scholarly journals Serum Biochemical Reference Values for Adult and Non-adult Chinese Alligators during the Deep and Late Hibernation Periods

2018 ◽  
Vol 44 (1) ◽  
pp. 7
Author(s):  
Mingyan Tang ◽  
Rongmei Fei ◽  
Yilong Wu ◽  
Yongkang Zhou
Keyword(s):  
Reference Values ◽  
Recovery Period ◽  
Serum Biochemistry ◽  
Serum Lactate ◽  
High Rate ◽  
Serum Lactate Dehydrogenase ◽  
Reproduction Rate ◽  
Chinese Alligator ◽  
Serum Biochemical ◽  
Deep Hibernation

Background: The Chinese alligator (Alligator sinensis) is a critically endangered species. Due to the rapid growth of the captive population, the susceptibility to disease during the recovery period after winter hibernation, especially in young alligators, have detrimentally affected Chinese alligator populations. Serum biochemistry, which relates to metabolism, nutritional status and disease, is enormously helpful in evaluating physical conditions in reptile. Many studies have reported the serum biochemical reference values of various reptilian species, including several crocodilians. However, reference values for Chinese alligators have not yet been reported. For captive Chinese alligators, hibernation is a crucial period because winter management has a direct influence on the survival rate of juveniles and the reproduction rate of adults. The main object of the present study refore was to measure the serum biochemical values of captive Chinese alligators during hibernation.Materials, Methods & Results: As such, this study investigates the serum biochemistry as a factor of age and hibernation stage. During the deep and late hibernation periods blood samples were drawn from 30 healthy captive Chinese alligators (adults, sub-adults, and juveniles) at the Anhui Research Center of Chinese Alligator Reproduction (ARCCAR). Serum biochemical measurements were performed using an automated biochemical analyzer and compared based on the age group and hibernation stage via two-way ANOVA. During late hibernation, serum lactate dehydrogenase, alkaline phosphatase, and aspartate aminotransferase activity increased in all age groups in comparison to that in deep hibernation, while the concentration of calcium decreased. Meanwhile, the concentration of serum phosphorus, uric acid, total protein, and globulin in sub-adults and juveniles considerably increased in comparison to that in deep hibernation, while cholesterol and albumin declined. However, in adults only slight changes were noted. Based on comprehensive statistical analysis, our results indicate that sub-adults and juveniles are at risk of developing renal disease during artificial hibernation.Discussion: Chinese alligators, especially sub-adults and juveniles, are particularly vulnerable to disease when they wake from hibernation. They often display symptoms such as depression, anorexia, lethargy, sluggish movement, slow, incremental weight gain, progressive muscle wasting, and even death. The high rate of morbidity in non-adult Chinese alligators may be associated with the high density of UA and other changes in multiple biochemical markers that occur during late hibernation. These altered serum biochemical profiles may indicate kidney damage. One of the most common diseases among reptiles is nephropathy, the symptoms of which are non-specific and tend to agree with those observed post-hibernation. In summary, this study has reported the serum biochemical values of Chinese alligators of varying ages in the deep and late hibernation phases. Based on statistical analyses, interesting differences between the serum biochemical values of adults and non-adults during the deep and late hibernation have been found. The observed changes suggest that, under an artificial hibernation environment, the kidneys of sub-adults and juveniles may become impaired. We believe that the data reported in this study will provide clinical guidance to facilitate more appropriate artificial wintering conditions for Chinese alligators, and assist the breeding and management of these reptiles, as well as disease prevention, during hibernation and recovery.

Rituximab (R) + Hypercvad Alternating with R-Methotrexate/Cytarabine after 9 Years: Continued High Rate of Failure-Free Survival in Untreated Mantle Cell Lymphoma (MCL)

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 833-833 ◽  
Author(s):  
Jorge Romaguera ◽  
Luis Fayad ◽  
Alma Rodriguez ◽  
Fb Hagemeister ◽  
Barbara Pro ◽  
...  
Keyword(s):  
Overall Survival ◽  
Complete Response ◽  
Serum Lactate ◽  
High Rate ◽  
Serum Lactate Dehydrogenase ◽  
High Dose ◽  
Free Survival ◽  
Mantle Cell ◽  
Rate Of Failure

