scholarly journals Results of the modification of antireflux subserosal and submucosal implantation of the ureter into the rectosigmoid urinary reservoir after total cystectomy

2011 ◽  
Vol 139 (7-8) ◽  
pp. 491-495
Author(s):  
Ivica Stojkovic ◽  
Ivan Ignjatovic ◽  
Dragoslav Basic
Keyword(s):  
Statistical Significance ◽  
Late Complications ◽  
Equal Frequency ◽  
Number Of Patients ◽  
Daily Frequency ◽  
The Difference ◽  
Group 5 ◽  
Comparison Of The Results ◽  
Ureteral Implantation ◽  
Urinary Reservoir

Introduction. Uretero-intestinal anastomisis has a large influence on derivation quality. Objective. The aim of the study was to present the modified serous lined extramural Abol-Enein method of implantation of low quality ureter into the sigma-rectum pouch and comparison of the results with Le Duc implantation. Methods. From 1995 to 2009, 62 dilated ureter units were implanted in the detubularized rectosigmoid urinary reservoir. In 28 units Le Duc, and in 34 Abol-Enein method was done. Urinary fistula and ileus were considered as early complications, while late complications included stenosis and reflux pyelonephritis. Frequency of urination was considered as a parameter of functionality. Results. Transitory urine fistulae occurred only in the ureters implanted according to Le Duc technique in 4/28 (14.2%); the difference between the examined groups was close but still below the level of statistical significance (p=0.07). Ileus occurred with nearly equal frequency in both groups. Stenosis on the ureteral implantation place was significantly more frequent (p=0.04) in the Le Duc group 5/28 (21.7%) than in the Abol-Enein group 0/34 (0%). Refluxive pyelonephritis occurred in 3/34 (8.8%) of the Abol-Enein group, and in 5/28 (21.7%) of patients in the Le Duc group. Concerning the daily frequency, there was no difference between the examined groups. Conclusion. Uretero-intestinal anastomisis of dilated ureters through a serous-lined extramural tunnel decreases the risk of reflux in a considerable number of patients, with an acceptable level of complications. There are several advantages in comparison with Le Duc method.

EFFECTS OF OESTROUS CYCLE VARIATIONS AND EXOGENOUS STEROID HORMONES ON THE PRODUCTION AND SECRETION OF CORTICOSTERONE BY THE RAT ADRENAL

1964 ◽  
Vol 45 (4_Suppl) ◽  
pp. S191-S201 ◽  
Author(s):  
Gregory Pincus ◽  
Masanao Hirai
Keyword(s):  
Adrenal Gland ◽  
Statistical Significance ◽  
Male Rats ◽  
Adrenal Vein ◽  
List Type ◽  
Intact Male ◽  
Significant Difference ◽  
The Difference ◽  
Group 5 ◽  
Adrenal Corticosterone

ABSTRACT Results with the adrenal gland: A significant difference (P < 0.01) was found between the elevated production of corticosterone in intact rats during dioestrus and the production at oestrus. At both 10 and 20 days after ovariectomy, the production of corticosterone was decreased as compared with the dioestrous rate. Production of corticosterone in adrenals was increased significantly (P < 0.01) by progesterone injection (500 μg/day for 5 days) and was decreased by oestradiol-17β injections 5 μg/day for 5 days). Corticosterone injection (10 μg/day for 5 days) also significantly (P < 0.01) increased the production of corticosterone in adrenals. Results with adrenal vein blood: Secretion of corticosterone of the intact rat at dioestrus was higher than at oestrus, but the difference was not statistically significant. At 10 and 20 days after ovariectomy, the secretion of corticosterone had decreased from the dioestrous level, but statistical significance was found only at 20 days after ovariectomy. Oestradiol-17β treatment (5 μg/day for 5 days) significantly (P < 0.01) decreased the secretion of corticosterone from the adrenal vein. Progesterone treatment (500 μg/day for 5 days) did not significantly affect the secretion of corticosterone into adrenal vein blood. Also, treatment with corticosterone (10 μg/day for 5 days) did not yield statistically significant changes in the secretion of this compound. Additional results: Nembutal anaesthesia in intact male rats significantly decreased the amount of corticosterone in the adrenal gland (P < 0.05). Ether anaesthesia led to a greater variation in adrenal corticosterone than in nonanaesthetized rats. Ovary weights decreased significantly (P < 0.05) in the progesteroneinjected group (500 μg/day for 5 days); on the other hand, the oestradiol-17β-injected group (5 μg/day for 10 days) exhibited a significant increase of adrenal weight (P < 0.05), and pituitary weight (P < 0.01) and a decrease of ovary weight (P < 0.05).

