scholarly journals Cranioschisis and Anencephaly in a Dog - challenging etiology

2019 ◽  
Vol 47 ◽  
Author(s):  
Idelvânia Dos Anjos Nonato ◽  
Marina Ribeiro Teixeira ◽  
Jéssica Lélis De Miranda ◽  
Heloísa Maria Bressan Braz ◽  
João Paulo Machado
Keyword(s):  
Morphological Characteristics ◽  
Cardiac Activity ◽  
Routine Care ◽  
Toxic Substances ◽  
Veterinary Clinic ◽  
Canine Herpesvirus ◽  
Maternal Genotype ◽  
Fetal Movements ◽  
Definition Of

Background: Congenital anomalies involve changes that may occur in the central nervous system during the period from gestation until birth. The present study reports a case of cranioschisis and anencephaly in a dog and aims to discuss the possible etiologies of these malformations in dogs.Case: A pinscher bitch was referred to a private veterinary clinic in the city of Muriaé - MG, for routine consultation and gestational diagnosis, which was carried out by ultrasound on the 39th day. Routine care was extended until delivery, and clinical and complementary examinations were performed to assess the health of the female dog and that of the fetuses. Vital parameters and morphological characteristics showed that all fetuses had present cardiac activity, correctly formed bone skeleton, definition of the head, trunk and limbs, presence of fetal movements, definition of the hepatic region and hepatic parenchyma typically hypoechoic, hyperechoic pulmonary parenchyma, and visualization of the stomach and bladder. The delivery lasted two hours, and three female puppies were born. A macroscopically significant cranial alteration was observed in the second pup; it was located in the middle line of the skull unprotected by skin. The placenta was dark in color. The puppy’s respiratory activity was present, but with dyspnea, body movements were limited and presented hypothermia. In the first 24 h, the female puppy was fed homemade milk compound through a syringe because of difficulty in performing the suction movement. Delay in urination and defecation were also observed in relation to the other neonates. Before completing the first 48 hours of birth, this newborn died, and his cadaver was submitted for necropsy. The necropsy procedure identified the presence of acrania (partial absence of the bones of the skull), aplasia of the skin of the eyes, meningoencephalocele demonstrating that the meningeal formed an external pocket, and partial anencephaly and exencephaly (brain outside the cranial cavity). Subsequently, organ samples were sent for evaluation by means of qualitative PCR for canine herpesvirus and the result was negative.Discussion: Anencephaly is a result of erroneous closure of the neural sulcus, causing partial formation or no formation of the brain. The etiology ranges from environmental factors or teratogenic effects such as radiation, viruses, toxic substances, maternal diseases, maternal genotype, enzymatic activity, and fetal susceptibility. CaHV-1 type 1 canine herpesvirus has been reported to cause abortion, fetal mummification, stillbirth, the birth of weak pups, or neonatal death. The anomalies involving cranial and encephalic malformation have a multifactorial etiology, which made it difficult to identify the actual cause that led the pup to present the reported characteristics. Despite the negative result of the PCR test, Canine herpesvirus (CaHV-1 type 1), as well as the use of some drugs during pregnancy, are major causes of this disease.

scholarly journals Coeliac disease is associated with depression in children and young adults with type 1 diabetes: results from a multicentre diabetes registry

2021 ◽  
Author(s):  
Sascha René Tittel ◽  
◽  
Désirée Dunstheimer ◽  
Dörte Hilgard ◽  
Burkhild Knauth ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Adults ◽  
Coeliac Disease ◽  
Diabetes Patient ◽  
Routine Care ◽  
Diabetes Registry ◽  
Increased Risk ◽  
Treatment Data ◽  
Children And Young Adults

