia and leukocytosis and hence possesses potential role in the treatment of asthma.

scholarly journals Experimental study of various central nervous system effects of eugenol in mice and rats

2012 ◽  
Vol 10 (3) ◽  
pp. 208-214 ◽  
Author(s):  
M Sharma ◽  
GP Rauniar ◽  
BP Das
Keyword(s):  
Central Nervous System ◽  
Experimental Study ◽  
Nervous System ◽  
Animal Models ◽  
Antinociceptive Effect ◽  
Test Group ◽  
Control Group ◽  
Anticonvulsant Effect ◽  
Research Activities ◽  
Group I

Background: Eugenol is an essential component of many medicinal herbs. It is a member of the allylbenzene class of chemical compounds. Since years, it is being used in dental practice to relieve pain arising from pulpitis and dentinal hypersensitivity. There are few reports of anticonvulsant effect but further effects are less reported. Lack of comprehensive studies and data of eugenol on the central nervous system effects in animal models thus necessitates further research activities. Objective: To observe and evaluate various neuropharmacological effects like antinociceptive effect, anticonvulsant effect, effect on motor co-ordination, pentobarbital induced sleeping time and anxiolytic effect of eugenol in mice and rats. Methods: It was a quantitative experimental study done in the laboratory setting of the department of Clinical Pharmacology and Therapeutics. For each test, respective animal models were used. Animals were divided into three groups of six each, group I as control, group II as standard control and group III as test group. Results: Significant effects were observed in analgesic, anticonvulsant and sedative model whereas no significant effect as compared to control was observed in test of motor co-ordination and in behavioral models. Conclusion: This study shows eugenol to possess analgesic, anticonvulsant and sedative effect whereas it didn.t have any effect on models of anxiety. Various target sites have been implicated but this study doesn.t conclude a plausible mechanism behind all these observed effects. DOI: http://dx.doi.org/10.3126/hren.v10i3.7137 Health Renaissance; September-December 2012; Vol 10 (No.3);208-214

scholarly journals Glycemia Lowering Effect of an Aqueous Extract of Hedychium coronarium Leaves in Diabetic Rodent Models

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 629 ◽  
Author(s):  
Ling-Shan Tse ◽  
Po-Lin Liao ◽  
Chi-Hao Tsai ◽  
Ching-Hao Li ◽  
Jiunn-Wang Liao ◽  
...  
Keyword(s):  
Animal Models ◽  
Aqueous Extract ◽  
Low Density Lipoprotein ◽  
Folk Medicine ◽  
Density Lipoprotein ◽  
Insulin Level ◽  
Diabetic Animal ◽  
Hedychium Coronarium ◽  
History Of ◽  
History Of Use

Hedychium coronarium has a long history of use worldwide as a food and in folk medicine. In this study, we aimed to investigate the effect of an aqueous extract of H. coronarium leaves (HC) on type 2 diabetes mellitus (T2DM). Two types of animal models were used in this study: Streptozotocin (STZ)-induced T2DM (Wistar rats; N = 8) and C57BKSdb/db mice (N = 5). After treatment with HC for 28 days, glucose tolerance improved in both of the diabetic animal models. As significant effects were shown after 14 days of treatment in the STZ-induced T2DM model, we carried out the experiments with it. After 28 days of treatment with HC, the levels of cholesterol, triglyceride, high-density lipoprotein, and low-density lipoprotein were significantly improved in the STZ-induced T2DM model. The lesions degree of islet β-cells was decreased after the HC treatment. Although the insulin level increased moderately, the aldosterone level was significantly decreased in the HC-treated groups, suggesting that aldosterone might play an important role in this effect. In summary, HC is a natural product and it is worth exploring its effect on T2DM.

Antinociceptive, anti-inflammatory and antipyretic effects of Muntingia calabura aqueous extract in animal models

2007 ◽  
Vol 61 (4) ◽  
pp. 443-448 ◽  
Author(s):  
Z. A. Zakaria ◽  
N. A. Mohd Nor Hazalin ◽  
S. N. H. Mohd Zaid ◽  
M. Abdul Ghani ◽  
M. H. Hassan ◽  
...  
Keyword(s):  
Animal Models ◽  
Aqueous Extract ◽  
Anti Inflammatory ◽  
Muntingia Calabura

scholarly journals Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models

2008 ◽  
Vol 62 (2) ◽  
pp. 179-187 ◽  
Author(s):  
Zainul Amiruddin Zakaria ◽  
Zuleen Delina Fasya Abdul Ghani ◽  
Raden Nur Suraya Raden Mohd. Nor ◽  
Hanan Kumar Gopalan ◽  
Mohd. Roslan Sulaiman ◽  
...  
Keyword(s):  
Animal Models ◽  
Experimental Animal ◽  
Aqueous Extract ◽  
Experimental Animal Models ◽  
Anti Inflammatory ◽  
Dicranopteris Linearis

scholarly journals Underlying Mechanisms of Anti-spasmodic, Antidiarrheal, Antioxidant and Acute Toxicity Assessments of Aqueous Extract of Mentha Suaveolens Ehrh and its Fourier Transform Infra-red Spectroscopy Analysis