scholarly journals NERVE CONDUCTION STUDY IN DIFFERENT CLINICAL GRADES OF DIABETIC FOOT

2019 ◽  
pp. 61-63
Author(s):  
Hemchandra. V. Nerlekar ◽  
Shekhar gouda
Keyword(s):  
Nerve Conduction Study ◽  
Diabetic Foot ◽  
Nerve Conduction ◽  
Mixed Type ◽  
Sensory Nerve ◽  
Electrical Stimulus ◽  
Late Complications ◽  
Autonomic Nerve ◽  
Number Of Patients ◽  
The Difference

Background:Diabetic neuropathy is one of the commonest late complications of diabetes. Diabetic neuropathy can be either peripheral or autonomic. Nerve conduction study (NCS) is the recording and measurement of the compound nerve and muscle action potentials elicited in response to an electrical stimulus. Currently, the principal uses of NCV (Nerve Conduction velocity) study are to evaluate paresthesias (numbness, tingling, burning) and /or weakness of arms or legs. Methods: All patients diagnosed as diabetic foot were sent for Nerve Conduction Study after obtaining their written informed consent. Three nerves were studied; two motor nerves, Common peroneal and Tibial nerves, and one purely sensory nerve, Sural nerve. Results: Mixed type neuropathy with bilateral lower limb involvement was the most common type encountered. Interpretation and Conclusion: Mixed type of neuropathy was the most common in my study with respect to sensory and motor types of neuropathy; and also axonal and demyelinating types of neuropathy. Number of patients with bilateral neuropathy detected by NCV study in my study is more than that detected clinically and the difference is significant by applying the test of significance. Hence, NCV is a better study to detect nerve conduction abnormalities than clinical examination in diabetic foot.

Recovery of binocular function in kitten visual cortex

1982 ◽  
Vol 48 (6) ◽  
pp. 1336-1346 ◽  
Author(s):  
F. B. Levitt ◽  
R. C. Van Sluyters
Keyword(s):  
Visual Cortex ◽  
Striate Cortex ◽  
Recovery Period ◽  
Receptive Fields ◽  
Cortical Input ◽  
Before And After ◽  
The Difference ◽  
Group 5 ◽  
Comparison Of The Results ◽  
The Relationship

1. This paper describes the results of an experiment designed to examine the ability of cells in the kitten's visual cortex to regain functional binocular connections following exposure to a brief period of visual deprivation. 2. Normal 4-wk-old kittens were exposed to a total of 12 h of optically induced strabismus over a period of 2 days, and single-unit recordings made the following day indicated that the proportion of striate cortex cells with binocular receptive fields had decreased sharply as a result of this episode of strabismic vision. 3. When these kittens were revived and allowed to experience a recovery period of normal binocular vision lasting either 3 or 7 wk, cortical binocularity returned to a normal level. 4. Statistical analysis revealed that the difference in the level of binocularity observed before and after the period of binocular recovery was highly significant, and comparison of the results from kittens allowed only a 3-wk recovery period with those from kittens allowed a 7-wk period indicated that a similar level of recovery was obtained in each group. 5. Histological reconstruction of electrode penetrations indicated that the recovery of binocular receptive fields occurred uniformly across all cortical laminae. 6. These data are discussed in terms of the results from previous recovery experiments, the relationship between cortical binocularity and the ability to maintain binocular fixation, and the possibility that subliminal cortical input plays a role in the recovery of functional binocular cells.

Pegfilgrastim Provides Safe and Rapid Neutrophil Support in Patients with Acute Myeloid Leukemia (AML) Undergoing Myelosuppressive Chemotherapy.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 4511-4511
Author(s):  
Oliver Ranze ◽  
Malte Arland ◽  
Heinz-Gert Hoeffkes
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Statistical Significance ◽  
Performance Status ◽  
Prospective Trial ◽  
Primary Objective ◽  
Myelosuppressive Chemotherapy ◽  
Number Of Patients ◽  
The Difference ◽  
Acute Myeloid