Abstract Aims To analyse the association between coeliac disease (CD) and depression in children, adolescents, and young adults with type 1 diabetes (T1D). Methods We included 79,067 T1D patients aged 6–20 years, with at least six months of diabetes duration, and treatment data between 1995 and 2019 were documented in the diabetes patient follow-up registry. We categorized patients into four groups: T1D only (n = 73,699), T1 + CD (n = 3379), T1D + depression (n = 1877), or T1D + CD + depression (n = 112). Results CD and depression were significantly associated (adjusted OR: 1.25 [1.03–1.53]). Females were more frequent in both the depression and the CD group compared with the T1D only group. Insulin pumps were used more frequently in T1D + CD and T1D + depression compared with T1D only (both p < .001). HbA1c was higher in T1D + depression (9.0% [8.9–9.0]), T1D + CD + depression (8.9% [8.6–9.2]), both compared with T1D only (8.2% [8.2–8.2], all p < .001). We found comorbid autism, attention deficit hyperactivity disorder, anxiety, schizophrenia, and eating disorders more frequently in the T1D + CD + depression group compared with T1D only (all p < .001). Conclusions CD and depression are associated in young T1D patients. The double load of T1D and CD may lead to an increased risk for depression. Depression was associated with additional psychological and neurological comorbidities. Aside from imperative CD screening after T1D diagnosis and regular intervals, depression screening might be helpful in routine care, especially in patients with diagnosed CD.

Consent for Medical Services for Children and Adolescents

PEDIATRICS ◽  
1993 ◽  
Vol 92 (2) ◽  
pp. 290-291
Author(s):  
Keyword(s):  
Emergency Department ◽  
Emergency Services ◽  
Routine Care ◽  
Emergency Department Visits ◽  
Medical Attention ◽  
Unaccompanied Minors ◽  
Sexually Transmitted ◽  
Practical Guidelines ◽  
Societal Changes ◽  
Definition Of

Major societal changes affecting the provision of child health care have occurred over the last few decades. In the area of emergency services, consent for medical treatment is an important issue. The purpose of this statement is to outline major considerations involving consent and provide the physician with practical guidelines concerning this issue. Today fewer than one third of children live in two-parent families in which only the father works outside the home.1,2 Because of foster care placement, or temporary or permanent arrangements with relatives or friends, parents may not be available to give consent for treatment of their children.3-6 Unaccompanied minors may seek medical attention in any one of a number of locations. Some go to the emergency department, 14% of which have no policy regarding consent for the care of these patients.7 Unaccompanied minors younger than 18 years of age account for 3.4% of all emergency department visits.7 Twenty-two states and the District of Columbia now have laws concerning the "mture minor." Most other states have provisions in which competent minors may arrange for care involving contraceptives, pregnancy, abortion, sexually transmitted diseases, drug and alcohol abuse, and psychiatric disorders.8 The dilemma for emergency physicians and practicing pediatricians alike is whether to follow a strict interpretation of the law or to adopt a more practical approach. Clearly, consent is not required in life- or limb-threatening emergencies,8,9 although the definition of emergency varies from state to state. However, in most instances, only routine care, not emergency care, is needed. As a result, many physicians fear charges of battery or litigation should their judgement regarding treatment be questioned.8

Neomisticius platypi n. sp. and N. variabilis n. sp. (Tylenchomorpha: Anguinidae) from dead oak trees in Japan

Nematology ◽  
2021 ◽  
pp. 1-21
Author(s):  
Natsumi Kanzaki ◽  
Hayato Masuya ◽  
Keiko Hamaguchi
Keyword(s):  
New Species ◽  
Vas Deferens ◽  
Morphological Characteristics ◽  
Platypus Quercivorus ◽  
Oak Trees ◽  
Two New Species ◽  
Previous Definition ◽  
Rectal Glands ◽  
Stylet Length ◽  
Definition Of

Summary Two new Neomisticius species, typologically and phylogenetically close to each other, are described and illustrated from dead Quercus trees and an ambrosia beetle, Platypus quercivorus. The two species share some stylet morphological characteristics, namely, they both possess a long conus occupying more than half of the total stylet length, a long crustaformeria composed of more than 160 cells (eight rows of more than 20 cells each), and a short and broad female tail with a digitate tip. They are distinguished from each other by N. variabilis n. sp. having a wide, spindle-shaped male bursa with a blunt terminus and N. platypi n. sp. having an oval bursa with a rounded terminus. In addition, the males and females of both species have three large rectal glands and the posterior end of the male testis (distal end of the vas deferens) bears three cells that seemingly function as a valve between the vas deferens and the cloacal tube. These characteristics have not been reported in other tylenchids. Currently, the genus contains only three species: the two new species and N. rhizomorphoides, which has a normal stylet with a short conus, a short crustaformeria, and lacks rectal glands and valve cells in the vas deferens. Therefore, the two new species are readily distinguished from N. rhizomorphoides and, based on the previous definition, may even represent a new genus. However, considering their phylogenetic closeness and biological similarities (e.g., association with ambrosia beetles), the generic definition of Neomisticius was emended to include these new species.

