scholarly journals Prevalence and Clinical Correlation of Vitamin D Inadequacy in Traumatic Hip Fracture among Elderly Patients

2019 ◽  
Vol 3 (4) ◽  
pp. 1-8
Author(s):  
Phruetthiphat O
Keyword(s):  
Vitamin D ◽  
Hip Fracture ◽  
Elderly Patients ◽  
Vitamin D Deficiency ◽  
Orthopedic Surgery ◽  
Normal Population ◽  
Mechanical Failure ◽  
Vitamin D Status ◽  
Clinical Correlation ◽  
Ambulatory Status

Introduction : High prevalence of vitamin D deficiency has been described in more than 1 billion people around the world, es pecially in Middle - East and Asia. In Thailand, the largest study of vitamin D status in normal population (N=2641) identified overall 45.2 percent of vitamin D inadequacy in normal population. However, there was no study focusing on Vitamin D inadequacy in traumatic elderly patients. The purpose of this study is going to define the prevalence of vitamin D inadequacy in traumatic hip fracture among elderly patients and to identify a clinical correlation. Materials and Methods : A prospective study of elderly patients (more than 60 years old) with low energy trauma who underwent orthopaedic surgery at Phramongkutklao Hospital between the period of January 2016 and December 2016. All hip fracture patients underwent orthopedic surgery were collected for demograph ic data, comorbidities including Charlson Comorbidity Index. Primary outcome was to identify a prevalence of vitamin D inadequacy (<30 ng/ml) and vitamin D deficiency (<20 ng/ml) in hip fracture underwent orthopedic surgery. Secondary outcome was to define association of demographic data, comorbidity with vitamin D level. Additionally, comparison the ambulatory status and mechanical failure between normal vitamin D and vitamin D inadequacy Results : The serum 25(OH)D levels for this study was normally distri buted, with a mean of 25.0±12.2 ng/ml in all patients, Prevalence of vitamin D inadequacy was 70.5 percent (n=103) and the prevalence of vitamin D deficiency was 37.7 percent (n=55). There was no significant difference of ambulatory status between vitamin D inadequacy and sufficient vitamin D groups (p=0.958). Additionally, there was not different in mechanical failure between groups (4.5% and 0%, p=1.000). Conclusion : Vitamin D inadequacy is so common in traumatic elderly patients. We should raise attentiveness among physician to determine vitamin D status. Public health strategy should add knowledge about diet, supplements or adequate sun exposure to elderly population . Vitamin D inadequacy did not affect the outcome including time to union and ambulatory status at 1 year follow up.

scholarly journals Preoperative Vitamin D Deficiency is Associated with Postoperative Functional Recovery and Complications after Hip Fracture Surgery

2021 ◽  
Vol 28 (4) ◽  
pp. 333-338
Author(s):  
Chaemoon Lim ◽  
Young Ho Roh ◽  
Saeil Kim ◽  
Kwang Woo Nam
Keyword(s):  
Vitamin D ◽  
Hip Fracture ◽  
Elderly Patients ◽  
Hospital Stay ◽  
Vitamin D Deficiency ◽  
Functional Recovery ◽  
Walking Ability ◽  
Preoperative Serum ◽  
The Mean ◽  
Deficient Group

Background: Low concentrations of vitamin D are considered one of the risk factors for hip fracture and are associated with worse outcomes. The purpose of this retrospective study was to compare vitamin D deficient group and vitamin D sufficient group and assess the association preoperative vitamin D deficiency and postoperative walking ability after hip fracture surgery.Methods: Between January 2014 and January 2020, 1,029 elderly patients with hip fracture (243 in men and 785 in women) were measured preoperative serum 25-hydroxy-vitamin D3 levels. Among 1,029 elderly patients, 702 patients were classified as Vitamin D deficient group (<20 ng/mL). Outcome parameters for functional recovery were the length of the hospital stay and KOVAL score, and those for complications were delirium, pneumonia, and thromboembolism.Results: The mean length of the hospital stay in the vitamin D deficient group was significantly longer than in the vitamin D sufficient group (27.7±17.8 vs. 2.9±11.8 days; odds ratio [OR], 1.03; 95% confidence interval [CI], 1.02-1.05; P=0.001). The mean postoperative KOVAL score in the deficient group was significantly higher than in the sufficient group (4.0±2.1 vs. 3.1±1.9 days; OR, 1.21; 95% CI, 1.11-1.32; P=0.001). Vitamin D deficiency was significantly associated with a higher risk of delirium and pneumonia in deficiency group.Conclusions: Preoperative vitamin D deficiency in hip fractures patients was associated with prolonged duration of hospital stay and decrease of postoperative ambulatory status, and may increase the risk of delirium and pneumonia. Therefore, it is necessary to evaluate the preoperative vitamin D level and recommend vitamin D supplementation in elderly patients with a high probability of hip fracture.