2020 ◽  
pp. 37-54
Author(s):  
EL-Akhal Jamila ◽  
Chda Alae ◽  
Tazi Abdelali ◽  
Boukir Abdelatif ◽  
Bencheikh Rachid
Keyword(s):  
Fourier Transform ◽  
Animal Models ◽  
Functional Groups ◽  
Aqueous Extract ◽  
Castor Oil ◽  
Butylated Hydroxytoluene ◽  
Calcium Antagonism ◽  
Small Intestinal Transit ◽  
Infra Red ◽  
Underlying Mechanisms

Objective: The aim of this present study is to investigate the antidiarrheal, spasmolytic and antioxidant activities of aqueous extract of Mentha suaveolens Ehrh (AEMS), to study their underlying mechanisms in animal models and to reveal its main functional groups using Fourier Transform Infra-Red Spectroscopy (FTIR). Methods: Mentha suaveolens Ehrh was studied for antidiarrheal activity on Wistar rats of both sexes at the doses of 200 and 800 mg/kg body weight using castor oil-induced diarrhea, castor oil-induced enteropooling and small intestinal transit models. The extract was studied for antispasmodic property in isolated rabbit jejunum using various spasmogenic agents including Ach (10-5M), KCl (100 mM) and in the absence and in the presence of L-NAME (10-4 M) and the methylene blue (10-5 M).The antioxidant capacity of AEMS was carried out using DPPH radical scavenging activity and the ferric reducing antioxidant potential (FRAP). Ascorbic acid and Butylated HydroxyToluene (BHT) were used as references. The functional chemical groups were determined by FTIR. Results: The great antidiarrheal potential of AEMS seems to be mediated through calcium antagonism. The marked and concentration-dependent induced spasmolytic effect of AEMS appears to involve Ca2+ voltage channel blockade and the NO/cGMP pathway activation. AEMS possessed strong and concentration-dependent antioxidant potency using DPPH and FRAP. Polyphenols, carboxyl and carbohydrates were found to be the main functional groups in the AEMS analyzed by FTIR. Conclusion: Overall, our current findings provide scientific proves in animal models for the traditional use of AEMS in folk medicine for the prevention or the treatment of gastrointestinal diseases in Morocco.

scholarly journals ANTI-PYRETIC AND ANTI-INFLAMMATORY ACTIVITY OF AQUEOUS EXTRACT OFSOLANUM XANTHOCARPUM BERRIES IN SUITABLE ANIMAL MODELS

2021 ◽  
Vol 9 (11) ◽  
pp. 954-959
Author(s):  
Leisangthem Tarinita Devi ◽  
◽  
Mayanglambam Medhabati Devi ◽  
Florence Lalvarmawi ◽  
Swagata Datta ◽  
...  
Keyword(s):  
Animal Models ◽  
Aqueous Extract ◽  
Inflammatory Activity ◽  
Active Principle ◽  
Traditional Medicines ◽  
Control Drug ◽  
Paw Oedema ◽  
Study Results ◽  
Anti Inflammatory ◽  
Solanum Xanthocarpum

Background: Use of traditional medicines for treating various diseases have become a topic of global importance because of their safety, less side effects and cost-effectiveness. The present study was undertaken to evaluate the anti-pyretic and anti-inflammatory activity of aqueous extract of Solanum xanthocarpum berries (SXB) in suitable animal models. Methods: Anti-pyretic activity was assessed by dried yeast induced pyrexia in rats. Anti-inflammatory activity was evaluated using carrageenan induced paw oedema in rats. Three doses of the plant extract (500, 1000 and 1500 mg/kg) prepared by dissolving the drugs in 2% gum acacia were used. Paracetamol 33 mg/kg and aspirin 100 mg/kg were used as standard drugs for anti-pyretic and anti-inflammatory activity respectively. Vehicle served as a control drug. Results: Acute toxicity study results demonstrated no mortality of animals after 24 hours. The aqueous extract of the plant significantly decreased the rectal temperature of the rats and significantly prevented increase in volume of paw oedema. Conclusion: The aqueous extract of Solanum xanthocarpum berries exerts its anti-pyretic and anti-inflammatory activity activity. However, further studies with the plant are required to evaluate the dose dependent activity and also to determine the active principle responsible for exact mechanism for both antipyretic and anti-inflammatory activity.

scholarly journals Anticonvulsant effect of the aqueous extract of Xeromphis nilotica in mice

2008 ◽  
Vol 2 (3) ◽  
Author(s):  
B Adzu ◽  
MB Amizan ◽  
AA Njan ◽  
JOC Ezeowumelu ◽  
DD Akumka
Keyword(s):  
Aqueous Extract ◽  
Anticonvulsant Effect
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