ANXIOLYTIC, ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITY OF MUCUNA PRURIENS SEEDS
2021 ◽
Vol 10
(4)
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pp. 3479-3483
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Behavioral models such as the elevated plus maze (EPM), light and dark method, Hole-board method, and Marble burying method were used to assess Methanolic extract of Mucuna pruriens seeds (MEMP) for anxiolytic function. MEMP in a dose of 200 and 300 mg/kg, p.o. was found to possess significant anxiolytic activity. In TST and FST, MEMP showed a substantial reduction in the time of immobility, indicating antidepressant action. MEMP significantly increased the latency for straub tail, extensor, myoclonic jerk, clonic convulsion and stupor in pentylenetetrazol (PTZ) and isoniazid-induced convulsion models. MEMP may be interfering with the level of monoamines; L-dopa, serotonin and histamine and produced antidepressant activity.
2020 ◽
Vol 26
(31)
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pp. 3895-3904
2016 ◽
Vol 2016
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pp. 1-10
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