Abstract Background: Administration of recombinant G-CSF has found extensive use in the support of chemotherapy-induced neutropenia in patients undergoing myelosuppressive chemotherapy. We retrospectively analyzed patients with acute myeloid leukemia (AML) who received either pegfilgrastim or lenograstim in this setting. Patients and Methods: Unselected patients with AML according to FAB, age &gt;18 years, performance status ECOG &lt; 3, excluding pregnancy received at least one cycle of chemotherapy. On day 1 after chemotherapy has ended G-CSF treatment was initiated with pegfilgrastim 6 mg once per cycle or lenograstim 5 micg/kg b.w. until leucocyte counts (LC) raised &gt; 1,000/micL. Primary objective was the difference in the time to elevating LC &gt; 1,000/micL in each G-CSF treatment groups if LC nadired &lt; 1,000/micL and the difference in the substitution of packed red blood (PRB) and platelets (PLT). Results: Twenty-eight patients, 12 males and 16 females, aged median 61.4 years (range: 27–75 years) received 46 cycles. Six patients died due to the underlying disease. In four patients (two patients in the pegfilgrastim and two patients in the lenograstim group) G-CSF treatment failed to elevate LC &gt; 1,000/micL. There was a difference in the time-to-recovery of leucocyte counts between pegfilgrastim 11.3 ± 3.8 days (range: 6 to 28 days) and lenograstim 13.3 ± 3.3 days (range: 6 to 22 days). The frequency of transfusions of PRB was 3.3 ± 2.6 in pegfilgrastim treated patients compared with 5.0 ± 2.9 in patients treated with lenograstim and the frequency of transfusions of PLT was 4.8 ± 2.5 vs. 6.0 ± 4.5. These differences received no statistical significance. Conclusion: In this retrospective analysis unselected patients received myelodepressive chemotherapy because of acute myeloid leukemia. Both G-CSF showed adequate recovery of leucocyte counts with a faster increase in those patients to whom pegfilgrastim was administered. No statistical difference in the frequency of donation of human blood products was recognized. This retrospective study was limited because of the small number of patients included, thus these promising results need to be confirmed in a larger, prospective trial.

A Double-Blind Evaluation of a Weight Reduction Programme in Private Practice

1975 ◽  
Vol 3 (6) ◽  
pp. 436-440
Author(s):  
N Glazer
Keyword(s):  
Private Practice ◽  
Statistical Significance ◽  
Placebo Patient ◽  
Double Blind ◽  
Treatment Groups ◽  
Physician Relationship ◽  
The Difference ◽  
Group 5 ◽  
Clinically Significant ◽  
Term Management

A double-blind, placebo-controlled, 16- week study was conducted in a private practice to evaluate a 5- point regimen ( diet, exercise, medication, motivation, patient-physician relationship) for short-term management of obesity. After 4 weeks of diet and excerise, patients were assigned to one of three treatment groups: continuous drug, intermittent drug (drug for 4 weeks, placebo for 4 weeks, drug for 4 weeks), and continuous placebo. The dosage for both drug ( Tenuate, 25 mg) and placebo was 1 tablet three times daily. At the end of 4 weeks of treatment, the difference between drug and placebo was statistically significant, in favour of drug. Statistical significance was lost at subsequent evaluations, but the difference between drug and placebo was considered clinically significant. Side-effects were reported by 5 patients in the continuous drug group, 5 in the intermittent group, and 4 in the placebo group. Clinically important changes in blood pressure were seen in 1 drug patient and 1 placebo patient.

scholarly journals Evaluation of Angiogenesis in Multiple Myeloma by VEGF Immunoexpression and Microvessel Density

2020 ◽  
Vol 12 (01) ◽  
pp. 38-43
Author(s):  
Anshu Palta ◽  
Manveen Kaur ◽  
Anita Tahlan ◽  
Kislay Dimri
Keyword(s):  
Multiple Myeloma ◽  
Microvessel Density ◽  
Plasma Cells ◽  
Statistical Significance ◽  
Antiangiogenic Therapy ◽  
Vegf Expression ◽  
Number Of Patients ◽  
The Mean ◽  
The Difference ◽  
Endothelial Growth Factor

