Papular-purpuric "gloves and socks" syndrome caused by parvovirus B19

This paper presents a 15-year-old boy with an acute febrile illness accompanied by purpuric and papular lesions located mostly on the dorsal areas of his hands and feet with the additional changes on his knees and elbows. Serologic studies confirmed the acute infection by parvovirus B19. Apart from mild leukocytosis there were no other abnormalities in hematologic and laboratory findings. The diagnosis of papular-purpuric "gloves and socks" syndrome (PPGSS) was made. Cutaneous changes completely resolved two weeks later. Herein the patient's condition was described together with a brief overview of the PPGSS literature concerning this relatively rare viral exanthema.

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Jamestown Canyon virus-mediated meningoencephalitis with unusual laboratory findings

BMJ Case Reports ◽

10.1136/bcr-2021-242014 ◽

2021 ◽

Vol 14 (7) ◽

pp. e242014

Author(s):

Dilpat Kumar ◽

Anmol Hans ◽

Fnu Warsha ◽

Nicholas Helmstetter

Keyword(s):

Febrile Illness ◽

Cross Reactivity ◽

Acute Febrile Illness ◽

Laboratory Findings ◽

Bacterial Cultures ◽

Csf Analysis ◽

The Usa ◽

Jamestown Canyon Virus ◽

Low Glucose ◽

Human Infections

Jamestown Canyon virus (JCV) is a mosquito-borne orthobunyavirus that causes an acute febrile illness, meningitis or meningoencephalitis. Human infections in the USA are rare. A 59-year-old man was admitted with fever, headache and hallucinations and required transfer to intensive care due to worsening agitation. Lumbar puncture was significant for neutrophilic pleocytosis, low glucose and high protein. Cerebral spinal fluid (CSF) bacterial cultures were negative, however, the CSF analysis via ELISA returned positive for JCV IgM. Plaque reduction neutralisation tests on a serum sample revealed IgM for JCV with titres of 1:160, which confirmed the diagnosis of JCV meningoencephalitis as the titres for other arboviruses were low. The patient improved significantly with supportive care. Our case highlights an atypical laboratory presentation of neutrophilic pleocytosis on CSF in a viral meningoencephalitis and draws attention to the potential cross-reactivity with other arboviruses.

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On Slow Lactose Fermenting B. Coli in Urinary and Intestinal Infections

Journal of Hygiene ◽

10.1017/s0022172400009153 ◽

1927 ◽

Vol 26 (3) ◽

pp. 285-304 ◽

Cited By ~ 22

Author(s):

Leonard S. Dudgeon ◽

R. J. V. Pulvertaft

Keyword(s):

Urinary Tract ◽

Pure Culture ◽

Acute Infection ◽

Acute Diarrhoea ◽

Febrile Illness ◽

Acute Febrile Illness ◽

Urinary Infections ◽

Intestinal Infections ◽

Paratyphoid Fever

(a) The slow lactose fermenting bacilli which we have investigated cause an acute febrile illness in man. The general symptoms may be so severe that the diagnosis of typhoid and paratyphoid fever has been made. Such cases are invariably due to an acute infection of the urinary tract, more specially acute pyelitis or pyelo-nephritis, but the general symptoms may be so severe at the onset of the illness that the urinary manifestations are masked.(b) Three fatal cases have occurred.(c) In cases of acute diarrhoea, with or without blood and mucus, these bacilli may be present in pure culture in the faeces.(d) Chronic urinary infections due to these bacilli are uncommon.(e) The bacillus of so-called columbensis fever is allied to these bacilli.