Abstract MCL has a poor outcome with current non-intense therapies. We present an update of our results utilizing an intense chemotherapy regimen comprising fractionated cyclophosphamide, doxorubicin, vincristine and dexamethasone to which rituximab has been added (R-HyperCVAD, one cycle), alternating with rituximab and high dose methotrexate/cytarabine (R-MA, one cycle) for a total of 6–8 cycles (J Clin Oncol 2006 Feb 1;24(4):724). Treatment was started at most within 2 months from the initial evaluation. Overall survival (OS) was defined as the time from start of treatment until recurrence or death from any cause. Failure-free survival (FFS) was defined as the time from start of treatment until recurrence or death from toxicity or death from treatment-related malignancy. Of 97 consecutive evaluable patients, 87% achieved a complete response (CR) or unconfirmed CR after 6 cycles and did not receive additional therapy. With a median follow up on 84 months (7 years), the overall survival and failure-free survival at 7 years was 60% and 43%, respectively. Among patients 65 years of age or younger, the 7-year OS and FFS was 68% and 52%, respectively. Important prognostic variables included age (65 yrs or less vs > 65 yrs; initial serum B2 microglobulin 3 or less mg/dL vs > 3); and initial serum lactate dehydrogenase (normal vs > normal). Further subset analysis will be presented at the meeting. Figure Figure

scholarly journals Reference values for chinchilla (Chinchilla laniger) blood cells and serum biochemical parameters

2005 ◽  
Vol 35 (3) ◽  
pp. 602-606 ◽  
Author(s):  
Tális de Oliveira Silva ◽  
Luiz Carlos Kreutz ◽  
Leonardo José Gil Barcellos ◽  
João Borella ◽  
Auren Benck Soso ◽  
...  
Keyword(s):  
Health Status ◽  
Reference Values ◽  
Blood Cells ◽  
Biochemical Parameters ◽  
Serum Biochemistry ◽  
Serum Biochemical Parameters ◽  
Adult Males ◽  
Blood Samples ◽  
Serum Biochemical ◽  
South Brazil

Raising chinchilla (Chinchilla laniger) for commercial purpose has increased significantly; however, hematological and serum biochemical reference values have not yet been determined for chinchillas raised in south Brazil. Establishing blood cells and serum biochemistry reference values might be helpful to evaluate health status of chinchillas and might be used as a tool by clinicians. The purpose of this study was to determine the reference values for blood cells and serum biochemistry of Chinchilla laniger. Blood samples were collected by cardiac puncture from 16 adult males, at the time they were killed to remove the fur coat, and from 8 adult males anesthetized with ketamine and xylazine. Blood cell counts and serum biochemistry analysis were performed using standard techniques and the results were expressed as mean ± SEM. Analysis of blood parameters from post-mortem cardiac punctured and from anesthetized chinchillas indicated that blood samples from anesthetized chinchillas had higher PCV, Hemoglobin, MCHC and WBC (P < .05); in contrast, had lower levels of monocytes, basophils and eosinophils (P < .05). Serum biochemical parameters were less affected by sampling method: anesthetized chinchillas had lower levels of urea, glucose and triglycerids (P < .05). The data obtained might be useful as a parameter to monitor the health status of chinchillas raised in south Brazil.

scholarly journals Study of some serum biochemical changes of experimental diabetes mellitus in Donkey

2013 ◽  
Vol 12 (1) ◽  
pp. 15
Author(s):  
A. H. Fadhil
Keyword(s):  
Diabetes Mellitus ◽  
Lactate Dehydrogenase ◽  
Experimental Diabetes ◽  
Serum Glucose ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Serum Urea ◽  
Control Groups ◽  
Serum Biochemical ◽  
Alloxan Monohydrate

This study was conducted to induce experimental diabetes in donkeys and assess some serum biochemical changes in diabetes mellitus. Fifteen donkeys were used in this experiment and divided into two groups:A. Treatment group which includes (11) donkeys. Diabetic group. denoted by Dm.B. Control group which includes (4) donkeys denoted by Cm.Animals were housed in the field. The animals were left tow weeks for adaptation. Diabetes mellitus was induced by i.v injection of alloxan monohydrate at dose rate 100 mg/kg dissolved in 25 ml of normal saline, while the control groups were injected with 25 ml of normal saline. Blood was collected before injection of alloxan monohydrate and after that (10,20.30,40)days to check fasting and random serum glucose. The laboratory tests including serum glucose, serum urea, serum creatinine, serum cholesterol, serum lactate dehydrogenase, We found out the following result according to the periods of the experiments: Serum glucose level was elevated starting from the 1st 10 days period after induction of diabetes mellitus. It reached its peak levels on the day(20,30,40). Serum urea, serum creatinine, serum cholesterol, serum lactate dehydrogenase was elevated in diabetic donkeys,in control groups, but there was no significant difference.

