scholarly journals Extracranial carotid ultrasound evaluation for ischemic moyamoya disease in adults with different collateral circulation patterns

2021 ◽  
Author(s):  
Xiaoxi Wu ◽  
Lingcui Meng ◽  
Yanhui Jiang ◽  
Junhe Zhou ◽  
Lin Zhao ◽  
...  
Keyword(s):  
Collateral Circulation ◽  
Circulation Pattern ◽  
Control Group ◽  
Hemodynamic Parameters ◽  
Carotid Ultrasound ◽  
Ultrasound Evaluation ◽  
Circulation Patterns ◽  
The Difference ◽  
Grade 3 ◽  
Group Grade

OBJECTIVE: To explore the possibility and application value of extracranial carotid ultrasound in assessing the progress of MMD. METHODS: We retrospectively analyzed the extracranial carotid ultrasound and DSA data of 89 cases of 53 patients with MMD (moyamoya group) and 90 cases of 45 control patients (control group). According to the DSA data of the moyamoya group, collateral circulation patterns’ grade and Suzuki stage were performed. We analyzed the correlation between collateral circulation patterns and Suzuki stage, and compared the difference of hemodynamic parameters between different grades of collateral circulation patterns. RESULTS: (1) As the Suzuki stage increased, the grade of the collateral circulation pattern subsequently increased. (2) Compared with the control group, the PSV of ICA in the moyamoya group was lower (P<0.01)，but the RI value of CCA and PSV of VA was increased (P<0.05). And the differences in hemodynamic parameters of ECA (including PSV and RI) were not statistically different. (3) Comparing hemodynamic parameters between the different grades of collateral circulation patterns of the control group, Grade 2 showed higher PSV of VA compared with Grade 1 (P <0.05); Grade 3 showed lower RI of ECA compared with Grade 1 and Grade 2 (P < 0.05). CONCLUSION: There is a correlation between collateral circulation patterns and Suzuki stage in adult ischemic MMD. There are differences in the hemodynamic parameters of extracranial carotid ultrasound in different grades of collateral circulation patterns. Extracranial carotid ultrasound can assess the progress of MMD in a timely, effective and convenient manner.

Evaluation of Real-Time Three-Dimensional Echocardiography in Right Ventricular Function and Hemodynamics in Patients with Idiopathic Pulmonary Hypertension

2020 ◽  
Vol 10 (9) ◽  
pp. 2022-2026
Author(s):  
Yedan Li ◽  
Hao Wang. ◽  
Weichun Wu ◽  
Yong Jiang
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Statistical Significance ◽  
Control Group ◽  
Transverse Diameter ◽  
Hemodynamic Parameters ◽  
Right Heart ◽  
Idiopathic Pulmonary Hypertension ◽  
The Difference ◽  
Dimensional Echocardiography

Objective: Oriented with the assessment on real-time echocardiography based upon three dimensions (RT-3DE) in estimating right ventricular function and hemodynamics in the patients undergoing idiopathic pulmonary hypertension. Methods: Sixty patients living with idiopathic pulmonary hypertension admitted to our hospital from September 2018 to June 2019 were enrolled. Another 20 healthy examiners were selected as healthy controls. According to pulmonary systolic blood pressure, 60 patients were divided into 20 mild patients, 20 moderate ones as well as 20 severe ones. RT-3DE was used to measure right heart structure related parameters in all subjects, including left ventricular transverse diameter (LVTD), right ventricular transverse diameter (RVTD), right ventricular global end diastolic volume (EDV), right ventricular ejection fraction (RVEF). End-systolic volume (ESV), stroke volume (SV), as well as hemodynamic parameters, including pulmonary systolic pressure (SPAP), right heart output (RCO), pulmonary diastolic blood pressure (DPAP), pulmonary arterial pressure (MPAP). The differences in right heart structure parameters and hemodynamic parameters betwixt the PH Group and the healthy control Group were compared. In addition, conventional two-dimensional echocardiography (2DE) and RT-3DE were used to compare the images of the patients who had serious pulmonary hypertension and those of the Control Group to analyze the tricuspid annulus systolic displacement (TAPSE), the Tei index, and the tricuspid annulus systolic peak velocity (S’) value. The Result is that SPAP, DPAP, and MPAP achieved higher level in the PH Group compared to those in the Healthy Group, and P < 0005, the difference took on statistical significance. Those data of SPAP, DPAP and MPAP in the moderate and severe PH Group were higher than those in the mild PH Group, and P < 0005, the difference was of statistical significance. The RCO of the patients from the PH Group as well as the Healthy Group got under comparison, and P < 0005. They presented statistics-based dramatic difference. In addition, RCO showed a gradual decline in the patients who came down with mild, moderate, and serious PH, and the results were statistically significant. In addition, the comparison between RT-3DE and conventional echocardiography shows that RT-3DE has higher accuracy and diagnostic value.