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Mycoplasma pneumoniae Infection Presenting as Bullous Papular Purpuric Gloves and Socks Syndrome

Clinical Pediatrics ◽

10.1177/0009922811414290 ◽

2011 ◽

Vol 50 (12) ◽

pp. 1140-1143 ◽

Cited By ~ 5

Author(s):

Sree Mallikarjuna Pemira ◽

Robert W. Tolan

Keyword(s):

Young Adults ◽

Mycoplasma Pneumoniae ◽

Parvovirus B19 ◽

Febrile Illness ◽

Adolescent Male ◽

Children And Young Adults ◽

Mucosal Lesions ◽

Hands And Feet ◽

Mycoplasma Pneumoniae Infection

Papular purpuric gloves and socks syndrome (PPGSS) is a self-limited, often febrile illness with symmetric edema and erythema of the hands and feet; papular, petechial, and purpuric acral dermatosis; and mucosal lesions in children and young adults. Most of the cases of PPGSS have been reported to be caused by parvovirus B19 and other viruses. This study describes a case resulting from Mycoplasma pneumoniae infection in an adolescent male and reviews the literature.

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A newer approach for the serodiagnosis of leptospirosis using outer membrane proteins of leptospira interrogans serovar tarassovi

Asian Journal of Medical Sciences ◽

10.3126/ajms.v4i2.6693 ◽

2013 ◽

Vol 4 (2) ◽

pp. 41-46 ◽

Cited By ~ 2

Author(s):

MM Premlatha ◽

IR Kaur ◽

R Avasthi ◽

AB Dey ◽

R Chaudhry

Keyword(s):

Outer Membrane Proteins ◽

Acute Infection ◽

Febrile Illness ◽

Acute Febrile Illness ◽

Medical Sciences ◽

Study Materials ◽

Group I ◽

Igm Elisa ◽

Significant Health ◽

Sera Samples

Objective: Leptospirosis in humans occurs throughout the world as an acute infection ranging imperceptible to severe, potentially fatal, renal and liver failure accompanied by haemorrhage and jaundice. In India, according to number of reports, Leptospirosis has been a significant health problem since 1980. This disease mimics influenza, hepatitis, dengue owing to which it often goes undiagnosed due to lack of awareness and diagnostic facilities in most of the laboratories in the country. This study was undertaken to diagnose suspected cases of Leptospirosis by IgM ELISA, DRIDOT and MAT, and also to standardize an in house IgM ELISA using OMP antigens of the L.tarassovi the predominant serovar in the study Materials & Methods: Blood samples were collected from a total of 287 patients (186 male and 101 female) presenting with acute febrile illness and fulfilling the criteria of clinical diagnosis of Leptospirosis. All the samples & healthy controls were subjected to ELISA (IgM serion), dridot, MAT, and Leptospira serovar Tarassovi OMP IgM ELISA, and for isolation of Leptospira. Results: IgM antibody could be detected by ELISA, Dridot and OMP ELISA of L. Tarassovi from Group I and Group II sera samples. It was observed by MAT that L.Tarassovi was the predominant serovar followed by L.australis, L.autumnalis, L.sejroe, L.pyrogenes, L.ballum, L.canicola, L.icterocopenhageni, L.cynopteri. A total of 5 isolates were recovered from Group I patients. Conclusion: IgM ELISA using sarcosyl extracted OMP antigens of serovar Tarassovi when compared with MAT the overall sensitivity and specificity was 72% and 81% respectively. The same sera reacted with serovar Australis, serovar Tarassovi, serovar Sejroe, serovar Pyrogenes, serovar Ballum and serovar Icterocopenhageni in MAT. DOI: http://dx.doi.org/10.3126/ajms.v4i2.6693 Asian Journal of Medical Sciences 4(2013) 41-46

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Digitale Durchblutungsstörungen und Parvovirus B19 Infektion

VASA ◽

10.1024/0301-1526.31.4.274 ◽

2002 ◽

Vol 31 (4) ◽

pp. 274-275 ◽

Cited By ~ 1

Author(s):

Kern

Keyword(s):

Differential Diagnosis ◽

White Woman ◽

Parvovirus B19 ◽

Febrile Illness ◽

Acute Febrile Illness ◽

Erythema Infectiosum ◽

The Family ◽

Parvovirus B19 Infection ◽

Occlusive Arteriopathy

We report a case of a 37-year-old white woman, who presented with digital arterial occlusions associated with parvovirus B19 infection. Two other member of the family presented acute febrile illness, polyarthralgia (husband), and erythema infectiosum (son) during the same month. This new report gives weight to the concept that acute human parvovirus infection could become part of the differential diagnosis of acute digital occlusive arteriopathy.

