scholarly journals AKTIVITAS DIURETIK KOMBINASI EKSTRAK BIJI PEPAYA (Carica papaya L) DAN BIJI SALAK (Salacca zalacca varietas zalacca (Gaert.)Voss) PADA TIKUS JANTAN GALUR WISTAR (Rattus norvegicus L)

2015 ◽  
Vol 1 (2) ◽  
pp. 105-112
Author(s):  
Nurihardiyanti Nurihardiyanti ◽  
Yuliet Yuliet ◽  
Ihwan Ihwan
Keyword(s):  
Rattus Norvegicus ◽  
Carica Papaya ◽  
Activity Index ◽  
Urine Volume ◽  
Negative Control ◽  
Seed Extract ◽  
Diuretic Activity ◽  
Urine Ph ◽  
Dose Combination ◽  
Papaya Seed

Research on diuretic activity of seed extract combination of papaya (Carica papaya L) and snake fruit (Salacca zalacca (Gaert.) Voss) to male wistar strain rats (Rattus norvegicus L.) has been conducted. This study aimed to determine the diuretic effect of the seed extract combination and its effective dose combination as diuretics. The extract was prepared by maceration method using ethanol 96%. Diuretic activity test was divided into 5 treatment groups. Each group consisted of 5 rats. Group 1 (negative control) was given suspension of Na-CMC 0.5%; Group 2 (positive control) was given furosemide 3.6 mg/kgBW; Group 3, 4, and 5 were given dose combination of snake fruit seed extract and papaya seed extract successively at “37.5 mg/kgBW + 7.5 mg/kgBW”; “70 mg/kgBW + 15mg/kgBW”; and “140 mg/kgBW + 30 mg/kgBW”. Each rat was then orally given warm distilled water (70°C) 10ml/100gBW as loading dose. The excreted urine volume was measured and recorded every 30 minutes for 6 hours which was continued to cumulative urine volume calculation. Furthermore, sample was taken from the cumulative urine to measure levels of sodium (Na), potassium (K), and the pH of the urine. Data were statistically analyzed using ANOVA (Analysis of Variance). The results showed that the effective extract dose combination was found in Group 5’s dose (140 mg/kgBW of snake fruit seed extract and 30 mg/kgBW papaya seed extract) with diuretic activity index of 1.48; urine pH of 7.52; sodium saluretic index of 1.62; and potassium saluretik index of 1.56 

Diuretic activity of ethanol extract of Mirabilis jalapa (Linn.) leaf in normal male Wistar rats

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Musa T. Yakubu ◽  
Adenike M Oyagoke ◽  
Luqman A. Quadri ◽  
Anthonia O. Agboola ◽  
Hussein O.B. Oloyede
Keyword(s):  
Body Weight ◽  
Carbonic Anhydrase ◽  
Urine Volume ◽  
Ethanol Extract ◽  
The Body ◽  
Male Rats ◽  
Normal Male ◽  
Diuretic Activity ◽  
Urine Ph ◽  
Mirabilis Jalapa

Background: Ethanol extract of Mirabilis jalapa leaf (EEMJL) has been used in the folk medicine of Nigeria as diuretics without any scientific evidence.Aim: Ethanol extract of Mirabilis jalapa leaf at 200, 400 and 600 mg/kg body weight was investigated for diuretic activity in male Wistar rats.Setting: Fresh leaf of M. jalapa was collected from a farmland at the Alanamu area in Ilorin, Kwara State, Nigeria, authenticated and processed for the study.Methods: Thirty male rats (231.50 g ± 13.51 g) were assigned into five groups (A–E) of six rats each. Rats in group A (control) received 1.0 mL of physiological saline (the vehicle). Animals in groups B (positive control), C, D and E received 1.0 mL equivalent to 100 mg/kg body weight of furosemide, 200, 400 and 600 mg/kg body weight of EEMJL, respectively. All administrations were done by oral gavage. The animals were monitored for indicators of diuresis for 5 h using standard methods.Results: Ethanol extract of Mirabilis jalapa leaf dose-dependently increased (p < 0.05) urine volume, urine concentrations of Na+, K+ and Cl− and decreased (p < 0.05) the body weight of the animals. Ethanol extract of Mirabilis jalapa leaf increased the urine pH, saliuretic activity, saliuretic index, Na+ index, K+ index, Cl− index, diuretic action (diuretic index), kaliuretic index, Lipschitz value and percentage saline load excreted, whereas the latency of urination, natriuretic index, carbonic anhydrase inhibitory activity and carbonic anhydrase inhibition index were decreased. The EEMJL treatment-related changes in these parameters were essentially similar to those of the furosemide-treated animals.Conclusion: This study has thus validated diuretic activity of M. jalapa leaf with the 600 mg/kg body weight of EEMJL being the most effective.

scholarly journals UJI EFEK ANTIPIRETIK EKSTRAK DAUN PEPAYA (Carica papaya L.) PADA TIKUS WISTAR (Rattus norvegicus)

