scholarly journals Critique potential of common sense in Goffman’s frame analysis

Sociologija ◽  
2017 ◽  
Vol 59 (2) ◽  
pp. 139-155
Author(s):  
Srdjan Prodanovic
Keyword(s):  
Common Sense ◽  
Frame Analysis ◽  
Everyday Practice ◽  
Erving Goffman ◽  
Critical Insight ◽  
Insight Into

In this paper, I will try to appraise the critique potential of Erving Goffman?s sociology. The starting hypothesis will be that Goffman?s understanding of common sense offered in Frame Analysis opens the possibility of attaining a critical insight into the structural givens of everyday practice. I will also try to show that Goffman?s understanding of common sense was under heavy influence of pragmatism and phenomenology - and that the often-overseen epistemological differences between these two schools of thought had significant consequences on his sociology. Namely, in the Frame Analysis we can easily find a certain tension between insistence on the autonomous theoretical importance of common sense put forward by the pragmatist and reductionist tendencies towards this type of thought found among the phenomenologists. Therefore, I will argue that this ambivalence regarding the role of common sense in interpreting social realty is the main reason why critique potential of Goffman?s sociology remains implicit in its character.

scholarly journals Metabolic alterations mediated by STAT3 promotes drug persistence in CML

Leukemia ◽  
2021 ◽  
Author(s):  
Sweta B. Patel ◽  
Travis Nemkov ◽  
Davide Stefanoni ◽  
Gloria A. Benavides ◽  
Mahmoud A. Bassal ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Glycolytic Enzyme ◽  
Molecule Inhibitor ◽  
Stem And Progenitor Cells ◽  
Critical Insight ◽  
Primary Focus ◽  
Tki Treatment ◽  
Rate Limiting ◽  
Insight Into

AbstractLeukemic stem cells (LSCs) can acquire non-mutational resistance following drug treatment leading to therapeutic failure and relapse. However, oncogene-independent mechanisms of drug persistence in LSCs are incompletely understood, which is the primary focus of this study. We integrated proteomics, transcriptomics, and metabolomics to determine the contribution of STAT3 in promoting metabolic changes in tyrosine kinase inhibitor (TKI) persistent chronic myeloid leukemia (CML) cells. Proteomic and transcriptional differences in TKI persistent CML cells revealed BCR-ABL-independent STAT3 activation in these cells. While knockout of STAT3 inhibited the CML cells from developing drug-persistence, inhibition of STAT3 using a small molecule inhibitor sensitized the persistent CML cells to TKI treatment. Interestingly, given the role of phosphorylated STAT3 as a transcription factor, it localized uniquely to genes regulating metabolic pathways in the TKI-persistent CML stem and progenitor cells. Subsequently, we observed that STAT3 dysregulated mitochondrial metabolism forcing the TKI-persistent CML cells to depend on glycolysis, unlike TKI-sensitive CML cells, which are more reliant on oxidative phosphorylation. Finally, targeting pyruvate kinase M2, a rate-limiting glycolytic enzyme, specifically eradicated the TKI-persistent CML cells. By exploring the role of STAT3 in altering metabolism, we provide critical insight into identifying potential therapeutic targets for eliminating TKI-persistent LSCs.

Exercise and Depression: Considering Variability and Contextuality

2004 ◽  
Vol 26 (1) ◽  
pp. 3-18 ◽  
Author(s):  
Guy Faulkner ◽  
Stuart J.H. Biddle
Keyword(s):  
Physical Activity ◽  
Well Being ◽  
Clinical Population ◽  
Adjunctive Treatment ◽  
Psychological Well Being ◽  
Barriers To Exercise ◽  
Critical Insight ◽  
The Relationship ◽  
Insight Into

Research continues to support the consideration of exercise as an adjunctive treatment for depression. Adopting a qualitative approach, the aim of this study was to extend our understanding of the motives and barriers to exercise faced by this clinical population, and to explore the role of physical activity in promoting psychological well-being, in a way that encompasses the variability and contextuality of the lives of individuals. Marking a departure from standard content analyses reported in the literature, instrumental case studies are developed that offer a different format for representing qualitative data. Given its longitudinal nature, this study demonstrates the fundamental importance of considering the wider context of participants’ lives in order to understand the relationship between physical activity and psychological well-being. This association is likely to be complex and highly idiosyncratic. Such an understanding may inform a more critical insight into the potential of exercise as an antidepressant in terms of process and effectiveness.

scholarly journals Strengthening the Preventive Role of the Committee for the Prevention of Torture in Africa

2018 ◽  
Vol 7 (2) ◽  
pp. 249-273
Author(s):  
Isobel Renzulli
Keyword(s):  
Legal Framework ◽  
Specific Reference ◽  
Legal Obligation ◽  
Effective Prevention ◽  
Context Sensitive ◽  
Preventive Work ◽  
Critical Insight ◽  
Insight Into ◽  
Preventive Role