scholarly journals Evaluation of vitamin D status in children with refractory epilepsy

2014 ◽  
Author(s):  
Pakize Karaoğlu ◽  
Ayşe İpek Polat ◽  
Müge Ayanoğlu ◽  
Uluç Yiş ◽  
Semra Hız
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Antiepileptic Drugs ◽  
Refractory Epilepsy ◽  
Vitamin D Status ◽  
Ambulatory Status ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D

OBJECTIVE: Vitamin D deficiency has been implicated in children using antiepileptic drugs. Multiple antiepileptic drugs may increase the risk of vitamin D deficiency. The aim of this study is to evaluate the vitamin D status and risk factors for vitamin D deficiency in children with refractory epilepsy. METHODS: Forty children with refractory epilepsy seen in our tertiary pediatric neurology outpatient clinic were included and serum 25-hydroxy vitamin D, parathyroid hormone, calcium, phosphate and alkaline phosphatase were measured. Vitamin D deficiency was defined as 25-hydroxy vitamin D levels <20 ng/mL, and insufficiency between 21 and 29 ng/mL. Correlation between vitamin D levels and type of epilepsy (generalized or localization related), etiology of epilepsy (symptomatic vs idiopathic), body mass index, seizure frequency, number of antiepileptic drugs, type of antiepileptic drugs (old or new; enzyme inducing or not), presence of intellectual disability, ambulatory status and gross motor function classification scores were evaluated. RESULTS: The study group consisted of 17 boys and 23 girls with a mean age of 6.65 ± 5.29 years. Vitamin D deficiency was identified in 25 (62.5%) and insufficiency in 6 (15%) of the patients. There was no correlation between vitamin D levels and type of epilepsy, etiology of epilepsy, body mass index, seizure frequency, number of antiepileptic drugs, type of antiepileptic drugs, presence of intellectual disability, ambulatory status and gross motor function classification scores. CONCLUSION: We found that vitamin D deficiency was high in this cohort of children with refractory epilepsy. Vitamin D level should be monitored in patients with refractory epilepsy irrespective of the potential risk factors.

Getting hip to vitamin D: A hospitalist project for improving the assessment and treatment of vitamin D deficiency in elderly patients with hip fracture

2014 ◽  
Vol 9 (11) ◽  
pp. 714-719 ◽  
Author(s):  
John R. Stephens ◽  
Christine Williams ◽  
Eric Edwards ◽  
Paul Ossman ◽  
Darren A. DeWalt
Keyword(s):  
Vitamin D ◽  
Hip Fracture ◽  
Elderly Patients ◽  
Vitamin D Deficiency ◽  
Assessment And Treatment

Vitamin D Deficiency in Patients with Acute Myocardial Infarction: An Italian Single-Center Study

2015 ◽  
Vol 85 (1-2) ◽  
pp. 23-30 ◽  
Author(s):  
Aneta Aleksova ◽  
Rita Belfiore ◽  
Cosimo Carriere ◽  
Salam Kassem ◽  
Salvatore La Carrubba ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Primary Source ◽  
Sun Exposure ◽  
Female Gender ◽  
Developed Countries ◽  
Vitamin D Status ◽  
High Exposure