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Seila Apriliani Yapian
Keyword(s):  
Body Weight ◽  
Rectal Temperature ◽  
Rattus Norvegicus ◽  
Wistar Rats ◽  
Carica Papaya ◽  
Temperature Drop ◽  
Negative Control ◽  
Control Group ◽  
Test Substance ◽  
Body Weight Dose

Abstract: The aim of this study is to investigate the effect of papaya leaves extract (Carica papaya) on rectal temperature drop of Wistar rats (Rattus norvegicus) by using fever induction method. Method:15 Wistar rats is divided into 5 groups, each consisting of 3 rats. Negative control group was given aquadest, the positive control group was given paracetamol and 3 intervention groups were given papaya leaves extract each with a dose of 50, 100 and 200mg body weight of rats. Fever is induced in test animals using DPT-HB vaccine 0,3ml. Rectal temperature measurements are taken before and after the administration of vaccine and after the administration of the test substance at 30, 60, 90 and 120 minute consecutively. Result: Administration of papaya leaves extract at a doseof 200mg/kg body weight showed greater rectal temperature drop effect compared to 100 and 50mg/kg body weight dose. Administration of paracetamol showed a greater rectal temperature drop compared to the 200mg/kg body weight dose of papaya leaves extract. Conclusion: Papaya leaf extract showed antipyretic effects in Wistar rats, but has lower antipyretic effect compared to paracetamol.. Keywords:antipyretic, papaya leaf, DPT-HB, Wistar rat    Abstrak: Penelitian ini bertujuan untuk mengetahui adanya pengaruh pemberian ekstrak daun pepaya (Carica papaya) terhadap penurunan suhu rektal tikus Wistar (Rattus norvegicus) dengan menggunakan metode induksi demam. Metode:Hewan uji yang digunakan berupa 15 ekor tikus Wistar yang dibagi ke dalam 5 kelompok, masing-masing kelompok terdiri dari 3 ekor tikus. Kelompok kontrol negatif diberikan aquades, kelompok kontrol positif diberikan parasetamol, dan 3 kelompok eksperimental diberikan ekstrak daun pepaya masing-masing dengan dosis 50, 100 dan 200mg/kgBB tikus. Induksi demam pada hewan uji menggunakan vaksin DPT-HB 0,3ml. Pengukuran suhu rektal dilakukan sebelum dan sesudah pemberian vaksin dan setelah pemberian zat uji berturut-turut pada menit ke-30, 60, 90 dan 120. Hasil: Pemberian ekstrak daun pepaya dengan dosis 200mg/kgBB menunjukkan penurunan suhu rektal lebih besar dibanding dengan dosis 100 dan 50mg/kgBB. Pemberian parasetamol menunjukkan penurunan suhu rektal lebih tinggi dibanding dengan dosis ekstrak 200mg/kgBB.Kesimpulan: Ekstrak daun pepaya menunjukkan adanya efek antipiretik pada tikus Wistar namun efek antipiretiknya lebih rendah dari parasetamol. Kata Kunci: antipiretik, daun pepaya, DPT-HB, tikus Wistar

Anti-epileptic Activity of Carica papaya seed extract in Experimental Animals

2019 ◽  
Vol 12 (12) ◽  
pp. 6007
Author(s):  
Divya ◽  
Prasanna Shama Khandige ◽  
Ullas Prakash D’ Souza ◽  
Himanshu Joshi ◽  
Zeena Fernandes ◽  
...  
Keyword(s):  
Carica Papaya ◽  
Epileptic Activity ◽  
Seed Extract ◽  
Experimental Animals ◽  
Carica Papaya Seed ◽  
Papaya Seed

scholarly journals Narrative Review: Nano Kapsul Ekstrak Biji papaya (Carica Papaya L.) sebagai Antifertilitas

2021 ◽  
Vol 6 (2) ◽  
pp. 10-24
Author(s):  
Shinta Nur Fajriyah ◽  
Yuliana Eka Lestari ◽  
Nadiatul Istiqamah Suaka ◽  
Endang Darmawan
Keyword(s):  
Carica Papaya ◽  
Skin Diseases ◽  
Diarrheal Disease ◽  
Seed Extract ◽  
Narrative Review ◽  
Human Needs ◽  
Digestive Disorders ◽  
Carica Papaya Seed ◽  
Papaya Seed ◽  
Research Show