The article provides a critical insight into the legal framework for the prevention of torture in Africa, with specific reference to the Robben Island Guidelines (rig) and its special mechanism, the Committee for the Prevention of Torture in Africa (cpta). The Guidelines undoubtedly represent a milestone in the development of a torture preventive work in Africa. They bring together a number of provisions covering different aspects of the prohibition and prevention of torture. However they do not elaborate and clarify what is meant by prevention as a concept and what it entails as a legal obligation. Furthermore the cpta’s interpretative drive has largely focused on the other, normatively more robust, areas of intervention, namely the prohibition of torture and redress for victims, at times conflating prevention with the prohibition of torture. If it is to live up to its name, the cpta needs to expand its understanding of prevention of torture. This in turn will allow it to play an important role in detecting, collecting, analysing data and information on situations of risk in Africa, and formulating new and appropriate context-sensitive strategies for the effective prevention of torture.

scholarly journals The Intricate Network of Adipokines and Stroke

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Ema Kantorová ◽  
Ľubica Jesenská ◽  
Daniel Čierny ◽  
Kamil Zeleňák ◽  
Štefan Sivák ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Ischemic Stroke ◽  
Energy Homeostasis ◽  
Cerebrovascular Disorders ◽  
Overweight And Obesity ◽  
Central Energy ◽  
Critical Insight ◽  
Ambiguous Data ◽  
Insight Into

Cerebrovascular disorders, particularly ischemic stroke, are one of the most common neurological disorders. High rates of overweight and obesity support an interest in the role of adipose tissue and adipose tissue releasing cytokines in inducing associated comorbidities. Adipokines can serve as a key messenger to central energy homeostasis and metabolic homeostasis. They can contribute to the crosstalk between adipose tissue and brain. However recent research has offered ambiguous data on the network of adipose tissue, adipokines, and vascular disorders. In our paper we provide a critical insight into the role of adipokines in evolution of ischemic stroke.

Plasminogen Activation In Vivo upon Intravenous Infusion of DDAVP

1992 ◽  
Vol 67 (01) ◽  
pp. 111-116 ◽  
Author(s):  
Marcel Levi ◽  
Jan Paul de Boer ◽  
Dorina Roem ◽  
Jan Wouter ten Cate ◽  
C Erik Hack
Keyword(s):  
Monoclonal Antibodies ◽  
Plasminogen Activator ◽  
Plasma Levels ◽  
Fold Increase ◽  
Fibrinolytic System ◽  
Plasminogen Activation ◽  
Plasminogen Activator Activity ◽  
Insight Into

SummaryInfusion of desamino-d-arginine vasopressin (DDAVP) results in an increase in plasma plasminogen activator activity. Whether this increase results in the generation of plasmin in vivo has never been established.A novel sensitive radioimmunoassay (RIA) for the measurement of the complex between plasmin and its main inhibitor α2 antiplasmin (PAP complex) was developed using monoclonal antibodies preferentially reacting with complexed and inactivated α2-antiplasmin and monoclonal antibodies against plasmin. The assay was validated in healthy volunteers and in patients with an activated fibrinolytic system.Infusion of DDAVP in a randomized placebo controlled crossover study resulted in all volunteers in a 6.6-fold increase in PAP complex, which was maximal between 15 and 30 min after the start of the infusion. Hereafter, plasma levels of PAP complex decreased with an apparent half-life of disappearance of about 120 min. Infusion of DDAVP did not induce generation of thrombin, as measured by plasma levels of prothrombin fragment F1+2 and thrombin-antithrombin III (TAT) complex.We conclude that the increase in plasminogen activator activity upon the infusion of DDAVP results in the in vivo generation of plasmin, in the absence of coagulation activation. Studying the DDAVP induced increase in PAP complex of patients with thromboembolic disease and a defective plasminogen activator response upon DDAVP may provide more insight into the role of the fibrinolytic system in the pathogenesis of thrombosis.

On Metaphysics and the Political: A Polemics of Reading Baudelaire in the 1930s

2019 ◽  
Vol 58 (2) ◽  
pp. 249-259
Author(s):  
Joseph Acquisto
Keyword(s):  
Twentieth Century ◽  
Political Crisis ◽  
The Political ◽  
Modern Poetry ◽  
Progressive Politics ◽  
The World ◽  
Relationship Of ◽  
The Relationship ◽  
Insight Into

This essay examines a polemic between two Baudelaire critics of the 1930s, Jean Cassou and Benjamin Fondane, which centered on the relationship of poetry to progressive politics and metaphysics. I argue that a return to Baudelaire's poetry can yield insight into what seems like an impasse in Cassou and Fondane. Baudelaire provides the possibility of realigning metaphysics and politics so that poetry has the potential to become the space in which we can begin to think the two of them together, as opposed to seeing them in unresolvable tension. Or rather, the tension that Baudelaire animates between the two allows us a new way of thinking about the role of esthetics in moments of political crisis. We can in some ways see Baudelaire as responding, avant la lettre, to two of his early twentieth-century readers who correctly perceived his work as the space that breathes a new urgency into the questions of how modern poetry relates to the world from which it springs and in which it intervenes.