Geostatistical approach for multi-scale seismic liquefaction risk assessment

2021 ◽  
Author(s):  
Rose Line Spacagna ◽  
Massimo Cesarano ◽  
Stefania Fabozzi ◽  
Edoardo Peronace ◽  
Attilio Porchia ◽  
...  
Keyword(s):  
Regional Scale ◽  
Morphological Characteristics ◽  
Predisposing Factors ◽  
Data Availability ◽  
Hazard Maps ◽  
Multi Scale ◽  
Seismic Liquefaction ◽  
Research Activities ◽  
Geostatistical Approach ◽  
Definition Of

&lt;p&gt;The Seismic Microzonation studies (SMs), promoted all over the Italian territory by the Department of Civil Protection, provide fundamental knowledge of the subsoil response in seismic conditions at the urban scale. Amplification phenomena related to lithostratigraphic and morphological characteristics, instabilities and permanent deformations activated by the earthquake, are highlighted in hazard maps produced at increasing reliability levels (level 1 to 3 of SM). In particular, zones prone to liquefaction instability are firstly identified following the predisposing factors, such as geological and geotechnical characteristics and seismicity. The robustness of the definition of these areas is strongly correlated to the availability and the spatial distribution of surveys. Moreover, the typology and quality of the investigations considerably influence the method of analysis and the degree of uncertainty of the results.&lt;/p&gt;&lt;p&gt;This work aims to establish an updated procedure of the actual SM guidelines and integrates recent research activities at different levels of SMs, to improve the hazard maps accuracy in terms of liquefaction susceptibility. For the scope, the case of the Calabria region in the south of Italy, well known for the high level of seismicity, was studied. At a regional scale, the base-level analysis was implemented for a preliminary assessment of the Attention Zones (AZ), potentially susceptible to liquefaction. The predisposing factors were implemented at a large scale, taking advantage of geostatistical tools to quantify uncertainties and filter inconsistent data. The regional-scale analysis allowed to highlight areas prone to liquefaction and effectively addressed the subsequent level of analysis. At a local scale, the quantitative evaluation of the liquefaction potential was assessed using simplified methods, integrating data from different survey types (CPT, SPT, Down-Hole, Cross-Hole, MASW) available in SM database. The definition of Susceptibility Zones (SZ) was provided considering additional indexes, combining the results obtained from different surveys typologies and quantifying the uncertainty due to the limited data availability with geostatistical methods. The analyses at the regional and municipality scale were matched with seismic liquefaction evidence, well documented in past seismic events. This multi-scale process optimises resource allocation to reduce the level of uncertainty for subsequent levels of analysis, providing useful information for land management and emergency planning.&lt;/p&gt;

Abstract 350: Assessment of Clinicians’ Attitudes and Knowledge About Cardiac Troponin Testing

2020 ◽  
Vol 13 (Suppl_1) ◽  
Author(s):  
Sandeep Jain ◽  
Andrew Hammes ◽  
Eric Rudofker ◽  
Karen Ream ◽  
Andrew E Levy
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Troponin ◽  
Myocardial Injury ◽  
The United States ◽  
Advanced Practice ◽  
Attitudes And Knowledge ◽  
Universal Definition ◽  
Definition Of ◽  
Attending Physicians