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Desquamation in Kawasaki Disease

Children ◽

10.3390/children8050317 ◽

2021 ◽

Vol 8 (5) ◽

pp. 317

Author(s):

Ling-Sai Chang ◽

Ken-Pen Weng ◽

Jia-Huei Yan ◽

Wan-Shan Lo ◽

Mindy Ming-Huey Guo ◽

...

Keyword(s):

Coronary Artery ◽

Kawasaki Disease ◽

Laboratory Data ◽

Ivig Treatment ◽

Low Grade ◽

High Grade ◽

Laboratory Findings ◽

Coronary Artery Abnormalities ◽

Cell Counts ◽

Hands And Feet

(1) Background: Desquamation is a common characteristic of Kawasaki disease (KD). In this study, we analyzed patients’ varying desquamation levels in their hands or feet, in correlation with clinical presentation, to assess the relationship. (2) Methods: We retrospectively reviewed children with KD. We analyzed their age, laboratory data before intravenous immunoglobulin (IVIG) treatment and coronary artery abnormalities (CAA) based on the desquamation level of their hands and feet. We classified the desquamation level from 0 to 3 and defined high-grade desquamation as grade 2 and 3. (3) Results: We enrolled a total 112 patients in the study. We found the hands’ high-grade desquamation was positively associated with age and segmented neutrophil percentage (p = 0.047 and 0.029, respectively) but negatively associated with lymphocyte and monocyte percentage (p = 0.03 and 0.006, respectively). Meanwhile, the feet’s high-grade desquamation was positively associated with total white blood cell counts (p = 0.033). Furthermore, we found that high-grade hand desquamation had less probability of CAA formation compared with that of a low grade (7.1% vs. 40.8%, p = 0.016). (4) Conclusions: This report is the first to demonstrate that the desquamation level of hands or feet in KD is associated with different coronary artery abnormalities and laboratory findings.

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Prediction of disease severity in young children presenting with acute febrile illness in resource-limited settings: a protocol for a prospective observational study

BMJ Open ◽

10.1136/bmjopen-2020-045826 ◽

2021 ◽

Vol 11 (1) ◽

pp. e045826

Author(s):

Arjun Chandna ◽

Endashaw M Aderie ◽

Riris Ahmad ◽

Eggi Arguni ◽

Elizabeth A Ashley ◽

...

Keyword(s):

Observational Study ◽

Prediction Model ◽

Prospective Observational Study ◽

Model Building ◽

Venous Blood ◽

Febrile Illness ◽

Nasopharyngeal Swab ◽

Acute Febrile Illness ◽

Clinical Prediction ◽

Open Access Journals

IntroductionIn rural and difficult-to-access settings, early and accurate recognition of febrile children at risk of progressing to serious illness could contribute to improved patient outcomes and better resource allocation. This study aims to develop a prognostic clinical prediction tool to assist community healthcare providers identify febrile children who might benefit from referral or admission for facility-based medical care.Methods and analysisThis prospective observational study will recruit at least 4900 paediatric inpatients and outpatients under the age of 5 years presenting with an acute febrile illness to seven hospitals in six countries across Asia. A venous blood sample and nasopharyngeal swab is collected from each participant and detailed clinical data recorded at presentation, and each day for the first 48 hours of admission for inpatients. Multianalyte assays are performed at reference laboratories to measure a panel of host biomarkers, as well as targeted aetiological investigations for common bacterial and viral pathogens. Clinical outcome is ascertained on day 2 and day 28.Presenting syndromes, clinical outcomes and aetiology of acute febrile illness will be described and compared across sites. Following the latest guidance in prediction model building, a prognostic clinical prediction model, combining simple clinical features and measurements of host biomarkers, will be derived and geographically externally validated. The performance of the model will be evaluated in specific presenting clinical syndromes and fever aetiologies.Ethics and disseminationThe study has received approval from all relevant international, national and institutional ethics committees. Written informed consent is provided by the caretaker of all participants. Results will be shared with local and national stakeholders, and disseminated via peer-reviewed open-access journals and scientific meetings.Trial registration numberNCT04285021.