Papaya (Carica Papaya L.) is a plant commonly found in Indonesia. Interestingly, its seeds traditionally used as antifertility. All parts of the Carica Papaya tree can be used for human needs from the fruit, leaves, seeds, sap, and stems. Carica Papaya seed extract contains secondary metabolite compounds in class Triterpenoids, flavonoids, alkaloids, saponins, and tannins which have functioned as antifertility. Nanocapsule is an innovation of nanoparticle dosage form with small particle size, that can accelerate the drug to the target. This Narrative Review purposed to determine the usefulness of the nanocapsules of Carica Papaya seed extract as antifertility. This research is a Narrative Review. A total of 36 articles that met the inclusion and exclusion criteria were analyzed descriptively, which include the efficacy of Carica Papaya, nanocapsules, and antifertility. The articles used include articles published in national journals and international journals. The result of the Narrative Review is presented in descriptive form. The results of the research show that Carica Papaya can be used traditionally to treat skin diseases, diarrheal disease, overcoming digestive disorders, and by research can be used as antifertility, The size of the nanoparticles obtained in the study ranged from 76.47 nm to 693.8 nm, and Carica Papaya seed extract is used as an antifertility by reducing sperm quantity, semen pH, spermatogenesis process, interfering the action of pituitary gonads, by preclinical reducing the number of ovum quality and the number of de Graff Follicles in female mice. Overall, it can be concluded that Carica Papaya nanocapsules in particle sizes between 76.46 nm to 693.8 nm can be used as antifertility that preclinically can affect the reproduction of female and male mice.

scholarly journals Perbandingan kualitas spermatozoa tikus wistar (rattus norvegicus) yang diberi ekstrak buah pare (momordica charantia L) dengan ekstrak biji pepaya (carica papaya L)

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Kyrie E. Wenur ◽  
Lusiana Satiawati ◽  
Lydia Tendean
Keyword(s):  
Rattus Norvegicus ◽  
Wistar Rats ◽  
Carica Papaya ◽  
Seed Extract ◽  
Momordica Charantia ◽  
Bitter Melon ◽  
Fruit Extract ◽  
Treatment Groups ◽  
Papaya Seeds

Abstract: Male participation in contraception is still lacking. Pare (Momordica charantia L) is known having an inhibitory effect spermatogenesis and seeds of papaya (Carica papaya L) contain the alkaloid compounds that are anti-fertility, both can be used as a male contraceptive. The purpose of this study was to determine sperm quality comparison Wistar rats (Rattus norvegicus) were given a fruit extract of pare (Momordica charantia L) with the seed extract of papaya (Carica papaya L). The research used a completely randomized experimental design. There are nine samples of Wistar rats (Rattus norvegicus) males were divided into three groups and one group consisting three Wistar rats. Over the past 50 days, extracts of pare (Momordica charantia L) is given to the group 1 at 70mg / kg/day, while in the group 2 given seed extract of papaya (Carica papaya L) of 70mg / kg/day and the control group was given no treatment. The results showed significant differences in sperm motility among the treatment groups 1 with extract of bitter melon fruit (Momordica charantia L) and 2 treatment groups with the extract of papaya seeds (Carica papaya L), namely a decrease in sperm motility (p = 0.002). Conclusion, the fruit extract of bitter melon (Momordica charantia L) and seed extract of papaya (Carica papaya L) affects the quality of spermatozoa.Keywords: pare, papaya seeds, quality of spermatozoa. Abstrak: Partisipasi pria dalam menggunakan alat kontrasepsi masih sangat kurang. Pare (Momordica charantia L) diketahui memiliki efek penghambatan spermatogenesis dan biji pepaya (Carica papaya L) mengandung senyawa alkaloid yang bersifat antifertilitas, keduanya dapat digunakan sebagai bahan kontrasepsi pria. Tujuan penelitian ini adalah mengetahui perbandingan kualitas spermatozoa tikus wistar (Rattus norvegicus) yang diberi ekstrak buah pare (Momordica charantia L) dengan ekstrak biji pepaya (Carica papaya L). Penelitian ini menggunakan metode penelitian eksperimental dengan menggunakan rancangan acak lengkap. Sampel yang digunakan adalah sembilan tikus wistar (Rattus norvegicus) jantan yang dibagi menjadi tiga kelompok dan satu kelompok terdiri dari tiga ekor tikus wistar. Selama 50 hari, ekstrak buah pare (Momordica charantia L) diberikan pada kelompok perlakuan 1 sebesar 70mg/kgBB per hari, sedangkan pada kelompok perlakuan 2 diberikan ekstrak biji pepaya (Carica papaya L) sebesar 70mg/kgBB per dan kelompok kontrol tidak diberikan perlakuan. Hasil penelitian menunjukan adanya perbedaan signifikan pada motilitas spermatozoa antara kelompok perlakuan 1 dengan pemberian ekstrak buah pare (Momordica charantia L) dan kelompok perlakuan 2 dengan pemberian ekstrak biji pepaya (Carica papaya L) yaitu penurunan motilitas spermatozoa ( p = 0,002).Kesimpulan, ekstrak buah pare (Momordica charantia L) dan ekstrak biji pepaya (Carica papaya L) berpengaruh terhadap kualitas spermatozoa. Kata kunci: buah pare, biji pepaya, kualitas spermatozoa

scholarly journals Carica papaya seed extract slows human sperm

2019 ◽  
Vol 241 ◽  
pp. 111972 ◽  
Author(s):  
V. Ghaffarilaleh ◽  
D. Fisher ◽  
R. Henkel
Keyword(s):  
Carica Papaya ◽  
Human Sperm ◽  
Seed Extract ◽  
Carica Papaya Seed ◽  
Papaya Seed
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