Abstract Background Multiple myeloma (MM) is a plasma cell disorder characterized by monoclonal proliferation of plasma cells in bone marrow. Plasmablastic MM is a morphologic subset of MM, containing ≥2% plasmablasts of all plasma cells. Methods The study included 30 consecutively diagnosed patients of MM (6 plasmablastic, 24 nonplasmablastic) over a span of 2 years. Angiogenesis in MM was assessed by analysis of vascular endothelial growth factor (VEGF) immunoexpression by plasma cells and microvessel density (MVD) using anti-CD34 antibody. CD34 and VEGF immunohistochemical staining was performed in all the 30 cases. Angiogenesis was studied in relation to plasmablastic morphology and clinical profile to determine if any correlation exists between these. Results The mean VEGF expression of 80.83 ± 7.36 in plasmablastic myeloma cases was significantly higher compared with a mean VEGF of 53.54 ±17.09 in nonplasmablastic cases. Most of the cases (66.6%) of plasmablastic myeloma exhibited strong (3+) VEGF expression. The difference in mean VEGF expression between plasmablastic and nonplasmablastic cases was found to be statistically significant (p = 0.001). The mean MVD in plasmablastic cases was 44.8 ± 3.69, while in the nonplasmablastic category, the mean MVD was 23.7 ± 5.14, difference being statistically significant (p < 0.05). Also, a positive correlation was found between VEGF expression and MVD. Conclusion A moderate/strong VEGF intensity and higher MVD were found in cases of plasmablastic MM, suggesting that a more aggressive histological disease may be associated with increased production of VEGF. This finding might be helpful to identify a subset of patients with adverse prognosis and to provide antiangiogenic therapy to improve their survival. However, studies comprising larger number of patients are required to bring out a statistical significance to further substantiate these findings.

scholarly journals Observing of the asymmetry of hippocampal formation on patients with complex partial attacks

2003 ◽  
Vol 3 (1) ◽  
pp. 18-29
Author(s):  
Aida Sarač - Hadžihalilović ◽  
Faruk Dilberović
Keyword(s):  
Hippocampal Formation ◽  
Statistical Significance ◽  
Temporal Epilepsy ◽  
Anatomical Basis ◽  
Number Of Patients ◽  
Focus Of Infection ◽  
The Asymmetry ◽  
The Difference ◽  
The Right ◽  
Patients With Epilepsy

Lobus limbicus is anatomical basis for explaining the temporal epilepsy because it not only includes the focus of infection of temporal lobe but also the frontal lobe, and with it we can explain many of the phenomenon's of the epilepsy (hallucinations, the change of the effects, and so on.). The goal of this assignment was to explore the asymmetry of hippocampal formation on the patients with complex partial attacks. The results show that the least number of patients with epilepsy have a symmetric (same) size of the hippocampal formation both from the left and the right side. The number is statistically significantly lower than the number of patients with epilepsy who has asymmetric (different size) hippocampal formation both from the left and the right side. By the direction of asymmetry the difference in the number of patients with epilepsy isn't statistically significant. Coefficient. of asymmetry shows that the asymmetry on the left side is more common to men, while it is distributed evenly on sides, left and right in women. Testing of significance in age differences depends on the sim./asim. of the hippocampal formation of both the right and the left side of coronal slice is a statistical significance. While with axial and sagittal slices, we have a statistical significance between a women and a man on the level of the course of asymmetry. So, the use of MRI technique in examining asymmetry of the hippocampal formation, that we used on this asymmetry, we suggest it as an template of future examinations in a sense of shedding light of the anatomical functions that is located on the basis of neuropsychiatrics dysfunctions.

Diclofenac (Voltaren®) for the Treatment of Osteo-Arthrosis: A Double-Blind Comparison with Naproxen

1977 ◽  
Vol 5 (3) ◽  
pp. 169-174 ◽  
Author(s):  
P Siraux
Keyword(s):  
Side Effects ◽  
Statistical Significance ◽  
Comparative Trial ◽  
Double Blind ◽  
Number Of Patients ◽  
Daily Dose ◽  
The Difference ◽  
Blind Comparison

A double-blind, between-patient, comparative trial of diclofenac (Voltaren) and naproxen was carried out in 30 patients suffering from osteo-arthrosis of the hip or the knee. The drugs were given twice daily, morning and evening, during a period of two weeks. The daily dose was 100 mg for Voltaren and 500 mg for naproxen. The results indicate that Voltaren brought relief of pain and stiffness in a greater number of patients than did naproxen. The same finding was made regarding the influence on the range of joint movements, the difference reaching statistical significance. Voltaren appeared also to be better tolerated since the number of patients reporting side-effects was smaller and the complaints of less severity.