In the United States, the positive predictive value (PPV) of cardiac troponin for type 1 myocardial infarction is substantially lower than in Europe (15% vs. 50%). Further, even with publication of the 4 th Universal Definition of Myocardial Infarction, recent studies have shown that inaccurate classification of myocardial injury is common among clinicians in the United States. These findings are at least partly attributable to clinicians’ knowledge and attitudes about cardiac troponin testing; a survey of these parameters has never been conducted. Clinicians at the University of Colorado completed a brief 8-question multiple-choice survey related to troponin use, definitions of myocardial infarction and clinical assessment of elevated troponin levels. The survey was distributed via secure email and administered electronically using the Qualtrics™ platform. Responses were anonymous, completion was estimated to take 3 minutes and a lottery award system was used as an incentive for participation. Respondents included trainees, advanced practice providers and attending physicians from internal medicine, emergency medicine and medical subspecialties. We plan to obtain a total of 300 responses with descriptive findings of preliminary results included below. The survey was completed by 114 clinicians: 37 interns (32%), 45 residents (39%), 9 advanced practice providers (8%), 11 fellows (10%), and 12 attending physicians (11%). Regarding indications for troponin testing, 93% (106/114) indicated that they “usually” or “always” check troponin levels in patients with chest pain. More interestingly, 46% (52/112) reported checking troponin on “undifferentiated patients” at least half the time. For troponin interpretation, 97% (110/114) of participants identified that troponin levels alone cannot rule in or rule out coronary artery disease. In contrast, only 36% (41/114) and 55% (63/114), respectively, identified the NPV and PPV of a contemporary troponin assay for type 1 MI. Further, only 50% (57/114) of respondents identified that the likelihood of type 1 MI increases as troponin levels increase. Three brief clinical vignettes revealed that, while 78% (89/114) and 74% (45/61) of participants, respectively, identified type 1 MI and type 2 MI presentations, only 40% (21/53) of respondents correctly identified a vignette for non-ischemic myocardial injury. Concordant with this finding, 54% (61/114) of clinicians correctly identified the 4 th Universal Definition of Myocardial Infarction. These preliminary findings highlight important facets of clinician attitudes and knowledge about troponin testing that help explain the poor PPV for troponin and diagnostic misclassification observed among U.S. clinicians. These results could help guide curricular and clinical decision support interventions designed to improve the use and interpretation of cardiac troponin testing.

Forms of Pre-Caucasian brown trout S. trutta caucasicus (Dorofeeva, 1967) of the Caspian basin

Fisheries ◽  
2020 ◽  
Vol 2020 (5) ◽  
pp. 71-73
Author(s):  
Gazimagomed Magomedov ◽  
Zarema Alibekova ◽  
Rystam Rabazanov
Keyword(s):  
Brown Trout ◽  
Reproductive Potential ◽  
Morphological Characteristics ◽  
Limited Range ◽  
Biological Properties ◽  
Small Rivers ◽  
Continuous Change ◽  
The Caspian Sea ◽  
Natural Reproduction ◽  
Definition Of

A morphological analysis of brooks trout in Dagestan showed that each spawning herd is morphologically unique and differs from the rest in a certain set of characters. However, all of them, when comparing the age composition, spawning conditions, the extent of spawning migrations in rivers, etc. have a lot in common. All of them meet the definition of a population as a group of individuals united by panmixia, a single territory and isolated to one degree or another from similar groups within the species. The morphological characteristics of trout in the upper of rivers Avar, Andi, and Kara-Koysu further confirms the validity of this approach. Presumably, the structure of trout populations is in continuous change and the differences in morphological indicators are phenotypic in nature and reflect the biotic and abiotic conditions prevailing in this region. The interaction of variability and selection in the population maintains a mobile equilibrium of biological properties forms the passing (brown trout) and residential (trout) forms. The trout of Sulakriver breaks up into several local herds (trout of Avar Koysu, Andi Koysu, Kara-Koysu, etc.) with a specific and limited range of its migrations. To a certain extent, differing from neighboring ones, each of the herds maintains its integrity and does not mix with the rest. Thus, the brooks trout of Dagestan seem to combine two functions - the self-reproduction of local settled populations and generating migrant individuals in the Caspian trout (Terek, Samur, Kara-Su rivers, etc.). In the rivers of the Kara-Su system, regardless of the place of fishing and the season, trout is represented by almost 100% males. Naturally, the question arises: who ensures the reproduction of trout herds in the absence of females? At the same time, the Salmo truttacis caucasicus (Dorofeyeva, 1967) comes to spawn in these rivers, and its livestock is represented exclusively by females (70-80%). Therefore, brooks trout of the Kara-Su system rivers and the Salmo truttacis caucasicus, coming here to spawn, should be considered as a single reproduction fund. Eggs, laid by either a brown trout female or a trout female, can leave individuals, that roll into the sea and turn into a passing trout, and individuals that remain in the river will be called brooks trout. The total reproductive potential of small rivers of the Dagestan coast of the Caspian Sea is currently no less than in native salmon rivers (Terek, Samur). That is why small rivers play an important role in the natural reproduction of trout and brown trout. Among the small salmon rivers of Dagestan, the greatest fishery value have tributaries of the Sulak river, rivers of the Kara-Su system, Shura-ozen, Manas-ozen, etc. Significant differences in the climatic features of these areas inevitably affect the biology of trout inhabiting them.