Athletes as Health Testing Examinees

1993 ◽  
Vol 32 (03) ◽  
pp. 211-213 ◽  
Author(s):  
K. Miura ◽  
S. Miyakawa ◽  
S. Narayama ◽  
H. Hirano ◽  
K. Kanai ◽  
...  
Keyword(s):  
Ventricular Hypertrophy ◽  
Female Athletes ◽  
Serum Biochemistry ◽  
Left Ventricular ◽  
High Rate ◽  
Age At Menarche ◽  
Male Athletes ◽  
Menstrual Dysfunction ◽  
Test Items ◽  
Serum Biochemical

Abstract:Health-testing examination data of 91 male and 54 female athletes were studied, together with age-matched controls, on serum biochemistry, ECG findings, hematology, and some data on gynecological physiology. Analysis of serum biochemical values revealed statistically significant differences in 14 of 18 routine test items as compared with the age-matched controls. In ECG findings, the combination of bradycardia and left ventricular hypertrophy was most frequently found in male athletes, whereas that of bradycardia and sinus arrythmia was observed predominantly in female athletes. The incidence of anemia and menstrual dysfunction was higher in female athletes than in controls, especially in the basketball team. In the same team, a high rate of deviant ECG records and a different distribution of the age at menarche were also observed.

scholarly journals The Effects of Electrostimulation and Core Exercises on Recovery After High-Intensity Exercise

2017 ◽  
Vol 6 (4) ◽  
pp. 46-53 ◽  
Author(s):  
Ahmet Mor ◽  
Gökhan İpekoğlu ◽  
Cansel Arslanoglu ◽  
Kursat Acar ◽  
Erkal Arslanoglu
Keyword(s):  
Heart Rate ◽  
High Intensity ◽  
Recovery Period ◽  
Serum Lactate ◽  
High Intensity Exercise ◽  
Serum Lactate Dehydrogenase ◽  
Active Recovery ◽  
Significant Difference ◽  
Lactate Levels ◽  
Recovery Methods

Introduction and objectives: The purpose of this study was to determine the effects of electrostimulation and core exercises on recovery after high-intensity exercise. Methods: The participants of this study consists of 12 male bodybuilders who regularly train and between the ages 18-30. Tabata high intensity interval training (HIIT) was applied with different recovery methods to the athletes on three different days and the recovery levels of athletes were analysed. Heart rate and blood lactate levels were measured at baseline (PRE) at immediately after the HIIT (POST), at the 1 minutes after HIIT (1min), at the 5 minutes after HIIT (5min), and at the 10 minutes after HIIT (10min). On the rest days, serum lactate dehydrogenase (LDH) and serum creatine kinase (CK)  measurements were done to determine the muscle damage. Results: The in-group comparisons for lactate levels showed no significant difference (p>0,01). The level of lactate on the 10min was found to be significantly lower than the 5min in the core exercise group (p<0,01). Similarly in the electrostimulation group, 10m lactate levels are significantly lower than 5min (p<0,01). There were no statistically significant differences in the heart rate measurements (p<0,01). The results showed no statistically significant difference between the groups although the averages of LDH and CK showed variations (p>0,01). These results show that the lactate level reaches to the maximum level after HIIT, and the level of lactate decreases between the 5th and the 10th minutes. Discussion and conclusion: These indicate that the active recovery methods are more effective than the passive. It was found that the active recovery methods accelerate the lactate removal from the metabolism and provide effective recovery in short time during the recovery period after exercise.

Serum Lactate Dehydrogenase Isoenzyme 1 and Relapse in Patients with Nonseminomatous Testicular Germ Cell Tumors Clinical Stage I

2001 ◽  
Vol 40 (4) ◽  
pp. 536-540 ◽  
Author(s):  
Finn Edler von Eyben ◽  
Ebbe Lindegaard Madsen ◽  
Ole Blaabjerg ◽  
Per Hyltoft Petersen ◽  
Hans von der Maase ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Germ Cell ◽  
Clinical Stage ◽  
Germ Cell Tumors ◽  
Serum Lactate ◽  
Stage I ◽  
Serum Lactate Dehydrogenase ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Dehydrogenase Isoenzyme

scholarly journals The incremental value of computed tomography of COVID-19 pneumonia in predicting ICU admission