Abstract. Background: Hypovitaminosis D is a vitamin deficiency that has been increasing in developed countries; it was also suggested as an emerging risk factor for developing of atherosclerosis and acute myocardial infarction. The primary source of vitamin D is its cutaneous synthesis under exposure to sunlight. It has been suggested that 30 min of sun exposure twice weekly leads to sufficient vitamin D synthesis. The residents of Trieste (Italy) are well-known for their high exposure to sunlight in all seasons. We aimed to investigate the vitamin D status in subjects with acute myocardial infarction living in this area. Methods: Vitamin D status was identified in 478 subjects diagnosed with acute myocardial infarction. Results: The median serum 25-hydroxyvitamin D concentration was 14.5 [7.8 - 22.7] ng/mL. Vitamin D deficiency and insufficiency were present in 324 (68 %) and 107 (22 %) subjects, respectively. Vitamin D deficiency was less frequent among subjects enrolled in the period from July to the end of September (p < 0.001). In a multivariate analysis vitamin D deficiency was predicted by older age (p = 0.02), female gender (p = 0.002), higher body mass index (p = 0.05), autumn/winter sampling (p < 0.001), increased parathyroid hormone (p = 0.03) and alkaline phosphatase (p = 0.003). Conclusions: We observed very high prevalence of vitamin D deficiency among subjects with myocardial infarction in all seasons of enrollment. However, it was lower in the summer when sun exposure is higher. The exposure to sunlight may be a cost-saving therapeutic strategy for the management of vitamin D deficiency.

Vitamin D Deficiency/Insufficiency and Challenges in Developing Global Vitamin D Fortification and Supplementation Policy in Adults

2012 ◽  
Vol 82 (4) ◽  
pp. 237-259 ◽  
Author(s):  
Moshe Ben-Shoshan
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Search Strategy ◽  
Epidemiologic Studies ◽  
Vitamin D Supplementation ◽  
Vitamin D Status ◽  
Societal Burden ◽  
Time Period ◽  
New Guidelines ◽  
In Cis

This review summarizes studies discussing vitamin D status in adults and reveals that vitamin D deficiency/insufficiency is highly prevalent in adults and that current fortification and supplementation policies are inadequate. Background and aims: Studies suggest a crucial role for adequate vitamin D status in various health conditions including bone metabolism, cancer, cardiovascular diseases, and allergies. However, relatively little is known about poor vitamin D status and unmet needs in adults. This report aims to highlight the contribution of epidemiologic studies (through the identification of health effects and societal burden) to the development of vitamin D fortification and supplementation policies and reveal unmet global challenges in adults. Methods: In order to assess worldwide vitamin D status in adults, the search strategy combined the medical literature database MEDLINE (using PubMed) for the time period between January 1, 1980 and February 28, 2011, using the key words “vitamin D” “deficiency” and “insufficiency”, and included articles in which access to full text was possible and in which healthy adults were assessed according to one of four commonly used vitamin D threshold classifications. Results: This report reveals that vitamin D deficiency occurs in 4.10 % [95 % CI (confidence interval), 3.93 %, 4.27 %] to 55.05 % (54.07 %, 56.03 %) of adults, while insufficiency occurs in 26.07 % (24.82 %, 27.33 %) to 78.50 % (77.85 %, 79.16 %), depending on the classification used. However, lack of overlap in CIs and high value of I2 statistics indicate considerable heterogeneity between studies. Further, certain populations (i. e. dark-skinned individuals, immigrants, and pregnant women) may be at higher risk for poor vitamin D status. Conclusion: Current policies for vitamin D supplementation and fortification are inadequate and new guidelines are required to improve vitamin D status in adults.

scholarly journals Vitamin D and Cardiovascular Disease: An Updated Narrative Review

2021 ◽  
Vol 22 (6) ◽  
pp. 2896
Author(s):  
Armin Zittermann ◽  
Christian Trummer ◽  
Verena Theiler-Schwetz ◽  
Elisabeth Lerchbaum ◽  
Winfried März ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin D ◽  
High Risk ◽  
General Population ◽  
Vitamin D Deficiency ◽  
Specific Gene ◽  
Vitamin D Status ◽  
Cvd Risk ◽  
Severe Vitamin ◽  
Increased Risk