scholarly journals Comparison of prophylactic dexmedetomidine and ketamine for the control of shivering under spinal anaesthesia

2021 ◽  
Vol 8 (5) ◽  
pp. 685
Author(s):  
Rituparna Murmu ◽  
Amartya Das ◽  
Swarupa Roychoudhury
Keyword(s):  
Side Effects ◽  
Spinal Anaesthesia ◽  
Hemodynamic Parameters ◽  
Neuraxial Block ◽  
The Difference ◽  
Prophylactic Use ◽  
Grade 3 ◽  
To Receive ◽  
Group D ◽  
Single Blind

Background: Shivering is a common problem during neuraxial block. Thermoregulatory control gets compromised by neyraxial block and as a result the incidence of shivering can go up to 56.7%. Aim of the current investigation was to evaluate the effectiveness of prophylactic use of intravenous dexmedetomidine and ketamine for the control of shivering and to note any side-effects of the drugs used during subarachnoid block.Methods: This randomised single blind study was conducted in 151 ASA grade I and II patients. SAB was performed with 3.0mL (15 mg) of 0.5% bupivacaine heavy in all patients. Patients were randomly allocated into two groups of 75 and 76each to receive dexmedetomidine (0.5 µg/kg) in group D and ketamine (0.5 mg/kg) in group K respectively. Temperature and hemodynamic parameters were recorded at every 15mins interval. Shivering was graded from 0 to 4 according to Tsai and Chu and if grade 3 shivering occurred, the study was stopped and pethidine 25 mg was given intravenously as rescue drug.Results: 2.67% of patients in group D had shivering whereas 38.16% patients in group K experienced shivering at the 5th minute after spinal anaesthesia and it was statistically significant. However the difference in the incidence of shivering was not statistically significant between the two groups after the initial 5 minutes till the end of surgery.Conclusions: The prophylactic use of dexmedetomidine reduced incidences of shivering more effectively as compared to prophylactic use of ketamine. None of the drugs caused any untoward side effects.

scholarly journals Is metronidazole a panacea for post-hemorrhoidectomy pain?

2018 ◽  
Vol 5 (11) ◽  
pp. 3598 ◽  
Author(s):  
Probal Neogi ◽  
Anuvrat Sinha ◽  
Mayank Singh
Keyword(s):  
Pain Relief ◽  
Controlled Trial ◽  
Control Group ◽  
Post Operative Period ◽  
Post Operative Pain ◽  
Topical Metronidazole ◽  
Background Pain ◽  
The Difference ◽  
Clinically Significant ◽  
Grade 3

Background: Pain following Milligan Morgan hemorrhoidectomy is a significant cause of morbidity. The present study was carried out to find out if using metronidazole in the post-operative period of these patients results in less post-operative pain.Methods: This was a prospective randomized controlled trial which was conducted on 67 consecutive patients attending the Surgical OPD at SRN Hospital, Allahabad during the study period between August 2016 and July 2017 who underwent surgery for grade 2, grade 3 and grade 4 hemorrhoids. The patients were allocated to 3 groups-one group was the control group, the second group received oral metronidazole post-operatively for 7 days while the third group received only topical metronidazole for 7 days. All the three groups received 500 mg of metronidazole in 100 ml infusion pre-operatively. The post-operative analgesic usage was standardized for all the three groups. Appropriate tests of significance were applied to assess if the difference in the intensity of post-operative pain was significant in the immediate post-operative period and on days 1, 3 and 7 post-surgery.Results: Pain relief was significantly better in the groups using metronidazole at post-operative day 1, 3 and 7 and this was also borne in the lesser number of analgesics used by the patients of these groups.Conclusions: Use of oral or topical metronidazole in the post-operative period results in clinically significant pain relief. There is no additional benefit of one over the other and hence either can be used.

scholarly journals Is There any Relationship Between the Grade of Mucoid Degeneration of Torn Menisci and Biochemical Marker Levels in Synovial Fluid?