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Differential Laboratory Diagnosis of Acute Fever in Guinea: Preparedness for the Threat of Hemorrhagic Fevers

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18116022 ◽

2021 ◽

Vol 18 (11) ◽

pp. 6022

Author(s):

Vladimir G. Dedkov ◽

N’Faly Magassouba ◽

Olga A. Stukolova ◽

Victoria A. Savina ◽

Jakob Camara ◽

...

Keyword(s):

Ebola Virus ◽

Febrile Illness ◽

Laboratory Diagnosis ◽

Acute Febrile Illness ◽

Causative Pathogen ◽

Hemorrhagic Fevers ◽

Wide Range ◽

Causative Agents ◽

Pathognomonic Sign

Acute febrile illnesses occur frequently in Guinea. Acute fever itself is not a unique, hallmark indication (pathognomonic sign) of any one illness or disease. In the infectious disease context, fever’s underlying cause can be a wide range of viral or bacterial pathogens, including the Ebola virus. In this study, molecular and serological methods were used to analyze samples from patients hospitalized with acute febrile illness in various regions of Guinea. This analysis was undertaken with the goal of accomplishing differential diagnosis (determination of causative pathogen) in such cases. As a result, a number of pathogens, both viral and bacterial, were identified in Guinea as causative agents behind acute febrile illness. In approximately 60% of the studied samples, however, a definitive determination could not be made.

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Scrub Typhus and Molecular Characterization of Orientia tsutsugamushi from Central Nepal

Pathogens ◽

10.3390/pathogens10040422 ◽

2021 ◽

Vol 10 (4) ◽

pp. 422

Author(s):

Rajendra Gautam ◽

Keshab Parajuli ◽

Mythili Tadepalli ◽

Stephen Graves ◽

John Stenos ◽

...

Keyword(s):

Genetic Diversity ◽

Scrub Typhus ◽

Febrile Illness ◽

Acute Febrile Illness ◽

Limited Information ◽

Orientia Tsutsugamushi ◽

Health Measures ◽

Central Nepal ◽

Vector Borne

Scrub typhus is a vector-borne, acute febrile illness caused by Orientia tsutsugamushi. Scrub typhus continues to be an important but neglected tropical disease in Nepal. Information on this pathogen in Nepal is limited to serological surveys with little information available on molecular methods to detect O. tsutsugamushi. Limited information exists on the genetic diversity of this pathogen. A total of 282 blood samples were obtained from patients with suspected scrub typhus from central Nepal and 84 (30%) were positive for O. tsutsugamushi by 16S rRNA qPCR. Positive samples were further subjected to 56 kDa and 47 kDa molecular typing and molecularly compared to other O. tsutsugamushi strains. Phylogenetic analysis revealed that Nepalese O. tsutsugamushi strains largely cluster together and cluster away from other O. tsutsugamushi strains from Asia and elsewhere. One exception was the sample of Nepal_1, with its partial 56 kDa sequence clustering more closely with non-Nepalese O. tsutsugamushi 56 kDa sequences, potentially indicating that homologous recombination may influence the genetic diversity of strains in this region. Knowledge on the circulating strains in Nepal is important to the development of diagnostic tests and vaccines to support public health measures to control scrub typhus in this country.

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