Importance of the Intersection of Library and Information Sciences with Systems Theory

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Hannah Lee
Keyword(s):  
System Theory ◽  
General System ◽  
General System Theory ◽  
Von Bertalanffy ◽  
Meta Level ◽  
Professional Field ◽  
The Subject ◽  
Critical Insight ◽  
Insight Into ◽  
Information Sciences

This paper is the attempt to show how system theory could provide critical insight into the transdisciplinary field of library and information sciences (LIS). It begins with a discussion on the categorization of library and information sciences as an academic and professional field (or rather, the lack of evidence on the subject) and what is exactly meant by system theory, drawing upon the general system theory established by Ludwig von Bertalanffy. The main conversation of this paper focuses on the inadequacies of current meta-level discussions of LIS and the benefits of general system theory (particularly when considering the exponential rapidity in which information travels) with LIS.

Intimacy as Transgression and the Problem of Freedom

2018 ◽  
Vol 1 (1) ◽  
pp. 18
Author(s):  
Kym Maclaren
Keyword(s):  
Intimate Relationships ◽  
Critical Analysis ◽  
Mutual Recognition ◽  
Public Institutions ◽  
The Other ◽  
Social Forces ◽  
Critical Insight ◽  
Insight Into ◽  
What Matters

“To consent to love or be loved,” said Merleau-Ponty, “is to consent also to influence someone else, to decide to a certain extent on behalf of the other.” This essay explicates that idea through a meditation on intimacy. I propose, first, that, on Merleau-Ponty’s account, we are always transgressing into each other’s experience, whether we are strangers or familiars; I call this “ontological intimacy.” Concrete experiences of intimacy are based upon this ontological intimacy, and can take place at two levels: (1) at-this-moment (such that we can experience intimacy even with strangers, by sharing a momentary but extra-ordinary mutual recognition) and (2) in shared interpersonal institutions, or habitual, enduring, and co-enacted visions of who we are, how to live, and what matters. Through particular examples of dynamics within these layers of intimacy (drawing upon work by Berne and by Russon), I claim that we are always, inevitably, imposing an “unfreedom” upon our intimate others. Freedom, then, can only develop from within and by virtue of this “unfreedom.” Thus, what distinguishes empowering or emancipating relationships from oppressive ones is not the removal of transgressive normative social forces; it is rather the particular character of those transgressive forces. Some transgressions upon others’ experience—some forms of “unfreedom”—will tend to promote freedom; others will tend to hinder it. This amounts to a call for promoting agency and freedom not only through critical analysis of public institutions, practices and discourses, but also through critical insight into and transformation of our most private and intimate relationships.

Dažu vācu muzikālo tradīciju pārnese latviešu kultūrtelpā 18. gadsimta II pusē

Letonica ◽  
2020 ◽  
Author(s):  
Māra Grudule
Keyword(s):  
18Th Century ◽  
Musical Instrument ◽  
German Society ◽  
Original Form ◽  
Musical Life ◽  
Popular Songs ◽  
Death Of Jesus ◽  
Musical Traditions ◽  
Insight Into

The article gives insight into a specific component of the work of Baltic enlightener Gotthard Friedrich Stender (1714–1796) that has heretofore been almost unexplored — the transfer of German musical traditions to the Latvian cultural space. Even though there are no sources that claim that Stender was a composer himself, and none of his books contain musical notation, the texts that had been translated by Stender and published in the collections “Jaunas ziņģes” (New popular songs, 1774) and “Ziņģu lustes” (The Joy of singing, 1785, 1789) were meant for singing and, possibly, also for solo-singing with the accompaniment of some musical instrument. This is suggested, first, by how the form of the translation corresponds to the original’s form; second, by the directions, oftentimes attached to the text, that indicate the melody; and third, by the genres of the German originals cantata and song. Stender translated several compositions into Latvian including the text of the religious cantata “Der Tod Jesu” (The Death of Jesus, 1755) by composer Karl Heinrich Graun (1754–1759); songs by various composers that were widely known in German society; as well as a collection of songs by the composer Johann Gottlieb Naumann (1741–1801) that, in its original form, was published together with notation and was intended for solo-singing (female vocals) with the accompaniment of a piano. This article reveals the context of German musical life in the second half of the 18th century and explains the role of music as an instrument of education in Baltic-German and Latvian societies.

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