2014 ◽  
Vol 2 (11_suppl3) ◽  
pp. 2325967114S0019
Author(s):  
Halit İbrahim Pınar ◽  
Oktay Iscen ◽  
Didem Keles ◽  
Sermin Ozkal ◽  
Gulgun Oktay
Keyword(s):  
Synovial Fluid ◽  
Control Group ◽  
Meniscal Tears ◽  
Mucoid Degeneration ◽  
Group A ◽  
The Difference ◽  
Grade 3 ◽  
Group B ◽  
Stage 1 ◽  
Staging Classification

Objectives: Mucoid degeneration (MD) leads to nontraumatic tears of the meniscus even in the young population. The tears are often irrepairable. The purpose of this study is to find out if there is any relationship between the severity of mucoid degeneration (MD) and the biochemical environment of the knee. Our hypothesis is that meniscal tears due to more severe MD are associated with higher levels of markers in the synovial fluid. Methods: Synovial fluid samples were taken during isolated arthroscopic meniscectomies. Samples of excised menisci were sent to the department of pathology for grading of MD. According to the Copenhaver staging classification, stage 1-2 menisci comprised group A (n:13), and grade 3 menisci group B (n:19). Cases with instability and with greater than grade 2 chondral lesions were excluded. Synovial fluid samples were also aspirated from 9 normal knees of individuals operated from other sites of lower extremities; these comprised the control group (C). The synovial fluids were examined for MMP-3,TIMP-1,COMP and proteoglycan (PG)fragment levels. Results were statistically analyzed with nonparametric Mann Whitney's U test. Results: PG fragment levels were significantly higher in group B as compared to group A (p=0.044).When groups B and C were compared, the difference between PG fragment levels almost displayed significance (p=0.055).There were no significant differences between the groups A,B and C for MMP-3,TIMP-1,and COMP levels. MMP-3 levels were significantly higher for traumatic meniscal tears than nontraumatic tears (p=0.025). Conclusion: In this study, our hypothesis was partially confirmed. Higher levels of PG fragments were found in knees with higher grade of meniscal mucoid degeneration. MD may be associated with an insidious degenerative process in the knee.

scholarly journals A clinical study of pegylated recombinant human granulocyte colony stimulating factor (PEG-rhG-CSF) in preventing neutropenia during concurrent chemoradiotherapy of cervical cancer

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dongling Zou ◽  
Mingfang Guo ◽  
Qi Zhou
Keyword(s):  
Cervical Cancer ◽  
Control Group ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Prolonged Time ◽  
The Difference ◽  
Grade 3 ◽  
And Control ◽  
Experimental Group ◽  
Stimulating Factor

Abstract Purpose To evaluate the effectiveness and safety of pegylated recombinant human granulocyte colony stimulating factor (PEG-rhG-CSF) in preventing neutropenia during chemoradiotherapy in patients with cervical cancer. Methods From August 2018 to April 2020, 60 patients who were pathologically confirmed as cervical cancer were randomly divided into two groups at a ratio of 2:1: PEG-modified-rhG-CSF experimental group and control group. The primary endpoints were the incidence of grade 3–4 neutropenia. Secondary endpoints included the duration of grade 3–4 neutropenia, the incidence of grade 4 neutropenia, the incidence of febrile neutropenia (FN), delay rate of chemotherapy, prolonged time of chemotherapy, time to complete radiotherapy and safety. Results The incidence of grade 3–4 neutropenia in the experimental group was significantly lower than the control group (10% vs. 77.78%, P < 0.001). However, there was no statistical significance between the two groups in the duration of grade 3–4 neutropenia (3.75 days vs. 5.07 days, P = 0.871). The experimental group was better than the control group in the incidence of grade 4 neutropenia, the incidence of FN and delay rate of chemotherapy, and the difference was statistically significant (P < 0.05). Besides, the prolonged time of chemotherapy and the time to complete radiotherapy in the experimental group were less than those in the control group, but the difference was not statistically significant (P > 0.05). The incidence of adverse events in the experimental group and control group were 55.00 and 94.44%, respectively, and the difference was statistically significant (P = 0.003). Conclusion PEG-rhG-CSF preventive treatment used in the course of chemoradiotherapy for patients with cervical cancer can reduce the incidence of neutropenia and improve the incidence of delayed chemotherapy cycles. Trial registration ClinicalTrials.gov, NCT04542356. Registered 9 September 2020 - Retrospectively registered.

scholarly journals Study to assess the effect of mini-dose Succinylcholine for ease of laryngeal mask airway insertion