scholarly journals Glycera sheikhmujibi n. sp. (Annelida: Polychaeta: Glyceridae): A New Species of Glyceridae from the Saltmarsh of Bangladesh

Diversity ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 213
Author(s):  
M. Hossain ◽  
Pat Hutchings
Keyword(s):  
Electron Microscope ◽  
New Species ◽  
Scanning Electron Microscope ◽  
Morphological Characteristics ◽  
Longitudinal Ridge ◽  
Type 3 ◽  
A New Species ◽  
Scanning Electron

A new species of glycerid polychaete, Glycera sheikhmujibi, is described from the saltmarsh on the central coast of Bangladesh. The species is identified based on morphological characteristics using both a light microscope and scanning electron microscope (SEM). The species is characterized by the presence of three distinct types of proboscideal papillae: type 1 papillae (conical with three transverse ridges), type 2 (conical with a straight, median, longitudinal ridge), and type 3 (round, shorter, and broader, with a straight, median, longitudinal ridge). It has a Y-shaped aileron with gently incised triangular base, almost equal-size digitiform noto- and neuropodial lobes in the mid-body, and long ventral cirri at the posterior end. The new species is compared with its related species, previously described from the Bay of Bengal region. A key to all these species is provided.

scholarly journals Regeneration of experimental long bone defect after implantation in its cavity of osteoplastic material “Calc-i-oss®”

2016 ◽  
Vol 33 (02) ◽  
pp. 099-102
Author(s):  
O. Korenkov
Keyword(s):  
Bone Tissue ◽  
Morphological Characteristics ◽  
Compact Bone ◽  
Long Bone ◽  
Electron Microscopic ◽  
Time In Literature ◽  
Microscopic Features ◽  
Definition Of ◽  
Osteoplastic Material ◽  
Long Bone Defect

Abstract Introduction: There is a significant divergence of data on the rate of resorption and replacement by the bone tissue of osteoplastic materials based on β-tricalcium phosphate in cancellous bone. At the same time in literature missing morphometric and electron microscopic features of bone tissue of the regenerate of compact substance of bone in these conditions. This study was aimed at the assessment of the healing of compact bone tissue defect after implantation of osteoplastic material “Calc-i-oss®” with the definition of the dynamics of resorption and morphological characteristics of bone tissue of the regenerate. Material and Methods: In the middle third of the diaphysis of the femur of rats there was reproduced the perforated defect to the bone-brain channel that was filled with osteoplastic material “Calc-i-oss®”. After surgery the fragments of injured bones were studied at the 60th and 120th day by methods of light microscopy with morphometry and scanning electron microscopy. Results: The conducted research revealed no inflammatory reaction at the site of the defect, signs of necrobiosis and necrosis of osteocytes in adjacent to the site of implantation maternal bone. The site of defect was filled with lamellar bone tissue high in osteoblasts, osteocytes and with integrated into its structure remains of “Calc-i-oss®”. On the surface and inside the implant there were found osteogenic cells and bone foci. It was established that the osteoplastic material throughout the observation period is subjected to development and replacement by bone tissue of the regenerate, the ratio of which on the 60th day of the experiment was 25.72 ± 2.06% to 74.28 ± 2.06%, and on the 120th day - 18.31 ± 1.54% to 81.69 ± 1.54%. Conclusion: Osteoplastic material “Calc-i-oss®” exhibits biocompatibility, osteoconductive properties, ability to resorption and is replaced by bone tissue, with which it integrates well.

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