During the last two decades, the potential impact of vitamin D on the risk of cardiovascular disease (CVD) has been rigorously studied. Data regarding the effect of vitamin D on CVD risk are puzzling: observational data indicate an inverse nonlinear association between vitamin D status and CVD events, with the highest CVD risk at severe vitamin D deficiency; however, preclinical data and randomized controlled trials (RCTs) show several beneficial effects of vitamin D on the surrogate parameters of vascular and cardiac function. By contrast, Mendelian randomization studies and large RCTs in the general population and in patients with chronic kidney disease, a high-risk group for CVD events, largely report no significant beneficial effect of vitamin D treatment on CVD events. In patients with rickets and osteomalacia, cardiovascular complications are infrequently reported, except for an increased risk of heart failure. In conclusion, there is no strong evidence for beneficial vitamin D effects on CVD risk, either in the general population or in high-risk groups. Whether some subgroups such as individuals with severe vitamin D deficiency or a combination of low vitamin D status with specific gene variants and/or certain nutrition/lifestyle factors would benefit from vitamin D (metabolite) administration, remains to be studied.

scholarly journals High prevalence of vitamin D deficiency in elderly patients with advanced osteoarthritis scheduled for total knee replacement associated with poorer preoperative functional state

2013 ◽  
Vol 95 (8) ◽  
pp. 569-572 ◽  
Author(s):  
JA Jansen ◽  
FS Haddad
Keyword(s):  
Vitamin D ◽  
Total Knee Replacement ◽  
Elderly Patients ◽  
Knee Osteoarthritis ◽  
Vitamin D Deficiency ◽  
Knee Replacement ◽  
Functional State ◽  
High Prevalence ◽  
Outcome Scores ◽  
Total Knee

Vitamin D deficiency has been reported previously in patients with osteoarthritis undergoing total hip arthroplasty. We found a high prevalence of vitamin D deficiency in elderly patients with advanced knee osteoarthritis scheduled for total knee replacement and also a significant association with a lower preoperative functional state. A review of the literature is given on vitamin D deficiency in patients with knee osteoarthritis and the association with lower outcome scores after arthroplasty is discussed.

scholarly journals Vitamin D status and bone turnover marker levels in Greek women with fragility hip fracture

2017 ◽  
Vol 3 (1i) ◽  
pp. 564-567
Author(s):  
Efstathios Drampalos ◽  
Lazaros Oikonomidis ◽  
Jeremy Oakley ◽  
Ioannis Michos ◽  
fstathios Chronopoulos
Keyword(s):  
Vitamin D ◽  
Hip Fracture ◽  
Bone Turnover ◽  
Bone Turnover Marker ◽  
Vitamin D Status ◽  
Fragility Hip Fracture

scholarly journals Vitamin D status in pregnant women and their newborns in a tertiary care hospital

2018 ◽  
Vol 7 (12) ◽  
pp. 5071
Author(s):  
Harleen Kour ◽  
Shashi Gupta ◽  
Swarn K. Gupta ◽  
Bawa Ram Bhagat ◽  
Gagan Singh
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Tertiary Care ◽  
North India ◽  
Care Hospital ◽  
Vitamin D Status ◽  
Pregnant Females ◽  
Vitamin D Levels ◽  
Maternal And Newborn

Background: In the recent years there has been an increased understanding of the role that vitamin D plays in regulation of cell growth, calcium absorption and immunity and its impact on the developing fetus and maternal health is of significant concern. This study aims at evaluating the Vitamin D status in pregnant women and their newborns.Methods: A cross sectional study was done on 100 pregnant females according to inclusion and exclusion criteria. At the time of delivery, maternal blood was collected, and newborn samples were taken from newborn side of umbilical cord and sent for analysis.Results: The prevalence of Vitamin D deficiency has been found to be 85% of pregnant females and 91% of the newborns. Only 5% of pregnant females and 1% of the newborns showed Vitamin D sufficiency. Maternal and newborn vitamin D levels show a positive correlation. Mean maternal and newborn Vitamin D levels were found to be 16.78±7.04 ng/mL and 11.29±5.75 ng/ml.Conclusions: Vitamin D deficiency is highly prevalent among pregnant women in north India. Low maternal vitamin D levels lead to vitamin D deficiency in the newborns also.

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