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maurizio Bartolucci ◽  
Matteo Benelli ◽  
Margherita Betti ◽  
Sara Bicchi ◽  
Luca Fedeli ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Confidence Interval ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Receiver Operating Characteristic Curves ◽  
Icu Admission ◽  
Reactive Protein ◽  
Incremental Value ◽  
Validation Set ◽  
Radiological Model

AbstractTriage is crucial for patient’s management and estimation of the required intensive care unit (ICU) beds is fundamental for health systems during the COVID-19 pandemic. We assessed whether chest computed tomography (CT) of COVID-19 pneumonia has an incremental role in predicting patient’s admission to ICU. We performed volumetric and texture analysis of the areas of the affected lung in CT of 115 outpatients with COVID-19 infection presenting to the emergency room with dyspnea and unresponsive hypoxyemia. Admission blood laboratory including lymphocyte count, serum lactate dehydrogenase, D-dimer and C-reactive protein and the ratio between the arterial partial pressure of oxygen and inspired oxygen were collected. By calculating the areas under the receiver-operating characteristic curves (AUC), we compared the performance of blood laboratory-arterial gas analyses features alone and combined with the CT features in two hybrid models (Hybrid radiological and Hybrid radiomics)for predicting ICU admission. Following a machine learning approach, 63 patients were allocated to the training and 52 to the validation set. Twenty-nine (25%) of patients were admitted to ICU. The Hybrid radiological model comprising the lung %consolidation performed significantly (p = 0.04) better in predicting ICU admission in the validation (AUC = 0.82; 95% confidence interval 0.73–0.97) set than the blood laboratory-arterial gas analyses features alone (AUC = 0.71; 95% confidence interval 0.56–0.86). A risk calculator for ICU admission was derived and is available at: https://github.com/cgplab/covidapp. The volume of the consolidated lung in CT of patients with COVID-19 pneumonia has a mild but significant incremental value in predicting ICU admission.

scholarly journals Outcomes of Adult Ewing Sarcoma Treated with Multimodality Therapy: A Single-Institute Experience

2020 ◽  
Vol 09 (04) ◽  
pp. 191-194
Author(s):  
Ravi Chandran ◽  
Siva Prasad Kuruva ◽  
Rachana Chennamaneni ◽  
Stalin Bala ◽  
Meher Lakshmi Konatam ◽  
...  
Keyword(s):  
Metastatic Disease ◽  
Ewing Sarcoma ◽  
Univariate Analysis ◽  
Lactate Dehydrogenase Level ◽  
Serum Lactate ◽  
Normal Serum ◽  
Multimodality Therapy ◽  
Serum Lactate Dehydrogenase ◽  
Common Symptom ◽  
Localized Disease

Abstract Introduction Ewing sarcoma (ES) is more common in children and relatively rare in adults. Adult ES has poor prognosis than children. Treatment approaches for adults have been extrapolated from pediatric experience. Data on adult ES are very few because of its rarity in adults. The present study was done to analyze the clinical profile and outcome of adult ES. Aims The aim was to study the clinical and pathological treatment and outcomes in adult ES. Subjects and Methods Between 2010 and 2017, a total of 73 ES patients with age more than 18 years were retrospectively analyzed. Survival analysis was done by plotting Kaplan–Meier curves. Results A total of 73 patients were diagnosed with ES during 2010 to 2017. Among them, 43 (58.9%) had localized disease with a median age of 24.5 years. Males were 44 (60.3%) and females were 29 (39.7). Pain (75.3%) was the most common symptom at presentation. Nine patients had incomplete details and were excluded from the analysis. Among 21 (28.8%) patients, the lung (61.9%) was the most common site of metastasis followed by the bone, bone marrow, and brain. The median number of chemotherapy cycles in the localized disease was 14 (range 1–17), and in metastatic disease, it was 4 (range 1–7). Univariate analysis was done with respect to age (< 25 vs. ≥25), gender, elevated or normal serum lactate dehydrogenase level, tumor size (< 8 cm versus ≥8 cm), site (axial versus extremity), and neoadjuvant chemotherapy (NACT) given or not. NACT had a significant impact on overall survival (OS) and the rest had no effect. At a median follow-up of 40 months, the 3-year OS in localized disease was 87.4%. In metastatic disease, the median OS was 13 months with 3-year OS of 26%. Conclusions Outcomes with multimodality therapy in adult ES patients with localized disease are comparable to that of a pediatric cohort. However, metastatic disease has poor survival.

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