COMPARATIVE EVALUATION OF MULTIPARAMETRIC ENDORECTAL ULTRASOUND AND ENHANCED IMAGING COLONOSCOPY IN THE DIAGNOSIS OF EARLY COLORECTAL CANCER

2020 ◽  
Vol 19 (3) ◽  
pp. 49-64
Author(s):  
E. M. Bogdanova ◽  
Yu. L. Trubacheva ◽  
O. M. Yugai ◽  
S. V. Chernyshov ◽  
E. G. Rybakov ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Statistical Significance ◽  
Muscle Layer ◽  
Endorectal Ultrasound ◽  
Diagnostic Methods ◽  
Early Colorectal Cancer ◽  
Morphological Examination ◽  
Optical Magnification ◽  
The Difference ◽  
Enhanced Imaging

AIM: to compare multiparametric endorectal ultrasound (ERUS) and enhanced imaging colonoscopy in the diagnosis of early colorectal cancer.PATIENTS AND METHODS: the study included 78 patients with epithelial rectal tumor. All the patients underwent multiparametric ERUS and colonoscopy with examination by narrow beam imaging (NBI) at optical magnification. All the patients were operated.RESULTS: a morphological examination removed specimens revealed adenomas in 48 cases, in 19 specimens – adenocarcinomas in situ and T1, and in 11 specimens – adenocarcinomas with invasion of the muscle layer or deeper. When calculating the accuracy indicators of diagnostic methods for groups of patients with adenoma, Tis-T1 adenocarcinoma, and T2-T3 adenocarcinoma, the difference in the sensitivity and specificity of the methods in none of the presented groups did not reach the level of statistical significance (p>0.05).ROC analysis showed that ultrasound has a prognostic value comparable to colonoscopy. The area difference was 0.013 (p=0.85).CONCLUSION: endoscopy and ultrasound have similar value in the diagnosis of malignant transformation of rectal adenomas.

Clinical Study of Qingpeng Ointment Treatment of Shoulder-Hand Syndrome After Cerebral Hemorrhage During the Rehabilitation Period

2020 ◽  
Vol 23 ◽  
Author(s):  
Ruihuan Pan ◽  
Shanshan Ling ◽  
Haodong Yang ◽  
Yan Huang ◽  
Lechang Zhan ◽  
...  
Keyword(s):  
Treatment Group ◽  
Cerebral Hemorrhage ◽  
Clinical Medicine ◽  
External Rotation ◽  
Statistical Significance ◽  
Hand Function ◽  
Tibetan Medicine ◽  
Controlled Study ◽  
Control Group ◽  
The Difference

Background: Shoulder-hand syndrome (SHS) refers to a syndrome causing sudden edema, shoulder pain and limited hand function. Qingpeng ointment, a kind of Tibetan medicine, can reduce swelling, relieve pain, tonify stagnation and clear the meridians, which is consistent with the pathological mechanism of SHS after stroke. Therefore, if clinical trials can be used to explore the effectiveness of Qingpeng ointment for treatment of poststroke SHS and promote its application in clinical medicine, this is of specific significance for the treatment of poststroke SHS. Objective: To investigate the clinical efficacy and safety of Qingpeng ointment in the treatment of poststroke SHS. To provide an objective basis for a better therapeutic treatment for poststroke SHS． Method: A prospective, randomized, controlled study was conducted. This study recruited 120 patients with poststroke SHS who met the inclusion criteria. They were randomized into the treatment group and the control group, with 60 patients allocated to each group. The treatment group received routine medical treatment and rehabilitative care after using the Qingpeng ointment, while the patients in the control group received only routine treatment without the ointment. All patients received clinical assessment with the Visual Analogue Scale (VAS), measurement of the range of motion (ROM) of the upper-limb joints, the Fugl-Meyer Assessment of Upper Extremity (FMA-U) and the Modified Barthel Index Score (MBI) before and after the whole treatment. Results: After 4 weeks of treatment, the VAS scores of both groups were decreased significantly (P＜0.05), and the difference between the two groups was statistically significant (P < 0.05). There is no statistical significance for the difference between the treatment group and control group in terms of the FMA-U and MBI scores and the forward bend, backward, outstretch, external rotation and pronation angles after treatment. The increases in the values of VAS, FMA-M and MBI in the treatment group were greater than those in the control group, and the difference was statistically significant (P < 0.05). The increases in the values of the forward bend, outreach and external rotation angles in the treatment group were greater than those in the control group, and the difference was statistically significant (P < 0.05). Conclusion: The treatment group showed better results than the control group in terms of the relief of pain symptoms, the improvement of motor function and the improvement of the activities of daily living for patients with shoulder-hand syndrome after cerebral hemorrhage. Qingpeng ointment is effective and safe in treating poststroke SHS.

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