2019 ◽  
Vol 7 (6) ◽  
pp. 2089
Author(s):  
Megha P. Tajne ◽  
Heena D. Pahuja ◽  
Lalit K. Rathi ◽  
Aditi Bhatnagar ◽  
Amitkumar H. Belokar
Keyword(s):  
Sodium Chloride ◽  
Laryngeal Mask Airway ◽  
Small Sample ◽  
Laryngeal Mask ◽  
Control Group ◽  
Induction Agent ◽  
Laryngeal Mask Airway Insertion ◽  
Hemodynamic Parameters ◽  
Significant Difference ◽  
Grade 3

Background: Propofol as sole induction agent is often insufficient for the laryngeal mask airway insertion and higher doses are at times required. The present study proposes to assess the effectiveness of 0.25mg/kg mini dose succinylcholine towards facilitation of laryngeal mask airway (LMA) insertion.Methods: In a single blinded randomized controlled trial, 68 patients posted for elective general and orthopaedic surgery were equally assigned to two groups during LMA insertion: Group S (Study group)- patients received a bolus of succinylcholine 0.25mg/kg diluted in 2 ml of 0.9% sodium chloride. Group C (Control group)-patients received a bolus dose of 2 ml of 0.9% sodium chloride. The number of attempts required and ease of LMA insertion, hemodynamic parameters and adverse responses were noted and compared between the groups.Results: The LMA was inserted in first attempt in 32 (94.11%) patients in group S and in 24 (70.58%) patients in group C. The control group had 67.62% grade 1, 32.38% grade 2 and 0% grade 3, while succinylcholine group had 73.53% grade 1, 26.47% grade 2 and 0% grade 3. Hemodynamic parameters didn’t differ significantly between the two groups at any point, but significant difference was observed between occurrence of fasciculation, head and limb movements, sore throat and coughing.Conclusions: Succinylcholine does seem to help in insertion of the laryngeal mask airway but the results could not gain the level of statistical significance, partly attributed to small sample size.

The Effects of a Caffeine Placebo and Experimenter Expectation on Blood Pressure, Heart Rate, Well-Being, and Cognitive Performance

2001 ◽  
Vol 6 (1) ◽  
pp. 15-25 ◽  
Author(s):  
Harald Walach ◽  
Stefan Schmidt ◽  
Yvonne-Michelle Bihr ◽  
Susanne Wiesch
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Cognitive Task ◽  
Well Being ◽  
Control Group ◽  
Double Blind ◽  
Main Effect ◽  
The Difference ◽  
Being There ◽  
To Receive

We studied the effect of experimenter expectations and different instructions in a balanced placebo design. 157 subjects were randomized into a 2 × 4 factorial design. Two experimenters were led to expect placebos either to produce physiological effects or not (pro- vs. antiplacebo). All subjects except a control group received a caffeine placebo. They were either made to expect coffee, no coffee, or were in a double-blind condition. Dependent measures were blood pressure, heart rate, well-being, and a cognitive task. There was one main effect on the instruction factor (p = 0.03) with the group “told no caffeine” reporting significantly better well-being. There was one main effect on the experimenter factor with subjects instructed by experimenter “proplacebo” having higher systolic blood pressure (p = 0.008). There was one interaction with subjects instructed by experimenter “proplacebo” to receive coffee doing worse in the cognitive task than the rest. Subjects instructed by experimenter “antiplacebo” were significantly less likely to believe the experimental instruction, and that mostly if they had been instructed to receive coffee. Contrary to the literature we could not show an effect of instruction, but there was an effect of experimenters. It is likely, however, that these experimenter effects were not due to experimental manipulations, but to the difference in personalities.

Peritoneal Fluid and Plasma Fibrinolytic Activity in Women with Pelvic Inflammatory Disease

1992 ◽  
Vol 68 (02) ◽  
pp. 102-105 ◽  
Author(s):  
P J Dörr ◽  
E J P Brommer ◽  
G Dooijewaard ◽  
H M Vemer
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Peritoneal Fluid ◽  
Fibrinolytic Activity ◽  
Degradation Products ◽  
Adhesion Formation ◽  
High Rate ◽  
Control Group ◽  
The Difference ◽  
Fibrinolytic Parameters

SummaryPrevious studies have shown that the fibrinolytic activity of peritoneum is depressed in local inflammation. We measured fibrinolytic parameters in peritoneal fluid and in plasma of 10 women with pelvic inflammatory disease (PID). Nine women, in whom laparoscopy for sterilisation was performed, served as a control group.In the peritoneal fluid of women with PID, PAI-Ag, t-PA-Ag and u-PA-Ag were many times higher than in the control group. In contrast to the antigens which may be present in inert complexes, the potentially active compounds, measured as t-PA activity and plasmin-activable scu-PA, were not significantly different in the two groups, and in none of the samples was the active enzyme tcu-PA detectable. Nevertheless, the mean peritoneal fluid TDP and FbDP concentrations were about twenty times higher in the PID group than in the control group. In plasma of PID patients, none of the parameters except u-PA-Ag differed from those in the control group. The difference between control and patient plasma u-PA-Ag was statistically significant, but too small to attach any relevance to the observation.Our data suggest that, in contrast to the classical concept of decreased fibrinolytic activity as a cause of adhesion formation, intraperitoneal fibrinolysis is enhanced in peritoneal inflammation through stimulation of the local production of t-PA and u-PA. Despite concomitant production of PAI, fibrinolysis occurs at a high rate, resulting in high levels of fibrin degradation products. Since this activated fibrinolysis does not meet the demand, therapeutic enhancement should be considered to prevent adhesions.

Changes in Platelet Aggregability after Ovariectomy

1979 ◽  
Vol 42 (04) ◽  
pp. 1332-1339 ◽  
Author(s):  
Hiroh Yamazaki ◽  
Takeshi Motomiya ◽  
Minoru Sonoda ◽  
Noboru Miyagawa
Keyword(s):  
Platelet Count ◽  
Platelet Activation ◽  
Ovarian Hormones ◽  
Control Group ◽  
Platelet Aggregability ◽  
Appearance Rate ◽  
Before And After ◽  
The Difference ◽  
Induced Aggregation ◽  
Observation Period

SummaryChanges in platelets in 48 patients with uterine myoma before and after hysterectomy with and without ovariectomy were examined. Bilateral ovariectomy in 25 cases (ovariec-tomized group) and unilateral or non-ovariectomy in 23 cases (control group) were performed at the hysterectomy. Platelet count and an appearance rate of secondary aggregation decreased at one day after and increased at one week after the operation, similarly in both the ovariectomized and the control group. The appearance rate of secondary aggregation was reflected in an intensity of aggregation at 5 min after the addition of reagent to PRP. At one month after the operation, the appearance rate of secondary aggregation induced by 3 μM ADP showed a statistically significant decrease in comparison with the preoperation value (P <0.05) and the enhancement of 5-min aggregation was still observed in the control group, while ceased in the ovariectomized group. The difference between the two groups was significant (P < 0.05). There was almost no change in the speed and intensity of primary and secondary aggregation during the observation period. No significant differences in collagen-induced aggregation were noted between the two groups. The results suggest that ovarian hormones, mainly estrogen, facilitate platelet activation which is mediated by the so-called secondary aggregation.

PENGARUH TERAPI TERTAWA TERHADAP PENURUNAN TEKANAN DARAH LANSIA DI UPT PANTI WREDHA BUDHI DHARMA YOGYAKARTA

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Niken Setyaningrum ◽  
Andri Setyorini ◽  
Fachruddin Tri Fitrianta
Keyword(s):  
Blood Pressure ◽  
Data Analysis ◽  
The Elderly ◽  
Control Group ◽  
Group Comparison ◽  
Control Blood Pressure ◽  
Men And Women ◽  
Treatment Of Hypertension ◽  
Before And After ◽  
The Difference

ABSTRACTBackground: Hypertension is one of the most common diseases, because this disease is suffered byboth men and women, as well as adults and young people. Treatment of hypertension does not onlyrely on medications from the doctor or regulate diet alone, but it is also important to make our bodyalways relaxed. Laughter can help to control blood pressure by reducing endocrine stress andcreating a relaxed condition to deal with relaxation.Objective: The general objective of the study was to determine the effect of laughter therapy ondecreasing elderly blood pressure in UPT Panti Wredha Budhi Dharma Yogyakarta.Methods: The design used in this study is a pre-experimental design study with one group pre-posttestresearch design where there is no control group (comparison). The population in this study wereelderly aged over> 60 years at 55 UPT Panti Wredha Budhi Dharma Yogyakarta. The method oftaking in this study uses total sampling. The sample in this study were 55 elderly. Data analysis wasused to determine the difference in blood pressure before and after laughing therapy with a ratio datascale that was using Pairs T-TestResult: There is an effect of laughing therapy on blood pressure in the elderly at UPT Panti WredhaBudhi Dharma Yogyakarta marked with a significant value of 0.000 (P <0.05)

Sign in / Sign up

Export Citation Format

Share Document